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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) | 2012 | 中华神经科杂志2012，45，5： | 51 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 3 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 4 | Role of nitric oxide in regulation of long- term pressure-natriuresis relationship in Dahl rats 显示文摘 | Hu L Manning RD Jr | 1995 | Am J Physiol1995，268，6： | 1 |
| 5 | Reduced expression of connexin-43 and functional gap junction coupling in human gliomes显示文摘 | Soreceanu L Manning TJ Jr Sontheimer H | 2001 | Glia2001，33，2： | 1 |
| 6 | Sugar-sweetened beverages and incidence of type 2 diabetes mellitus in African American women 显示文摘 | Palmer JR Boggs DA Kris|man S | 2008 | Arch lntern Med2008，168，14： | 1 |
| 7 | In silico struc- ture-function analysis of pathological variation in the HSD 11 B2 gene sequence 显示文摘 | Manning JR Bailey MA Soares DC | 2010 | Physio] Genomics2010，42，3： | 1 |
| 8 | Map manager QTX,cross-platform software for genetic mapping显示文摘 | Manly K F Jr Cudmore R H Meer J M | 2001 | Mammalian Genome2001，12，12： | 1 |
| 9 | Isolation and culture of chondrocytesfrom human adult articular cartilage显示文摘 | Manning W K Bonner W M Jr | 1967 | Arthritis Rheum1967，10，3： | 1 |
| 10 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 11 | Role of neuronal nitric oxide synthase in Dahl salt-sensitive hypertension显示文摘 | Tan DY Meng S Manning RD Jr | 1999 | Hypertension1999，33，1： | 1 |
| 12 | Modulation of glioma cell migration and invasion using Cl^- and K^+ ion channel blockers 显示文摘 | Soroceanu L Manning T J Jr Sontheimer H | 1999 | J Neurosci1999，19，14： | 1 |
| 13 | Reduced expression of connexin-43 and functional gap junction coupling in human gliomas显示文摘 | Soroceanu L Manning TJ Jr Sontheimer H | 2001 | Glia2001，33，2： | 1 |
| 14 | Isolation and culture of chondrocytes from human adult articular cartilage显示文摘 | Manning WK Bonner WM Jr | 1967 | Arthritis Rheum1967，10，3： | 1 |
| 15 | 脑一氧化氮合酶和盐敏感性高血压显示文摘目的:本工作探讨了在不同盐摄取的条件下,脑一氧化氮合酶(brain nitric oxide synthase, b N O S)对 Dahl 盐敏感( S)及 Dahl盐不敏感( R)大鼠的血液动力学、血浆肾素活性(plasm a renin activity, P R A)、肾小球滤过率(glum erilar fil┐tration rate, G F R)及有效肾血浆流量(effective renalplasm a flow , E R P F)等的影响。 方法:7 周~8 周龄的 S及 R大鼠经股静脉导管给予低盐(0.87 m m ol/d)及高盐(20.6 m m ol/d)溶液输注,并经与计算机系统相联的主动脉导管记录血液动力学等的变化。所有动物在经 5 天的对照观察后,其中部分动物在低盐或高盐溶液中加入b N O S特异抑制剂 7┐nitroindazole (7┐ N I, 1.67 m g/kg/h), 继续观察 5 天。 结果:单纯低盐及高盐输注的 R 大鼠,其血压无显著变化,同时给予高盐及 7┐ N I输注的大鼠,其血压较对照期间大幅上升(120±6% )。同样,在给予高盐及高盐+ 7┐ N I输注的 S大鼠,其血压亦分别较对照期间上升了 1? | 谭天然 Manning R.D Jr | 1999 | 高血压杂志1999，7，3： | 1 |
| 16 | Sinus histiocytosis with massive lymphadenopathy and malignant lymphoma involving the same lymph node : a report of four cases and review of the literature 显示文摘 | Lu D Estalilla O C Manning J T Jr | 2000 | Mod Pathol2000，13，4： | 1 |
| 17 | Comprehensive geriatric assess- ment- a guide for the non - specialist显示文摘 | Welsh T J Gordon AL Glad man JR | 2014 | Int J Clin Pract2014，68，3： | 1 |
| 18 | The ratio of 2rid to 4th digit length and male homosexuality 显示文摘 | Robinson SJ Manning Jr | 2000 | Evolution and Human Behavior2000，21，5： | 1 |
| 19 | Conjugate addition reactions of α-silylated α,β-unsaturated carboxyylic acid salts显示文摘 | Manning P Cooke Jr | | 0，，： | 1 |
| 20 | Mechanisms of action of arsenic trioxide 显示文摘 | Miller WH Jr Schipper HM Lee JS Singer J Wax- man S | 2002 | Cancer Res2002，62，1： | 1 |
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