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| 1 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 4 | Full-thickness intraperitoneal excision by transanal endoscopic microsurgery does not increase short-term complications显示文摘 | Justine A Gavagan Mark H Whiteford Lee L Swanstrom | 2004 | The American Journal of Surgery2004，，5： | 2 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Protein targeting by tyrosine-and di leucine-based signals: evidence for distinct saturable components显示文摘 | Marks MS Woodruff L Ohno H | 1996 | J Cell Biol1996，135，： | 1 |
| 7 | Amiodarone or an implant- able cardioverter-defibrillator for congestive heart failure 显示文摘 | Bardy G H Lee K L Mark D B | 2005 | N Engl J Med2005，352，3： | 1 |
| 8 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 9 | Earthworm eoelomocytes in vitro 显示文摘 | Toupin J Marks D H Cooper E L | 1977 | In Vitro1977，13，4： | 1 |
| 10 | Photoscattering effect in supercontinuum - generating photonic crystal fiber显示文摘 | TU H MARKS D L JIANG Z | 2008 | Appl Phys Lett2008，92，06： | 1 |
| 11 | Growth curve changes associated with long-term selection for body weight in Japanese quails显示文摘 | Mark H L | 1978 | Growth1978，42，： | 1 |
| 12 | Environ Sci Technol 显示文摘 | Snoeyink V L Weber W J Mark H B | 1969 | 3(10): 9181969，3，10： | 1 |
| 13 | SUN: A Bayesianframework for saliency using natural statistics显示文摘 | Zhang L Y Tong M H Marks T K | 2008 | Journal ofVision2008，8，7： | 1 |
| 14 | Dietary Fiber, Weight Gain, and Cardiovascular Disease Risk Factors in Young Adults 显示文摘 | David S L Mark A P Candyce H K | 1999 | American Medical Association1999，282，16： | 1 |
| 15 | Influences of redox transformation, metal complexation and aggregation of fulvic acid and humic acid on Cr( Ⅵ) and As ( V ) removal by zero-valent iron 显示文摘 | MARK S H M IRENE M C L | 2011 | Chemosphere2011，84，： | 1 |
| 16 | Lead(Pb+2)promotes apoptosis in newborn rat cerebellar neurons:path-ologic implications显示文摘 | OBERTO A MARKS N EVANS H L | 1996 | J Pharmacol Exp Ther1996，279，1： | 1 |
| 17 | Accurate parametric modeling of folded waveguide circuits for millimeter-wave traveling wave tubes 显示文摘 | John H Booske Mark C Converse Carol L Kory | 2005 | IEEE Transactions on Electron Devices2005，52，5： | 1 |
| 18 | Using a positive lens to complicate the positive in identity research显示文摘 | Mark L Michael H | | 0，，： | 1 |
| 19 | Benign pros-tate-specific antigen (BPSA) in serum is increased in be-nign prostate disease显示文摘 | Linton H J marks L S Millar L S | | 0，，13： | 1 |
| 20 | Inflammatory cytokine profiles associated with chondraldamage in the anterior cruciate liga- ment-deficient knee 显示文摘 | Marks P H Donaldson M L | 2005 | Arthroscopy2005，21，11： | 1 |
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