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| 1 | High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization显示文摘Photoacoustic microscopy(PAM)is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes.This report describes an integrated multimodality imaging system that combines PAM,optical coherence tomography(OCT),and fluorescence microscopy(FM)to evaluate angiogenesis in larger animal eyes.High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor(VEGF)-induced retinal neovascularization(RNV).The results demonstrate that our multimodality imaging system can noninvasively visualize RNV in both albino and pigmented rabbits to determine retinal pathology using PAM and OCT and verify the leakage of neovascularization using FM and fluorescein dye.This work presents high-resolution visualization of angiogenesis in rabbits using a multimodality PAM,OCT,and FM system and may represent a major step toward the clinical translation of the technology. | Wei Zhang Yanxiu Li Van Phuc Nguyen Ziyi Huang Zhipeng Liu Xueding Wang Yannis M.Paulus | 2018 | Light(Science & Applications)2018，7，1： | 7 |
| 2 | 14-3-3 λ protein interacts with ADF1 to regulate actin cytoskeleton dynamics in Arabidopsis显示文摘Actin cytoskeleton dynamics is critical for variety of cellular events including cell elongation, division and morphogenesis, and is tightly regulated by numerous groups of actin binding proteins. However it is not well understood how these actin binding proteins are modulated in a physiological condition by their interaction proteins. In this study, we describe that Arabidopsis 14-3-3 λ protein interacted with actin depolymerizing factor 1(ADF1) in plant to regulate F-actin stability and dynamics. Loss of 14-3-3 λin Arabidopsis resulted in longer etiolated hypocotyls in dark and changed actin cytoskeleton architecture in hypocotyl cells. Overexpression of ADF1 repressed 14-3-3 λ mutant hypocotyl elongation and actin dynamic phenotype. In addition, the phosphorylation level of ADF1 was increased and the subcellular localization of ADF1 was altered in 14-3-3 λ mutant. Consistent with these observations, the actin filaments were more stable in 14-3-3 λ mutant. Our results indicate that 14-3-3 λ protein mediates F-actin dynamics possibly through inhibiting ADF1 phosphorylation in vivo. | ZHAO ShuangShuang ZHAO YanXiu GUO Yan | 2015 | Science China(Life Sciences)2015，58，11： | 6 |
| 3 | Slip Rate of Yema River–Daxue Mountain Fault since the Late Pleistocene and Its Implications on the Deformation of the Northeastern Margin of the Tibetan Plateau显示文摘The slip rate of Yema River–Daxue Mountain fault in the western segment of Qilian Mountains was determined by the dated offset of river risers or gullies. Results indicate that the left-lateral fault slip rate is 2.82 ± 0.20 mm/a at Dazangdele site,2.00 ± 0.24 mm/a at Shibandun site,and 0.50 ± 0.36 and 2.80 ± 0.33 mm/a at two sites in Zhazihu. The ideal average slip rate of the whole fault is 2.81 ± 0.32 mm/a. The lower slip rate confirms part of the displacement of Altyn Tagh fault was transformed into an uplifting of the strap mountains in the western segment of Qilian Mountains,whereas another part transformed into sinistral displacement of Haiyuan fault. This study illustrates that the slip of large strike-slip faults in the northeastern margin of the plateau transforms into crust thickening at the tip of the fault without large-scale propagation to the outer parts of the plateau. | LUO Hao HE Wengui YUAN Daoyang SHAO Yanxiu | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 5 |
| 4 | Evaluation of COC183B2 antibody targeting ovarian cancer by near-infrared fluorescence imaging显示文摘Objective: To evaluate the imaging potential of a novel near-infrared(NIR) probe conjugated to COC183 B2 monoclonal antibodies(MAb) in ovarian cancer(OC).Methods: The expression of OC183 B2 antigen in OC was determined by immunohistochemical(IHC) staining using tissue microarrays with the H-score system and immunofluorescence(IF) staining of tumor cell lines.Imaging probes with the NIR fluorescent dye cyanine 7(Cy7) conjugated to COC183 B2 Mab were chemically engineered. OC183 B2-positive human OC cells(SKOV3-Luc) were injected subcutaneously into BALB/c nude mice. Bioluminescent imaging(BLI) was performed to detect tumor location and growth. COC183 B2-Cy7 at 1.1,3.3, 10, or 30 μg were used for in vivo fluorescence imaging, and phosphate-buffered saline(PBS), free Cy7 dye and mouse isotype immunoglobulin G(IgG)-Cy7(delivered at the same doses as COC183 B2-Cy7) were used as controls.Results: The expression of OC183 B2 with a high H-score was more prevalent in OC tissue than fallopian tube(FT) tissue. Among 417 OC patients, the expression of OC183 B2 was significantly correlated with the histological subtype, histological grade, residual tumor size, relapse state and survival status. IF staining demonstrated that COC183 B2 specifically expressed in SKOV3 cells but not HeLa cells. In vivo NIR fluorescence imaging indicated that COC183 B2-Cy7 was mainly distributed in the xenograft and liver with optimal tumor-to-background(T/B)ratios in the xenograft at 30 μg dose. The highest fluorescent signals in the tumor were observed at 96 h postinjection(hpi). Ex vivo fluorescence imaging revealed the fluorescent signals mainly from the tumor and liver. IHC analysis confirmed that xenografts were OC183 B2 positive.Conclusions: COC183 B2 is a good candidate for NIR fluorescence imaging and imaging-guided surgery in OC. | Chen Zhang Xinyu Ling Yanxiu Guo Cunzhong Yuan Hongyan Cheng Xue Ye Ruiqiong Ma Yinli Zhang Yi Li Xiaohong Chang Beihua Kong Tao Liu Heng Cui | 2019 | Chinese Journal of Cancer Research2019，31，4： | 4 |
| 5 | Estimate of NO_X production in the lightning channel based on three-dimensional lightning locating system显示文摘Based on the VHF lightning locating system,a three-dimensional-space cell-gridded approach is used to extract the lighting channel and calculate the length of the channel.Through clustering of the located radiation sources and then extracting the lightning channel,it can accurately obtain the length of the channel.To validate the feasibility of the approach,a simulation experiment is designed,and it shows the length error is no more than 10%.The relationship between the NO production of per unit arc length and atmospheric pressure obtained in laboratory is applied to the NOX production of per unit flash length at different altitudes in this paper.The channel length and the NOX production of 11 negative cloud-to-ground flashes and 59 intracloud flashes in an isolated thunderstorm in the northeastern Qinghai-Tibet Plateau are calculated.The results show that the average channel lengths of per cloud-to-ground and intracloud flash are 28.9 and 22.3 km respectively;the average NOX productions of per cloud-to-ground and intracloud flash are 1.89×1025 and 0.42×1025 molecules,respectively. | ZHANG Rong ZHANG GuangShu LI YaJun WANG YanHui WU Bin YU Hai LIU YanXiu | 2014 | Science China Earth Sciences2014，57，7： | 4 |
| 6 | Experimental study on location accuracy of a 3D VHF lightning-radiation-source locating network显示文摘This paper reports the investigation of the location accuracy of a three-dimensional(3D) lightning-radiation-source locating system using sounding balloon measurements. By comparing the information from the balloon-borne VHF transmitter flight path and locations using simple geometric models, the location uncertainties of sources both over and outside the network were estimated. For radiation sources inside the network and below an altitude of 7 km, the horizontal uncertainty was 12–48 m and the total mean value was 21 m(rms), and the vertical uncertainty was 20–78 m and the total mean value was 49 m(rms). Outside the network, the location uncertainties increased with distance. The geometric model showed that range and altitude errors increased as a function of the range squared whereas the range errors increased parabolically with distance, and that was confirmed by the covariance calculation results. The standard deviation was used inside the network and covariance was used outside the network. The results indicated that location errors from a simple geometric model exhibited good agreement with standard experimental data. The geometry of the network, set of measurements, and calculation method were verified as suitable. The chi-square values of the least squares goodness of fit algorithm were verified and the timing error(?trms) of the fitting formula was estimated. The distribution of the chi-square values was less than 5, corresponding to a timing error of 50–66 ns(rms). | ZHANG GuangShu LI YaJun WANG YanHui ZHANG Tong WU Bin LIU YanXiu | 2015 | Science China Earth Sciences2015，58，11： | 3 |
| 7 | High-resolution structure-from-motion models covering 160 km-long surface ruptures of the 2021 M_(W)7.4 Madoi earthquake in northern Qinghai-Tibetan Plateau显示文摘The May 222021 M_(W)7.4 Madoi,Qinghai,China earthquake presented a rare opportunity to apply the modern unmanned aerial vehicle(UAV)photography method in extreme altitude and weather conditions to image surface ruptures and near-field effects of earthquake-related surface deformations in the remote Tibet.High-resolution aerial photographs were acquired in the days immediately following the mainshock.The complex surface rupture patterns associated with this event were covered comprehensively at 3-6 cm resolution.This effort represents the first time that an earthquake rupture in the interior of the Qinghai-Tibetan Plateau has been fully and systematically captured by such high-resolution imagery,with an unprecedented level of detail,over its entire length.The dataset has proven valuable in documenting subtle and transient rupture features,such as the significant mole-tracks and opening fissures,which were ubiquitous coseismically but degraded during the subsequent summer storm season.Such high-quality imagery also helps to document with high fidelity the fractures of the surface rupture zone(supplements of this paper),the pattern related to how the faults ruptured to the ground surface,and the distribution of off-fault damage.In combination with other ground-based mapping efforts,the data will be analyzed in the following months to better understand the mechanics of earthquake rupture related to the fault zone rheology,rupture dynamics,and frictional properties along with the fault interface. | Jing Liu-Zeng Wenqian Yao Xiaoli Liu Yanxiu Shao Wenxin Wang Longfei Han Yan Wang Xianyang Zeng Jinyang Li Zijun Wang Zhijun Liu Hongwei Tu | 2022 | Earthquake Research Advances2022，2，2： | 3 |
| 8 | The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal. | Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma | 2018 | Journal of Integrative Plant Biology2018，60，7： | 3 |
| 9 | Novel BiVO4@C3N4@GO Composites with Higher Photocatalytic Performance显示文摘BiVO4, BiVO4@C3N4 and BiVO4@C3N4@GO composite photo-catalysts were synthesized, and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), transmission electron microscopy (TEM), ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS), Fourier transform infrared spectroscopy (FT-IR), and Brunauer-Emmett-Teller (BET) surface area techniques. The photocatalytic activity was evaluated on the degradation of methylene blue (MB) under visible light irradiation, which denoted that the BiVO4@C3N4@GO ternary composite outperformed the binary composite BiVO4@C3N4 and BiVO4. Then the effects of catalyst dosage, initial pH value, and initial methylene blue concentration on the degradation process were investigated systematically. The improvement of visible-light photocatalytic degradation performance was attributed to the enhanced visible light absorption, larger surface area, higher adsorption ability, and prolonged lifetime of photo-generated electron-hole pairs. The recycle experiments results showed that the BiVO4@C3N4@GO composite had excellent photo-stability for MB photocatalytic degradation. | Liu Yanxiu Guo Zhi Wang Lijuan Lyu Wenxue Song Hua Wang Xueqin | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，2： | 2 |
| 10 | SiOx/C-Ag nanosheets derived from Zintl phase CaSi_(2) via a facile redox reaction for high performance lithium storage显示文摘As one of the high-capacity anodes in lithium-ion batteries(LIBs),silicon oxide(SiOx)has attracted wide attention due to its high theoretical capacity,low cost,and proper working voltage.However,the huge volume change and the intrinsic poor conductivity of SiOx still hinder the practical applications.How to address the issues is the focus of current research.In this work,firstly,hydrogen passivated Si nanosheets(Si6H6)were prepared from Zintl phase CaSi2,then,two-dimensional Ag nanoparticle modified SiOVC nanocomposite was prepared via a facile complex redox reaction between SieH6 and AgN03-aniline complexing agent.In this design,aniline was served as carbon sources,and Si6H6could be transformed to SiOx by AgN03 in mild solution condition.The obtained Ag modified SiOVC(SiOx/C-Ag)electrode exhibited high specific capacity(550 mAh·g^(-1)at 0.6 A·g^(-1)),superior rate,and cycling performance when served as anode for LIBs. | Jie Xie Lin Sun Yanxiu Liu Xinguo Xi Ruoyu Chen Zhong Jin | 2022 | Nano Research2022，15，1： | 2 |
| 11 | Silicon saturation coefficient changes in hydrogarnets during the Bayer process with lime addition显示文摘The relationship between the silicon saturation coefficient of hydrogarnets and Bayer reaction parameters was studied. The peak position, crystal plane spacing, and cell edge length of typical hydrogarnet patterns were calculated to find the key factors influencing the relationship. The results showed that the crystal face(420) is the optimal garnet growth direction during hydration and crystal growth along the faces(521) and(611) were not affected significantly by the varying experimental conditions. The reaction temperature significantly influenced the silicon saturation coefficient of hydrogarnets. The silicon saturation coefficient of hydrogarnets increased from 0.2 to about 1.0 in the temperature range of 30–270 °C and a rapid expansion process was observed in the temperature range of 120–150 °C. Moreover, the reaction time, alumina concentration, and C/S were shown to be less important factors. Averaging the results obtained by the 3 methods was shown suitable for calculating the SiO2 saturation coefficient of hydrogarnets. The calculated results of the Al2O3 and SiO2 contents matched the actual ones. However, the actual SiO2 content was about10 % less than the calculated one for SiO2 saturation coefficients higher than 1. | Guozhi Lü Ting’an Zhang Xiaofeng Zhu Chaozhen Zheng Yanxiu Wang Weiguang Zhang Zimu Zhang | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 2 |
| 12 | Loss of Halophytism by Interference with SOS1 Expression1[W][OA]显示文摘 | Oh Dong-Ha Leidi Eduardo Zhang Quan Hwang Sung-Min Li Youzhi Quintero Francisco J Jiang Xingyu D’Urzo Matilde Paino Lee Sang Yeol Zhao Yanxiu Bahk Jeong Dong Bressan Ray A Yun Dae-Jin Pardo José M Bohnert Hans J | 2009 | Plant Physiology2009，，1： | 1 |
| 13 | Overexpression of SOD2 Increases Salt Tolerance of Arabidopsis显示文摘 | Xiuhua Gao Zhonghai Ren Yanxiu Zhao | 2003 | Plant Physiology2003，133，： | 1 |
| 14 | A simple and effective method for protein subcellular localization using Agrobacterium-mediated transformation of onion epidermal cells显示文摘 | Wei Sun Ziyi Cao Yan Li Yanxiu Zhao Hui Zhang | 2007 | Biologia2007，，5： | 1 |
| 15 | Response Surface Optimized Extraction of Flavonoids from Cacumen platycladi and Antioxidant Activities In vitro显示文摘[Objectives]To explore the optimal extraction process and the antioxidant activity of flavonoidsof Cacumen platycladi. [Methods]FCPwas obtained from C. platycladi by a new set extraction process of microwave-assisted extraction,freeze thawing,superfine crushingand freeze drying technology and purification. On the basis of single-factor tests,the quadratic regression parasitism model was established by the extraction amount of total flavonoids with microwave power,alcohol concentration,and liquid-to-solid ratio through the response surface methodology. [Results] The optimal extraction conditions were microwave power of 757 W,alcohol concentration of 69%,liquid-to-solid ratio of21∶ 1,with the optimal extraction yield of 15. 302 9 mg/g. Under the real conditions( microwave power of 800 W,alcohol concentration of69%,liquid-to-solid ratio of 21∶ 1) in our laboratory,the maximum yield of total flavonoids was 15. 9 mg/g,the results fitwell with the prediction of quadratic regression parasitism model. The good antioxidant activity has been determined byscavenging effect of FCP on 1,1-diphenyl-2-picrylhydrazyl( DPPH) radical and superoxide anion free radical with the scavenging yield of 70. 2% and 68. 8% respectively. [Conclusions]All results established a good foundation for furtherdevelopment of C. platycladi products. | Hongxia DU Xiang WANG Yanxiu LIU Xuan YU | 2018 | Medicinal Plant2018，9，5： | 1 |
| 16 | 显示文摘 | ZHOU Yanxiu YU Bin KALLE L | 2003 | Chem Mater2003，15，： | 1 |
| 17 | Evaluation of luminol- H2Oz-KIO4 chemiluminescence system and its application to hydrogen peroxide, glucose and ascorbic acid assays显示文摘 | ZHOU Yanxiu NAGAOKA T LI Feng | 1999 | Talanta1999，48，2： | 1 |
| 18 | Utilizing import refuse effectively, preventing causing pollution risk显示文摘 | Yanxiu C | 2007 | China Academic J Electronic Pub- lishing House2007，，1： | 1 |
| 19 | RNA-seq reveals hormone-regulated synthesis of non-cellulose polysaccharides associated with fiber strength in a single-chromosomal-fragmentsubstituted upland cotton line显示文摘Cotton fibers are the main raw materials of the textile industry.Exogenous superior fiber genes have been introduced into upland cotton to develop high-yield cultivars with excellent fiber quality.We used a single chromosomal segment on the chromosome A07 substitution line SL7,with high fiber strength,to investigate the molecular mechanism underlying its fiber quality.RNA-seq and KEGG analysis showed that 70 differentially expressed genes were enriched in plant hormone transduction pathways,including auxin,ethylene and abscisic acid,in fibers at 10 days post-anthesis(DPA).Among these,fiberdevelopment related transcription factors MYB and NAC,including Gh_A11G0981(MYB108),Gh_A03G0887(NAC029),and Gh_A08G1691(NAC021),were significantly upregulated in SL7,as were numerous cellulose synthase-like(CSL)genes involved in non-cellulose polysaccharide and cell wall synthesis.The hemicellulose content of SL7 was significantly higher than that of L22,an upland cotton cultivar.These results suggest that key genes in the introgressed chromosomal segment of SL7 regulate the expression of transcription-factor genes via hormone-transduction pathways,thereby inducing the expression of genes involved in secondary wall synthesis and ultimately improving fiber quality.This study has shed light on the molecular mechanism of fiber development and will contribute to the improvement of fiber quality of upland cotton by molecular breeding. | Zhangqiang Song Yu Chen Chuanyun Zhang Jingxia Zhang Xuehan Huo Yang Gao Ao Pan Zhaohai Du Juan Zhou Yanxiu Zhao Zhi Liu Furong Wang Jun Zhang | 2020 | The Crop Journal2020，8，2： | 1 |
| 20 | Genetic analysis and molecular mapping of two dominant complementary genes determining resistance to sugarcane mosaic virus in maize显示文摘 | Wu JianYu Ding JunQiang Du YanXiu | 2007 | Euphytica2007，156，3： | 1 |
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