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| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 4 | Validation of a model for the absorption process of HzO(vap) by a LiBr(aq) in a horizontal tube bundle, using a multi-factorial analysis 显示文摘 | Frances S Manuel V Ojer P | 2003 | International Journal of Heat and Mass Transfer2003，46，17： | 1 |
| 5 | High DHA content in Artemiais ineffective to improve Octopus vulgaris paralarvae rearing 显示文摘 | Pedro S Manuel R M Lulsa M P V | 2010 | Aquaculture2010，300，： | 1 |
| 6 | Antitumor activity of(-)-alpha-bisabololbased thiosemicarbazones against human tumor cell lines显示文摘 | Alan P da Silvaa Manuele V Martinia Cecília M de Oliveira | 2010 | Eur J Med Chem2010，45，7： | 1 |
| 7 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 8 | Hysteretic current-voltage characteristics in RF-sputtered nanocrystalline TiO2 thin films显示文摘 | Manuel V Gabriel J Silvia P D H | | 0，，： | 1 |
| 9 | Cell-Free Supernatants Obtained from Fermentation of Cheese Whey Hydrolyzates and Phenylpyruvic Acid by Lactobacillus plantarum as a Source of Antimicrobial Compounds, Bacteriocins, and Natural Aromas显示文摘 | Noelia Rodríguez-Pazo Laura Vázquez-Araújo Noelia Pérez-Rodríguez Sandra Cortés-Diéguez José Manuel Domínguez | 2013 | Applied Biochemistry and Biotechnology2013，，4： | 1 |
| 10 | Efficiency, equity, and sustainability in a water quantity-quality optimization model in the Rio Grande basin显示文摘 | Ward F A Manuel P V | 2008 | Ecological Economics2008，66，1： | 1 |
| 11 | Dimensional changes, gel layer evolu tion and drug release studies in hydrophilic matrices loaded with drugs of different solubility 显示文摘 | Manuel E Ioulia P Marilena V | 2007 | Int J Pharm2007，339，12： | 1 |
| 12 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 13 | Agents for process goherence in virtual enterprises显示文摘 | Anuj K Jain Manuel Aparicio I V Munindar P Sinag | 1999 | Communication of TKE ACMM1999，42，8： | 1 |
| 14 | 查看详情显示文摘 | Manuel G R Fiona F John E O Andrew I M Wemer J B Johannes G V Marcinhet P | | 0，，： | 1 |
| 15 | Increased circulating pro-Inflammatory cytokines and Thl7 lymphocytes in Hashim- oto's thyroiditis显示文摘 | Nict F V Manuel A P Ignacio B | 2010 | J Clin Endocrinol Metab2010，95，2： | 1 |
| 16 | Mathematical assessment of qualitative diagnostic calibration for respiratory inductive ple- thysmography显示文摘 | Anne de G Manuel P Yves V | 2001 | J Appl Physio2001，90，： | 1 |
| 17 | The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘 | Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R | 2007 | Science2007，318，5848： | 1 |
| 18 | Affect of polydispersity on the properties of waterborne polyurethane dispersions based on polycarbonate polyol显示文摘 | Vanesa G P V í ctor C Manuel C | | 0，，06： | 1 |
| 19 | Waterborne polyurethane dispersions obtained with polycarbonate of hexanediol intended for use as coatings显示文摘 | Vanesa G P V i ctor C Manuel C | 2011 | Progress in Organic C oatings2011，71，： | 1 |
| 20 | Hysteretic current- voltage characteristics in RF- sputtered nano- crystalline TiO2 thin films 显示文摘 | Manuel V Gabriel J Silvia P D H | 2007 | Physics B2007，398，： | 1 |
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