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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Dynamic condylar screw or hip joint (spanning) external fixator for treatment of pathological fractures of femoral neck and trochanter secondary to benign lesions显示文摘 | ZHANG Chun-lin ZENG Bing-fang DONG Yang Daria brooks Terrell Martin M. Malawer | 2008 | Chinese Medical Journal2008，，2： | 6 |
| 3 | Coal mine roof rating(CMRR),rock mass rating(RMR)and strata control:Carborough Downs Mine,Bowen Basin,Australia显示文摘The rock mass rating(RMR)has been used across the geotechnical industry for half a century.In contrast,the coal mine roof rating(CMRR)was specifically introduced to underground coal mines two decades ago to link geological characterization with geotechnical risk mitigation.The premise of CMRR is that strength properties of mine roof rock are influenced by defects typical of coal measures stratigraphy.The CMRR has been used in longwall pillar design,roof support methods,and evaluation of extended cuts,but is rarely evaluated.Here,the RMR and CMRR are applied to a longwall coal mine.Roof rock mass classifications were undertaken at 67 locations across the mine.Both classifications showed marked spatial variability in terms of roof conditions.Normal and reverse faulting occur across the mine,and while no clear relationships exist between rock mass character and faulting,a central graben zone showed heterogeneous rock mass properties,and divergence between CMRR and RMR.Overall,the CMRR data fell within the broad envelope of results reported for extended cuts at Australian and U.S.coal mines.The corollary is that the CMRR is useful,and should not be used in isolation,but rather as a component of a strata control programme. | Martin Brook Bruce Hebblewhite Rudrajit Mitra | 2020 | International Journal of Mining Science and Technology2020，30，2： | 3 |
| 4 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D'Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 2 |
| 5 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D’Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 1 |
| 6 | Cerebral metabolism following traumatic brain injury:new discoveries with implications for treatment 显示文摘 | Brooks GA Martin NA | 2014 | Front Neurosci2014，8，： | 1 |
| 7 | Sympatry between altemate hosts affects population structure of poplar leaf rust显示文摘 | MARTIN B LOUIS B BROOK G | 1998 | Proc First Rust of Forest Trees1998，712，： | 1 |
| 8 | Spinal cord injury and its treatment: current management and experimental perspectives 显示文摘 | SCHOLTES F BROOK G MARTIN D | 2012 | Adv Tech Stand Neurosurg2012，38，： | 1 |
| 9 | Paroxysmal Lone Atrial Fibrillation Is Associated With an Abnormal Atrial Substrate显示文摘 | Martin K. Stiles Bobby John Christopher X. Wong Pawel Kuklik Anthony G. Brooks Dennis H. Lau Hany Dimitri Kurt C. Roberts-Thomson Lauren Wilson Paolo De Sciscio Glenn D. Young Prashanthan Sanders | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
| 10 | Tuberculosis edu- cation in an endemic setting: application of participatory methods to video development in the Gambia 显示文摘 | MARTIN M BROOKES L CHAM A | 2005 | Int J Tu- berc Lung Dis2005，9，5： | 1 |
| 11 | Long-Term Fine Particulate Matter Exposure and Mortality From Diabetes in Canada显示文摘 | Robert D. Brook Sabit Cakmak Michelle C. Turner Jeffrey R. Brook Dan L. Crouse Paul A. Peters Aaron van Donkelaar Paul J. Villeneuve Orly Brion Michael Jerrett Randall V. Martin Sanjay Rajagopalan Mark S. Goldberg C. Arden Pope Richard T. Burnett | 2013 | Diabetes Care2013，，10： | 1 |
| 12 | Indications for spine surgery: validation of an administrative coding algorithm to classify degenerative diagnoses 显示文摘 | Brook I Martin JD Lurie NA | 2014 | Spine2014，39，9： | 1 |
| 13 | Endoscopic transluminal drainage and necrosectomy using a novel, through-the-scope, fully covered, large-bore esophageal metallic stent: preliminary experience in 10 patients显示文摘 | Rajeev Attam Guru Trikudanathan Mustafa Arain Yukako Nemato Brooke Glessing Shawn Mallery Martin L. Freeman | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 14 | Storage length, storage temperature, and lean formulation influence the shelf-life and stability of traditionally packaged ground beef 显示文摘 | Martin J N Brooks J C Brooks T A | 2013 | Meat Science2013，95，3： | 1 |
| 15 | Temporal constraints on glacial valley cross-profile evolution: Two Thumb Range, central Southern Alps, New Zealand显示文摘 | Martin S. Brook Martin P. Kirkbride Ben W. Brock | 2007 | Geomorphology2007，，1： | 1 |
| 16 | Alumina/silicon carbide nanocomposites by hybrid polymer/ powder processing: microstructures and mechanical properties显示文摘 | Brain Derby Richard J Brook | 1998 | J Am Ceram Soc1998，81，1： | 1 |
| 17 | Repeat surgery after lumbar decompression for herniated disc: the quality implications of hospital and surgeon variation显示文摘 | Brook I. Martin Sohail K. Mirza David R. Flum Thomas M. Wickizer Patrick J. Heagerty Alex F. Lenkoski Richard A. Deyo | 2012 | The Spine Journal2012，，2： | 1 |
| 18 | ACR Appropriateness Criteria Colorectal Cancer Screening显示文摘 | Judy Yee David H. Kim Max P. Rosen Tasneem Lalani Laura R. Carucci Brooks D. Cash Barry W. Feig Kathryn J. Fowler Douglas S. Katz Martin P. Smith Vahid Yaghmai | 2014 | Journal of the American College of Radiology2014，，： | 1 |
| 19 | Spinal cord injury and its treatment:current management and experimental perspectives显示文摘 | Scholtes F Brook G Martin D | 2012 | Adv Tech Stand Neurosurg2012，38，： | 1 |
| 20 | A Prospective, Randomized Trial of Early Enteral Feeding After Resection of Upper Gastrointestinal Malignancy显示文摘 | Martin J. Heslin Lianne Latkany Denis Leung Ari D. Brooks Steven N. Hochwald Peter W. T. Pisters Moshe Shike Murray F. Brennan | 1997 | Annals of Surgery1997，，4： | 1 |
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