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| 1 | Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus显示文摘Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region.Three-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone repair.Here,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG scaffolds.Moreover,MSNs sustainably released BMP-4 for long-term effectiveness.In 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory factors.BMP-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted scaffolds.Furthermore,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory microenvironment.And 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone repair.In conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2. | Xin Sun Zhenjiang Ma Xue Zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang Jinzhong Zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang | 2021 | Bioactive Materials2021，6，3： | 12 |
| 2 | Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2显示文摘MicroRNAs (miRNAs ) 是在 posttranscriptional 水平调整目标基因表示的 noncoding RNA 的一个类,导致进一步生物的函数。我们证明了 microvesicles (MV ) 能作为细胞间的通讯的一个新奇方法交付 miRNAs 进目标房间。在中央神经系统, glial 房间释放 MV,这被报导,它处于正常状况调制 neuronal 功能。阐明在疾病的 glial MV 的潜在的角色,我们在压力状况上评估了分泌 astrocytic MV 的效果。我们的结果证明在 Lipopolysaccharide (LPS ) 刺激以后,星形细胞释放了流提高了 dopaminergic 神经原的危险到神经毒素的泡(SV ) 。进一步的调查证明在 SV 的那增加的 astrocytic miR-34a 经由在 dopaminergic 神经原指向 anti-apoptotic 蛋白质 Bcl-2 涉及这进步。我们也发现在 LPS 刺激以后的 astrocytic miR-34a 的抑制能在神经毒素应力下面推迟 dopaminergic 神经原损失。这些数据揭示了在疾病位于星形细胞神经原相互作用下面的新奇机制。 | Susu Mao | 2015 | Protein & Cell2015，6，7： | 7 |
| 3 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 4 | Integration of Multiple Heterointerfaces in a Hierarchical 0D@2D@1D Structure for Lightweight,Flexible,and Hydrophobic Multifunctional Electromagnetic Protective Fabrics显示文摘The development of wearable multifunctional electromagnetic protective fabrics with multifunctional,low cost,and high efficiency remains a challenge.Here,inspired by the unique flower branch shape of“Thunberg’s meadowsweet”in nature,a nanofibrous composite membrane with hierarchical structure was constructed.Integrating sophisticated 0D@2D@1D hierarchical structures with multiple heterointerfaces can fully unleash the multifunctional application potential of composite membrane.The targeted induction method was used to precisely regulate the formation site and morphology of the metal–organic framework precursor,and intelligently integrate multiple heterostructures to enhance dielectric polarization,which improves the impedance matching and loss mechanisms of the electromagnetic wave absorbing materials.Due to the synergistic enhancement of electrospinning-derived carbon nanofiber“stems”,MOF-derived carbon nanosheet“petals”and transition metal selenide nano-particle“stamens”,the CoxSey/NiSe@CNSs@CNFs(CNCC)composite membrane obtains a minimum reflection loss value(RL_(min))of-68.40 dB at 2.6 mm and a maximum effective absorption bandwidth(EAB)of 8.88 GHz at a thin thickness of 2.0 mm with a filling amount of only 5 wt%.In addition,the multi-component and hierarchical heterostructure endow the fibrous membrane with excellent flexibility,water resistance,thermal management,and other multifunctional properties.This work provides unique perspectives for the precise design and rational application of multifunctional fabrics. | Shuo Zhang Xuehua Liu Chenyu Jia Zhengshuo Sun Haowen Jiang Zirui Jia Guanglei Wu | 2023 | Nano-Micro Letters2023，15，11： | 3 |
| 5 | Spirobifluorene-Based Three-Dimensional Covalent Organic Frameworks with Rigid Topological Channels as Efficient Heterogeneous Catalyst显示文摘Although the past decade has witnessed tremendous progress in the development of covalent organic frameworks(COFs),three-dimensional(3D)COFs fabrications and characterizations are still much less studied compared with two-dimensional(2D)COFs,due to their complicated topology structures caused by interpenetration and limited choices of node-building blocks.In this work,we constructed a novel 3D COF(SP-3D-COF-BPY)successfully using orthogonal dual-planar spirobifluorene and bipyridine as building blocks.Also,we demonstrated the application of 3D COF-supported Pd(II)catalyst in heterogeneous catalysis.A sevenfold interpenetrated dia structure was revealed for SP-3DCOF-BPY by powder X-ray diffraction(PXRD)in conjunction with structural simulation and Pawley refinement.The bipyridine-linked frameworks bear one-dimensional(1D)unobstructed rigid channels and offer a high density of discrete coordination sites for chelating Pd(II)species.Very high loading of Pd(II)(∼15 wt%)was achieved in the asymmetric(as)-prepared Pd(II)@3D-COF-BYP.The generated highly ordered porous channels and easily accessible catalytic sites,such as COF-supported Pd(II)complex,serves as a highly active and stable microporous heterogeneous catalyst in Suzuki–Miyaura coupling reactions.The observed catalytic efficiency was high and the catalyst could be conveniently reused multiple times without any noticeable decay in catalytic performance. | Yamei Liu Chenyu Wu Qingzhu Sun Fan Hu Qingyan Pan Jing Sun Yinghua Jin Zhibo Li Wei Zhang Yingjie Zhao | 2021 | CCS Chemistry2021，3，4： | 1 |
| 6 | Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo显示文摘 | Zhimei Song Runliang Feng Min Sun Chenyu Guo Yan Gao Lingbing Li Guangxi Zhai | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 7 | Tertiary lymphoid structure patterns predicted anti-PD1 therapeutic responses in gastric cancer显示文摘Objective:Recent studies have highlighted the distinct value of tertiary lymphoid structure(TLS)for immunotherapeutic response prediction.However,it remains unclear whether TLS could play such roles in gastric cancer(GC).Methods:In this study,tumor tissue slices from 292 GC patients from Zhongshan Hospital were firstly reviewed to explore the correlation between TLS and clinical characteristics.Subsequently,we curated 38 reported genes that may function as triggers of TLS and performed consensus molecular subtyping in public RNA-seq datasets to determine TLS patterns in GC.Based on the differentially expressed genes acquired from two TLS patterns,we quantified TLS-related genes on the principal component analysis(PCA)algorithm to develop TLS score.A Zhongshan immunotherapy cohort including 13 patients who received programmed cell death 1(PD1)blockade therapy was established to conduct RNA sequencing analysis and multiplex immunohistochemistry(mIHC)tests using formalin-fixed and paraffin-embedded(FFPE)tissues.The corresponding TLS score and immune cell counts were further compared based on therapeutic response variations.Results:Mature TLS was revealed as an independent prognostic factor in 292 GC patients.Patients with higher TLS score was characterized by prolonged survival time and superior response to immunotherapy.TLS score was correlated with immunotherapy-related characters,such as microsatellite instability(MSI)and tumor mutation burden(TMB).In addition,RNA-seq data analysis in the Zhongshan immunotherapy cohort indicated that a higher TLS score was correlated with a superior response to PD1 blockade therapy.mIHC tests also revealed that PD1+CD8+T cell counts were significantly increased in the high-TLS score group.Conclusions:This study highlighted that TLS was significantly associated with immune landscape diversity and complexity.Quantitatively evaluating TLS patterns of individual tumor will strengthen our understanding of TME characteristics and promote more effective immunotherapy strategies. | Quan Jiang Chenyu Tian Hao Wu Lingqiang Min Hao Chen Lingli Chen Fenglin Liu Yihong Sun | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 8 | Profile and development of microsatellite primers for Acanthogobius ommaturus based on high-throughput sequencing technology显示文摘Acanthogobius ommaturus,a fish species of the Family Gobiidae,is a marine commercial fish perched on the bottom of seawater.In this study,Illumina high-throughput sequencing technology was applied to obtain the candidate microsatellite markers of A.ommaturus.A total of 4746 microsatellite-rich fragments were found,of which 4542 microsatellites are with primer fragments,containing 971 dinucleotide sequences,2643 trinucleotide sequences,569 tetranucleotide sequences,406 pentanucleotide sequences,and 212 hexanucleotide sequences.Based on the results of high-throughput sequencing,a total of 141 pairs of the microsatellite primers were designed and screened.And then 24 polymorphic primers were finally obtained by polyacrylamide gel electrophoresis.In total,271 alleles were detected in the 24 pairs of primers.The number of alleles for different primers ranged from 5 to 19.The average number of effective alleles(Na)was 11.292;the average observed heterozygosity(Ho)of the 24 pairs of primers was 0.665,the average expected heterozygosity(He)was 0.880,and the average polymorphic information content was 0.846.All sites were highly polymorphic(PIC>0.50). | SONG Chenyu FENG Ziyi LI Chunhou SUN Zhicheng GAO Tianxiang SONG Na LIU Lu | 2020 | Journal of Oceanology and Limnology2020，38，6： | 1 |
| 9 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 10 | Identification of a stable major QTL for fresh-seed germination on chromosome Arahy.04 in cultivated peanut(Arachis hypogaea L.)显示文摘Fresh-seed germination(FSG)impairs peanut production,especially in areas where the peanut harvest season coincides with rainy weather.Developing FSG-resistant cultivars by molecular breeding is expected to mitigate yield loss and quality impairment caused by FSG.However,the genetic control of FSG awaits elucidation.In this study,FSG at 1,3,5,7,and 9 days post-imbibition in three environments were tested,and quantitative-trait loci(QTL)associated with FSG were mapped in a peanut recombinant inbred line population by leveraging existing high-density peanut genetic maps.Of 24 QTL identified in 13 linkage groups,qFSGA04 was a stable major QTL on linkage group 04(LG04).It was consistently detected in five germination stages and three environments.By designing and validating DNA markers in the confidence interval of qFSGA04,we identified one single-nucleotide polymorphism and one In Del closely associated with FSG that could be used as linked markers for FSG resistance in peanut breeding. | Maoning Zhang Qing Zeng Hua Liu Feiyan Qi Ziqi Sun Lijuan Miao Xiaona Li Chenyu Li Debing Liu Junjia Guo Mengyuan Zhang Jing Xu Lei Shi Mengdi Tian Wenzhao Dong Bingyan Huang Xinyou Zhang | 2022 | The Crop Journal2022，10，6： | 0 |
| 11 | Peptidoglycan-inspired autonomous ultrafast self-healing bio-friendly elastomers for bio-integrated electronics显示文摘Elastomers are essential for stretchable electronics,which have become more and more important in bio-integrated devices.To ensure high compliance with the application environment,elastomers are expected to resist,and even self-repair,mechanical damage,while being friendly to the human body.Herein,inspired by peptidoglycan,we designed the first room-temperature autonomous self-healing biodegradable and biocompatible elastomers,poly(sebacoyl 1,6-hexamethylenedicarbamate diglyceride)(PSe HCD)elastomers.The unique structure including alternating ester-urethane moieties and bionic hybrid crosslinking endowed PSeHCD elastomers superior properties including ultrafast self-healing,tunable biomimetic mechanical properties,facile reprocessability,as well as good biocompatibility and biodegradability.The potential of the PSeHCD elastomers was demonstrated as a super-fast self-healing stretchable conductor(21 s)and motion sensor(2 min).This work provides a new design and synthetic principle of elastomers for applications in bio-integrated electronics. | Luzhi Zhang Jiahui Liang Chenyu Jiang Zenghe Liu Lijie Sun Shuo Chen Huixia Xuan Dong Lei Qingbao Guan Xiaofeng Ye Zhengwei You | 2021 | National Science Review2021，8，5： | 0 |
| 12 | Model of NBTI combined with mobility degradation显示文摘The mobility degradation induced by negative bias temperature instability(NBTI) is usually ignored in traditional NBTI modeling and simulation, resulting in overestimation of the circuit lifetime, especially after longterm operation. In this paper, the mobility degradation is modeled in combination with the universal NBTI model.The coulomb scattering induced by interface states is revealed to be the dominant component responsible for mobility degradation. The proposed mobility degradation model fits the measured data well and provides an accurate solution for evaluating coupling of NBTI with HCI(hot carrier injection) and SHE(self-heating effect), which indicates that mobility degradation should be considered in long-term circuit aging simulation. | Xuezhong Wu Chenyue Ma Shucheng Gao Xiangbin Li Fu Sun Lining Zhang Xinnan Lin | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 13 | Different response of bacterial community to the changes of nutrients and pollutants in sediments from an urban river network显示文摘Microbial communities in sediment are an important indicator linking to environmental pollution in urban river systems.However,how the diversity and structure of bacterial communities in sediments from an urban river network respond to different environmental factors has not been well studied.The goal of this study was to understand the patterns of bacterial communities in sediments from a highly dense urbanized river network in the lower Yangtze River Delta by Illumina MiSeq sequencing.The correlations between bacterial communities,the environmental gradient and geographical distance were analyzed by redundancy analysis(RDA)and network methods.The diversity and richness of bacterial community in sediments increased from upstream to downstream consistently with the accumulation of nutrient in the urban river network.Bacterial community composition and structure showed obvious spatial changes,leading to two distinct groups,which were significantly related to the characteristics of nutrient and heavy metal in sediments.Humic substance,available nitrogen,available phosphorus,Zn,Cu,Hg and As were selected as the key environmental factors shaping the bacterial community in sediments based on RDA.The co-occurrence patterns of bacterial networks showed that positive interaction between bacterial communities increased but the connectivity among bacterial genera and stability of sediment ecosystem reduced under a higher content of nutrient and heavy metal in average.The sensitive and ubiquitous taxa with an overproportional response to key environmental factors were detected as indicator species,which provided a novel method for the prediction of the pollution risk of sediment in an urban river network. | Fang Zhang Hao Zhang Ying Yuan Dun Liu Chenyu Zhu Di Zheng Guanghe Li Yuquan Wei Dan Sun | 2020 | Frontiers of Environmental Science & Engineering2020，14，2： | 0 |
| 14 | Way to efficient microbial paclitaxel mass production显示文摘The microbial synthesis of paclitaxel is attractive for its short-cycle,cost-effectiveness,and sustainability.However,low paclitaxel productivity,depleted capacity during subculture and storage,and unclear biosynthesis mechanisms restrain industrial microbial synthesis.Along with the isolation of various paclitaxel-producing microorganisms and the development of versatile molecular tools,tremendous promises for microbial paclitaxel synthesis have become increasingly prominent.In this review,we summarize the progress of microbial synthesis of paclitaxel in recent years,focusing on paclitaxel-producing endophytes and representative engineering microorganism hosts that were used as chassis for paclitaxel precursor synthesis.Numerous wide-type microbes can manufacture paclitaxel,and fermentation process optimization and strain improvement can greatly enhance the productivity.Engineered microbes can efficiently synthesize precursors of paclitaxel by introducing exogenous synthetic pathway.Mining paclitaxel synthetic pathways and genetic manipulation of endophytes will accelerate the construction of microbial cell factories,indefinitely contributing to paclitaxel mass production by microbes.This review emphasizes the potential and provides solutions for efficient microbial paclitaxel mass production. | Chenyue Li Yanli Qi Zhongke Sun Mengwan Jiang Chengwei Li | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 15 | Direct Synthesis of Crystalline Graphtetrayne-A New Graphyne Allotrope显示文摘We report a bottom-up synthesis of a new graphyne allotrope-graphtetrayne(GTTY),which features four acetylene linkages between the adjacent benzene on the surface of copper under low temperature.The as-prepared GTTY exhibited nanosheet morphology with an average thickness of 4.5 nm.Structural analysis based on high-resolution transmission electron microscopy(HR-TEM)/selected area electron diffraction(SAED)characterizations revealed high crystallinity formed with a ninefold stacking structure.The GTTY displayed excellent semiconductor properties bearing a band gap of 1.3 eV and a conductivity of 0.285 S m^(−1)at room temperature.Moreover,by the space-charge-limited current(SCLC)method,the measured hole and electron mobilities of the GTTY films reached up to 1.47×10^(3) cm^(2) V^(−1)S^(−1)and 2.98×10^(3)cm^(2)V^(−1)S^(−1),respectively. | Qingyan Pan Siqi Chen Chenyu Wu Feng Shao Jing Sun Lishui Sun Zhaohui Zhang Yixiao Man Zhibo Li Lixia He Yingjie Zhao | 2021 | CCS Chemistry2021，3，4： | 0 |
| 16 | States of graphene oxide and surface functional groups amid adsorption of dyes and heavy metal ions显示文摘Water pollution regarding dyes and heavy metal ions is crucial facing the world.How to effectively separate these contaminants from water has been a key issue.Graphene oxide(GO)promises the greenwater world as a long-lasting spotlight adsorbent material and therefore,harnessing GO has been the research hotspot for over a decade.The state of GO as well as its surface functional groups plays an important role in adsorption.And the way of preparation and structural modification matters to the performance of GO.In this review,the significance of the state of existence of stock GO and surface functional groups is explored in terms of preparation,structural modification,and adsorption.Besides,various adsorbates for GO adsorption are also involved,the discussion of which is rarely established elsewhere. | Zhaoyang Han Ling Sun Yingying Chu Jing Wang Chenyu Wei Qianlei Jiang Changbao Han Hui Yan Xuemei Song | 2023 | Chinese Journal of Chemical Engineering2023，63，11： | 0 |
| 17 | Application of Novel Design Bone Grafting for Treatment of Segmental Acetabular Rim Defects During Revision Total Hip Arthroplasty显示文摘The study aimed to develop efficient techniques with different novel graft structures to enhance the treatment of acetabular bone deficiency.The inhomogeneous material properties Finite Element Analysis(FEA)model was reconstructed according to computed tomography images based on a healthy patient without any peri-acetabular bony defect according to the American Academy of Orthopedic Surgeons(AAOS).The FEA model of acetabular bone deficiency was performed to simulate and evaluate the mechanical performances of the grafts in different geometric structures,with the use of fixation implants(screws),along with the stress distribution and the relative micromotion of graft models.The stress distribution mainly concentrated on the region of contact of the screws and superolateral bone.Among the different structures,the mortise-tenone structure provided better relative micromotion,with suitable biomechanical property even without the use of screws.The novel grafting structures could provide sufficient biomechanical stability and bone remodeling,and the mortise-tenone structure is the optimal treatment option for acetabulum reconstruction. | Xin Zhao Haowen Xue Yang Sun Aobo Zhang Yang Liu Hao Chen Qian Wan Jiangbo Zhang Jianlin Xiao Chenyu Wang Qing Han Jincheng Wang | 2021 | Journal of Bionic Engineering2021，18，6： | 0 |
| 18 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
| 19 | 利用微孔板测序技术绘制小鼠细胞图谱显示文摘文章简介长久以来,生命科学的研究主要基于群体细胞水平的分析,近几年所涌现的单细胞组学技术,使我们能够从单个细胞的水平上更为精确的解析细胞的分化、再生、衰老以及病变。在本研究中,科研团队自主开发了一套完全国产化的Microwell-seq高通量单细胞测序平台. | Xiaoping Han Renying Wang Yincong Zhou Lijiang Fei Huiyu Sun Shujing Lai Assieh Saadatpour Ziming Zhou Haide Chen Fang Ye Daosheng Huang Yang Xu Wentao Huang Mengmeng Jiang Xinyi Jiang Jie Mao Yao Chen Chenyu Lu Jin Xie Qun Fang Yibin Wang Rui Yue Tiefeng Li He Huang Stuart H.Orkin Guo-Cheng Yuan Ming Chen 郭国骥 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Subtle Side Chain Triggers Unexpected Two-Channel Charge Transport Property Enabling 80%Fill Factors and Efficient Thick-Film Organic Photovoltaics显示文摘To clearly show how important the impact of side chains on organic solar cells(OSCs)is,we designed three acceptors IDIC-CxPh(x=4,5,or 6)via subtle side-chain regulation.Despite this small change,significant distinctions were detected.IDIC-C4Ph devices achieve an optimal efficiency of 13.94%under thermal annealing,but thermal-assistant solvent-vapor annealing hugely suppresses the efficiencies to 10%.However,the C6Ph side chain endows extremely disordered stacking orientations,generating moderate efficiencies of~12.50%.Excitingly,the IDIC-C5Ph affords an unexpected two-channel p-p charge transport(TCCT)property,boosting the fill factor(FF)by up to 80.02%and efficiency to 14.56%,ranking the best among five-ring fused-ladder-type acceptors.Impressively,the special TCCT behavior of IDIC-C5Ph enables 470 nm thick-film OSC with a high FF of up to 70.12%and efficiency of 13.01%,demonstrating the great promise in fabricating largescale OSCs. | Yonghai Li Lu Yu Liangliang Chen Chenyu Han Huanxiang Jiang Zitong Liu Nan Zheng Jiuxing Wang Mingliang Sun Renqiang Yang Xichang Bao | 2021 | The Innovation2021，2，1： | 0 |
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