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| 1 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 2 | Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the health | ZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian | 2017 | Biomedical and Environmental Sciences2017，30，8： | 20 |
| 3 | Danggui Buxue decoction ameliorates lipid metabolic defects involved in the initiation of diabetic atherosclerosis;identification of active compounds显示文摘OBJECTIVE: To determine the constituent compounds of Danggui buxue decoction(DBD) involved and the potential mechanisms mediating its effects, with specific reference to lipids playing a role in the initiation of diabetic atherosclerosis.METHODS: Liquid chromatography-tandem mass spectrometry was used to identify and quantify the absorbed bioactive compounds(ABCs) present in DBD. Goto-Kakizaki(GK) rats were randomly allocated to a diabetes atherosclerosis(DA) group, a DBD group, and an ABC group(10 per group), which were all high-fat diet-fed. The treated rats were administered DBD(4 g/kg) or ABCs(in amounts equal to those present in DBD) once daily for 28 d, and a control group of Wistar rats were administered vehicle. Body mass gain, fasting blood glucose, and homeostasis assessment of insulin resistance(HOMAIR) were measured. Serum triglyceride(TG), cholesterol(CHOL), high density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDLC) and tumor necrosis factor-α(TNF-α) concentrations were determined. Hematoxylin and eosin staining and microscopy were used to characterize the abdominal aorta and the expression of lipogenic genes was quantified in this vessel.RESULTS: Seven ABCs were identified in rat serum:ferulic acid, formononetin, calycosin, astragaloside,caffeic acid, ligustilide, and butyphthalide. DBD significantly reduced HOMA-IR, the serum concentrations of TG, CHOL, and LDL-C, and the expression of the lipogenic genes monocyte chemotactic protein1, Fas, intercellular adhesion molecule 1, and Cd36 in aorta;and significantly increased the mRNA expression of Scd1 in aorta.CONCLUSION: DBD affects lipid metabolism in the early stage of atherosclerosis in diabetic GK rats,with the mechanism likely involving the regulation of lipid metabolic genes in vessels. The contribution of ABCs to the effect of DBD on lipid metabolism was 24%-101%. | Xue Mei Bian Yong Liu Yalin Zhou Junjie Xu Jianjun Zhang Liang Huang Xi | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 13 |
| 4 | Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma显示文摘AIM To determine the prevalence and diagnostic value of autoantibodies inα-fetoprotein(AFP)-negative hepatocellular carcinoma(HCC).METHODS Fifty-six serum samples from AFP-negative HCC cases,86 from AFP-positive HCC cases,168 from chronic liver disease cases,and 59 from normal human controls were included in this study.Autoantibodies to nucleophosmin(NPM)1,14-3-3zeta and mouse double minute 2 homolog(MDM2)proteins in AFP-negative HCC serum were evaluated by enzymelinked im munosorbent assay.Partially positive sera were further evaluated by western blotting.Immunohistochemistry was used to detect the expression of three tumor-associated antigens(TAAs)in AFP-negative HCC and normal control tissues.RESULTS The frequency of autoantibodies to the three TAAs in AFP-negative HCC sera was 21.4%,19.6%and 19.6%,which was significantly higher than in the chronic liver disease cases and normal human controls(P<0.01)as well as AFP-positive HCC cases.The sensitivity of the three autoantibodies for diagnosis of AFP-negative HCC ranged from 19.6%to 21.4%,and the specificity was approximately 95%.When the three autoantibodies were combined,the sensitivity reached 30.4%and the specificity reached 91.6%.CONCLUSION Autoantibodies to NPM1,14-3-3zeta and MDM2 may be useful biomarkers for immunodiagnosis of AFP-negative HCC. | Ting Wang Mei Liu Su-Jun Zheng Dan-Dan Bian Jin-Yan Zhang Jia Yao Qing-Fen Zheng A-Meng Shi Wen-Han Li Lu Li Yu Chen Jin-Hai Wang Zhong-Ping Duan Lei Dong | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 5 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 6 | Effect of Jiawei Shenfu decoction on tumor necrosis factor-alpha and nuclear factor-kappa B in patients who have chronic heart failure with syndromes of deficiency of heart Yang显示文摘OBJECTIVE:To examine the clinical efficacy of Jiawei Shenfu decoction on tumor necrosis factor-alpha (TNF-cα) and nuclear factor-kappa B (NF-KB) levels in patients who have chronic heart failure with syndromes of deficiency of heart Yang.METHODS:A total of 63 patients with syndromes of deficiency of heart Yang (chronic heart failure)were enrolled.Patients were randomly divided into the control group and Jiawei Shenfu group.All patients received standard medications for treatment of chronic heart failure.Patients in the Jiawei Shenfu group were additionally provided Jiawei Shenfu decoction one dose daily.Treatments continued for 4 consecutive weeks.The primary endpoint was the change in plasma B-type natriuretic peptide (BNP),NF-KB,and TNF-cα levels during 4 weeks of treatment.RESULTS:At the 4-week follow-up,a significant reduction in BNP levels compared with baseline was observed in both groups,but the Jiawei Shenfu decoction group showed a significantly greater reduction than did the control group.The Jiawei Shenfu group also showed superior performance regarding the Minnesota Living with Heart Failure Questionnaire score,the Chinese medicine syndrome score,heart rate,left ventricular ejection fraction,and 6-min walking distance compared with the control group.The degree of changes in NF-KB and TNF-α levels in the Jiawei Shenfu group was more significant than that in the control group.CONCLUSION:Routine medicine combined with Jiawei Shenfu decoction for patients with heart Yang deficiency syndrome in chronic heart failure can improve the left ventricular ejection fraction and cardiac function,and reduce BNP levels.The mechanism may be related to inhibition of pro-inflammatory cytokines and the NF-KB-induced kinase pathway,leading to amelioration of the inflammatory response. | Yu Mei Guo Hangyuan Ye Lingling Bian Jiaping Ma Lijuan Zheng Chunli | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 6 |
| 7 | Performance of Fasting Plasma Glucose and Postprandial Urine Glucose in Screening for Diabetes in Chinese High-risk Population显示文摘 | Bing-Quan Yang Yang Lu Jia-Jia He Tong-Zhi Wu Zuo-Ling Xie Cheng-Hao Lei Yi Zhou Jing Han Mei-Qi Bian Hong You De-Xian Mei Zi-Lin Sun | 2015 | Chinese Medical Journal2015，，24： | 6 |
| 8 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 9 | ADS Injector-I 2 K superfluid helium cryogenic system显示文摘The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in China.High-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting accelerators.In this study,the ADS Injector-I 2 K cryogenic system is examined in detail.The cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic system.The ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in China.The ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the requirements.The research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems. | Rui Ge Shao-Peng Li Rui-Xiong Han Miao-Fu Xu Liang-Rui Sun Min-Jing Sang Rui Ye Zhuo Zhang Jie-Hao Zhang Xiang-Zhen Zhang Lin Bian Jian-Qin Zhang Mei Li Chang-Cheng Ma Zheng-Ze Chang Tong-Xian Zhao Yong-Cheng Jiang | 2020 | Nuclear Science and Techniques2020，31，4： | 4 |
| 10 | Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells显示文摘85 kDa (CIN85 ) 的最新发现的交往 Cbl 蛋白质在大脑涉及许多细胞的过程,而是它的功能,在 neurodegenerative,疾病仍然保持不清楚。在这篇论文,我们用蛋白质印迹分析和免疫组织化学在成年老鼠大脑的不同区域调查了 CIN85 蛋白质的分发,并且发现 CIN85 无所不在地在老鼠大脑被表示。在条纹弦音器和 substantia nigra,二个区域最深深地在 Parkinson 的疾病影响了, CIN85 蛋白质的水平相对高。在 Parkinson 的疾病的 MPTP 鼠标模型,在条纹弦音器和 substantia nigra 的 CIN85 的表达式是复杂的。但是在 1-methyl-4-phenyl-pyridinium 对待离子的人的 dopaminergic SH-SY5Y 房间, CIN85 的表示戏剧性地增加了。由短发卡 RNA CIN85 击倒减少了 SH-SY5Y 房间死亡。因此, CIN85 可能在神经毒素挑战下面在 dopaminergic 房间线并且在老鼠大脑的 nigrostriatum 起不同作用。 | Minjuan Bian Mei Yu Shanzheng Yang Hui Gao Yalin Huang Chunguang Deng Yanqin Gao Fengyan Sun Fang Huang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 3 |
| 11 | Features of the type Ill-like source rock and its generated natural gas显示文摘The mother matter of Ordovician source are mainly sapropelic and generate oil in mature stage, since the high plants did not appear in Ordovician period, which is well known by internal and external scholars. Now we find a kind of Orodovician source rock generating mainly light oil and gas in mature stage during appraising source rocks in the Tarim Basin. The organic matters of this source rock are chiefly constructed by benthic brown algae in organisms (showing as macro algae), and are similar to humic source in hydrocarbon generation. The natural gas generated by this kind of source matters is obviously different from the sapropelic gas. | ZHAO Mengjun, ZHANG Baomin, BIAN Lizeng, XIAO Zhongyao, LI Mei, PENG Yan & QIN Shengfei1. Research Center of Exploration of TPEDB, CNPC, Korla 841000, China 2. Research Institute of Petroleum Exploration & Development, CNPC, Beijing 100083, China 3. Department of Earth Science, Nanjing University, Nanjing 210002, China | 2000 | Chinese Science Bulletin2000，45，9： | 2 |
| 12 | 2 K superfluid helium cryogenic vertical test system for superconducting cavity of ADS Injector I显示文摘Purpose The accelerator-driven subcritical system(ADS)is the internationally recognized key technology of nuclear waste problem treatment,of which superconducting proton linac is an important part.With the support of the strategic science and technology pilot project of the Chinese Academy of Sciences,the Institute of High Energy Physics of the Chinese Academy of Sciences took the lead in the research of 325 MHz superconducting proton linac,which is called ADS Injector I.The superconducting accelerator part of ADS Injector I mainly consists of 14 spoke-type superconducting cavities withβ0.12.At the same time,the research work of various cavities with differentβvalues and different frequencies is also carried out to lay the technical and technological foundation for ADS main accelerator.The only way to determine whether the superconducting cavity can reach the design target and whether it can be installed into the cryostat is the vertical test at cryogenic.As the only way to test the microwave performance of the superconducting cavity at low temperature,the vertical test can accurately test the acceleration gradient Eacc and the corresponding quality factor Q0 of the superconducting cavity.The design and construction of the superconducting cavity vertical test facility is based on the practical needs of the pilot project and the long-term development of the superconducting accelerator.Methods This paper mainly introduces the design and construction of the cryogenic vertical test system for the superconducting cavity of ADS Injector I,including the system scheme design,process design,heat load analysis,2 K superfluid helium obtaining method,system commissioning and operation,etc.Results and Conclusion The static heat leakage at 2 K of the 2 K superfluid helium vertical test system of ADS Injector I is 1.624W,which has reached the international advanced level.The 2 K superfluid helium vertical test system of ADS Injector I after constructed not only meets the test requirements of ADS pilot project,but also conducts 4 K and 2 K vertical tests for other different types of superconducting cavities and relevant cryogenic experiments. | Rui Ge Liangrui Sun Miaofu Xu Rui Ye Xiangzhen Zhang Minjing Sang Ruixiong Han Zhuo Zhang Jiehao Zhang Lin Bian Mei Li Changcheng Ma Tongxian Zhao Yongcheng Jiang Zhengze Chang Shaopeng Li | 2020 | Radiation Detection Technology and Methods2020，4，2： | 2 |
| 13 | Cervical Intervertebral Disc Degeneration Induced by Unbalanced Dynamic and Static Forces: A Novel In Vivo Rat Model显示文摘 | Yong-Jun Wang Qi Shi W W. Lu K C. M. Cheung Michael Darowish Tian-Fang Li Yu-Feng Dong Chong-Jian Zhou Quan Zhou Zhi-jun Hu Mei Liu Qin Bian Chen-Guang Li K D. K. Luk J C. Y. Leong | 2006 | Spine2006，，14： | 2 |
| 14 | Cold water stress attenuates dopaminergic neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice显示文摘在现在的学习,我们在导致的 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 在 dopaminergic 神经原上测试了冷水应力(CWS ) 的效果 Parkinson 是疾病(PD ) 老鼠模型,并且发现那个 CWS 预告的处理得到了更少的 MPTP neurotoxicity。理解位于这现象下面的分子的机制,我们在试验性的鼠标的 striatum 检测了热吃惊蛋白质 70 的表达式(Hsp70 ) ,并且发现那个 CWS 预告的处理能显著地在对待 MPTP 的鼠标增加 striatal Hsp70。与 Hsp70 的正式就职同时,而且, striatal -synuclein 的导致 MPTP 的增加在 CWS +对待 MPTP 的老鼠被禁止。CWS 预告的处理显著地也在 striatum 禁止了 anti-apoptotic 分子 Bcl-2 表示的减小并且在对待 MPTP 的老鼠的 substantia nigra 提高了 Bcl-2 抄写。一起拿,这些数据显示 Hsp70 可能是为对导致 MPTP 的 dopaminergic 毒性的 CWS 的 neuroprotective 效果的重要中介。 | Mingfeng Xia Minjuan Bian Qian Yu Jie Liu Yufang Huang Xueting Jin Shiduo Lu Mei Yu Fang Huang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 1 |
| 15 | Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma显示文摘 | Liang Yi Hualiang Xiao Minhui Xu Xianzong Ye Jun Hu Fei Li Mei Li Chunxia Luo Shicang Yu Xiuwu Bian Hua Feng | 2010 | Journal of Neuroimmunology2010，，1： | 1 |
| 16 | Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Sclerodermatous Chronic Graft-versus-Host Disease: Clinical Report显示文摘 | Hong Zhou Mei Guo Chunjing Bian Zhao Sun Zhuo Yang Yang Zeng HuiSheng Ai Robert Chunhua Zhao | 2010 | Biology of Blood and Marrow Transplantation2010，，： | 1 |
| 17 | Magnetic alloy cores for the HIRFL-CSRm compressor cavity显示文摘Four types of magnetic alloy cores,labeled as V1,V2,A1 and A2,were produced by Liyuan Corp.Ltd.,for the radio frequency compression cavity of HIRFL-CSRm.In this work,their permeability,quality factor (Q value) and shunt impedance were measured before installing them into the cavity.The results show that the V1,V2 and A2 have higher permeability and shunt impedance,and lower Q value,and are suitable to the radio frequency compression cavity. | MEI Lirong XU Zhe YUAN Youjin JIN Peng BIAN Zhibin ZHAO Hongwei | 2011 | Nuclear Science and Techniques2011，22，2： | 1 |
| 18 | Gender and magnetic resonance imaging classification-related differences in clinical and biochemical characteristics of Cushing's disease: a single-centre study显示文摘 | Chen Yufan Mei Xiaobo Jian Fangfang Ma Qinyun Chen Xiao Bian Liuguan Sun Qingfang | 2014 | Chinese Medical Journal2014，，22： | 1 |
| 19 | Kinetic of dissolved phosphorus from the calcination products of mixed rare earth minerals 显示文摘 | Bian Xue Wu Wenyuan Yang Mei | 2007 | Journal of Rare Earths2007，1，： | 1 |
| 20 | 3D origami electrochemical immunodevice for sensitive point-of-care testing based on dual-signal amplification strategy显示文摘 | Chao Ma Weiping Li Qingkun Kong Hongmei Yang Zhaoquan Bian Xianrang Song Jinghua Yu Mei Yan | 2015 | Biosensors and Bioelectronics2015，，： | 1 |
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