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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 3 | Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer显示文摘 | Yasuhiko Mohri Yasuhiro Inoue Koji Tanaka Junichirou Hiro Keiichi Uchida Masato Kusunoki | 2013 | World Journal of Surgery2013，，11： | 3 |
| 4 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 5 | Single‐incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum显示文摘 | Masaki Ohi Hiromi Yasuda Yoshito Ishino Masaki Katsurahara Susumu Saigusa Kyosuke Tanaka Koji Tanaka Yasuhiko Mohri Yasuhiro Inoue Keiichi Uchida Masato Kusunoki | 2013 | Asian J Endosc Surg2013，，4： | 2 |
| 6 | Long-term outcomes after a variety of video-assisted thoracoscopic lobectomy approaches for clinical stage IA lung cancer: A multi-institutional study显示文摘 | Norihisa Shigemura Akinori Akashi Soichiro Funaki Tomoyuki Nakagiri Masayoshi Inoue Noriyoshi Sawabata Hiroyuki Shiono Masato Minami Yukiyasu Takeuchi Meinoshin Okumura Yoshiki Sawa | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，3： | 2 |
| 7 | D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function显示文摘 | Masato Sasaki Christiane B. Knobbe Momoe Itsumi Andrew J. Elia Isaac S. Harris Iok In Christine Chio Rob A. Cairns Susan McCracken Andrew Wakeham Jillian Haight Annick You Ten Bryan Snow Takeshi Ueda Satoshi Inoue Kazuo Yamamoto Myunggon Ko Anjana Rao Kat | 2012 | Genes & Development2012，，18： | 1 |
| 8 | A large, solitary, semipedunculated gastric polyp in pediatric juvenile polyposis syndrome显示文摘 | Kohei Otake Keiichi Uchida Mikihiro Inoue Kohei Matsushita Kiyoshi Hashimoto Yuji Toiyama Koji Tanaka Kaname Nakatani Kazuo Kawai Masato Kusunoki | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 9 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 10 | Overexpression of the miR-34 family suppresses invasive growth of malignantmelanoma with the wild-type p53 gene显示文摘 | Hitoshi Yamazaki Tsuyoshi Chijiwa Yoshimasa Inoue Yoshiyuki Abe Hiroshi Suemizu Kenji Kawai Masatoshi Wakui Daisuke Furukawa Masaya Mukai Sadahito Kuwao Makoto Saegusa Masato Nakamura | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 11 | Functional differentiation of the auditory association area in prelingually deaf subjects显示文摘 | Shigeru Hirano Yasushi Naito Hisayoshi Kojima Iwao Honjo Masato Inoue Kazuhiko Shoji Ichiro Tateya Nobuya Fujiki Sadahiko Nishizawa Junji Konishi | 2000 | Auris Nasus Larynx2000，，4： | 1 |
| 12 | Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer显示文摘 | Yasuhiro Inoue Takehiko Yokobori Takeshi Yokoe Yuji Toiyama Chikao Miki Koshi Mimori Masaki Mori Masato Kusunoki | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
| 13 | The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis显示文摘 | Keiichi Uchida Yuhki Koike Kiyoshi Hashimoto Susumu Saigusa Mikihiro Inoue Kohei Otake Koji Tanaka Kohei Matsushita Yoshiki Okita Hiroyuki Fujikawa Toshimitsu Araki Yasuhiko Mohri Masato Kusunoki Paolo Gionchetti | 2015 | Gastroenterology Research and Practice2015，，： | 1 |
| 14 | High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells显示文摘 | Hiroyuki Fujikawa Koji Tanaka Yuji Toiyama Susumu Saigusa Yasuhiro Inoue Keiichi Uchida Masato Kusunoki | 2012 | Journal of Gastroenterology2012，，7： | 1 |
| 15 | Soluble CXCL16 in Preoperative Serum is a Novel Prognostic Marker and Predicts Recurrence of Liver Metastases in Colorectal Cancer Patients显示文摘 | Kohei Matsushita Yuji Toiyama Koji Tanaka Susumu Saigusa Junichiro Hiro Keiichi Uchida Yasuhiro Inoue Masato Kusunoki | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 16 | Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma显示文摘 | Masayoshi Inoue Mitsunori Ohta Keiji Iuchi Akihide Matsumura Kan Ideguchi Tsutomu Yasumitsu Katsuhiro Nakagawa Kenjiro Fukuhara Hajime Maeda Shin-ichi Takeda Masato Minami Yuko Ohno Hikaru Matsuda | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 17 | Huge scrotal, flank, and retroperitoneal lymphangioma successfully treated by OK-432 sclerotherapy显示文摘 | Keiichi Uchida Mikihiro Inoue Toshimitsu Araki Chikao Miki Masato Kusunoki | 2002 | Urology2002，，6： | 1 |
| 18 | T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma显示文摘 | Moriwaki Atsushi Inoue Hiromasa Nakano Takako Matsunaga Yuko Matsuno Yukiko Matsumoto Takafumi Fukuyama Satoru Kan-o Keiko Matsumoto Koichiro Tsuda-Eguchi Miyuki Nagakubo Daisuke Yoshie Osamu Yoshimura Akihiko Kubo Masato Nakanishi Yoichi | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，4： | 1 |
| 19 | Should We Emergently Revascularize Occluded Coronaries for Cardiac Arrest?: Rapid-Response Extracorporeal Membrane Oxygenation and Intra-Arrest Percutaneous Coronary Intervention显示文摘 | Eisuke Kagawa Keigo Dote Masaya Kato Shota Sasaki Yoshinori Nakano Masato Kajikawa Akifumi Higashi Kiho Itakura Akihiko Sera Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Satoshi Kurisu | 2012 | Circulation2012，，： | 1 |
| 20 | Aggressive surgical treatment for T4 gastric cancer显示文摘 | Akihiko Kobayashi M.D. Toshio Nakagohri M.D. Masaru Konishi M.D. Kazuto Inoue M.D. Shinichirou Takahashi M.D. Masaaki Itou M.D. Masanori Sugitou M.D. Masato Ono M.D. Norio Saito M.D. Taira Kinoshita M.D | 2004 | Journal of Gastrointestinal Surgery2004，，4： | 1 |
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