|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 2 | Studies on Antiviral and Immuno-Regulation Activity of Low Molecular Weight Fucoidan from Laminaria japonica显示文摘The antiviral activity in vitro and in vivo and the effect of the immune system of two fucoidan fractions with low molecular weight and different sulfate content from Laminaria japonica(LMW fucoidans) were investigated in order to examine the possible mechanism. In vitro, I-type influenza virus, adenovirus and Parainfluenza virus I were used to infect Hep-2, Hela and MDCK cells, respectively. And 50% tissue culture infective dose was calculated to detect the antiviral activity of two LMW fucoidans. The results indicated that compared with the control group, 2 kinds of LMW fucoidans had remarkable antiviral activity in vitro in middle and high doses, while at low doses, the antiviral activity of 2 kinds of LMW fucoidans was not statistically different from that in the blank control group. And there was no statistically difference between two LMW fucoidans in antiviral activity. In vivo, LMW fucoidans could prolong the survival time of virus-infected mice, and could improve the lung index of virus-infected mice significantly, which have statistical differences with the control group significantly(p < 0.01). However, the survival time of the two LMW fucoidans was not statistically significant(p > 0.05). In this study, it was shown that both of two LMW fucoidans(LF1, LF2) could increase the thymus index, spleen index, phagocytic index, phagocytosis coefficient and half hemolysin value in middle and high doses, which suggested that LMW fucoidans could play an antiviral role by improving the quality of immune organs, improving immune cell phagocytosis and humoral immunity. | SUN Taohua ZHANG Xinhui MIAO Ying ZHOU Yang SHI Jie YAN Meixing CHEN Anjin | 2018 | Journal of Ocean University of China2018，17，3： | 8 |
| 3 | Geographical genetic diversity and divergence of common wild rice (O. rufipogon Griff.) in China显示文摘Using 36 SSR markers and 889 accessions of common wild rice in China, the genetic diversity and the divergence among different geographical populations are investigated. Guangdong Province has the largest number of alleles, which account for 84% of the total alleles detected in the study, followed by Guangxi Province. The Nei's gene diversity indices, from high to low, are in the sequence of Hainan, Guangdong, Guangxi, Fujian, Hunan, Jiangxi, and Yunnan provinces. Two genetic diversity centers of Chinese common wild rice are detected on the basis of geographic analysis, i.e., the region covering Boluo, Zijin, Lufeng, Haifeng, Huidong and Huiyang counties of Guangdong Province and the region covering Yongning, Longan, Laibin and Guigang counties of Guangxi Province. The common wild rice in Yunnan, Hunan, Jiangxi, and Fujian provinces are diverged into respectively independent populations with relatively large genetic distances, whereas, those in Hainan, Guangdong and Guangxi provinces have relatively low genetic divergence. Under the condition of geographic separation, natural selection is considered as one of the primary forces contributing to the divergence of common wild rice in China. | WANG MeiXing ZHANG HongLiang ZHANG DongLing PAN DaJian LI DaoYuan FAN ZhiLan QI YongWen SUN JunLi YANG QingWen LI Chen LI ZiChao | 2008 | Chinese Science Bulletin2008，53，22： | 8 |
| 4 | Assessing indica-japonica differentiation of improved rice varieties using microsatellite markers显示文摘To assess the indica-japonica differentiation of improved rice varieties, a total of 512 modern varieties including 301 indica and 211 japonica accessions were analyzed using 36 microsatellites. The Fst coefficients ranged from 0.002 to 0.730 among the loci with an average of 0.315. Significant differentiation was detected at 94.4% of the loci studied (P<0.05, pairwise Fst tests), indicating that there was a high level of indica-japonica differentiation within the improved varieties. At 18 loci, about 74%-98% of the alleles of indica and japonica accessions were distributed in two ranges of amplicon length. Linkage disequilibrium analysis showed that the distribution trends were significantly nonrandomly associated. Using the differentiation trends at the 18 loci, microsatellite index (MI) was proposed for discrimination of the two subspecies. When rice accessions with MI value greater than zero were classified as indica, and those with MI value smaller than zero were classified as japonica, about 96.1% of the accessions could be classified. This result agrees with the classification based on morphological-physiological characters, indicating that this method is feasible and effective. | Yongwen Qi Hongliang Zhang Dongling Zhang Meixing Wang Junli Sun Li Ding Fenghua Wang Zichao Li | 2009 | Journal of Genetics and Genomics2009，36，5： | 5 |
| 5 | Genetic structure and diversity of Oryza sativa L. in Guizhou,China显示文摘Preserving many kinds of rice resources and rich variations, Guizhou Province is one of the districts with the highest genetic diversity of cultivated rice (Oryza sativa L.) in China. In the current research, genetic diversity and structure of 537 accessions of cultivated rice from Guizhou were studied using 36 microsatellite markers and 39 phenotypic characters. The results showed that the model-based genetic structure was the same as genetic-distance-based one using SSRs but somewhat different from the documented classification (mainly based on phenotype) of two subspecies. The accessions being classified into indica by phenotype but japonica by genetic structure were much more than that being classified into japonica by phenotype but indica by genetic structure. Like Ding Ying’s taxonomic sys- tem of cultivated rice, the subspecific differentiation was the most distinct differentiation within culti- vated rice. But the differentiation within indica or japonica population was different: japonica presented clearer differentiation between soil-watery ecotypes than indica, and indica presented clearer differen- tiation between seasonal ecotypes than japonica. Cultivated rices in Guizhou revealed high genetic diversity at both DNA and phenotypic levels. Possessing the highest genetic diversity and all the nec- essary conditions as a center of genetic diversity, region Southwestern of Guizhou was suggested as the center of genetic diversity of O. sativa L. from Guizhou. | ZHANG DongLing ZHANG HongLiang WEI XingHua QI YongWen WANG Meixing SUN JunLi DING Li TANG ShengXiang QIU Zong'En CAO YongSheng WANG XiangKun LI ZiChao | 2007 | Chinese Science Bulletin2007，52，3： | 5 |
| 6 | Genetic structure and eco-geographical differentiation of cultivated Hsien rice(Oryza sativa L.subsp.indica) in China revealed by microsatellites显示文摘Indica is not only an important rice subspecies widely planted in Asia and the rest of the world,but it is also the genetic background of the majority of hybrid varieties in China.Studies on genetic structure and genetic diversity in indica germplasm resources are important for the classification and utilization of cultivated rice in China.Using a genetically representative core collection comprising 1482 Chinese indica landraces,we analysed the genetic structure,geographic differentiation and diversity.Model-based structure analysis of varieties within three ecotypes revealed nine eco-geographical types partially accordant with certain ecological zones in China.Differentiation of eco-geographical types was attributed to local ecological adaption and physical isolation.These groups may be useful for developing heterotic groups of indica.To facilitate the identification of different ecotypes and eco-geographical types,we identified characteristic SSR alleles of each ecotype and eco-geographical type and a rapid index of discrimination based on characteristic alleles.The characteristic alleles and rapid discrimination index may guide development of heterotic groups,and selection of hybrid parents. | ZHANG DongLing ZHANG HongLiang QI YongWen WANG MeiXing SUN JunLi DING Li LI ZiChao | 2013 | Chinese Science Bulletin2013，58，3： | 3 |
| 7 | Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘 | Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 8 | 双膦酸盐对骨转移癌骨痛治疗及血清钙磷影响(英文)显示文摘Objective: Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods: One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results: Ostealgia degree did not change significantly after diphosphonates treatment from one to two months (P > 0.05). The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month (54%) and two months (56%) were significantly increased than that before treatment (36%) (χ2 = 6.55, P = 0.011; χ2 = 8.05, P = 0.005). Serum calcium and serum phosphorus were both decreased after treatment one month (t = 4.39, P = 0.000; t = 2.50, P = 0.014) and two months (t = 4.32, P = 0.000; t = 2.49, P = 0.010). There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion: Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus. | Yuedi Dai Meixing Wang Li Tao Anqi Li Haixia Wu Mi Xiao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，6： | 2 |
| 9 | Insights into flavonoid biosynthesis during cucumber fruit peel coloration based on metabolite profiling and transcriptome analyses显示文摘The fruit peel color is a crucial trait of cucumber.To better understand the molecular mechanisms underlying cucumber peel coloration,we compared the UPLC-ESI-MS/MS-based flavonoid metabolomic and RNA sequencing-based transcriptomic profiling of the brown peeled cucumber line‘PW’at six developmental stages.A total of 210 flavonoid metabolites were identified.Of which,117 flavonoid metabolites were differentially accumulated.In this study,weighted gene co-expression network analysis combined with Kyoto Encyclopedia of Gene and Genomes enrichment analysis revealed key genes coding for seven enzymes and eight transcription factors(TFs)associated with flavonoid biosynthesis.Among them,the R2R3MYB CsaV3_4G001130 is the best candidate gene that is responsible for controlling mature fruit colors in cucumber.Sanger sequencing revealed one nonsynonymous SNP in the exon of CsaV3_4G001130 among the selected 11 cucumber lines,which introduced a premature stop codon,generating a truncated protein in pale yellow or creamy peeled fruits.Yeast two-hybrid assays showed a direct interaction of CsaV3_4G001130 with the bHLH TF CsaV3_1G002260 and the WD40 protein CsaV3_5G001800.However,the interactions were influenced by the nonsynonymous SNP we identified.Our finding revealed that the integrated transcriptome and metabolome analysis further demonstrated that the abundance of some pigmented flavonoids(especially anthocyanins and chalcones)contributed to the coloration of‘PW’fruits.These findings pave the way for elucidation of flavonoid biosynthesis and improvement of cucumber peel color in the future. | Shuying He Yi Ye Ying Yuan Mai Lv Meixing Wang Qiang Xu Xuewen Xu Xuehao Chen | 2023 | Horticultural Plant Journal2023，9，4： | 2 |
| 10 | Mechanism Study of Endothelial Protection and Inhibits Platelet Activation of Low Molecular Weight Fucoidan from Laminaria japonica显示文摘Several studies have indicated that fucoidan fractions with low molecular weight and different sulfate content from Laminaria japonica could inhibit the activation of platelets directly by reducing the platelet aggregation. To explore the direct effect of LMW fucoidan on the platelet system furthermore and examine the possible mechanism, the endothelial protection and inhibits platelet activation effects of two LMW fucoidan were investigated. In the present study, Endothelial injury model of rats was made by injection of adrenaline(0.4 mg kg-1) and human umbilical vein endothelial cells were cultured. v WF level was be investigated in vivo and in vitro as an important index of endothelial injury. LMW fucoidan could significantly reduce v WF level in vascular endothelial injury rats and also significantly reduce v WF level in vitro. The number of EMPs was be detected as another important index of endothelial injury. The results showed that LMW fucoidan reduced EMPs stimulated by tumor necrosis factor. In this study, it was found that by inhibiting platelet adhesion, LMW fucoidan played a role in anti-thrombosis and the specific mechanism of action is to inhibit the flow of extracellular Ca2+. All in a word, LMW fucoidan could inhibit the activation of platelets indirectly by reducing the concentration of EMPs and v WF, at the same time; LMW fucoidan inhibited the activation of platelets directly by inhibiting the flow of extracellular Ca2+. | CHEN Anjin ZHANG Fang SHI Jie ZHAO Xue YAN Meixing | 2016 | Journal of Ocean University of China2016，15，5： | 2 |
| 11 | Influence of annealing on the microwave-absorption properties of Ni/TiO 2 nanocomposites显示文摘 | Naikun Sun Baosheng Du Feng Liu Pingzhan Si Meixing Zhao Xueyuan Zhang GuiMei Shi | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 12 | Effect of Annealing on the Microwave-absorption Properties of Ni/Al_2O_3 Nanocomposites显示文摘Ni/Al2O3 nanocomposites were prepared by the mechanochemical synthesis method.The annealing process enlarges the grain size of both the metal Ni and insulating Al2O3 in the as-milled nanocomposite and leads to an increase of the saturation magnetization and a decrease of the surface anisotropy.An optimal reflection loss(RL) of 23 dB is obtained in the as-milled nanocomposite at 17.8 GHz for an absorber thickness of 6.6 mm.The annealed sample exhibits a RL exceeding 20 dB in the whole K u-band for an absorber thickness of 6.6-9.7 mm with an optimal RL of 54.7 dB at 13.2 GHz for a layer thickness of 9.3 mm.The excellent microwave-absorption properties are a consequence of a proper match of the dielectric and magnetic losses. | Songning XU Meixing ZHAO Zongqi CAI Naikun SUN Feng LIU Baosheng DU Xueyuan ZHANG Zhoujun LING | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 1 |
| 13 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 14 | Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant,CAL.20C显示文摘Dear Editor,New variants of SARS-CoV-2 have been emerging since the initial outbreak in 2019;1 one of the latest ones was identified in Southern California in October 2020 and was subsequently detected in 26 other states in the United States as well as other countries as of January 2021. | Zhongcheng Zhou Peng Du Meixing Yu Daniel T.Baptista-Hon Man Miao Andy P.Xiang Johnson Yiu-Nam Lau COVID-Immunity Investigation Group Gen Li Kang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 15 | Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides显示文摘 | Jing Wang Li Wang Meixing Li Qiaoying Jin Shouliang Dong | 2011 | Peptides2011，，5： | 1 |
| 16 | The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera显示文摘To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA assay.Pseudotyped virus carrying a L452R-E484Q variant showed a comparable infectivity compared with D614G.However,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA vaccine.In addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman primates.These results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of SARS-CoV-2.Reduced neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development. | Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu Chengbin Guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 17 | Crustal Electrical Structure of the Wuwei Basin,Lower Yangtze Region of China,and Its Geological Implications显示文摘The Wuwei Basin is one of the most important oil-and gas-bearing basins in the Meso-Cenozoic basin groups in the Lower Yangtze River region.It has great shale gas resource prospects.The formation mechanism of this basin is poorly studied for lack of constraining data for deep structures.In this paper,a crustal electrical structure model of the Wuwei Basin and the adjacent areas is constructed based on the two-dimensional inversion of a magnetotelluric(MT)sounding profile achieved with the nonlinear conjugate gradient method.The results show that large-scale low-resistance bodies have developed in the underlying middle and lower crust of the Wuwei Basin,and are different from the uplifts on the two sides according to their high-resistance electrical characteristics.The electrical structure and regional geological and geophysical data suggest that the peak zone of the Chuzhou-Chaohu foreland fold-and-thrust belt is located on the east bank of the Yangtze River(Wuhu Section),which,together with the main thrust fault belt in the east,forms a typical thrust structure belt.An early Yanshanian sinistral strike-slip fault developed in the deep part of the Wuwei Basin,which may have controlled the formation and evolution of the basin,whereas the tectonic inversion of the early-developed thrust faults is relatively weak.These findings provide a geophysical basis for future studies of basin tectonic evolution and regional tectonic frameworks. | Xiaobo Zhang Penghui Zhang Meixing He Dashuang He Fagen Pei Yaoyang Zhang Yan Peng | 2023 | Journal of Earth Science2023，34，6： | 0 |
| 18 | Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped positive-sense single-stranded RNA(ssRNA)virus responsible for the global COVID-19 pandemic.Although vaccines for SARS-CoV-2 have been developed and applied worldwide,research on vaccine adjuvant is lacking.Viral infections normally elicit a range of innate immune responses through the activation of pattern recognition receptors(PRRs). | Gen Li Meixing Yu Qiong Ke Jing Sun Yanwen Peng Chuanfeng Xiong Olivia Monteiro COVID-Infection and Immunity Investigation Group Jincun Zhao Andy P.Xiang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 19 | mpaired NK cell antiviral cytokine response against nfluenza virus in small-for-gestational-age neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Fan Yang Ting Feng Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Meng Mao Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，5： | 0 |
| 20 | DNA methylation markers in the diagnosis and prognosis of common leukemias显示文摘The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of patients.Using genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal blood.We established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and specificity.We then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia type.Together,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection. | Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员