|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospect and prospect of Geographical Sciences in China: A comparison with the Strategic Directions for Geography in the USA显示文摘理解变化行星:为地理科学(UCP ) 的战略方向,出版了由国家研究委员会(美国) ,和它在职业地理学者的评价建议那大写和复数地理科学(GS ) 是为在为我们的很快变化的行星的更好的理解的下一十年的地理的战略方向。根据这些评价, UCP 过分地珍视技术和工具(任务) ,并且没对方法论(纪律) 给予许多注意。实际上,任务和纪律是地理翅膀,特别在大科学的时间。从 UCP 和它的注释的启发是应该在任务和学科之间被平衡的战略方向, GS 应该是一个纪律系统,方法论,和技术和工具的三维的构造,并且这个系统应该是基于科学精神的科学人性并且由人性指导。在最后 60 年期间,中国地理学者把自己奉献给 GS,包括实践和理论。显然,进步和眼界作为学科交差的 GS,地球表面科学(S 字) 和地理建设(GC ) 被建议。GS 的纪律系统是很复杂的,并且由象科学,技术,工程,和哲学的如此的人的知识领域构成。主要使命是研究户外,建筑群,和宏地球系统(不仅科学地,而且人性地) ,并且一重要方法论是质、量的工具(CIQQM ) 的全面集成。同时,在中国地理的另一个变化方向是人经济的地理(HEG ) 。 | SUN Jun PAN Yujun TANG Maolin WU Youde | 2013 | Journal of Geographical Sciences2013，23，6： | 4 |
| 2 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 3 | Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma显示文摘Objective:To establish a new classification of biliary tumor thrombus(BTT).Methods:Overall survival of patients with BTT was first used to determine whether it correlated with current hepatocellular carcinoma staging systems.Univariate and multivariate analyses were used to determine factors affecting the overall survival(OS)to form the basis of our new classification for BTT.Results:All 6 international staging systems showed overlapping survival curves.Univariate followed by multivariate analyses showed that total bilirubin and intrahepatic/extrahepatic BTT were significant risk factors of OS.Based on these data,a new BTT classification was defined as:TypeⅠ:intrahepatic BTT;and TypeⅡ:extrahepatic BTT involving a common bile duct or common hepatic duct.TypeⅠwas further subdivided into type Ia:BTT involving a second-order intrahepatic duct or above,and type Ib:BTT involving a first-order intrahepatic duct.TypeⅡwas further subdivided into typeⅡa and typeⅡb using a cut-off total bilirubin(TB)>300μmol/L.The numbers(percentages)of patients with typesⅠandⅡBTT were 69(34.2%)and 133(65.8%),respectively.The median OS of typeⅠpatients was significantly higher than that of typeⅡpatients(37.5 months vs.23.2 months;P=0.002).Using subgroup analyses,OS outcomes were significantly different between the subgroups of typeⅡb and type IIa,although there was no significant difference between the type Ia and type Ib subgroups(P=0.07).Conclusions:A new BTT classification was established to predict prognoses of HCC patients with BTT who underwent liver resection. | Juxian Sun Jiayi Wu Chang Liu Jie Shi Yonggang Wei Jianyin Zhou Zhibo Zhang Wan Yee Lau Maolin Yan Shuqun Cheng | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 4 | Particle simulation of grid system for krypton ion thrusters显示文摘The transport processes of plasmas in grid systems of krypton(Kr) ion thrusters at different acceleration voltages were simulated with a 3 D-PIC model, and the result was compared with xenon(Xe) ion thrusters. The variation of the screen grid transparency, the accelerator grid current ratio and the divergence loss were explored. It is found that the screen grid transparency increases with the acceleration voltage and decreases with the beam current, while the accelerator grid current ratio and divergence loss decrease first and then increase with the beam current. This result is the same with Xe ion thrusters. Simulation results also show that Kr ion thrusters have more advantages than Xe ion thrusters, such as higher screen grid transparency, smaller accelerator grid current ratio, larger cut-off current threshold, and better divergence loss characteristic. These advantages mean that Kr ion thrusters have the ability of operating in a wide range of current. Through comprehensive analyses, it can be concluded that using Kr as propellant is very suitable for a multimode ion thruster design. | Maolin CHEN Anbang SUN Chong CHEN Guangqing XIA | 2018 | Chinese Journal of Aeronautics2018，31，4： | 2 |
| 5 | DeceFL:a principled fully decentralized federated learning framework显示文摘Traditional machine learning relies on a centralized data pipeline for model training in various applications;however,data are inherently fragmented.Such a decentralized nature of databases presents the serious challenge for collaboration:sending all decentralized datasets to a central server raises serious privacy concerns.Although there has been a joint effort in tackling such a critical issue by proposing privacy-preserving machine learning frameworks,such as federated learning,most state-of-the-art frameworks are built still in a centralized way,in which a central client is needed for collecting and distributing model information(instead of data itself)from every other client,leading to high communication burden and high vulnerability when there exists a failure at or an attack on the central client.Here we propose a principled decentralized federated learning algorithm(DeceFL),which does not require a central client and relies only on local information transmission between clients and their neighbors,representing a fully decentralized learning framework.It has been further proven that every client reaches the global minimum with zero performance gap and achieves the same convergence rate O(1=T)(where T is the number of iterations in gradient descent)as centralized federated learning when the loss function is smooth and strongly convex.Finally,the proposed algorithm has been applied to a number of applications to illustrate its effectiveness for both convex and nonconvex loss functions,time-invariant and time-varying topologies,as well as IID and Non-IID of datasets,demonstrating its applicability to a wide range of real-world medical and industrial applications. | Ye Yuan Jun Liu Dou Jin Zuogong Yue Tao Yang Ruijuan Chen Maolin Wang Chuan Sun Lei Xu Feng Hua Yuqi Guo Xiuchuan Tang Xin He Xinlei Yi Dong Li Guanghui Wen Wenwu Yu Hai-Tao Zhang Tianyou Chai Shaochun Sui Han Ding | 2023 | National Science Open2023，2，1： | 1 |
| 6 | Pre-incubated with BSA-complexed free fatty acids alters ER stress/autophagic gene expression by carboxylated multi-walled carbon nanotube exposure in THP-1 macrophages显示文摘Recently we found that multi-walled carbon nanotube (MWCNT) exposure alters the mRNA levels of endoplasmic reticulum (ER) stress/autophagic genes, but the impact of biological molecules on this response is unclear. Herein, we compared the different actions of carboxylated MWCNTs (c-MWCNTs) pre-incubated with bovine serum albumin (BSA) or BSA-complexed free fatty acid (denoted as FFA) on macrophages derived from THP-1 monocytes (denoted as THP-1 macrophages). C-MWCNTs exhibited increased diameter and hydrodynamic size as well as decreased absolute zeta potential value after pre-incubation with BSA or FFA, which suggested a coating effect. Cytotoxicity or oxidative stress were not significantly induced after exposure to BSA-or FFA-coated c-MWCNTs. BSA-pre-incubated c-MWCNTs significantly enhanced the expression of the ER stress gene, DDIT3 and the autophagic genes, ATG5, BECN1, and PLIN2, but the mRNA levels of these genes was significantly decreased by FFA-pre-incubated c-MWCNTs. FFA-pre-incubated c-MWCNTs induced significantly higher lipid accumulation and interleukin-6 (IL-6) protein level compared with BSA-pre-incubated c-MWCNTs, which suggested that FFA-pre-incubated c-MWCNTs may more effectively induce the formation of macrophage foam cells. Collectively, our data indicated that pre-incubation with FFA may influence c-MWCNT-induced ER stress/autophagic gene expression and foam cell formation in THP-1 macrophages. | Qianyu Yang Maolin Wang Yongbing Sun Shengming Peng Yanhuai Ding Yi Cao | 2019 | Chinese Chemical Letters2019，30，6： | 1 |
| 7 | New advances in airflow measurements applied in airflow characteristics test of pneumatic components显示文摘Pneumatic components have the explosion-proof,high reliability,and pollution-free characteristics,and have been applied in high-end equipment such as aerospace.With the pneumatic system technology developing,the quality of pneumatic components is required improving[1].High-frequency airflow dynamic characteristics need to be applied in pneumatic components. | SHI Yan HAN ChengWei CAI MaoLin WANG YiXuan SUN ZhiBo | 2021 | Science China(Technological Sciences)2021，64，12： | 0 |
| 8 | A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate显示文摘Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃ in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity. | Liming Cao Maolin Sun Chaoming Liang Lei Yang Yueyue Ma Ruihua Cheng Yanxiong Ke Wei Yu Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 9 | Thermal buckling and postbuckling of FGM circular plates with in-plane elastic restraints显示文摘Based on von Karman's plate theory, the axisymmetric thermal buckling and post-buckling of the functionally graded material(FGM) circular plates with inplane elastic restraints under transversely non-uniform temperature rise are studied. The properties of the FGM media are varied through the thickness based on a simple power law. The governing equations are numerically solved by a shooting method. The results of the critical buckling temperature, post-buckling equilibrium paths, and configurations for the in-plane elastically restrained plates are presented. The effects of the in-plane elastic restraints, material property gradient, and temperature variation on the responses of thermal buckling and post-buckling are examined in detail. | Yun SUN Maolin WANG Shirong LI | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，10： | 0 |
| 10 | Effect of Intermolecular Interaction on Stability of Asphaltene-Hydrogen Donor System显示文摘The stability of three asphaltene-hydrogen donor systems,namely asphaltene-1-methylnaphthalene,asphaltene-tetralin,and asphaltene-decalin,with a mass ratio of 1:10 was investigated using the Turbiscan stability analyzer.The interactions between hydrogen donor molecules and asphaltene units were simulated and calculated using Gaussian and Multiwfn,and then,noncovalent interaction analysis was performed.The results showed that the stability of the three asphaltene-hydrogen donor systems decreased as follows:asphaltene-1-methylnaphthalene>asphaltene-tetralin>asphaltene-decalin.The stability differences among the three systems were due to the different interactions between the hydrogen donor molecules and the asphaltene unit.The T-stacking interaction strength between the hydrogen donor molecules and the asphaltene units decreased as follows:1-methylnaphthalene-asphaltene unit>tetralin-asphaltene unit>decalin-asphaltene unit.Qualitative analysis indicates that the T-stacking interactions between the hydrogen donor molecules and the asphaltene units were mainly van der Waals forces,and the proportions of hydrogen bonds in the weak interaction differed among the systems. | Sun Yudong Li Maolin Liu Ziyuan Xiao Shengyu | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，4： | 0 |
| 11 | Gas sensing selectivity of oxygen-regulated SnO2 films with different microstructure and texture显示文摘The selectivity of gas sensing materials is increasingly important for their applications. The oxygenregulated SnO2 films with(110) and(101) preferred orientation were obtained through magnetron sputtering, followed by annealing treatment. Their micro-structure, surface morphology and gas response were investigated by advanced structural characterization and property measurement. The results showed that the as-prepared(110)-oriented SnO2 film was oxygen-rich and had more adsorption sites while the as-prepared(101)-oriented SnO2 film was oxygen-poor and more sensitive to de-oxidation.H2 gas sensitivity, response speed, selectivity between H2 and CO of the(110)-orientated SnO2 film was superior to that of the(101)-orientated SnO2 film. After treated at high temperature and high vacuum,the reduction of gas-sensing properties of the annealed(110) SnO2 film was much more than that of the annealed(101) SnO2 film. The lattice oxygen was responsible for the difference in gas-sensing response between(110) and(101)-oriented SnO2 films under oxygen regulation. This work indicated the gassensing selectivity of the different crystal planes in SnO2 film, providing a significant reference for design and extension of the related materials. | Ruiwu Li Yanwen Zhou Maolin Sun Zhen Gong Yuanyuan Guo Xitao Yin Fayu Wu Wutong Ding | 2019 | Journal of Materials Science & Technology2019，35，10： | 0 |
| 12 | Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor显示文摘A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production. | Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 13 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
| 14 | Interferogram Phase Noise Filter Using Nonlinear Anisotropic Diffusion Equation显示文摘 | SUN Long HU Maolin | 2005 | Chinese Journal of Electronics2005，14，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员