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| 1 | Exploiting novel molecular targets in gastrointestinal cancers显示文摘Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targeted successfully in colorectal cancer with cetuximab, panitunumab and bevacizumab. Similarly, EGFR-targeting with erlotinib yielded significant survival benefit in pancreatic cancer when combined with gemcitabine. The multi-targeting approach with sorafenib has made it the first agent to achieve significant survival benefit in hepatocellular carcinoma. Efforts to exploit the dysregulated Akt/mTOR pathway in GI cancer therapy are ongoing. These molecular targets can be disrupted by various approaches, including the use of monoclonal antibody to intercept extracellular ligands and disrupt receptor-ligand binding, and small molecule inhibitors that interrupt the activation of intracellular kinases. | Wen W Ma Manuel Hidalgo | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 2 | Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and src activation 显示文摘 | Thomas H Manuel A Mark W | 2004 | J Biol Chem2004，22，23： | 1 |
| 3 | Preparation of submicron-scale,electrospun cellulose fibers via direct dissolution显示文摘 | CHOO Won Kim MARGARET W Frey MANUEL Marquez | 2005 | Pulymer Physics2005，，43： | 1 |
| 4 | ECG sig- nal denoising and baseline wander correction based on the empirical mode decomposition 显示文摘 | MANUEL B V WENG B W BARNER K E | 2008 | Computers in Biology and Medicine2008，38，1： | 1 |
| 5 | Maxillary protraction using a hybrid hyrax-facemask combination显示文摘 | Manuel N Benedict W Alexander P | 2013 | Progress in Orthodontics2013，14，5： | 1 |
| 6 | Management of helicotylenchus multicinctus in sugarcane with intercrops and organic amendments nematol显示文摘 | Jonathan E I Gajendran G Manuel W W | 1999 | Medit1999，27，： | 1 |
| 7 | Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement, for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the american heart association显示文摘 | Manuel D Cerqueira N J W Dilsizian V | 2002 | J Nucl Cardiol2002，9，2： | 1 |
| 8 | Intelligent scheduling with Tabu search: an application to jobs with linear delay penalties and sequence-dependent setup costs and times 显示文摘 | Manuel L Barnes J W Glover F | 1993 | Applied Intelligence1993，，3： | 1 |
| 9 | Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by ? 1-integrin signaling pathways显示文摘 | Florian W Manuel M Qingbo X | 2003 | Hypertension2003，41，： | 1 |
| 10 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a显示文摘 | Manuel Serrano Athena W Lin Mila E McCurrach David Beach Scott W Lowe | 1997 | Cell1997，，5： | 1 |
| 11 | ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer显示文摘 | Matthias Preusser Anna S. Berghoff Ayseguel Ilhan-Mutlu Manuel Magerle Carina Dinhof Georg Widhalm Karin Dieckmann Christine Marosi Adelheid W?hrer Monika Hackl Sabine Z?chbauer-Müller Andreas von Deimling Sebastian F. Schoppmann Christoph C. Zielinski Be | 2013 | Lung Cancer2013，，： | 1 |
| 12 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a显示文摘 | Manuel Serrano Athena W Lin Mila E McCurrach David Beach Scott W Lowe | 1997 | Cell1997，，： | 1 |
| 13 | The soil and water assessment tool:Historical,development,applications,and future research directions显示文摘 | Philip W G Manuel R R Colleen H G | 2007 | Trans ASAE2007，50，4： | 1 |
| 14 | Intelligent scheduling with tabu search : An application to jobs with linear delay penalties and sequence-dependent setup costs and times 显示文摘 | Manuel L Barnes J W Glover F | 1993 | Applied Intelligence1993，，3： | 1 |
| 15 | Resolving difficult phylogenetic questions:why more sequences are not enough显示文摘 | Philippe H Brinkmann H Lavrov DV Littlewood DTJ Manuel M W(O)rheide G Baurain D | | 0，，： | 1 |
| 16 | Mechanical properties of visible light-cured resins reinforced with hydroxyapatite for dental restoration显示文摘 | RAUL W ARCIS ANABEL LOPEZ-MACIPE MANUEL TOLEDANO | 2002 | Dental Materials2002，，18： | 1 |
| 17 | A systematic lit- erature review of diabetes self - management education fea- tures to improve diabetes education in women of Black African/Caribbean and Hispanic/Latin American ethnieity 显示文摘 | Gucciardi E Chan V W Manuel L | 2013 | Patient Educ Couns2013，，： | 1 |
| 18 | Influence of pitch additions on coal carbonization: Coke strength and structural properties 显示文摘 | Manuel John W | 1987 | Fuel1987，66，8： | 1 |
| 19 | Outbreak of Acinetobacter bau-mannii in an intensive care unit associated with tracheotomy显示文摘 | Manuel W Ziad A Larson E | 2001 | Am Infect Control2001，29，5： | 1 |
| 20 | ECG signal denoising and baseline wander correction based on the empirical mode decomposition显示文摘 | MANUEL B V WENG B W BARNER k E | 2008 | Computers in Biology and Medicine2008，38，1： | 1 |
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