|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | c-Met: Structure, functions and potential for therapeutic inhibition显示文摘 | Patrick C. Ma Gautam Maulik James Christensen Ravi Salgia | 2003 | Cancer and Metastasis Reviews2003，，4： | 2 |
| 4 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 2 |
| 5 | Role of receptor tyrosine kinase in lung cancer显示文摘 | Maulik G Kijima T Salgia R | 2003 | Methods Mol Med2003，74，1： | 2 |
| 6 | Medical image segmentation using genetic algorithms显示文摘 | Maulik U | 2009 | IEEE Transactions on Information Technology in Biomedicine2009，13，2： | 1 |
| 7 | Genetic algorithm-based clustering teehnique 显示文摘 | MAULIK U BANDYOPADHAY S | 2000 | Pattern Recognition2000，33，9： | 1 |
| 8 | Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion 显示文摘 | Maulik N Yoshida T Engelman RM | 1998 | Mol Cell Biochem1998，186，12： | 1 |
| 9 | Apoptotic cell death during ischemia/reperfusion and its attenuation by antioxidant therapy显示文摘 | Galang N Sasaki H Maulik N | 2000 | Toxicology2000，148，23： | 1 |
| 10 | Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts显示文摘 | Maulik N Watanabe M Zu Y L | 1996 | FEBS Lett1996，396，23： | 1 |
| 11 | An essential role of NF kappa B in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia 显示文摘 | Maulik N Sato M Price B D | 1998 | Febs Lett1998，429，3： | 1 |
| 12 | Development of the human cancer microRNA network 显示文摘 | Bandyopadhyay S Mitra R Maulik U | 2010 | Silence2010，1，1： | 1 |
| 13 | Protective role ofintracoronary vasoactive intestinal peptide in ischemnic and reperfused myocardium 显示文摘 | Kalfm R Maulik N Engelmann MR | 1994 | J Pharmcol Exp Ther1994，268，： | 1 |
| 14 | Role of the hepatocyte growth factor receptor,c-Met,in oncogenesis and potential for therapeutic inhibition显示文摘 | Gautam Maulik a Amol Shrikhande a Takashi Kijima a | 2002 | Cytokin & Growth FactorReviews2002，13，： | 1 |
| 15 | The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury显示文摘 | Ray PS Maulik G CordisGA | 1999 | Free Radic Biol Med1999，27，： | 1 |
| 16 | Pharmacological preconditioning with resveratrol:role of CREB-dependent bcl-2 signaling via adenosine A3 receptor activation显示文摘 | Samarjit Das Gerald A Cordis Nilanjana Maulik | 2005 | Am J Physiol2005，288，1： | 1 |
| 17 | JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion显示文摘 | Mascareno E EI-Shafei M Maulik N | 2001 | Circulation2001，104，： | 1 |
| 18 | Oxidative stress and cardiac hypertrophy 显示文摘 | Maulik SK Kumar S | 2012 | Toxicol Mech Methods2012，22，5： | 1 |
| 19 | The red wine antioxidant res- veratrol protects isolated rat hearts from ischemia reperfusion injury 显示文摘 | Ray PS Maulik G Cordis GA | 1999 | Free Radic Biol Med1999，27，12： | 1 |
| 20 | Reactive oxygen species function as second messenger during ischemic preconditioning of heart显示文摘 | Dipak K. Das Nilanjana Maulik Motoaki Sato Partha S. Ray | 1999 | Molecular and Cellular Biochemistry (-)1999，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员