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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Diagnostic approaches for cholangiocarcinoma显示文摘Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to be challenging. Cholangiocarcinomas often grow longitudinally along the bile duct rather than in a radial direction. Thus, large tumor masses are frequently absent and imaging techniques, including ultrasound, CT, and MRI have only limited sensitivity. Tissue collection during endoscopic (ERCP) and/or percutaneous transhepatic (PTC) procedures are usually used to confirm a definitive diagnosis of cholangiocarcinoma. However, forceps biopsy and brush cytology provide positive results for malignancy in about only 50% of patients. Percutaneous and peroral cholangioscopy using fiber-optic techniques were therefore developed for direct visualization of the biliary tree, yielding additional information about endoscopic appearance and tumor extension, as well as a guided biopsy acquistion. Finally, endoscopic ultrasonography (EUS) complements endoscopic and percutaneous approaches and may provide a tissue diagnosis of tumors in the biliary region through fine-needle aspiration. In the future, new techniques allowing for early detection, including molecular markers, should be developed to improve the diagnostic sensitivity in this increasing tumor entity. | Andreas Weber Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，26： | 21 |
| 3 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 4 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 5 | Proteomic Analysis of the Proplastid Envelope Membrane Provides Novel Insights into Small Molecule and Protein Transport across Proplastid Membranes显示文摘Proplastids 是综合的 meristematic 纸巾的无差别的质体为为 DNA 的蛋白质合成和 RNA 合成的氨基酸。不同于叶绿体, proplastids 取决于供应与减少电源,从房间的剩余物的精力,和先锋代谢物。比较 proplastid 和叶绿体信封 proteomes 和叶子和射击顶的相应 transcriptomes 揭示了 proplastid 信封的一篇清楚地不同的作文。它为很快划分的房间面向新陈代谢的先锋的进口和产品代谢物的出口。分析也在 meristematic 纸巾为 triosephosphate translocator 建议了一个新角色,识别了器官的氮进口的线路进 proplastids,并且检测了一个腺嘌核苷酸出口商。蛋白质进口建筑群包含进口受体 Toc120 和 Toc132 并且缺乏察觉到 Tic32, Tic55,和 Tic62 的复杂子单元的氧化还原作用,它在叶子和射击顶反射相应基因的表示模式。我们推进内部膜系统的蛋白质作文类似于 etioplasts 的表演,当它被 ATP synthase 建筑群统治并且显著地因此不同于叶绿体 thylakoids 的。 | Andrea Brautigam | 2009 | Molecular Plant2009，2，6： | 7 |
| 6 | Intracellular Metabolite Transporters in Plants显示文摘由于质体的存在,真核细胞的光合的房间代表最高度划分的真核细胞的房间。分隔的这高度由特定的膜 transporters 越过细胞内部的膜系统要求溶质的运输。在这评论,我们在机能上地描绘的细胞内部的植物膜 transporters 上总结最近的进步,我们连接 transporter 函数到 Arabidopsis 基因标识符并且到 transporter 分类系统。另外,我们在进一步的阐明构画出挑战植物膜 permeome 和我们为膜 transporters 的功能的描述提供新奇途径的一个轮廓。 | Nicole Linka Andreas RM. Weber | 2010 | Molecular Plant2010，3，1： | 7 |
| 7 | Machine Learning Techniques for Predicting Crop Photosynthetic Capacity from Leaf Reflectance Spectra显示文摘在光合的能力利用自然变化是向收益增加的一条有希望的线路,但是生理的 phenotyping 为大规模基因屏幕仍然是太勤劳的。这里,我们评估叶反射光谱学的潜力预言在 Brassica oleracea 和 Zea mays, C 3 和 C 4 的光合的能力的参数分别地收割。到这个目的,我们系统地评估了反射系列的性质并且发现他们在大量种类上是令人惊讶地类似的。我们估计了 untransformed 系列上的方法和选择递归的特征消除作为产出最高预兆的力量的比较喜欢的算法由部分最少的广场回归跟随了的大量机器学习的表演。这个算法的学习曲线建议最佳的种类特定的样品尺寸。用 Brassica 相对 Moricandia,我们评估了在种类之间的模型可转移性并且发现跨种类的性能不能从种系发生的最近被预言。最后的 intra 种类模型预言庄稼有高精确性的光合的能力。在估计的模型精确性上基于,我们在选择繁殖实验模仿了模型的使用,并且证明用我们的方法的高产量的光合的 phenotyping 有潜力极大地改善引起成功。我们的结果显示叶反射 phenotyping 是为改善的一个有效方法收割光合的能力。 | David Heckmann Urte Schluter Andreas P.M. Weber | 2017 | Molecular Plant2017，10，6： | 4 |
| 8 | Open cellular magnesium alloys for biodegradable orthopaedic implants显示文摘Replication processing using NaCl spaceholders offers the possibility to produce cellular structures for a range of Mg alloys. Four Mg alloys (AZ63, M2, ZM21 and MZX211) were processed into open cellular structures with a pore size near 500 μm and a porosity of 75% using an optimized NaCl leaching procedure. The production method was found to be robust and yielded samples of acceptable strength and stiffness. Their dissolution rate (by H2 release in simulated body fluid) and mechanical properties (by cyclic compression) were measured. For all 4 alloys the initial mechanical properties mimic those of cancellous bone;however, the dissolution rate is too high for direct use in the human body, leading to excessive hydrogen evolution and overly rapid degradation of mechanical properties. Further post-processing of the material is thus required. | Karel Lietaert Ludger Weber Jan Van Humbeeck Andreas Mortensen Jan Luyten Jan Schrooten | 2013 | Journal of Magnesium and Alloys2013，1，4： | 3 |
| 9 | Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts显示文摘 | Andreas Weber Jochen Gaa Bogdan Rosca Peter Born Bruno Neu Roland M. Schmid Christian Prinz | 2008 | European Journal of Radiology2008，，3： | 3 |
| 10 | Plastid Signals and the Bundle Sheath: Mesophyll Development in Reticulate Mutants显示文摘一片植物叶的发展是生产包括多样的细胞类型的一个复杂器官的事件的一个细致地安排的序列。叶上色异种的 reticulate 班在叶肉房间的发展由于特定的错误显示在静脉和 interveinal 区域之间的形成对照的色素沉着。因此, reticulate 异种提供一个有势力工具调查 cell-type-specific 发展过程。大多数异种在强烈在联系 vasculature 的纸巾被表示的质体局部性的、新陈代谢的小径被影响的发现含有为在叶肉房间的合适的开发的捆鞘和他们的叶绿体的一个关键角色。这里,我们考察 reticulate 异种和他们的 phenotypic 特征,与在 Arabidopsis thaliana 的那些的一个焦点。二个其他的模型被提出了解释在质体新陈代谢和叶肉房间开发之间的关系,我们这里把它称为供应和发信号的假设。我们极其估计这些建议模型并且在 C3 种类为叶开发和捆鞘功能讨论他们的含意。reticulate 异种的描述支持质体的意义后退在 C3 光合作用在细胞开发和热点表明捆鞘的意义。 | Peter K. Lundquist Christian Rosar Andrea Brautigam Andreas P.M. Weber | 2014 | Molecular Plant2014，7，1： | 3 |
| 11 | Treatment strategies for proximal femur fractures in osteoporotic patients显示文摘 | Felix Bonnaire Henry Zenker Christoph Lill Andreas T. Weber Berend Linke | 2005 | Osteoporosis International2005，，2： | 2 |
| 12 | In Vivo Function of Tic22, a Protein Import Component of the Intermembrane Space of Chloroplasts显示文摘进叶绿体的 Preprotein 进口在外部、内部的叶绿体信封膜(TOC 和 TIC ) 取决于 macromolecular 机械。两机械被 intermembrane 空间(IMS ) 的部件互连,这被建议。也就是说在其它之中, Tic22,二仔细联系了 isoforms 在 Arabidopsis thaliana 存在,也就是 atTic22-III 和 atTic22-IV。我们由分析相应基因的 T-DNA 插入线在 vivo 调查了 Tic22 的功能。当在单个基因的 T-DNA 插入引起了仅仅细微的缺点时,两 isoforms 的双异种在植物的光合的表演显示出延迟的生长,在热点条件下面的苍白的显型,减少的进口率,和减小。后者被变化在变异的植物的代谢物内容支持什么时候与相比野类型。因此,我们的结果支持 Tic22 直接涉及叶绿体 preprotein 进口并且可能在叶绿体生物的续生说指向到 Tic22 的特别重要性高进口率的时间的观点。 | Mareike Rudolf Anu B. Machettira Lucia E. Groβ Katrin L. Weber Kathrin Bolte Tihana Bionda Maik S. Sommer Uwe G. Maier Andreas RM. Weber Enrico Schleiff Joanna Tripp | 2013 | Molecular Plant2013，6，3： | 2 |
| 13 | Chemokine-like functions of MIF in atherosclerosis显示文摘 | Andreas Schober Jürgen Bernhagen Christian Weber | 2008 | Journal of Molecular Medicine2008，，7： | 1 |
| 14 | Active Labour Market Policy Evaluations: A Meta- Analysis显示文摘 | David Card Jochen Kluve Andrea Weber | 2010 | Economic Journal2010，4524，77： | 1 |
| 15 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 16 | Lexical competition in non-native spoken-word recognition显示文摘 | Andrea Weber Anne Cutler | 2003 | Journal of Memory and Language2003，，1： | 1 |
| 17 | Ocular Pulse Amplitude Before and After Cataract Surgery显示文摘 | Niklas Plange Corinna Rennings Anne Herr Anke Weber Gernot F. Roessler Babac E. Mazinani Marion Kaup Andreas Remky | 2012 | Current Eye Research2012，，2： | 1 |
| 18 | Distribution and speciation of arsenic around roots in a contaminated riparian floodplain soil: Micro-XRF element mapping and EXAFS spectroscopy显示文摘 | Andreas Voegelin Frank-Andreas Weber Ruben Kretzschmar | 2007 | Geochimica et Cosmochimica Acta2007，，23： | 1 |
| 19 | Long-term outcome of endoscopic and/or percutaneous transhepatic therapy in patients with biliary stricture after orthotopic liver transplantation显示文摘 | Andreas Weber Christian Prinz Carlos Gerngro? Leopold Ludwig Wolfgang Huber Bruno Neu Matthias P. Ebert Alexander Meining Hans Weidenbach Roland M. Schmid Ewert Schulte-Frohlinde | 2009 | Journal of Gastroenterology2009，，12： | 1 |
| 20 | Characterization of the Hydra Lamin and Its Gene: A Molecular Phylogeny of Metazoan Lamins显示文摘 | Andreas Erber Dieter Riemer Helmut Hofemeister Marc Bovenschulte Reimer Stick Georgia Panopoulou Hans Lehrach Klaus Weber | 1999 | Journal of Molecular Evolution1999，，2： | 1 |
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