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| 1 | A study protocol of population-based cancer screening cohort study on esophageal,stomach and liver cancer in rural China显示文摘Objective:National Health Commission of the People's Republic of China collaborated with many ministries and commissions government and initiated a population-based cancer screening program in high-risk area of rural China,targeting three types of cancer that are most prevalent in these areas,including esophageal,stomach and liver cancer.This study protocol was reported to show the design and evaluate the effectiveness of cancer screening and appropriate screening strategies of three cancers in rural China.Methods and analysis:A two-step design with cancer risk assessment based on questionnaire interview,Hepatitis B surface antigen(HBsAg)test strip and subsequent clinical intervention for high-risk populations was adopted&ee of charge at the local hospitals designated in the program.Ethic and dissemination:This study was approved by the Institutional Review Board of Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College.The results will evaluate the effectiveness of cancer screening and appropriate screening strategies in rural China. | Jiang Li He Li Hongmei Zeng Rongshou Zheng Maomao Cao Dianqin Sun Jiansong Ren Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 10 |
| 2 | Association of cancer prevention awareness with esophageal cancer screening participation rates: Results from a population-based cancer screening program in rural China显示文摘Objective: : China have implemented population-based esophageal cancer(EC) screening programs, however,the participant rates were relatively low. This study was conducted to examine the association between cancer prevention knowledge and EC screening participation rates(PRs).Methods: : Data in the analyses were obtained from a population-based cancer screening program in four provinces in China since 2007. In the course of 2007-2016, participants who were evaluated as high risk for EC and subsequently recommended for endoscopy examination were included in the final analysis. One-way analysis of variance test, Chi-square test and logistic regression analysis were applied.Results: : A total of 28,543 individuals assessed as high-risk population for EC were included in this study, with13,036 males(45.67%) and 15,507 females(54.33%). The prevalence rates of current smoking and alcohol drinking were higher in males(58.25% and 44.22%, respectively) than in females(5.35% and 4.05%, respectively).Participants of females, and those who had older age, lower income, as well as higher education level and cancer prevention knowledge level were more likely to undergo endoscopy. Multivariable analysis showed that higher cancer prevention knowledge was associated with higher PR for endoscopic screening [adjusted odd ratio(aORQ4/Q1) =1.511, 95% confidence interval(95% CI): 1.398-1.632] among our study subjects. This association between cancer prevention knowledge and compliance with endoscopic screening also tends to be strong within subgroups of males, females, aged below 60 years, aged 60 years and above, and lower level of education(illiterate individuals and those with junior high education or less).Conclusions: : Our results displayed a positive relationship between cancer prevention knowledge and PRs for endoscopic screening, implying cancer prevention awareness being an independent influence factor for compliance with EC screening. Promoting public campaigns about comprehensive knowledge of cancer prevention seemed to be a reasonable and effective strategy to improve population PRs for EC screening. | Shangchun Jia He Li Hongmei Zeng Rongshou Zheng Jiang Li Jufang Shi Zhixun Yang Maomao Cao Wanqing Chen | 2019 | Chinese Journal of Cancer Research2019，31，4： | 10 |
| 3 | Improved esophageal squamous cell carcinoma screening effectiveness by risk-stratified endoscopic screening:evidence from high-risk areas in China显示文摘Background:Risk-stratified endoscopic screening(RSES),which offers endoscopy to those with a high risk of esophageal cancer,has the potential to increase effectiveness and reduce endoscopic demands compared with the universal screening strategy(i.e.,endoscopic screening for all targets without risk prediction).Evidence of RSES in high-risk areas of China is limited.This study aimed to estimate whether RSES based on a 22-score esophageal squamous cell carcinoma(ESCC)risk prediction model could optimize the universal endoscopic screening strategy for ESCC screening in high-risk areas of China.Methods:Eight epidemiological variables in the ESCC risk prediction model were collected retrospectively from 26,618 individuals aged 40-69 from three high-risk areas of China who underwent endoscopic screening betweenMay 2015 and July 2017.The model’s performance was estimated using the area under the curve(AUC).Participants were categorized into a high-risk group and a low-risk group with a cutoff score having sensitivities of both ESCC and severe dysplasia and above(SDA)at more than 90.0%.Results:The ESCC risk prediction model had an AUC of 0.80(95% confidence interval:0.75-0.84)in this external population.We found that a score of 8(ranging from 0 to 22)had a sensitivity of 94.2% for ESCC and 92.5% for SDA.The RSES strategy using this threshold score would allow 50.6% of endoscopies to be avoided and save approximately US$0.59 million compared to universal endoscopic screening among 26,618 participants.In addition,a higher prevalence of SDA(1.7%vs.0.9%),a lower number need to screen(60 vs.111),and a lower average cost per detected SDA(US$3.22 thousand vs.US$5.45 thousand)could have been obtained by the RSES strategy.Conclusions:The RSES strategy based on individual risk has the potential to optimize the universal endoscopic screening strategy in ESCC high-risk areas of China. | He Li Chao Ding Hongmei Zeng Rongshou Zheng Maomao Cao Jiansong Ren Jufang Shi Dianqin Sun Siyi He Zhixun Yang Yiwen Yu Zhe Zhang Xibin Sun Guizhou Guo Guohui Song Wenqiang Wei Wanqing Chen Jie He | 2021 | Cancer Communications2021，41，8： | 3 |
| 4 | Processing stage-guided effects of spices on the formation and accumulation of heterocyclic amines in smoked and cooked sausages显示文摘Heterocyclic amines (HAs) could be generated though sausage processing.The results showed that garlic,black pepper,chili inhibited the formation of HAs (584.29 ng/g,613.11 ng/g,677.23 ng/g) whereas ginger and Sichuan pepper intensified (965.66 ng/g,916.59 ng/g) compare with control sausage 863.86 ng/g.Furthermore,the study showed that garlic,black pepper,chilli all inhibited the formation of total HAs at stage of raw,drying,baking and steaming and had different inhibitory effect at every stage.Black pepper had the best inhibitory effect across four stages and inhibition rate reached 65%,69%,66%,84% after each stage.Chilli was the only one had inhibitory effect on both free and protein-bound HAs at every stage and inhibition rate about free and protein-bound HAs reached 38% and 76% in finished sausage.Adding certain spices properly during processing would be helpful to obtain fewer HAs in sausage. | Diaodiao Yang Zhiyong He Zhaojun Wang Qin Fang Fatih Oz Jie Chen Maomao Zeng | 2022 | Food Bioscience2022，47，3： | 2 |
| 5 | GC-MS Based Plasma Metabolic Pro?ling of Type 2 Diabetes Mellitus显示文摘 | Maomao Zeng Zhihong Che Yizeng Liang | 2009 | Chromatographia2009，69，910： | 1 |
| 6 | Simultaneous determination of N~-(carboxymethyl) lysine and N~-(carboxyethyl) lysine in cereal foods by LC-MS/MS显示文摘 | HE Jialiang ZENG Maomao ZHENG Zongpin | 2014 | European Food Research and Technology2014，238，3： | 1 |
| 7 | Plasma metabolic fingerprinting of childhood obesity by GC/MS in conjunction with muhivariate statistical analysis 显示文摘 | Zeng Maomao Liang Yizeng Li Hongdong | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，52，2： | 1 |
| 8 | Establishment of reliable mass spectra and retention indices library: Identification of fatty acids in human plasma without authentic standards显示文摘 | Liangxiao Zhang Binbin Tan Maomao Zeng Hongmei Lu Yizeng Liang | 2011 | Talanta2011，，： | 1 |
| 9 | Antioxidant capacity and major phenolic compounds of spices commonly consumed in China显示文摘 | Mei Lu Bo Yuan Maomao Zeng Jie Chen | 2010 | Food Research International2010，，2： | 1 |
| 10 | Metabolic alterations of impaired fasting glucose by GC/MS based plasma metabolic profiling combined with chemometrics显示文摘 | Maomao Zeng Yang Xiao Yizeng Liang Bing Wang Xian Chen Dongsheng Cao Hongdong Li Mei Wang Zhiguang Zhou | 2010 | Metabolomics2010，，2： | 1 |
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