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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Preparation, structu re, and properties of starch/rubber composites prepared by cocoagulating rubber latex and starch paste 显示文摘 | You ping Wu Meiqin J i Qing Qi | 2004 | Macromolecular Rapid Communication2004，25，4： | 1 |
| 3 | Preparation, Structure, and Properties of Starch/Rubber Composites Prepared by Co-Coagulating Rubber Latex and Starch Paste显示文摘 | Wu Youping Ji Meiqin Qi Qing etc | 2004 | Macromolecular Rapid Communications2004，25，： | 1 |
| 4 | Preparation,structure,and properties of starch/rubber composites prepared by co-coagulating rubber latex and starch paste显示文摘 | Wu Youping Ji Meiqin Qi Qing | 2004 | Macromolec Rapid Commun2004，25，4： | 1 |
| 5 | Preparation,structure and properties of starch/rubber composites prepared by co-coagulating rubber latex and starch paste显示文摘 | Youping Wu Meiqin Ji Qing Qi | 2004 | Macromol Rapid Commun2004，25，： | 1 |
| 6 | Exponential H∞ synchronization of general discrete-time chaotic neural networks with or without time delays 显示文摘 | Qi Donglian Liu Meiqin Qiu Meikang | 2010 | IEEE Trans Neural Networks2010，21，8： | 1 |
| 7 | Effect of harvesting method on seed bank dynamics in a boreal mixedwood forest in northwestern Ontatio 显示文摘 | Meiqin Qi Scarratt J B | 1998 | Canada Journal of Batany1998，76，： | 1 |
| 8 | Cloud-assisted cognition adaptation for service robots in changing home environments显示文摘Robots need more intelligence to complete cognitive tasks in home environments.In this paper,we present a new cloud-assisted cognition adaptation mechanism for home service robots,which learns new knowledge from other robots.In this mechanism,a change detection approach is implemented in the robot to detect changes in the user’s home environment and trigger the adaptation procedure that adapts the robot’s local customized model to the environmental changes,while the adaptation is achieved by transferring knowledge from the global cloud model to the local model through model fusion.First,three different model fusion methods are proposed to carry out the adaptation procedure,and two key factors of the fusion methods are emphasized.Second,the most suitable model fusion method and its settings for the cloud–robot knowledge transfer are determined.Third,we carry out a case study of learning in a changing home environment,and the experimental results verify the efficiency and effectiveness of our solutions.The experimental results lead us to propose an empirical guideline of model fusion for the cloud–robot knowledge transfer. | Qi WANG Zhen FAN Weihua SHENG Senlin ZHANG Meiqin LIU | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，2： | 0 |
| 9 | The Concept and Nature of Northern Ethnic Dynasties from the Historical View on the Chinese Nation显示文摘In recent years,the concept'northern ethnic dynasties'has been widely used when referring to dynasties established by ethnic groups from northern China,including Liao,Jin,Yuan,and Qing dynasty.When it comes to the prolonged debates on the relation between ethnic groups and state,the traditional narrative of the dynastic history of Central Plains,which holds'sinicization'as its principal line,has been challenged;and the academia has been focusing on how to elaborate features and state forms of these northern ethnic dynasties.This article argues that,only by returning to the dynasty-based narrative of the evolvement of northern ethnic regimes,can we break the shackle of western-style'nation state'narrative;can we understand the fact that dynasticity transcends ethnicity in Chinese history;and can we thereby establish the correct view of history on the Chinese nation. | Meiqin QI Jun CHEN Jie JI Yue SUN Li LIU | 2023 | Journal of the Chinese Nation Studies2023，2，2： | 0 |
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