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| 1 | 国际糖尿病足工作组:糖尿病足溃疡分类指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)自1999年以来一直以循证为基础发布糖尿病足病的预防和管理指南。本文中针对日常临床工作中糖尿病足溃疡的分类提出了新指南,并对既有的分类进行了综述。新指南只对现患糖尿病足溃疡进行分类,不包括用于定义未来溃疡风险的分类系统。本指南的制定是基于对现有文献的综述以及专家对最大程度影响临床结局的8个关键因素的鉴定。分类级别是根据关键因素的数量、内部和外部有效性验证以及使用意向而制定的。判定分类评分的关键因素有3种:患者相关的因素(终末期肾衰竭)、肢体相关的因素(周围动脉病变和保护性感觉丧失)和溃疡相关的因素(面积、深度、部位、单发或多发以及感染)。特殊分类系统要考虑以下5种临床情况:①卫生专业人员之间交流;②预测单个溃疡预后;③对个案临床决策的辅助;④伤口评估,有感染或无感染及周围动脉病变(评估灌注及血管重建的潜在益处);⑤用于地方、区域或国家人群结局的稽查。指南推荐:①医务人员之间交流使用SINBAD系统。②无适用于预测个体溃疡预后的分类。③感染的评估采用美国传染病学会/国际糖尿病足工作组(IDSA/IWGDF)分类系统。④评估灌注及血管重建的潜在获益使用创面、缺血、足感染(WIfI)系统。⑤人群结局的稽查使用SINBAD系统。 | Matilde Monteiro-Soares David Russell Edward J Boyko William Jeffcoate Joseph L Mills Stephan Morbach Fran Game 无 王爱红(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 2 | Loss of Halophytism by Interference with SOS1 Expression1[W][OA]显示文摘 | Oh Dong-Ha Leidi Eduardo Zhang Quan Hwang Sung-Min Li Youzhi Quintero Francisco J Jiang Xingyu D’Urzo Matilde Paino Lee Sang Yeol Zhao Yanxiu Bahk Jeong Dong Bressan Ray A Yun Dae-Jin Pardo José M Bohnert Hans J | 2009 | Plant Physiology2009，，1： | 1 |
| 3 | Signaling Functions of Reactive Oxygen Species 显示文摘 | Henry J F Matilde M Fulvio U | 2010 | Biochemistry2010，49，： | 1 |
| 4 | Plant cell wall glycoproteins and their genes显示文摘 | Matilde J E Puigdomènech P | 2000 | Plant Physiol Biochem2000，38，： | 1 |
| 5 | The eight-cysteine motif, a versatile structure in plant proteins显示文摘 | Matilde J E | 2004 | Plant Physiology and Biochemistry2004，42，： | 1 |
| 6 | Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells显示文摘AIM:To investigate the effect of aspirin on neuroendocrine tumor(NET)cell growth and signaling in vitro.METHODS:Human pancreatic BON1,bronchopulmonary NCI-H727 and midgut GOT1 neuroendocrine tumor cells were treated with different concentrations of aspirin(from 0.001 to 5 mmol/L),and the resulting effects on metabolic activity/cell proliferation were measured using cell proliferation assays and SYBR-DNAlabeling after 72,144 and 216 h of incubation.The effects of aspirin on the expression and phosphorylation of several critical proteins that are involved in the most common intracellular growth factor signaling pathways(especially Akt protein kinase B)and mammalian target of rapamycin(mTOR)were determined by Western blot analyses.Propidium iodide staining and flow cytometry were used to evaluate changes in cell cycle distribution and apoptosis.Statistical analysis was performed using a 2-tailed Student’s t-test to evaluate the proliferation assays and cell cycle analyses.The results are expressed as the mean±SD of 3 or 4 independently performed experiments.Statistical significance was set at P<0.05.RESULTS:Treatment with aspirin suppressed the viability/proliferation of BON1,NCI-H727 and GOT1 cells in a time-and dose-dependent manner.Significant effects were observed at starting doses of 0.5-1 mmol/L and peaked at 5 mmol/L.For instance,after treatment with 1 mmol/L aspirin for 144 h,the viability of pancreatic BON1 cells decreased to 66%±13%(P<0.05),the viability of bronchopulmonary NCI-H727 cells decreased to 53%±8%(P<0.01)and the viability of midgut GOT1 cells decreased to 89%±6%(P<0.01).These effects were associated with a decreased entry into the S phase,the induction of the cyclin-dependent kinase inhibitor p21 and reduced expression of cyclindependent kinase 4 and cyclin D3.Aspirin suppressed mTOR downstream signaling,evidenced by the reduced phosphorylation of the mTOR substrates 4E binding protein 1,serine/threonine kinase P70S6K and S6 ribosomal protein and inhibited glycogen synthase kinase3 activity.We observed the(compensatory)activation of tuberous sclerosis 2,the serine/threonine specific protein kinase AKT and extracellular signal-regulated kinases.CONCLUSION:Aspirin demonstrates promising anticancer properties for NETs in vitro.Further preclinical and clinical studies are needed. | Matilde Spampatti George Vlotides Gerald Spttl Julian Maurer Burkhard Gke Christoph J Auernhammer | 2014 | World Journal of Gastroenterology2014，20，29： | 1 |
| 7 | Different mechanisms generating sequence variability are revealed in distinct regions of the hydroxyproline-rich glycoprotein gene from maize and related species 显示文摘 | Raz R Matilde J Moya A | 1992 | Molecular and General Gene- tics1992，233，： | 1 |
| 8 | Color- copigmentation study by tristimulus eolorimetry (CIELAB) in red wines obtained from Tempranillo and Graciano varieties 显示文摘 | MATILDE G M MARIA L E FRANCISCO J H | 2013 | Food Research International2013，51，1： | 1 |
| 9 | Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR显示文摘 | Schoppy David W Ragland Ryan L Gilad Oren Shastri Nishita Peters Ashley A Murga Matilde Fernandez-Capetillo Oscar Diehl J Alan Brown Eric J | 2012 | Journal of Clinical Investigation2012，，1： | 1 |
| 10 | All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells:involvement of retinoic acid receptors and extracellular-regulated kinase 1/2 显示文摘 | Matilde A Juan FH Francisco J | 2007 | J Neuroinflammation2007，4，： | 1 |
| 11 | Different mechanisms generating sequence variability are revealed in distinct regions of the hydroxyproline-rich glycoprotein gene from maize and related species显示文摘 | Raz R Matilde J Moya A | 1992 | Molecular and General Genetics1992，233，： | 1 |
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