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| 1 | Nutritional status and nutritional therapy in inflammatory bowel diseases显示文摘Underweight and specific nutrient deficiencies are frequent in adult patients with inflammatory bowel disease(IBD).In addition,a significant number of children with IBD,especially Crohn's disease(CD) have impaired linear growth.Nutrition has an important role in the management of IBD.In adults with CD,enteral nutrition(EN) is effective in inducing clinical remission of IBD,although it is less efficient than corticosteroids.Exclusive EN is an established primary therapy for pediatric CD.Limited data suggests that EN is as efficient as corticosteroids for induction of remission.Additional advantages of nutritional therapy are control of inflammation,mucosal healing,positive benefits to growth and overall nutritional status with minimal adverse effects.The available evidence suggests that supplementary EN may be effective also for maintenance of remission in CD.More studies are needed to confirm these findings.However,EN supplementation could be considered as an alternative or as an adjunct to maintenance drug therapy in CD.EN does not have a primary therapeutic role in ulcerative colitis.Specific compositions of enteral dietselemental diets or diets containing specific components-were not shown to have any advantage over standard polymeric diets and their place in the treatment of CD or UC need further evaluation.Recent theories suggest that diet may be implicated in the etiology of IBD,however there are no proven dietary approaches to reduce the risk of developing IBD. | Corina Hartman Rami Eliakim Raanan Shamir | 2009 | World Journal of Gastroenterology2009，15，21： | 44 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis显示文摘 | Axel Dignass Rami Eliakim Fernando Magro Christian Maaser Yehuda Chowers Karel Geboes Gerassimos Mantzaris Walter Reinisch Jean-Frederic Colombel Severine Vermeire Simon Travis James O. Lindsay Gert Van Assche | 2012 | Journal of Crohn’s and Colitis2012，，10： | 12 |
| 3 | Cytomegalovirus positive ulcerative colitis:A single center experience and literature review显示文摘AIM:To compare the clinical outcome of cytomegalovirus(CMV)-positive ulcerative colitis(UC) patients with and without antiviral therapy.METHODS:This was a retrospective case-controlled study.The database of UC patients in our institution was scanned for documented presence of CMV on colonic biopsies.Demographics,clinical data,endoscopy findings and pathology reports were extracted from the patients' charts and electronic records.When available,the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also ex-tracted.The primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the follow-up.RESULTS:Thirteen patients were included in the study,7(53.5%) of them were treated with gancyclovir and 6(46.5%) were not.Patients treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir,while none of the patients without antivirals required rescue therapy.One patient died and another patient underwent urgent colectomy during hospitalization,both of them from the gancyclovir-treatment group.For the entire follow-up time(13 ± 13 mo),a total of 3 colectomies and one death occurred,all among the antiviral-treated patients(for colectomy:3/7 vs 0/6 patients,P = 0.19;for combined adverse outcome:4/7 vs 0/6 patients,P = 0.07).In 9/13 patients,immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient only.CONCLUSION:Gancyclovir-treated patients had a more severe disease and outcome,probably unrelated to antiviral therapy.Immunohistochemistry-CMV-positive patients with mild disease may recover without antiviral therapy. | Uri Kopylov Gila Sasson Bella Geyshis Michal Tepperberg Oikawa Iris Barshack Rami Eliakim Shomron Ben-Horin | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 10 |
| 4 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 5 | Effect of smoking on inflammatory bowel disease: Is it disease or organ specific?显示文摘吸烟与在 ulcerative (UC ) 和 Crohn 的疾病(CD ) 的不同效果是在煽动性的肠疾病(IBD ) 的一个重要环境因素。从来不吸烟并且先前吸烟增加 UC 的风险,而吸烟加重 CD 的功课。涉及这种双关系的潜在的机制是还未知的。一个合理假设是吸烟穿上不同效果小并且大肠。这个假设基于动物,人学习在 CD 和 UC 上烟 / 烟碱的效果取决于的那表演发炎并且不在疾病的类型上的地点。 | A Karban R Eliakim | 2007 | World Journal of Gastroenterology2007，13，15： | 7 |
| 6 | Wireless capsule video endoscopy:Three years of experience显示文摘AIM:To review and summerize the current literatue regarding M2A wireless capsule endoscopy.METHODS:Peer reviewed publications regarding the use of capsule endoscopy as well as our personal experience were reviewed.RESULTS:Review of the literature dearly showed that capsule endoscopy was superior th enteroscopy,small bowel follow through and computerized tomography in aptients with obscure qastrointestinal bleeding,iron deficiency anemia,or suspected Crohn's disease.It was very sensitive for the diagnosis of small bowel tumors and for survailance of small bowel pathology in patients with Gardner syndrome or familial adenomatous polyposeis syndrome.Its role in celiac disease and in patients with kmown Crohn's disease was currently being investigated.CONGLUSION:Capsule video endoscopy is a superior and more sensitive diagnostic tool than barium follow through,enteroscopy and entero-CT in establishing the diagnosis of many small bowel pathologyes. | Rami Eliakim | 2004 | World Journal of Gastroenterology2004，10，9： | 7 |
| 7 | Capsule endoscopy in pediatric patients显示文摘Wireless capsule endoscope (WCE) for the investigation of the small bowel is an approved technique both in adults and children (more than 10 years old). The present review provides data on the indications, diagnostic yield, adverse events and limitations of the WCE technique in children and tries to predict the future of WCE usage in this population of patients. | Raanan Shamir Rami Eliakim | 2008 | World Journal of Gastroenterology2008，14，26： | 6 |
| 8 | Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%. | Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 4 |
| 9 | Video capsule endoscopy of the small bowel显示文摘 | Rami Eliakim | 2013 | Current Opinion in Gastroenterology2013，，2： | 3 |
| 10 | European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease显示文摘 | J.F. Rahier S. Ben-Horin Y. Chowers C. Conlon P. De Munter G. D’Haens E. Domènech R. Eliakim A. Eser J. Frater M. Gassull M. Giladi A. Kaser M. Lémann T. Moreels A. Moschen R. Pollok W. Reinisch M. Schunter E.F. Stange H. Tilg G. Van Assche N. Viget B. Vu | 2009 | Journal of Crohn’s and Colitis2009，，2： | 3 |
| 11 | Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease显示文摘 | Rami Eliakim Doron Fischer Alain Suissa Kamal Yassin Dalia Katz Nurit Guttman Michal Migdal | 2003 | European Journal of Gastroenterology & Hepatology2003，，4： | 3 |
| 12 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 13 | 胶囊内镜与常规上消化道内镜检查诊断食管静脉曲张准确性的比较:一项前瞻性、3中心先导性研究显示文摘Background and study aims: Variceal bleeding is a major complication of cirrhosis, and is associated with a 20% mortality at 6 weeks. Current international guidelines recommend that patients with cirrhosis are screened by conventional upper endoscopy (esophagogastroduodenoscopy, EGD) in order to detect esophageal varices. The recently developed PillCam ESO esophageal capsule endoscope has been shown to be an accurate diagnostic tool in the investigation of patients with gastroesophageal reflux and Barrett’ s esophagus. We compared the PillCam ESO capsule endoscope with EGD for the detection of esophagogastric varices and portal hypertensive gastropathy in patients with cirrhosis. Patients and methods: A pilot trial was conducted at three sites. Patients with cirrhosis who were undergoing clinically indicated EGD for screening or surveillance for esophageal varices underwent a PillCam ESO study followed by an EGD within 48 hours. Capsule videos were assessed by an investigator who was blinded to the patient’ s medical history and EGD findings. Results: A total of 23 of the 32 enrolled patients were found to have esophageal varices at both EGD and PillCam ESO endoscopy. In one patient PillCam ESO detected small varices that were not seen at EGD. The overall concordance between PillCam ESO and EGD was 96.9 % for the diagnosis of esophageal varices and 90.6% for the diagnosis of portal hypertensive gastropathy. There were no adverse events related to PillCam ESO endoscopy. Conclusions: In a high-prevalence population, PillCam ESO may represent an accurate noninvasive alternative to EGD for the detection of esophageal varices and portal hypertensive gastropathy. A large-scale trial is underway to validate and expand these findings. | Eisen G.M. Eliakim R. Zaman A. 纪泛扑 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，5： | 2 |
| 14 | Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study显示文摘 | Y. Niv S. Ilani Z. Levi M. Hershkowitz E. Niv Z. Fireman S. O’Donnel C. O’Morain R. Eliakim E. Scapa N. Kalantzis C. Kalantzis P. Apostolopoulos E. Gal | 2012 | Endoscopy2012，，01： | 2 |
| 15 | Rectal bleeding as a presenting symptom of AL amyloidosis and multiple myeloma显示文摘Amyloidosis of the gastrointestinal tract is a rare disease that presents with common,nonspecific signs and symptoms.It may affect any part of the gastrointestinal tract from mouth to anus.The clinical and endoscopic features are diverse and may mimic other diseases,such as inflammatory bowel disease,malignancy,ischemic colitis and,at times,collagenous colitis.We describe an uncommon case of rectal bleeding and anemia with polypoid lesions and ulcerations in the colon,as the presenting symptom of AL amyloidosis and light chain multiple myeloma. | Itay Maza Evgene Vlodavsky Rami A Eliakim | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 2 |
| 16 | European consensus on the histopathology of inflammatory bowel disease显示文摘 | F. Magro C. Langner A. Driessen A. Ensari K. Geboes G.J. Mantzaris V. Villanacci G. Becheanu P. Borralho Nunes G. Cathomas W. Fries A. Jouret-Mourin C. Mescoli G. de Petris C.A. Rubio N.A. Shepherd M. Vieth R. Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 17 | Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy显示文摘 | Juan M. Herrerias Jonathan A. Leighton Guido Costamagna Anthony Infantolino Rami Eliakim Doron Fischer David T. Rubin Howard D. Manten Eitan Scapa Douglas R. Morgan Ari J. Bergwerk Binyamin Koslowsky Samuel N. Adler | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 18 | NOD2/CARD15 mutation analysis and genotype-phenotype correlation in Jewish pediatric patients compared with adults with Crohn’s disease显示文摘 | Batia Weiss Raanan Shamir Yoram Bujanover Mati Waterman Corina Hartman Akiva Fradkin Drora Berkowitz Ilana Weintraub Ram Eliakim Amir Karban | 2004 | The Journal of Pediatrics2004，，2： | 2 |
| 19 | Aspects of leu- kocyte func--tion and the complement system follow- ing aerobic exercise in youngfemale gymnasts 显示文摘 | Wolach B Eliakim A Gavrieli R et a l | 1998 | Scand J Med Sci Sports1998，8，2： | 1 |
| 20 | The Bsm I vitamin 0 receptor gene polymorphism is associated with ulcerative colitis inJewish Ashkenazi patients显示文摘 | Dresner PR Ackerman Z Eliakim R Karban A Chewers Y Fidder HH | 2004 | Genet Test2004，8，4： | 1 |
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