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| 1 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 2 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 3 | Four color-measuring devices compared with a spectrophotometric reference system 显示文摘 | Karl Martin Lehmann Christophe r Igiel lrene Schmidtmann | 2010 | J Dent2010，38，： | 1 |
| 4 | Characterization and Quantification of Rat Bile Phosphatidylcholine by Electrospray–Tandem Mass Spectrometry显示文摘 | Wolf D. Lehmann Martin Koester Gerhard Erben Dietrich Keppler | 1997 | Analytical Biochemistry1997，，1： | 1 |
| 5 | Effect of chro- nic total coronary occlusion on treatment strategy显示文摘 | Christofferson RD Lehmann KG Martin GV | 2005 | Am J Cardiol2005，95，9： | 1 |
| 6 | Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry显示文摘 | Martin H?glund Fredrik Sandin Karin Hellstr?m Mats Bj?reman Magnus Bj?rkholm Mats Brune Arta Dreimane Marja Ekblom S?ren Lehmann Per Ljungman Claes Malm Berit Markev?rn Kristina Myhr-Eriksson Lotta Ohm Ulla Olsson-Str?mberg Anders Sj?lander Hans Wadenvik | 2013 | Blood2013，，： | 1 |
| 7 | The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity 显示文摘 | Michaloglou C Lehmann W Martin T A | 2013 | PLoS One2013，8，61： | 1 |
| 8 | Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses显示文摘 | Fabien P. Blanchet Arnaud Moris Damjan S. Nikolic Martin Lehmann Sylvain Cardinaud Romaine Stalder Eduardo Garcia Christina Dinkins Florence Leuba Li Wu Olivier Schwartz Vojo Deretic Vincent Piguet | 2010 | Immunity2010，，5： | 1 |
| 9 | Brain electrical source imaging in manic and depressive episodes of bipolar disorder显示文摘 | Annamaria Painold Pascal L Faber Patricia Milz Eva Z Reininghaus Anna K Holl Martin Letmaier Roberto D Pascual‐Marqui Bernd Reininghaus Hans‐Peter Kapfhammer Dietrich Lehmann | 2014 | Bipolar Disord2014，，7： | 1 |
| 10 | Effect of chronic total coronary occlusion on treatment strategy显示文摘 | Christofferson RD Lehmann KG Martin GV | 2005 | Am J Cardiol2005，95，9： | 1 |
| 11 | Effect of chronic total coronary occlusion on treatment strategy显示文摘 | CHRISTOFFERSON R D LEHMANN K G MARTIN G V | 2005 | Am J Cardial2005，95，9： | 1 |
| 12 | Insights into mitochondrial quality control pathwsys and Parkinson's disease显示文摘 | Lehmann S Martins LM | 2013 | J Mol Med (Berl)2013，91，： | 1 |
| 13 | Malpositioning of the Lag Screws by 1- or 2-screw Nailing Systems for Pertrochanteric Femoral Fractures: A Biomechanical Comparison of Gamma 3 and Intertan显示文摘 | Jakob V. Nüchtern Andreas H. Ruecker Kay Sellenschloh Martin Rupprecht Klaus Püschel Johannes M. Rueger Michael M. Morlock Wolfgang Lehmann | 2014 | Journal of Orthopaedic Trauma2014，，5： | 1 |
| 14 | Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells显示文摘 | Hana Janouskova Anne-Marie Ray Fanny Noulet Isabelle Lelong-Rebel Laurence Choulier Florence Schaffner Maxime Lehmann Sophie Martin Jan Teisinger Monique Dontenwill | 2013 | Cancer Letters2013，，2： | 1 |
| 15 | MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy显示文摘 | Andreas-Claudius Hoffmann Peter Wild Christina Leicht Simone Bertz Kathleen D. Danenberg Peter V. Danenberg Robert St?hr Michael St?ckle Jan Lehmann Martin Schuler Arndt Hartmann | 2010 | Neoplasia2010，，： | 1 |
| 16 | Strategies for dispatching AGVs at automated seaport container terminals显示文摘 | Martin Grunow Hans-Otto Günther Matthias Lehmann | 2006 | OR Spectrum2006，，4： | 1 |
| 17 | Effect of chronic total coronary occlusion on treatment strategy显示文摘 | Christofferson RD Lehmann KG Martin GV | 2005 | Am J Cardiol2005，95，9： | 1 |
| 18 | Dispatching multi-load AGVs in highly automated seaport container terminals显示文摘 | Martin Grunow Hans-Otto Günther Matthias Lehmann | 2004 | OR Spectrum2004，，2： | 1 |
| 19 | National Trends and Outcomes for the Surgical Therapy of Ileocolonic Crohn’s Disease: A Population-Based Analysis of Laparoscopic vs. Open Approaches显示文摘 | Kelly Lesperance Matthew J. Martin Ryan Lehmann Lionel Brounts Scott R. Steele | 2009 | Journal of Gastrointestinal Surgery2009，，： | 1 |
| 20 | Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)显示文摘 | Birgit Assmus Volker Sch?chinger Claudius Teupe Martina Britten Ralf Lehmann Natascha D?bert Frank Grünwald Alexandra Aicher Carmen Urbich Hans Martin Dieter Hoelzer Stefanie Dimmeler Andreas M. Zeiher | 2002 | Circulation: Journal of the American Heart Association2002，，24： | 1 |
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