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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro显示文摘 | Krulich L Dhariwal A P McCann S M | 1968 | Endocrinology1968，83，4： | 1 |
| 3 | Peritoneal dialy- sis in an ageing population: a 10-year experience显示文摘 | Smyth A Mccann E Redahan L | 2012 | Int Urol Nephrol2012，44，1： | 1 |
| 4 | Predictors of cardiac rehabilitation participation in older coronary patients显示文摘 | Ades P A Waldmann M L McCann W J | | 0，，05： | 1 |
| 5 | Aerobicexercise, but not flexibility/resistance exercise, reduces serumIL-18 CRP and IL-6 independent of beta-blockers * BMI and psy-chosocial factors in older adults显示文摘 | KOHUT M L MCCANN D A RUSSELL D W | 2006 | Brain Behav Immun2006，20，3： | 1 |
| 6 | Assessment of zygomatico-orbital complex fractures using ultrasonography显示文摘 | McCANN P J BROCKLEBANK L M AYOUB A F | 2000 | Br J Oral Maxillofac Surg2000，38，5： | 1 |
| 7 | Talin2 is Induced During Striated Muscle Differentiation and is Targeted to Stable Adhesion Complexes in Mature Muscle 显示文摘 | Senetar M A Moncman C L McCann R O | 2007 | Cell Motil Cytoskel2007，64，3： | 1 |
| 8 | Routine resite of pe- ripheral intravenous devices every 3 days did not reduce complica- tions compared with clinically indicated resite= a randomised con- trolled trial显示文摘 | Rickard C M McCann D Munnings J et a l | 2010 | BMC Medicine2010，8，： | 1 |
| 9 | The Sorghum bicolor genome and the diversification of grasses显示文摘 | PATERSON A H BOWERS J E BRUGGMANN R DUBCHAK I GRIMWOOD J GUNDLACH H HABERER G HELLSTEN U MITROS T POLIAKOV A SCHMUTZ J SPANNAGL M TANG H WANG X WICKER T BHARTI A K CHAPMAN J FELTUSF A GOWIK U GRIGORIEV I V LYONS E MAHER C A MARTIS M NARECHANIA A OTILLAR R P PENNING B W SALAMOV A A WANG Y ZHANG L CARPITA N C FREELING M GINGLE AR HASH CT KELLER B KLEIN P KRESOVICH S MCCANN M C MING R PETERSON D G MEHBOOBUR-RAHMAN WARE D WESTHOFF P MAYER K F MESSING J ROKHSAR D S | 2009 | Nature2009，457，： | 1 |
| 10 | Neuroendocrine regulation of salt and water metabolism显示文摘 | McCann S M Franci C R Favaretto A L | 1997 | Braz J Med Biol Res1997，30，4： | 1 |
| 11 | DNA fu- sion-gene vaccinati-on in patients with prostate can- cer induces high-frequency CD8 (+)T-cell responses and increases PSA doubling time 显示文摘 | Chudley L McCann K Mander A | 2012 | Cancer immu- nology immunotherapy : CII2012，61，11： | 1 |
| 12 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hor-mone release from rat pituitary in vitro显示文摘 | KRULICH L DHARIWAL A P MCCANN S M | 1968 | Endocrinology1968，83，： | 1 |
| 13 | Neurobehavioral treatment for cocaine dependency显示文摘 | Rawson R A Obert J L Mccann M J | 1990 | J Psychoactive Drugs1990，22，2： | 1 |
| 14 | Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle 显示文摘 | Senetar M A Moncman C L McCann R O | 2007 | Cell Motil Cytoskeleton2007，64，3： | 1 |
| 15 | Transaction cost measurement for evaluating environmental policies显示文摘 | McCann L Colby B Easter K W Kasterine A Kuperan K V | 2005 | Ecological Economics2005，52，： | 1 |
| 16 | Neuroendocrine regulation of salt and water metabolism显示文摘 | McCann S M Franci C R Favaretto A L | 1997 | Braz J Med Biol Res1997，30，4： | 1 |
| 17 | Reinfection of tall rescue cultivars with non-ergot alkaloid-producing endophytes显示文摘 | Bouton J H Latch G C M Hill N S Hoveland C S McCann M A Watson R H Parish J A Hawkins L L Thompson F N | 2002 | Agronomy Journal2002，94，3： | 1 |
| 18 | Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of tbe NADPH and xanthine oxidases 显示文摘 | Dudley S C Hoch N E McCann L A | 2005 | Circula tion2005，112，： | 1 |
| 19 | Interteukin 17 promotes angiotensin lI induced hypertension and vascular dysfunction 显示文摘 | MADHUR M S LOB H E McCANN L A | 2010 | Hypertension2010，55，： | 1 |
| 20 | DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer 显示文摘 | Low L Mander A McCann K | 2009 | Hum Gene Ther2009，20，11： | 1 |
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