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| 1 | Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells显示文摘这研究检验了 shikonin 导致的发信号的事件在 Bcr/Abl-positive 导致 apoptosis 的正式就职长期的骨髓内产生的白血病(电流型逻辑) 房间(例如, K562, LAMA84 ) 。有 shikonin 的 K562 细胞的处理(例如, 0.5 M )导致了反应的氧种类( ROS )的快速的产生伴随的 apoptosis 的深刻正式就职,打击 c-Jun-N-terminal kinase ( JNK )和 p38 的激活, mitochondrial 蛋白质细胞色素 c 和 Smac/DIABLO 的显著版本, PARP 的 caspase-9 和-3,和劈开的激活。完全 ROS 清除堵住了所有上述事件(即, apoptosis 的 JNK 和 p38 phosphorylation,细胞色素 c 和 Smac/DIABLO 版本, caspase 和 PARP 劈开,以及正式就职) 后面的 shikonin 处理。JNK 的抑制并且 JNK1 击倒显著地稀释的细胞色素 c 版本, caspase 劈开和 apoptosis,但是没影响调停 shikonin 的 ROS 生产。另外, caspase 激活的抑制完全堵住了导致 shikonin 的 apoptosis,但是有点没修改调停 shikonin 的细胞色素 c 版本或 ROS 产生。总的来说,这些调查结果证明导致 shikonin 的氧化损害在 apoptotic 发信号在一个近似的点操作串联,并且随后激活,并且导致 apoptosis 压力相关的 JNK 小径,扳机 mitochondrial 机能障碍,细胞色素 c 版本,和 caspase 激活。我们的数据也建议 shikonin 可以是为电流型逻辑的处理的一个有希望的代理人,, ROS 的一个发电机。 | Xin Mao Chun Rong Yu Wen Hua Li Wen Xin Li | 2008 | Cell Research2008，18，8： | 31 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | Progress in Nanocellulose Preparation and Application显示文摘Nanocellulose is a biodegradable, renewable, nonmeltable polymeric material that is insoluble in most solvents due to hydrogen bonding and crystallinity. Nanocellulose has attracted considerable attention in recent decades owing to its environmental friendliness, wide availability, good biocompatibility, high crystallinity, and high Young's modulus. This review presents the recent achievements in preparation and applications of nanocellulose, including a discussion of the advantages and disadvantages of various preparation methods and a summary of the applications of nanocellulose in composite materials research. Finally, we examine the mounting evidence of more widespread potential applications of nanocellulose. | HaiQuan Mao YongYang Gong YuanLi Liu ShiQi Wang LinLin Du Chun Wei | 2017 | Paper And Biomaterials2017，2，4： | 19 |
| 4 | Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess:a prospective study显示文摘Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome(PCOS).There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS.The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China.We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index(BMI),total testosterone(TT),modified Ferriman-Gallwey hirsutism score,sex hormone binding globulin(SHBG),homeostasis model assessment-estimated insulin resistance(HOMA-IR) and free androgen index(FAI) between PCOS patients and controls and subgroups of PCOS.The prevalence of acne and hirsutism did not differ significantly between the hyperandrogenic and non-hyperandrogenic subgroup.Patients with signs of hyperandrogenism had significantly higher BMI(P<0.05),but differences in TT,SHBG,FAI and waist/hip ratio were insignificant.The odds ratio of overweight was calculated for all PCOS patients.Our results suggest that PCOS patients with high BMI tend to have functional disorders of androgen excess;therefore,BMI may be a strong predictor of hyperandrogenism in PCOS. | Chun Yuan Xiaoqiang Liu Yundong Mao Feiyang Diao Yugui Cui Jiayin Liu | 2016 | The Journal of Biomedical Research2016，30，3： | 8 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Molecular evolution of the rice miR395 gene family显示文摘MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that play important roles in plant and animal development. They are usually processed from larger precursors that can form stem-loop structures. Among 20 miRNA families that are conserved between Arabidopsis and rice, the rice miR395 gene family was unique because it was organized into compact clusters that could be transcribed as one single transcript. We show here that in fact this family had four clusters of total 24 genes. Three of these clusters were segmental duplications. They contained miR395 genes of both 120 bp and 66 bp long. However, only the latter was repeatedly duplicated. The fourth cluster contained miR395 genes of two different sizes that could be the consequences of intergenic recombination of genes from the first three clusters. On each cluster, both 1-duplication and 2-duplication histories were observed based on the sequence similarity between miR395 genes, some of which were nearly identical suggesting a recent origin. This was supported by a miR395 locus survey among several species of the genus Oryza, where two clusters were only found in species with an AA genome, the genome of the cultivated rice. A comparative study of the genomic organization of Medicago truncatula miR395 gene family showed significant expansion of intergenic spaces indicating that the originally clustered genes were drifting away from each other. The diverse genomic organizations of a conserved microRNA gene family in different plant genomes indicated that this important negative gene regulation system has undergone dramatic tune-ups in plant genomes. | Sreelatha GUDDETI De Chun ZHANG Ai Li LI Chuck H. LESEBERG Hui KANG Xiao Guang LI Wen Xue ZHAI Mitrick A. JOHNS Long MAO | 2005 | Cell Research2005，15，8： | 7 |
| 7 | Research on carbon and oxygen isotopes in phosphorus-bearing rock series of the Late Neoproteroic-Early Cambrian Taozichong Formation in Qingzhen City, Guizhou Province, Southwest China显示文摘In the study of the phosphate-bearing stratum at the bottom of the Cambrian system, the authors found that there occurred carbon isotope negative anomalies in the Taozichong section phosphate-bearing stratum in Qingzhen, Guizhou Province; they can be correspondingly compared with other synsedimentary carbon isotope negative anomalies both at home and abroad. The results showed that there occurred three negative anomalies of carbon isotopes in the Neoproterozoic-Early Cambrian Taozichong Formation, indicating that the temporal palaeo-oceanographical environment changed significantly, in which there happened two times of intensive carbon isotope variation, corresponding to creature extinction. Meanwhile, it is believed that the carbon isotope negative anomalies in phosphorites were caused by the ascending water mass of ocean current with the negative carbon isotopic composition of deep-ocean hydrothermal deposits. | MAO Tie YANG Ruidong MAO Jiaren YE Chun LIU Kun GAO Junbo | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 6 |
| 8 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 9 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 10 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 11 | Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer:final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial显示文摘EMERGING-CTONG 1103 showed improved progression-free survival(PFS)with neoadjuvant erlotinib vs.chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer(NSCLC)(NCT01407822).Herein,we report the final results.Recruited patients were randomly allocated 1:1 to the erlotinib group(150 mg/day orally;neoadjuvant phase for 42 days and adjuvant phase to 12 months)or to the GC group(gemcitabine 1250 mg/m2 plus cisplatin 75 mg/m2 intravenously;2 cycles in neoadjuvant phase and 2 cycles in adjuvant phase).Objective response rate(ORR),complete pathologic response(pCR),PFS,and overall survival(OS)were assessed along with safety.Post hoc analysis was performed for subsequent treatments after disease recurrence.Among investigated 72 patients(erlotinib,n=37;GC,n=35),the median follow-up was 62.5 months.The median OS was 42.2 months(erlotinib)and 36.9 months(GC)(hazard ratio[HR],0.83;95%confidence interval[CI],0.47-1.47;p=0.513).The 3-and_(5-y)ear OS rates were 58.6%and 40.8%with erlotinib and 55.9%and 27.6%with GC(p_(3-y)=0.819,p_(5-y)=0.252).Subsequent treatment was administered in 71.9%and 81.8%of patients receiving erlotinib and GC,respectively;targeted therapy contributed mostly to OS(HR,0.35;95%CI,0.18-0.70).After disease progression,the ORR was 53.3%,and the median PFS was 10.9 months during the EGFR-TKI rechallenge.During postoperative therapy,grade 3 or 4 adverse events(AEs)were 13.5%in the erlotinib group and 29.4%in the GC group.No serious adverse events were observed.Erlotinib exhibited clinical feasibility for resectable IIIA-N2 NSCLC over chemotherapy in the neoadjuvant setting. | Wen-Zhao Zhong Hong-Hong Yan Ke-Neng Chen Chun Chen Chun-Dong Gu Jun Wang Xue-Ning Yang Wei-Min Mao Qun Wang Gui-Bin Qiao Ying Cheng Lin Xu Chang-Li Wang Ming-Wei Chen Xiao-Zheng Kang Wan-Pu Yan Ri-Qiang Liao Jin-Ji Yang Xu-Chao Zhang Si-Yang Liu Qing Zhou Yi-Long Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 4 |
| 12 | Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells显示文摘目的: 戊糖磷酸盐小径(PPP ) 涉及 glucose-6-phosphate 脱氢酶(G6PD ) 和 NADPH 的产生的活动,它在药新陈代谢起一个关键作用。这研究的目的是在 vitro 在药新陈代谢能力上调查 PPP 的调整的效果。 | Wen-jing XIAO Ting MA Chun GE Wen-juan XIA Yong MAO Run-bin SUN Xiao-yi YU Ji-ye AA Guang-ji WANG | 2015 | Acta Pharmacologica Sinica2015，36，2： | 3 |
| 13 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 14 | Carrier Cells for Delivery of Oncolytic Measles Virus into Tumors:Determinants of Efficient Loading显示文摘Oncolytic measles virus(OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies(NAbs) against the hemagglutinin(H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge, specific types of cells have been used as carriers for OMV.Differential loading strategies appear to result in different therapeutic outcomes; despite this, only few studies have reported practical ex vivo loading strategies required for effective treatment. To this end, we systematically evaluated the antitumor efficacy of OMV using different loading strategies; this involved varying the in vitro loading duration and loading dose of OMV. We found that improved oncolysis of carrier cells was achieved by a prolonged loading duration in the absence of NAbs. However, the enhanced oncolytic effect was abrogated in the presence of NAbs. Further, we found that the expression of H protein on the surface of carrier cells was predominantly determined by the loading duration rather than the loading dose. Finally, we showed that NAbs blocked viral transfer by targeting H protein prior to the occurrence of cell-to-cell interactions. Our results provide comprehensive information on the determinants of an effective loading strategy for carrier cell-based virotherapy; these results may be useful for guiding the application of OMV as an antitumor agent in clinical practice. | Chun Xu Mao Xia Gang Meng Chunyan Li Aiqin Jiang Jiwu Wei | 2018 | Virologica Sinica2018，33，3： | 3 |
| 15 | SERS Study of Co-doped TiO2 Nanoparticles显示文摘 | XUE Xiang-xin JI Wei MAO Zhu LI Zhi-shi GUO Zhi-nan ZHAO Bing ZHAO Chun | 2013 | Chemical Research in Chinese Universities2013，29，4： | 2 |
| 16 | Transcription factor networks involved in cell death in the dorsal root ganglia following peripheral nerve injury显示文摘The peripheral nervous system has the potential to regenerate after nerve injury owing to the intrinsic regrowth ability of neurons and the permissive microenvironment.The regenerative process involves numerous gene expression changes,in which transcription factors play a critical role.Previously,we profiled dysregulated genes in dorsal root ganglion neurons at different time points(0,3 and 9 hours,and 1,4 and 7 days) after sciatic nerve injury in rats by RNA sequencing.In the present study,we investigated differentially expressed transcription factors following nerve injury,and we identified enriched molecular and cellular functions of these transcription factors by Ingenuity Pathway Analysis.This analysis revealed the dynamic changes in the expression of transcription factors involved in cell death at different time points following sciatic nerve injury.In addition,we constructed regulatory networks of the differentially expressed transcription factors in cell death and identified some key transcription factors(such as STAT1,JUN,MYC and IRF7).We confirmed the changes in expression of some key transcription factors(STAT1 and IRF7) by quantitative reverse transcription-polymerase chain reaction.Collectively,our analyses provide a global overview of transcription factor changes in dorsal root ganglia after sciatic nerve injury and offer insight into the regulatory transcription factor networks involved in cell death. | Jing Qin Jian-Cheng Wu Qi-Hui Wang Song-Lin Zhou Su-Su Mao Chun Yao | 2018 | Neural Regeneration Research2018，13，9： | 2 |
| 17 | Further evidence for paternal DNA transmission in gynogenetic grass carp显示文摘Gynogenesis is an important breeding method in aquaculture and has been widely applied to many fish species.If gynogenetic progenies are to inherit paternal partial genomic DNA,this will increase genetic variation and will provide a useful outcome for breeding.In this study,we investigated the genetic variation in homeobox(Hox)gene clusters(Hox A4 a,Hox A9 a,Hox A11 b,Hox B1 b,Hox C4 a,Hox C6 b,and Hox D10 a)among koi carp(Cyprinus carpio haematopterus,KOC;the stimulation sperm source),grass carp(Ctenopharyngodon idellus),and gynogenetic grass carp(GGC).We found paternal DNA(a special DNA fragment and Hox C6 b)derived from KOC and a recombinant gene belonging to Hox C6 b in GGC.We are the first to report the recombinant Hox C6 b in GGC.Our study provides further evidence for paternal DNA transmission to gynogenetic progenies,which is a finding with great significance for the genetic breeding of fish. | Zhuangwen Mao Yeqing Fu Shi Wang Yude Wang Kaikun Luo Chun Zhang Min Tao Shaojun Liu | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 18 | Seedling-growing tray made of rice straw for maize seedling transplantation and its shear mechanics test显示文摘The plant-made seedling-growing tray cultivation technique is an effective way to improve maize yield and quality in China’s cold northern area.However,the corn seedling nursery carrier and tray cultivation technique has been proved poor in adaptability.After comparing several nursery carriers,a design for a plant-made seedling-growing tray that is suitable for maize transplantation was proposed in which rice straw was used as the primary raw material.The preparation method,processing and structural dimensions of the tray were investigated and designed,five types of plant-made seedling-growing trays with different formulations were proposed.The shear mechanical properties and the shear strength of the plant-made seedling-growing trays were tested to determine the shear force needed for cutting through trays prepared with increasing mass ratios of rice straw and the effect of the shearing rate on the shear strength.The results showed that at a shearing rate of 100 mm/min,the maximum shear force decreased gradually as the mass ratio of straw was increased and that the hardness of the tray decreased as its shear strength decreased.Under three shearing rates(100 mm/min,200 mm/min and 500 mm/min)and a blade displacement of 10 mm,the shear force was the highest at the point at which the tray was cut through;the required shear force to cut through the tray then gradually decreased.Trays with the same straw composition showed no significant influence of shearing rate on the tray’s shear strength at shearing rates of 100 mm/min,200 mm/min or 500 mm/min.This study describes a multi-tray,single-strip nursery carrier for use in plant-made seedling-growing tray cultivation and proposes a theoretical basis for the design of a rotary transplanting device,the key part of a maize plant-made seedling-growing tray transplanter. | Ma Yongcai Zhang Wei Wang Chun Mao Xin Zhang Bo Wang Haiyang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 2 |
| 19 | APPLICATIONS AND MANUFACTURE OF THE MICROSCALE LONG-OPTICAL-PATH ELECTROCHEMICAL CELL WITH A PLUG-IN THIN-LAYER ELECTRODE显示文摘The construction and characteristics of a microscale long-optical-path electrochemi-cal cell with a plug-in thin-layer electrode are described.Using ferricyanide as the testspecies,the thermodynamic parameters of electron transfer processes are determined at car-bon,plantinum,and gold electrodes. | Zhang Yu YU Mao Chun JING Shen Hua MIAO Department of Chemistry,Qufu Normal University,Qufu Shandong,273165 | 1993 | Chinese Chemical Letters1993，4，8： | 2 |
| 20 | Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults显示文摘Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q_(2),Q_(3),and Q_(4))were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q_(2),Q_(3),and Q_(4) were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment. | WU Bing LYU Yue Bin CAO Zhao Jin WEI Yuan SHI Wan Ying GAO Xiang ZHOU Jin Hui KRAUS Virginia Byers ZHAO Feng CHEN Xin LU Feng ZHANG Ming Yuan LIU Ying Chun TAN Qi Yue SONG Shi Xun QU Ying Li ZHENG Xu Lin SHEN Chong MAO Chen SHI Xiao Ming | 2021 | Biomedical and Environmental Sciences2021，34，11： | 2 |
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