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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 3 | End-stage renal disease and economic incentives:The international study of health care organization and fi- nancing显示文摘 | AviDor Mark V Pauly Margaret A Eichleay Philip J Held | 2007 | International Journal of Health Care Finance and Economics2007，，2： | 1 |
| 4 | Organizing pneu- monia and pulmonary lymphatic architecture in diffuse alveolar damage显示文摘 | MANDAL R V MARK E J KRADIN R L | 2008 | Human Pathology2008，39，8： | 1 |
| 5 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 6 | Environ Sci Technol 显示文摘 | Snoeyink V L Weber W J Mark H B | 1969 | 3(10): 9181969，3，10： | 1 |
| 7 | Fabrication of ZnO nanorods and nanotubes in aqueous solutions显示文摘 | Li Q Kumar V Li Y Zhang H Marks T J Chang P H R | 2005 | Chem Mater2005，17，5： | 1 |
| 8 | Radiotherapy dose-volume effects on salivary gland function显示文摘 | DEASY J O MOISEENKO V MARKS L | 2010 | Int J Radiat Oncol Biol Phys2010，76，： | 1 |
| 9 | The power of real-time PCR 显示文摘 | Mark A V Joyce J R | 2005 | Adv Physiol Educ2005，29，： | 1 |
| 10 | Motivating knowledge sharing through a knowledge management system显示文摘 | KING W R MARKS J P V | 2008 | Omega2008，36，1： | 1 |
| 11 | Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors : the Geisinger experience 显示文摘 | THOMAS C J WOOD G C MARKS V J | 2007 | Dermatol Surg2007，33，3： | 1 |
| 12 | Generalized SMASH imaging显示文摘 | David J Joseph V | 2002 | Magn Reson Med2002，47，1： | 1 |
| 13 | Algorithms for optimal area triangulations of a convex polygon显示文摘 | MARK K J TZVETALIN S V | 2006 | Computation- al Geometry: Theory and Applications2006，25，3： | 1 |
| 14 | The human drug metabolizing cytochromes P450显示文摘 | Seven A W Mark V B Barbara J R | 1996 | J Phannacokinet Biopharm1996，24，5： | 1 |
| 15 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 16 | Intemal and external integration for product development:the contingency effects of uncertainty, equivocality, and platform strategy显示文摘 | XENOPHON K MARK V JAYANTH J | 2005 | Decision Sciences2005，36，1： | 1 |
| 17 | The risk of contralateral lymphatic metastases for cancers of the larynx and pharynx显示文摘 | MARKS J E DEVINENI V R HARVEY J | 1992 | Am J Otolaryngol1992，13，： | 1 |
| 18 | Mutation of toxB and a truncated version of the efa-1 gene in Escherichia coli O157 : H7 influences the expression and secretion of locus of en- terocyte effacement-encoded proteins but not intestinal colonization in calves or sheep 显示文摘 | MARK P S ANDREW J R ISABELLA V | 2006 | Infection and Immunity2006，72，9： | 1 |
| 19 | A Cooperative Diversity Scheme Based on Quadrature Signaling显示文摘 | Mahinthan V Mark J W Shen X S | 2007 | IEEE Trans on Wireless Communication2007，6，1： | 1 |
| 20 | 'Spratly Solution Still at Sea'显示文摘 | | 1993 | The Pacific Review1993，6，2： | 1 |
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