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| 1 | All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members显示文摘As a potential chemo-therapeutic agent,all-trans retinoic acid(ATRA)can signif-icantly reverse epithelial-mesenchymal transition(EMT)of hepal-6 hepatocarcinoma cell line in vitro,but the mechanism is unclear.The expression profile of microRNA-200(miR-200)families is different in hepatocellular carcinoma.In this study,we found that ATRA trea tment could up-regulate the expression of miR-200a-3p,200c-3p,and 141-3p,which were involved in ATRA regulated proliferation and apoptosis of hepal-6 cell,but not colony formation.Meanwhile,miR-200a-3p,200c-3p,and 141-3p could recovery ATRA inhibited migration and invasion abilities of hepal-6 cells at various levels.miR-200a-3p and 200c-3p prevented ATRA from inducing the differentia tion and hepatic functions of hepal-6 cells.An-tagomir specific for miR-200a-3p and 200c-3p down-regulated the expression of CK18,but only miR-200a-3p anta gomir played prominent role in regula ting the expression of these mesenchymal markers,N-Cadherin,Snail and Twist.The transcriptional activities of 8 tran-scription factors were up-regulated and 35 transcription factors were down-regulated by ATRA.Compared with ATRA group,inhibition of miR-200a-3p,200c-3p,and 141-3p significantly strengthened the expression of Fra1/Jun(AP1),Ets1/PEA3,Brn3,and Zeb1/AREB6 at varying degrees.Therefore,this result suggested that ATRA may suppress EMT through down-regulating miR-200a-3p,200c-3p and 141-3p related transcription factors.miR-200 and their downstream genes might be the potentially specific targets for the treat-ment of hepatocarcinoma. | Jiejie Cui Mengjia Gong Shuyu Fang Chaoqun Hu Yi Wang Jingfang Zhang Ni Tang Yun He | 2021 | Genes & Diseases2021，8，4： | 2 |
| 2 | Molecular simulation study on K^+-Cl^- ion pair in geological fluids显示文摘This paper reports a classical molecular dynamics study of the potential of mean forces(PMFs),association constants,microstructures K^+-Cl^- ion pair in supercritical fluids.The constrained MD method is used to derive the PMFs of K^+-Cl^- ion pair from 673 to 1273 K in low-density water(0.10-0.60 g/cm).The PMF results show that the contact ion-pair(CIP) state is the one most energetically favored for a K^+-Cl^- ion pair.The association constants of the K^+-Cl^- ion pair are calculated from the PMFs,indicating that the K^+-Cl^- ion pair is thermodynamically stable.It gets more stable as T increases or water density decreases.The microstructures of the K^+-Cl^- ion pair in the CIP and solvent-shared ion-pair states are characterized in detail.Moreover,we explore the structures and stabilities of the KCl-Au(I)/Cu(I) complexes by using quantum mechanical calculations.The results reveal that these complexes can remain stable for T up to1273 K,which indicates that KCl may act as a ligand complexing ore-forming metals in hydrothermal fluids. | Mengjia He Xiandong Liu Xiancai Lu Rucheng Wang | 2017 | Acta Geochimica2017，36，1： | 2 |
| 3 | Characteristics of Uranium Mineralization in Red Clastic Formations in the Southwestern Margin of the Ordos Basin显示文摘In the southwestern margin of the Ordos Basin,uranium mineralization is primarily hosted by predominantly oxidative red clastic formations in the Lower Cretaceous.The main target layers for uranium exploration are the Madongshan and Liwaxia formations of the Liupanshan Group,followed by the Jingchuan Formation of the Zhidan Group.The host rocks(medium-fine feldspar quartz sandstone),which are bleached to a light grayish white color,contain a minor organic matter component and pyrite.Uranium mineralization changes from surficial infiltration or phreatic oxidation in the upper part to interlayer oxidation in the lower part.Uranium ore bodies are mostly lenticular or tabular in shape,locally shaped like crescent rolls.Individual ore bodies are typically small and shallow.Uranium predominantly manifests as pitchblende and coffinite.Coffinite is usually short and columnar or granular in habit,whereas pitchblende occurs as an irregular colloidal covering on the surface or in fissures of ferric oxide,silicate,clay or carbonate.Secondary uranium minerals are torbernite,uranophane,and uranopilite.Minerals associated with uranium are mainly pyrite,chalcopyrite and,to a minor extent,arsenopyrite and fluorite.The associated elements are Mo,V,Se,Co,Ni,and Mn,the host sandstone being high in Cu and Ba.Overall,the red clastic formations in the southwestern margin of the Ordos Basin are characterized by’five multiples but one low’which means multiple target layers,multiple stages of mineralization,multiple ore body shapes,multiple kinds of uranium minerals,multiple associated elements,but low organic matter.This implies an overall complex uranium metallogenic environment and mineralization process.It is recommended that future uranium exploration should take into consideration regional metallogenic conditions and mineralization features,with target layers in the wide-smooth synclinal slope being focused on.Most uranium deposits are small to medium in size,and the main type of uranium mineralization can vary by target layer. | ZHANG Zilong HE Feng YI Longsheng FAN Honghai CAI Yuqi LIU Hongxu LIU Xinyang CHEN Hongbin JIA Cui YANG Mengjia | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 4 | Reduction of rotor eddy current loss in high speed PM brushless machines by grooving retaining sleeve显示文摘 | Shen Jianxin He Hao Jin Mengjia | 2013 | IEEE Transactions on Magnetics2013，49，7： | 1 |
| 5 | Radiation-induced one-pot synthesis of grafted covalent organic frameworks显示文摘Post-synthetic functionalization of covalent organic frameworks(COFs)is an alternative way to enhance and broaden their properties and potential applications.However,the chemical functionalization of COFs is a great challenge because traditional procedures are often time-and energy-consuming,while the crystallinity of COFs can be damaged under harsh conditions.Here we report the in-situ introduction of functional graft chains onto the skeleton of COFs during the synthesis process through the combination of radiation-induced synthesis and graft polymerization techniques under ^(60)Co gamma-ray radiation.The synthesis and functionalization of COFs are simultaneously accomplished in a chemical system under ambient conditions yielding a large number of different functionalized COFs.The obtained carboxyl-functionalized COFs exhibit excellent radioactive uranium removal capabilities from aqueous solution with fast uptake dynamics,high adsorption capacity,and excellent selectivity over other competing metal ions. | Mingxing Zhang Mengjia Yuan Xiaofang Zhao Junchang Chen Linwei He Qianhong Gao Jiangtao Hu Guozhong Wu Zhifang Chai Shuao Wang | 2023 | Science China Chemistry2023，66，6： | 0 |
| 6 | Molecular dynamics study on mechanical behaviors of Ti/Ni nanolaminate with a pre-existing void显示文摘Metallic nanolaminated materials possess excellent mechanical properties due to their unique modulation structures and interfacial properties.However,how microdefects affect their mechanical properties is still uncertain.To evaluate the influences of void location(in the crystalline layer and the Ti/Ni interface),void diameter(d)and thickness of the intermediate layer(h)on overall tensile behaviors,various types of defective Ti/Ni nanolaminates with pre-existing void are established by the molecular dynamics method in this work.The results indicate that the strength and plastic deformation mechanisms are strongly dependent on those determinants.Yield stresses of Ti/Ni nanolaminates decrease distinctly with increasing void diameter,while peak stresses with a void in the crystalline layer decrease with increasing d/h.Different void locations lead eventually to disparate initial plastic deformation carriers around the void,and various evolutions in the microstructure of the defective Ti/Ni nanolaminates.The Ti/Ni interface plays a significant role in the tensile process.The semi-coherent interface impedes new grains and lattice dislocations from passing across the interface,while the incoherent interface facilitates dislocations generating and sliding along the interface,and absorbs the dislocations moving to the interface.The results also indicate that the strain rate significantly affects the evolution of the microstructure and the tensile properties of defective Ti/Ni nanolaminates. | Mengjia Su Qiong Deng Lanting Liu Lianyang Chen He He Yinggang Miao | 2022 | Nano Materials Science2022，4，2： | 0 |
| 7 | Design Methods of Transversally Laminated Synchronous Reluctance Machines显示文摘Transversally laminated synchronous reluctance machine(SynRM)are usually designed with multiple-layer flux barriers to achieve high electromagnetic performance.This paper summarizes three design methods to optimize the machine.Related implementation procedures are detailed.Besides,advantages and disadvantages of these methods are discussed.Based on these conventional techniques,a comprehensive optimization method is proposed,with which a prototype SynRM is designed.The performances of this prototype are discussed to verify the optimal design method. | Shun Cai Jianxin Shen He Hao Mengjia Jin | 2017 | CES Transactions on Electrical Machines and Systems2017，1，2： | 0 |
| 8 | A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m^(6)A-dependent activation of multiple oncogenes显示文摘Retinoblastoma, the most prevalent primary intraocular tumor in children, leads to vision impairment, disability and even death.In addition to RB1 inactivation, MYCN activation has been documented as another common oncogenic alteration in retinoblastoma and represents one of the high-risk molecular subtypes of retinoblastoma. However, how MYCN contributes to the progression of retinoblastoma is still incompletely understood. Here, we report that MYCN upregulates YTHDF1, which encodes one of the reader proteins for N6-methyladenosine(m^(6)A) RNA modification, in retinoblastoma. We further found that this MYCN-upregulated m^(6)A reader functions to promote retinoblastoma cell proliferation and tumor growth in an m^(6)A bindingdependent manner. Mechanistically, YTHDF1 promotes the expression of multiple oncogenes by binding to their m RNAs and enhancing m RNA stability and translation in retinoblastoma cells. Taken together, our findings reveal a novel MYCN-YTHDF1regulatory cascade in controlling retinoblastoma cell proliferation and tumor growth, pinpointing an unprecedented mechanism for MYCN amplification and/or activation to promote retinoblastoma progression. | Yingxiu Luo Mengjia He Jie Yang Feifei Zhang Jie Chen Xuyang Wen Jiayan Fan Xianqun Fan Peiwei Chai Renbing Jia | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 9 | Synthesis and characterization of fluorescence active G_(4)-quartet and direct evaluation of self-assembly impact on emission显示文摘Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-quadruplexes.The p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines were identified to give the strongest fluorescence with the formation of G_(8)-octamers(G_(8))both in solution(NMR)and solid state(X-ray).This well-defined G_(8)-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission(AIE),which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition. | Ying He Mengjia Liu Shun Teng Lukasz Wojtas Guangxin Gu Xiaodong Shi | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 10 | Tailoring Pore Structure and Morphologies in Covalent Organic Frameworks for Xe/Kr Capture and Separation显示文摘As a rising star among porous solid materials,covalent organic frameworks(COFs)with excellent properties including but not limit to facilely controllable structure,high porosity,and multi-chemical functionality represent significant potential for efficient 127Xe/85Kr capture and separation.In this study,through tuning the length of the organic ligands,two-dimensional(2D)COF materials with identical connection group but different pore properties,denoted as ATFG-COF and TpPa-COF with AA-stacking model and TpBD-COF with AB-stacking model were synthesized and tested for Kr and Xe adsorption for the first time.Adsorption measurements indicate that the narrower pore apertures and higher porosity are conducive for COF materials to capture Xe and Kr.Furthermore,the Henry’s constant,isosteric heat of adsorption(Q_(st)),and ideal adsorbed solution theory(IAST)selectivity of ATFG-COF,the pore size of which is closest to the kinetic diameter of the Xe atom(0.41 nm)among 2D COF materials,were carried out based on the single component sorption isotherms.The results illustrate that the high isosteric heat values of Xe/Kr adsorption on ATFG-COF are 25 and 16 kJ/mol at room temperature,respectively.Henry’s law predicts that the selectivity factor of Xe to Kr is 6.07,consistent with the adsorption selectivity(ca.6)calculated based on the IAST. | YUAN Mengjia WANG Xia CHEN Long ZHANG Mingxing HE Linwei MA Fuyin LIU Wei WANG Shuao | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 11 | Achieving high-strain-rate and low-temperature superplasticity in an ECAP-processed Mg-Y-Er-Zn alloy via Ag addition显示文摘The effect of adding a small amount of Ag on the microstructure evolution and superplastic properties of Mg-Y-Er-Zn(WEZ612) alloys was systematically studied.The basal texture of the refined WEZ612 alloy produced by equal channel angular pressing was altered to a non-basal structure upon the addition of Ag.Ag addition also refined the grain size and promoted the formation of a large number of nano-14H-long period stacking ordered phases.Using high-resolution transmission electron microscopy,many nano-precipitated phases were detected on the basal plane of the Mg-Y-Er-Zn-1Ag(WEZ612-1Ag) alloy,The nano-precipitated phases on the basal plane improved the thermal stability of the alloy,lowered the deformation activation energy(Q),and improved the stress sensitivity index(m).At 523 K with a strain rate of 10^(-2) s^(-1),the Q value of WEZ612 was higher than that of WEZ612-1Ag(299.14 and 128.5 kJ mol^(-1),respectively).In contrast,the m value of the WEZ612 alloy(0.16) was lower than that of the WEZ612-1Ag alloy(0.46).At 623 K with a tensile rate of 10^(-2) s^(-1),the WEZ612 and WEZ612-1Ag alloys were elongated by 182% and 495%,respectively,with the latter exhibiting high-strain-rate and low-temperature superplasticity.The improved superplasticity of the WEZ612-1Ag alloy is attributed to the nano-precipitated phases,which effectively limit the cavity extension during superplastic deformation. | Haoran Wu Jinghua Jiang Zhenquan Yang Mengjia Li He Huang Ningfei Ge Aibin Ma Huan Liu | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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