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| 1 | Systematic Identification of the Light-quality Responding Anthocyanin Synthesis-related Transcripts in Petunia Petals显示文摘Previous studies have shown that high light intensity can induce anthocyanin synthesis(AS)in petunia plants.To identifywhich kind of light quality plays a role in inducing such metabolic process,and what transcripts participate in controlling it,we carried out whole-transcriptome sequencing and analysis of petunia petals treated with different light-quality conditions.Among the red and white light treatments,a total of 2205 differentially expressed genes and 15,22,and 20 differentially expressed circRNAs,miRNAs,and lncRNAs,were identified respectively.The AS-related genes,including the structural genes CHSj,F3H,F35H,DFR,and ANS,and the regulatory genes AN4,DPL,PHZ and MYBx were found to be downregulated under red light condition compared with their levels under white light condition.Furthermore,the light photoreceptor Cryptochrome 3(CRY3)and a series of light-dependent genes,such as PIF,HY5,andBBXs,were also determined to respond to the light treatments.The anthocyanin contents in early petunia petals under red light were significantly lower than that under white and blue light.The results of qRT-PCR further confirmed the expression pattern of some AS-related and light-response genes in response to different light quality.Yeast two-hybrid results showed that the key elements in the light signal pathway,HY5 can interact with BBX19,BBX24 and BBX25.And PHZ,the important AS regulator can induce anthocyanin synthesis in response to blue light quality fromtransient expression analysis in petunia petals.These findings presented here not only deepen our understanding of how light quality controls anthocyanin synthesis,but also allow us to explore potential target genes for improving pigment production in petunia flower petals. | Zhenzhu Fu Hongquan Shang Hui Jiang Jie Gao Xiaoyu Dong Huijuan Wang Yanmin Li Limin Wang Jing Zhang Qingyan Shu Yacong Chao Menglan Xu Rui Wang Liangsheng Wang Hechen Zhang | 2020 | Horticultural Plant Journal2020，6，6： | 7 |
| 2 | Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years显示文摘Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research. | Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 3 | The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis显示文摘Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs. | Xiaoyang Xu Haiyan Yuan Xiaqing Yu Suzhen Huang Yuming Sun Ting Zhang Qingquan Liu Haiying Tong Yongxia Zhang Yinjie Wang Chunxiao Liu Lei Wu Menglan Hou Yongheng Yang | 2021 | Horticulture Research2021，8，1： | 2 |
| 4 | Component ratio effects of hyperbranched triazine compound and ammonium polyphosphate in flame-retardant polypropylene composites显示文摘 | Xu Menglan Chen Yajun Qian Lijun | 2014 | Journal of Applied Polymer Science2014，131，21： | 1 |
| 5 | Reliability analysis of ice-induced fatigue and damage in offshore engineering structures显示文摘 | Fang Huacan Duan Menglan XU Fayan | 2000 | China Ocean Engineering2000，14，1： | 1 |
| 6 | Reliability analysis of ice-induced fatigue and damage in offshore engineering structures显示文摘 | Fang Huacan Duan Menglan Xu Fayan Shen Zhonghan Liu Yubiao | 2000 | China Ocean Engineering2000，14，1： | 1 |
| 7 | Self-assembly of Pyrene-modified Rhomboidal Metalloden- drimers via Directional Metal-ligand Bonding Approach显示文摘设计并且经由方向性的 metal-ligand 的修改分核的长斜方形的 metallodendrimers R1R6 自己组装结合的途径被描述。由采用包含分核 120 敺搠獩牴扩瑵潩 ? 景 ? 偄华 ? 敷敲搠瑥牥業敮 ? 祢搠湹浡捩氠杩? | Menglan He Qing Han Jiuming He Quanjie Li Zeper Abliz Hongwei Tan Lin Xu Haibo Yang | 2013 | Chinese Journal of Chemistry2013，31，5： | 1 |
| 8 | Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy显示文摘Uniting dual-modality of fluorescence and photoacoustic(PA)imaging into theranostic nanoprobes is imperative for spatiotemporally tracking of drug delivery,distribution,and release.Herein,we present a rational design strategy of molecularly precise amphiphilic prodrugs BP_(n)-Cy-S-CPT(n=0,5,and 20,refers to the degree of polyethylene glycol(PEG)polymerization;CPT=camptothecin)to tune their self-assembly behaviour,innovatively integrating dual-modal PA and near-infrared(NIR)fluorescence imaging in a single-molecular framework.Among these elaborately designed prodrugs,it is found that only BP_(20)-Cy-S-CPT could form uniform and highly stable self-assemblies,especially in showing synergistically enhanced PA and dualchannel NIR signals.In detail,PA signal is employed to trace the in vivo delivery with high spatial resolution,meanwhile the glutathione(GSH)-triggered dual-channel fluorescence response could real-timely monitor drug distribution and release without'blind spot'.The results of in vivo dual-modal PA/NIR imaging have verified that BP_(20)-Cy-S-CPT displayed synergistic targeting(including passive,active,and activatable targeting)for tumor-specific delivery,and thereby executed CPT release in the tumor site.Consequently,our molecularly precise BP_(20)-Cy-S-CPT self-assemblies could make a breakthrough to spatiotemporally track the in vivo drug release profile,expanding the intelligent theranostic toolbox for precise cancer treatment. | Chenxu Yan Hongxia Xu Menglan Wu Zijun Zhao Weijun Zhao Jianbin Tang Zhiqian Guo | 2021 | Science China Chemistry2021，64，11： | 0 |
| 9 | In-service shear check of heated cased insulated flowlines显示文摘Starting friction would be induced and preserved somewhere along the seabed route of cased insulated flowlines(CIF) when the pipe carries service loads.The axial pipe-soil interaction can be divided into three pipe sections:the sliding section,the fixed section and the starting friction section.Although limited to a relatively small length of the pipe,the pipe coats of the starting friction section would suffer much higher shear force caused by thermal expansion than those of the sliding section or the fixed section.Based on the axial equilibrium equation of this kind of insulated pipeline,we developed a method for checking the shear force on CIF coats and their interfaces.The typical example shows that starting friction effect should be taken into account when checking the lap shear strength of heatshrinkable sleeves on CIF field joints. | Zhao Tianfeng Duan Menglan Jia Xu Jiao Bintian | 2012 | Petroleum Science2012，9，4： | 0 |
| 10 | Benzaldehyde lyase-catalyzed enantioselective C-C bond formation and cleavage:A review显示文摘Benzaldehyde lyase(BAL)is an enzyme which was originally found from Pseudomonas fluorescens biovar I.It has long been used in the formation of a C-C bond.BAL can exclusively yield(R)-enantioselective products from the synthesis ofα-hydroxy ketones and has so far been explored as an important enzyme to prepare the corresponding intermediate of pharmaceuticals.Due to its substrate spectrum and stereospecificity,this enzyme extends the synthetic potential for carboligations appreciably.In this review,we highlight the biotransformation applications of BAL in recent years,some of which have achieved intriguing results and provided the theoretical basis for drug development and industrial purpose in the future. | Zhiran Ju Junde Xu Zhiyun Li Jingjie Fang Menglan Li Daniel C.Howell FenEr Chen | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 11 | A comparative study of classroom culture between China and America显示文摘 | WAN Menglan YANG Xu PAN Shiling | 2016 | International English Education Research2016，，6： | 0 |
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