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| 1 | Estimating GFR Using Serum Cystatin C Alone and in Combination With Serum Creatinine: A Pooled Analysis of 3,418 Individuals With CKD显示文摘 | Lesley A. Stevens Josef Coresh Christopher H. Schmid Harold I. Feldman Marc Froissart John Kusek Jerome Rossert Frederick Van Lente Robert D. Bruce Yaping (Lucy) Zhang Tom Greene Andrew S. Levey | 2008 | American Journal of Kidney Diseases2008，，3： | 2 |
| 2 | Monitored Anesthesia Care with Dexmedetomidine: A Prospective, Randomized, Double-Blind, Multicenter Trial显示文摘 | Keith A. Candiotti Sergio D. Bergese Paula M. Bokesch Marc A. Feldman Wayne Wisemandle Alex Y. Bekker | 2010 | Anesthesia & Analgesia2010，，1： | 2 |
| 3 | Coronary stents: A materials perspective显示文摘 | Gopinath Mani Marc D. Feldman Devang Patel C. Mauli Agrawal | 2006 | Biomaterials2006，，9： | 2 |
| 4 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 5 | Coronary stents: A materials perspective显示文摘 | MANI G FELDMAN MARC D PATEL D AGRAWAL M | 2007 | Biomaterials2007，28，： | 1 |
| 6 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，： | 1 |
| 7 | Incomplete Resolution of ST-Segment Elevation Is a Marker of Transient Microcirculatory Dysfunction After Stenting for Acute Myocardial Infarction显示文摘 | Laurent J. Feldman Pierre Coste Alain Furber Patrick Dupouy Michel S. Slama Jean-Pierre Monassier Christophe Tron Antoine Lafont Marc Faraggi Dominique Le Guludec Jean-Luc Dubois-Randé P. Gabriel Steg | 2003 | Circulation: Journal of the American Heart Association2003，，21： | 1 |
| 8 | Coronary stents: a materials perspective 显示文摘 | Mani G Feldman Marc D Patel D | 2007 | Biomaterials2007，28，： | 1 |
| 9 | Multisociety (AATS, ACCF, SCAI, and STS) expert consensus statement: Operator and institutional requirements for transcatheter valve repair and replacement, part 1: Transcatheter aortic valve replacement显示文摘 | Carl L. Tommaso R. Morton Bolman Ted Feldman Joseph Bavaria Michael A. Acker Gabriel Aldea Duke E. Cameron Larry S. Dean Dave Fullerton Ziyad M. Hijazi Eric Horlick D. Craig Miller Marc R. Moon Richard Ringel Carlos E. Ruiz Alfredo Trento Bonnie H. Weiner | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 1 |
| 10 | Monitored Anesthesia Care with Dexmedetomidine: A Prospective, Randomized, Double-Blind, Multicenter Trial显示文摘 | Keith A. Candiotti Sergio D. Bergese Paula M. Bokesch Marc A. Feldman Wayne Wisemandle Alex Y. Bekker | 2010 | Anesthesia & Analgesia2010，，1： | 1 |
| 11 | Coronary Stents: A Materials Perspective 显示文摘 | Mani Gopinath Feldman Marc D Patel Devang | 2007 | Biomaterials2007，28，9： | 1 |
| 12 | Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice显示文摘 | Chinnasamy Dhanalakshmi Yu Zhiya Theoret Marc R Zhao Yangbing Shrimali Rajeev K Morgan Richard A Feldman Steven A Restifo Nicholas P Rosenberg Steven A | 2010 | Journal of Clinical Investigation2010，，11： | 1 |
| 13 | 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults显示文摘 | Sharon Ann Hunt William T. Abraham Marshall H. Chin Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Mariell Jessup Marvin A. Konstam Donna M. Mancini Keith Michl John A. Oates Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy | 2009 | Journal of the American College of Cardiology2009，，15： | 1 |
| 14 | Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload显示文摘 | James T. Colston William H. Boylston Marc D. Feldman Chris P. Jenkinson Sam D. de la Rosa Amanda Barton Rodolfo J. Trevino Gregory L. Freeman Bysani Chandrasekar | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 15 | Coronary stents:a materials perspective显示文摘 | Mani G Feldman Marc D Patel D Agrawal M | 2007 | Biomaterials2007，28，： | 1 |
| 16 | Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment显示文摘 | Timo Erkinjuntti Gustavo Román Serge Gauthier Howard Feldman Kenneth Rockwood Marc Fisher | 2004 | Stroke: Journal of the American Heart Association2004，，： | 1 |
| 17 | Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography显示文摘 | Amir Lotfi Allen Jeremias William F. Fearon Marc D. Feldman Roxana Mehran John C. Messenger Cindy L. Grines Larry S. Dean Morton J. Kern Lloyd W. Klein | 2014 | Cathet Cardiovasc Intervent2014，，4： | 1 |
| 18 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy | 2009 | Journal of the American College of Cardiology2009，，15： | 1 |
| 19 | MRI-Based Patient-Specific Left Ventricular Model to Determine the Effects of Trabeculae Carneae on the Diastolic and Systolic Functions显示文摘Introduction Trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles of human heart and account for a significant portion of the ventricular mass.However,the role of trabeculae carneae in left ventricular(LV)function is not well understood.Previous reports suggested that trabeculae help squeeze blood from the apical region during systole[1].Our recent study suggests that trabeculae carneae hypertrophy and fibrosis contribute to increased LV stiffness in patients with diastolic heart failure,and severing free-running trabeculae carneae may improve diastolic compliance of the LV[2].Objective To understand the role of trabeculae carneae in the left ventricular diastolic and systolic functions using anatomically detailed patient-specific finite element models of the human LV.Methods(1)Image acquisition An explanted human heart was collected from a 63 year old female donor with a history of stroke and congestive heart failure within 24 hours postmortem from South Texas Blood and Tissue Center(San Antonio,TX).The heart was de-identified in accordance with Institutional Review Board(IRB)requirements and informed consent for research was obtained from the donor’s family.Three-dimensional MRI scanning was conducted on a 3T(128 MHz)MRI system(TIM Trio,Siemens Medical Solutions),comprised of a superconducting magnet with a 60 cm diameter accessible bore,when the heart was submerged in a saline filled plastic container.(2)Finite element analysis Three distinct LV models were derived from the MR images.The first model was the intact trabeculated model(TM)which contained all trabeculae carneae and papillary muscles.This high-resolution anatomically detailed 3D model of the LV was segmented from 2D MR images in DICOM format using Mimics(Materialise NV,Leuven,Belgium).The second model was the papillary model(PM),in which the papillary muscles remain intact but most of the trabeculae carneae were excluded in the smoothing process.The third model was the smooth model(SM)in which the trabeculae carneae and papillary muscles were excluded during image segmentation.Finite element(FE)models of the TM,PM and SM were created by meshing 3D reconstructions of the acquired MR images using tetrahedral elements(ICEM,Ansys Inc.,Canonsburg,PA).The mesh size was selected after a pilot study on mesh sensitivity.The passive cardiac muscle was characterized as a hyperelastic,incompressible,transversely isotropic material with a Fung exponential strain energy function.The material constants were determined by matching the end-diastolic pressure-volume relationship with the empirical Klotz relation[3].A rule-based myocardial fiber algorithm was adopted to generate the myofiber directions [4].The active contraction(i.e.,systolic contraction)was modeled by the time varying'Elastance'active contraction model.The contractile parameter Tmax was determined and calibrated so that the FE predicted ejection fraction(EF)of TM matched the EF of a normal human heart at the specified end-systolic pressure[3].The analysis of the TM,PM,and SM models were implemented using the open-source finite element package FEBio(www.febio.org).In all models,the rigid body motion was suppressed by constraining the base from moving in all directions.The end-diastolic and end-systolic pressure-volume relationships(EDPVR and ESPVR)were obtained and characterized by an exponential function and the slope,respectively.Results Our simulation results showed that independent of the material model,the EDPVR curve shifts to the right in PM and SM compared to TM.However,the ESPVR curve may shift to the right or left in PM compared to TM,while shifting tothe right in SM for all material models.EDPVR was steeper in TM compared to PM and SM;however,ESPVR was found to be steeper in PM than in TM and SM.The predicted parameters of EDPVR and ESPVR showed lower average exponential term in PM and SM compared to TM,indicating a significant improvement in the compliance and global diastolic function of less trabeculated LV models(P<0.01).Similarly,the higher average elastance EEs and lower volume intersect in PM compared to TM,suggests that mild cutting of trabeculae carneae slightly improves the global systolic function of the LV(P=0.89).However,cutting all trabeculae carneae and papillary muscles in SM had a significant adverse effect on the global systolic function(P<0.01).Discussion and conclusions Most patient-specific LV studies in the literature have used smoothed ventricular geometries.We used high resolution MRI to capture the endocardial details of the LV.Though reproducing very fine trabeculae carneae was restricted by the MRI resolution,our results demonstrated the importance of considering endocardial structures,i.e.papillary muscles and trabeculae carneae,in the assessment of LV global function in patient-specific computational LV models.The present work is consistent with the observation that diastolic performance improved after severing trabeculae carneae due to a reduction in LV stiffness[2].Furthermore,our results also suggest that severing trabeculae carneae(without affecting papillary muscle)may improve LV systolic function.Our model results are consistent with experimental measurements using ex vivo rabbit heart perfusion [5].This improvement would be greater in hypertrophic hearts because trabeculae carneae are also hypertrophic and more fibrotic.Left ventricular hypertrophy is often associated with heart failure with preserved ejection fraction(HFpEF).There is no effective treatment for HFpEF,which is characterized by impaired diastolic relaxation due to increased LV stiffness.Our results indicate that trabecular cutting could be an effective treatment for HFpEF. | Fatemeh Fatemifar Marc Feldman Geoffrey Clarke Ender Finol Haichao Han | 2019 | 医用生物力学2019，34，A01： | 0 |
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