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| 1 | Hepatobiliary manifestations in inflammatory bowel disease: The gut,the drugs and the liver显示文摘Abnormal liver biochemical tests are present in up to30%of patients with inflammatory bowel disease(IBD),and therefore become a diagnostic challenge.Liver and biliary tract diseases are common extraintestinal manifestations for both Crohn’s disease and ulcerative colitis(UC),and typically do not correlate with intestinal activity.Primary sclerosing cholangitis(PSC)is the most common hepatobiliary manifestation of IBD,and is more prevalent in UC.Approximately 5%of patients with UC develop PSC,with the prevalence reaching up to 90%.Cholangiocarcinoma and colon cancer risks are increased in these patients.Less common disorders include autoimmune hepatitis/PSC overlap syndrome,IgG4-associated cholangiopathy,primary biliary cirrhosis,hepatic amyloidosis,granulomatous hepatitis,cholelithiasis,portal vein thrombosis,liver abscess,and non-alcoholic fatty liver disease.Hepatitis B reactivation during immunosuppressive therapy is a major concern,with screening and vaccination being recommended in serologically negative cases for patients with IBD.Reactivation prophylaxis with entecavir or tenofovir for 6to 12 mo after the end of immunosuppressive therapy is mandatory in patients showing as hepatitis B surface antigen(HBsAg)positive,independently from viral load.HBsAg negative and anti-HBc positive patients,with or without anti-HBs,should be closely monitored,measuring alanine aminotransferase and hepatitis B virus DNA within 12 mo after the end of therapy,and should be treated if the viral load increases.On the other hand,immunosuppressive therapy does not seem to promote reactivation of hepatitis C,and hepatitis C antiviral treatment does not influence IBD natural history either.Most of the drugs used for IBD treatment may induce hepatotoxicity,although the incidence of serious adverse events is low.Abnormalities in liver biochemical tests associated with aminosalicylates are uncommon and are usually not clinically relevant.Methotrexaterelated hepatotoxicity has been described in 14%of patients with IBD,in a dose-dependent manner.Liver biopsy is not routinely recommended.Biologics-related hepatotoxicity is rare,but has been shown most frequently in patients treated with infliximab.Thiopurines have been associated with veno-occlusive disease,regenerative nodular hyperplasia,and liver peliosis.Routine liver biochemical tests are recommended,especially during the first month of treatment.All these conditions should be considered in IBD patients with clinical or biochemical features suggestive of hepatobiliary involvement.Diagnosis and management of these disorders usually involve hepatologists and gastroenterologists due to its complexity. | María Rojas-Feria Manuel Castro Emilio Suárez Javier Ampuero Manuel Romero-Gómez | 2013 | World Journal of Gastroenterology2013，19，42： | 9 |
| 2 | Dyslipi- demia in obesity: mechanisms and potential targets 显示文摘 | Boudewijn K Elte JWF Manuel Castro C | 2013 | Nutrients2013，5，4： | 1 |
| 3 | Pulmonary Function Testing and Complications of Laparoscopic Bariatric Surgery显示文摘 | Astrid Huisstede Laser Ulas Biter Ronald Luitwieler Manuel Castro Cabezas Guido Mannaerts Erwin Birnie Christian Taube Pieter S. Hiemstra Gert-Jan Braunstahl | 2013 | Obesity Surgery2013，，10： | 1 |
| 4 | Urban wind energy exploitation systems:Behaviour under multidirectional flowconditionsOpportunities and challenges显示文摘 | Francisco Toja Silva Antonio Colmenar Santos Manuel Castro Gil | 2013 | Renewable and Sustainable Energy Reviews2013，24，： | 1 |
| 5 | Isolation and molecular cloning of a fish myeloperoxidase显示文摘 | Rosario Castro M. Carla Piazzon Manuel Noya José M. Leiro Jesús Lamas | 2007 | Molecular Immunology2007，，2： | 1 |
| 6 | Effects of bone remodeling oncalcium mass transfer during haeraodialysis显示文摘 | Cristina Karohl Juliana de Paiva Paschoal Manuel CarlosMartins de Castro | 2010 | NephrolDial Transplant2010，25，： | 1 |
| 7 | Assessment of Helicobacter pylori Eradication by Virgin Olive Oil显示文摘 | Manuel Castro Concepción Romero Antonio de Castro Julio Vargas Eduardo Medina Raquel Millán Manuel Brenes | 2012 | Helicobacter2012，，4： | 1 |
| 8 | State of the art of frameworks and middleware for facilitating ruobile and ubiquitous learning development 显示文摘 | Sergio Martin Gabriel Diaz Inmaeulada Plaza Elena Ruiz Manuel Castro Juan Peire | | The Jour- nal of Systems and Software0，201，： | 1 |
| 9 | Anatomic Renal Artery Branch Microdissection to Facilitate Zero-Ischemia Partial Nephrectomy显示文摘 | Casey K. Ng Inderbir S. Gill Mukul B. Patil Andrew J. Hung Andre K. Berger Andre Luis de Castro Abreu Masahiko Nakamoto Manuel S. Eisenberg Osamu Ukimura Duraiyah Thangathurai Monish Aron Mihir M. Desai | 2011 | European Urology2011，，1： | 1 |
| 10 | Dilute acid pretreatment of rapeseed straw for fermentable sugar generation 显示文摘 | Eulogio Castro Manuel J Dfaz Crist6bal Cara | 2011 | Bioresource Technology2011，102，： | 1 |
| 11 | Towards requirements-driven information systems engineering: the Tropos project显示文摘 | Jaelson Castro Manuel Kolp John Mylopoulos | 2002 | Information Systems2002，，6： | 1 |
| 12 | Comparison of two dimensional echocardiography and pulsed doppler tissue imaging during dobutamine-atropine stress testing detect coronary artery disease显示文摘 | Peteiro J Monserrat L Fabregas R Manuel J Calvino R Castro A | 2001 | Echocardiography2001，18，4： | 1 |
| 13 | A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma显示文摘 | José Carlos Machado Céu Figueiredo Paulo Canedo Paul Pharoah Ralph Carvalho Sérgio Nabais Catarina Castro Alves Maria Luisa Campos Leen-jan Van Doorn Carlos Caldas Raquel Seruca Fátima Carneiro Manuel Sobrinho-Sim?es | 2003 | Gastroenterology2003，，2： | 1 |
| 14 | PI3K/Akt signalling pathway and cancer显示文摘 | Juan ángel Fresno Vara Enrique Casado Javier de Castro Paloma Cejas Cristóbal Belda-Iniesta Manuel González-Barón | 2003 | Cancer Treatment Reviews2003，，： | 1 |
| 15 | A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantation显示文摘 | Mar??a Buti Antoni Mas Mart??n Prieto Fernando Casafont Antonio González Manuel Miras Jose-Ignacio Herrero Rossendo Jard?? Eva Cruz de Castro César Garc??a-Rey | 2003 | Journal of Hepatology2003，，6： | 1 |
| 16 | Zero Ischemia Anatomical Partial Nephrectomy: A Novel Approach显示文摘 | Inderbir S. Gill Mukul B. Patil Andre Luis de Castro Abreu Casey Ng Jie Cai Andre Berger Manuel S. Eisenberg Masahiko Nakamoto Osamu Ukimura Alvin C. Goh Duraiyah Thangathurai Monish Aron Mihir M. Desai | 2012 | The Journal of Urology2012，，： | 1 |
| 17 | PI3K/Akt signalling pathway and cancer显示文摘 | Juan ángel Fresno Vara Enrique Casado Javier de Castro Paloma Cejas Cristóbal Belda-Iniesta Manuel González-Barón | 2003 | Cancer Treatment Reviews2003，，2： | 1 |
| 18 | Expression Profile as Predictor of Relapse after Adjuvant Treatment in Gastric Cancer显示文摘 | María Sereno Javier Castro Paloma Cejas Miguel García-Cabezas Cristóbal Belda Enrique Casado Jaime Feliu César Gómez Miriam López Manuel Barón | 2012 | Journal of Gastrointestinal Cancer2012，，2： | 1 |
| 19 | Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease显示文摘 | Lidia Anguiano Marta Riera Julio Pascual José Manuel Valdivielso Clara Barrios Angels Betriu Sergi Mojal Elvira Fernández María José Soler Eva Castro Virtudes María Teresa Molí Meritxell Soria Aladrén Regidor Ma José Almirall Jaume Ponz Esther Arteaga Col | 2015 | Nephrology Dialysis Transplantation2015，，7： | 1 |
| 20 | Glucose-dependent Leukocyte Activation in Patients with Type 2 Diabetes Mellitus, Familial Combined Hyperlipidemia and Healthy Controls显示文摘 | Marijke A. de Vries Arash Alipour Boudewijn Klop Gert-Jan M. van de Geijn Hans W. Janssen Tjin L. Njo No?lle van der Meulen Arie P. Rietveld Anho H. Liem Elsbeth M. Westerman Wouter W. de Herder Manuel Castro Cabezas | 2014 | Metabolism2014，，： | 1 |
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