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| 1 | Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers显示文摘AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively). Predictors of outcome after the surgery of primary liver cancer were pathology of the resected mass, existence of microvascular invasion and accompanying satellite nodule. CONCLUSION: Primary liver cancers with biliary components tended to show poorer surgical outcome. This suggested that immuno-phenotype of liver cancers was as important as their morphological classification. | Jung Il Lee Jin-Woo Lee Joon Mee Kim Ja Kyung Kim Hyun Jung Chung Young Soo Kim | 2012 | World Journal of Gastroenterology2012，18，34： | 10 |
| 2 | Effect of preoperative biliary drainage on surgical results after pancreaticoduodenectomy in patients with distal common bile duct cancer:Focused on the rate of decrease in serum bilirubin显示文摘AIM: To examine if the rate of decrease in serum bilirubin after preoperative biliary drainagecan be used as a predicting factor for surgical complications and postoperative recovery after pancreaticoduodenectomy in patients with distal common bile duct cancer.METHODS: A retrospective study was performed in 49 consecutive patients who underwent pancrea-ticoduodenectomy for distal common bile duct cancer. Potential risk factors were compared between the complicated and uncomplicated groups. Also, the rates of decrease in serum bilirubin were compared pre- and postoperatively. RESULTS: Preoperative biliary drainage (PBD) was performed in 40 patients (81.6%). Postoperative morbidity and mortality rates were 46.9% (23/49) and 6.1% (3/49), respectively. The presence or absence of PBD was not different between the complicated and uncomplicated groups. In patients with PBD, neither the absolute level nor the rate of decrease in serum bilirubin was significantly different. Patients with rapid decrease preoperatively showed faster decrease during the first postoperative week (5.5 ± 4.4 μmol/L vs -1.7 ± 9.9 μmol/L, P = 0.004).CONCLUSION: PBD does not affect the surgical outcome of pancreaticoduodenectomy in patients with distal common bile duct cancer. There is a certain group of patients with a compromised hepatic excretory function, which is represented by the slow rate of decrease in serum bilirubin after PBD. | Yun Mee Choi Eung-Ho Cho Keon-Young Lee Seung-Ik Ahn Sun Keun Choi Sei Joong Kim Yoon Seok Hur Young Up Cho Kee-Chun Hong Seok-Hwan Shin Kyung Rae Kim Ze-Hong Woo | 2008 | World Journal of Gastroenterology2008，14，7： | 5 |
| 3 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 4 | Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea显示文摘Record-breaking high waves occurred during the passage of the typhoon Bolaven(1215)(TYB) in the East China Sea(ECS) and Yellow Sea(YS) although its intensity did not reach the level of a super typhoon.Winds and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and buoys.In order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical simulations.TYB winds were generated using the TC96 typhoon wind model with the best track data calibrated with the measurements.And then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave model.Wave fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study area.Thus the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than before.It is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon track.As the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction. | JUN Ki Cheon JEONG Weon Mu CHOI Jin Yong PARK Kwang Soon JUNG Kyung Tae KIM Mee Kyung CHAE Jang Won QIAO Fangli | 2015 | Acta Oceanologica Sinica2015，34，12： | 5 |
| 5 | Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma显示文摘Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discriminating CCA from BBD. | Hye Sook Han Mi Jin Kim Joung-Ho Han Jieun Yun Hee Kyung Kim Yaewon Yang Ki Bae Kim Seon Mee Park | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 6 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 7 | Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration显示文摘 | Sang Hyun Kim Sangyull Lee Chang Hun Lee Min Ki Lee Young Dae Kim Dong Hoon Shin Kyung Un Choi Jee Yeon Kim Do Youn Park Mee Young Sol | 2009 | Lung2009，，6： | 1 |
| 8 | Pseudomyxoma Peritonei: Extraperitoneal Spread to the Pleural Cavity and Lung显示文摘 | Bae Young Lee Hyeon Sook Kim Sang Haak Lee Hwa Sik Moon Song Mee Cho Kang Hoon Lee Kyung Sub Song Ki Ouk Min Eun Joo Seo Jae Moon Lee | 2004 | Journal of Thoracic Imaging2004，，2： | 1 |
| 9 | p53 Controls Autoimmune Arthritis via STAT‐Mediated Regulation of the Th17 Cell/Treg Cell Balance in Mice显示文摘 | Jin‐Sil Park Mi‐Ae Lim Mi‐La Cho Jun‐Geol Ryu Young‐Mee Moon Joo‐Yeon Jhun Jae‐Kyeong Byun Eun‐Kyung Kim Sue‐Yun Hwang Ji Hyeon Ju Seung‐Ki Kwok Ho‐Youn Kim | 2013 | Arthritis & Rheumatism2013，，4： | 1 |
| 10 | Association of low muscle strength with metabolic dysfunctionassociated fatty liver disease:A nationwide study显示文摘BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in Korea.METHODS This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and 2018.Odds ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression analysis.Additionally,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with MAFLD.RESULTS Of all the participants,29.3%had MAFLD.The prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,respectively.The ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both sexes.An inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes mellitus.In patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD. | Gyu Bae Lee Youn Huh Sang Hyun Lee Byoungduck Han Yang-Hyun Kim Do-Hoon Kim Seon Mee Kim Youn Seon Choi Kyung Hwan Cho Ga Eun Nam | 2023 | World Journal of Gastroenterology2023，29，45： | 1 |
| 11 | Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells显示文摘在这研究,我们调查了白果树 biloba 摘录(GBE ) 和 phosphodiesterase 类型的联合的效果 5 (PDE-5 ) 阴茎海绵体和下士的钾隧道活动的肌肉发达的音调上的禁止者弄平肌肉房间。从雄的新西兰白兔子的阴茎海绵体的脱衣为等轴的紧张研究在器官洗澡被装。在有 1 × 的收缩以后; 10 −5 mol l −1 新肾上素, GBE (0.01-1 mg ml −1) 和 mirodenafil (0.01-100 nmol l −1) 一起被增加进机关洗澡。在 electrophysiological 研究,整个房间的水流被常规补丁夹钳技术在人的阴茎海绵体的有教养的光滑的肌肉房间记录。阴茎海绵体以一种剂量依赖者方式响应 GBE 被放松(从 0.64 % ± 8.35 %在 0.01 mg ml −1 到 52.28 % ± 11.42 %在 1 mg ml −1) 。在有 0.03 的预告的处理以后; GBE 的 mg ml −1 , mirodenafil 的弛缓的效果根本被增加集中。在 tetraethylammonium (茶) 以后(1 mmol l −1) 管理,增加的效果被禁止(P< 0.01 ) 。GBE 的细胞外的管理增加了在一个剂量依赖者的外面的水流塑造的整个房间的 K + 。外面的水流的增加被 1 禁止; mmol l −1 茶。这些结果建议 GBE 能甚至在最低限度地有效的剂量增加 mirodenafil 的弛缓的力量。通过钾隧道的 K + 流动可能是涉及这 synergistic 松驰的机制之一。 | Jung Jun Kim Deok Hyun Han Soo Hyun Lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung Sung Chul Kam Ju-Hong Jeon Jong Kwan Parks Sung Won Lee | 2011 | Asian Journal of Andrology2011，13，5： | 1 |
| 12 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 1 |
| 13 | Melatonin inhibits MUC 5 AC production via suppression of MAPK signaling in human airway epithelial cells显示文摘 | In‐Sik Shin Ji‐Won Park Na‐Rae Shin Chan‐Mi Jeon Ok‐Kyoung Kwon Mee‐Young Lee Hui‐Seong Kim Jong‐Choon Kim Sei‐Ryang Oh Kyung‐Seop Ahn | 2014 | J. Pineal Res2014，，： | 1 |
| 14 | Enteropathy-associated T-cell lymphoma—a clinicopathologic and array comparative genomic hybridization study显示文摘 | Young Hyeh Ko Sivasundaram Karnan Kyeong Mee Kim Cheol Keun Park Eun Suk Kang Young Ho Kim Won Ki Kang Seok Jin Kim Won Seog Kim Woo Yong Lee Ho Kyung Chun Masao Seto | 2010 | Human Pathology2010，，9： | 1 |
| 15 | Inactivation of Nitric Oxide by Uric Acid显示文摘 | Christine Gersch Sergiu P. Palii Kyung Mee Kim Alexander Angerhofer Richard J. Johnson George N. Henderson | 2008 | Nucleosides, Nucleotides and Nucleic Acids2008，，8： | 1 |
| 16 | Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cells显示文摘 | Taek-Keun Kim Chang Sik Park Mee Hyun Jeoung Woo Ran Lee Nam Kyung Go Jong Rip Choi Tae Sup Lee Hyunbo Shim Sukmook Lee | 2015 | Biochemical and Biophysical Research Communicatio2015，，： | 1 |
| 17 | Eosinophil cationic protein in Henoch-Sch?nlein purpura and in IgA nephropathy显示文摘 | Mee Kyung Namgoong Baek Keun Lim Jong Soo Kim | 1997 | Pediatric Nephrology1997，，6： | 1 |
| 18 | Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases显示文摘 | Hee-Kyung Chang Eunsil Yu Jihun Kim Young Kyung Bae Kee-Taek Jang Eun Sun Jung Ghil Suk Yoon Joon Mee Kim Young-Ha Oh Han-Ik Bae Gwang Il Kim Soo Jin Jung Mi Jin Gu Jung Yeon Kim Kyu Yun Jang Sun-Young Jun Dae Woon Eom Kye Won Kwon Gyeong Hoon Kang Jae Bo | 2010 | Human Pathology2010，，8： | 1 |
| 19 | L ynch‐like syndrome: Characterization and comparison with EPCAM deletion carriers显示文摘 | So Young Kang Cheol Keun Park Dong Kyung Chang Jong Won Kim Hee Jung Son Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Moosik Kwon Kyoung‐Mee Kim | 2015 | Cancer2015，，7： | 1 |
| 20 | Effects of Aerobic Exercise Training on C1q Tumor Necrosis Factor α-Related Protein Isoform 5 (Myonectin): Association with Insulin Resistance and Mitochondrial DNA Density in Women显示文摘 | Soo Lim Sung Hee Choi Bo Kyung Koo Seon Mee Kang Ji Won Yoon Hak Chul Jang Soon Mi Choi Man Gyoon Lee Wan Lee Hayley Shin Young-Bum Kim Hong Kyu Lee Kyong Soo Park | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，1： | 1 |
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