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| 1 | 传统DNA疫苗载体与Semliki森林病毒复制子对HIV-1 Pr55^(gag)表达与体液免疫原性的比较性研究显示文摘为探索Semliki森林病毒 (SFV)衍生的复制型DNA载体可否用于HIV疫苗的候选载体 ,对该载体与传统DNA疫苗载体对HIV - 1Pr5 5 gag的表达与体液免疫原性进行了系统比较研究。将野生型 (wtgag)及密码子改造(syngag)的HIV - 1ⅢBgag 基因分别克隆于SFVDNA载体及传统DNA疫苗载体 [pCDNA3 1(+) ],对其Pr5 5 gag细胞内表达水平、Pr5 5 gag病毒样颗粒释放、以及在BALB/c鼠的体液免疫原性进行了比较。在 2 93T、H12 99、C2C12和BHK细胞系中 ,SFV -wtgag可以Rev非依赖方式有效表达Pr5 5 gag ,而 pC -wtgag转染的细胞不能有效表达Pr5 5 gag,从而不能诱导小鼠产生免疫反应。虽然SFV质粒的细胞转化效率明显低于pCDNA载体 ,SFV -wtgag和SFV -syngag在细胞内Pr5 5 gag的表达量与 pC -syngag相似 ,而Pr5 5 gag病毒样颗粒的释放明显低于 pC -syngag。在肌内注射免疫的小鼠中 ,低剂量 (0 1和 1 0 μg)的SFV及 pCDNAgag表达质粒均未诱导出GAG特异性免疫反应。在高剂量 (10 ,30 ,10 0 μg)免疫组中 ,与SFVgag表达质粒相比 ,pC -syngag可诱导出较高水平的TH1型GAG特异性抗体。SFV -syngag较SFV -wtgag可诱导出高水平的体液免疫反应。结果提示 ,SFV衍生的复制子单独使用不能在小鼠诱导出优于传统DNA疫苗载体的HIV - 1GAG特异性? | 张健慧 Jens Wild Kurt Bieler Marcus Graf Ludwig Deml Hans Wolf PeterLiljestrm Ralf Wagner 邵一鸣 | 2002 | 病毒学报2002，18，1： | 13 |
| 2 | On the relationship between environmental management, environmental innovation and patenting: Evidence from German manufacturing firms显示文摘 | Marcus Wagner | 2007 | Research Policy2007，，10： | 2 |
| 3 | Assessing the relationship between economic and ecological performance: Distinguishing system levels and the role of innovation显示文摘 | Frank Boons Marcus Wagner | 2009 | Ecological Economics2009，，7： | 1 |
| 4 | Empirical influence of environmental management on innovation: Evidence from Europe显示文摘 | Marcus Wagner | 2007 | Ecological Economics2007，，2： | 1 |
| 5 | Administration guidelines for radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-labeled anti-CD20 monoclonal antibody显示文摘 | Wagner HN Jr Wiseman GA Marcus CS | 2002 | J Nucl Med2002，43，2： | 1 |
| 6 | Assessing the Relationship between Economic and Ecological Performance:Distinguishing System Levels and the Role of Innovation显示文摘 | Frank Boons Marcus Wagner | 2009 | Ecological Economics2009，，6： | 1 |
| 7 | How to reconcile environmental and economic performance to improve corporate sustainability显示文摘 | Marcus Wagner | 2005 | Journal of Environmental Management2005，，76： | 1 |
| 8 | Corporate Social Performance and Innovation with High Social Benefits: A Quantitative Analysis显示文摘 | Marcus Wagner | 2010 | Journal of Business Ethics2010，，4： | 1 |
| 9 | Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury显示文摘 | Krisztina Rusai Daniel Sollinger Marcus Baumann Bettina Wagner Matthias Strobl Christoph Schmaderer Marcel Roos Carsten Kirschning Uwe Heemann Jens Lutz | 2010 | Pediatric Nephrology2010，，5： | 1 |
| 10 | Big Data Analytics for Earth Sciences:the EarthServer approach显示文摘Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced e-infrastructures.Earth and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and simulations.However,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of processing.Therefore,Big Earth Data Analytics requires specifically tailored techniques and tools.The EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and visualization.The result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains. | Peter Baumann Paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati Lorenzo Bigagli Enrico Boldrini Riccardo Bruno Antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu Antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek Marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner | 2016 | International Journal of Digital Earth2016，9，1： | 1 |
| 11 | Adiministration Guidelines for Radioimmutherapy of non-Hodgkin'Slymphoma with ^90y-labeled anti-CD20 MonoclonalAntibody显示文摘 | Wagner H N Wiseman G A Marcus C S | 2002 | J Nucl Med2002，43，2： | 1 |
| 12 | How to Reconcile Environmental and Economic Performance to Improve Corporate Sustainability显示文摘 | Marcus Wagner | 2005 | Journal of Environmental Management2005，，76： | 1 |
| 13 | The role of corporate sustainability performance for economic performance: A firm-level analysis of moderation effects显示文摘 | Marcus Wagner | 2010 | Ecological Economics2010，，7： | 1 |
| 14 | Empirical influence of environmental management on innovation:Evidence from Europe显示文摘 | Marcus Wagner | 2008 | Ecological Economics2008，66，23： | 1 |
| 15 | Administration guidelines for radioimmunotherapy of non-Hodgkin's lymphoma with ~(90)Y labelled anti-CD20 monoclonal antibody显示文摘 | Wagner HN Jr Wiseman GA Marcus CS | 2002 | J Nucl Med2002，43，2： | 1 |
| 16 | Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion显示文摘 | Erik Hedstr?m Karin ?str?m-Olsson Hans ?hlin Fredrik Frogner Marcus Carlsson Therese Billgren Stefan Jovinge Peter Cain Galen S. Wagner H?kan Arheden | 2007 | Scandinavian Cardiovascular Journal2007，，1： | 1 |
| 17 | Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion显示文摘 | Erik Hedstr? m Karin ? str? m-Olsson Hans ? hlin Fredrik Frogner Marcus Carlsson Therese Billgren Stefan Jovinge Peter Cain Galen S. Wagner H? kan Arheden | 2007 | Scandinavian Cardiovascular Journal2007，，1： | 1 |
| 18 | Guy Structure with Galvanic Corrosion: Case Study显示文摘 | Romildo Alves Berenguer Edmilson Raimundo de Oliveira Junior Marcus Wagner Pereira da Silva Glauber Beirao de Souza Paulo Helene Eliana Cristina Barreto Monteiro | 2016 | Journal of Civil Engineering and Architecture2016，10，7： | 0 |
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