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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 3 | Combustion characteristics of coal in a mixture of oxygen and recycled flue gas显示文摘 | Tan Y Croiset E Mark A | 2006 | Fuel2006，85，4： | 1 |
| 4 | Perceptualcognitive expertise in sport: a meta-analysis显示文摘 | DLEREK T Y MANN A MARK WILLIAMS | 2007 | J Sport Psychol2007，29，： | 1 |
| 5 | Characterization of a New Metallo-Lactamase Gene,bla NDM-1,and a novel erythromycin esterase gene carried on a unique genetic structure in klebsiella pneumoniae sequence type 14from India显示文摘 | DONGEUN Y MARK A | 2009 | Antimicrob Agents Chemother2009，53，12： | 1 |
| 6 | Longitudinal measurement of amniotic fluid index in posterm pregnancies and its association with fetal outcome显示文摘 | Divon M Y Mark A D Henderson C E | 1995 | Am J Obstet Gynecol1995，172，2： | 1 |
| 7 | Soluble Expression and Purification of Porcine Pepsinogen from Pichia pastoris显示文摘 | Mark A Y Ahn J K Takuji T | 2002 | Protein Expression and Purification2002，25，： | 1 |
| 8 | Stereocontrol in the polymerization of methyl methacrylate mediated by chiral organolanthanide metallocenes显示文摘 | GIARDELLO M A YAMAMOTO Y BRARD L MARKS T J | 1995 | J Am Chem Soc1995，117，11： | 1 |
| 9 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 10 | Climate controls on vegelation phonological patterns in northern mid-and-high latitudes inferred from MODIS data显示文摘 | Zhang X Y Mark A F | 2004 | Global Change Biology2004，，10： | 1 |
| 11 | Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis 显示文摘 | Mark FGourle Y Howard A Austin Ⅲ Dorothy Scorr | 1996 | Ann Intern Med1996，125，7： | 1 |
| 12 | Combustion characteristics of coal in a mixture of oxygen and recycled flue gas显示文摘 | TAN Y CROISET E MARK A | 2006 | Fuel2006，，4： | 1 |
| 13 | Experiment assessment of the ballistic response of composite pyramidal lattice truss structures 显示文摘 | Christian J Y Darren D R Mark A | 2008 | Composites B2008，39，： | 1 |
| 14 | A WD40 repeat protein from Medicago truncatula is necessary for tissue-specific anthocyanin and proanthocyanidin biosynthesis but not for trichome development 显示文摘 | Pang Y Wenger J P Saathoff K Peel G J Wen J Huhman D Allen S N Tang Y Cheng X Tadege M Ratct P Mysore K S Sumner L W Marks M D Dixon R A | 2009 | Plant Physiology2009，151，3： | 1 |
| 15 | Knowledge discovery in time series databases 显示文摘 | MARK L KLEIN Y KANDEL A | 2001 | IEEE Transactions on Systems Man and Cybernetics2001，31，1： | 1 |
| 16 | Receptor for advanced glycation end products and age-re- lated macular degeneration 显示文摘 | Howes KA Liu Y Dunalef JL Milam A Frederick JM Marks A | 2004 | Invest Ophthalmol Vis Sci2004，45，10： | 1 |
| 17 | Monitoring Vegeta- tion Phenology Using MODIS显示文摘 | Zhang X Y Mark A F Crystal B S | 2003 | Remote Sensing of Envi- ronment2003，84，3： | 1 |
| 18 | 查看详情显示文摘 | Chen M. C Kim C Chen S. Y Chiang Y.J Chung M.C Facchetti A Marks T J | | 0，，： | 1 |
| 19 | The influence of intellectual capital on the types of innovative capabilities 显示文摘 | Mohan S Mark A Y | 2005 | Academy of Management Journal2005，48，3： | 1 |
| 20 | Extension of strapdown attitude algorithm for high-frequency base motion显示文摘 | Lee J G Yoon Y J Mark J G Tazartes D A | 1990 | Journal of Guidance1990，13，4： | 1 |
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