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| 1 | High proton conductivity in metalloring-cluster based metalorganic nanotubes显示文摘Two novel anionic single-walled metal-organic nanotubes(MONTs),[(CH_(3))_(2)NH_(2)][ln(cdc)(thb)].2DMF.9.5H_(2)O(FJU-105)and[(CH_(3))_(2)NH_(2)][ln(cdc)(H-btc)]-2DMA·11H_(2)O(FJU-106)(H_(2)cdc=9H-carbazole-3,6-dicarboxylic acid,H_(2)thb=2,5-thiophene dicarboxylic acid,H3btc=1,3,5-benzene tricarboxylic acid),are achieved by employing[ln_(6)(cdc)_(6)]^(6+)metalloring cluster with largest diameter as the secondary building blocks(SBUs).The inner surface of FJU-106 is functionalized by uncoordinated-COOH groups of the H-btc linkers,leading to a higher proton conduction than FJU-105.At 70℃,FJU-106 displays the proton conduction performances among MONTs,up to 1.80×10^(-2)S·cm(^-1).And FJU-105 and FJU-106 are the first examples of MONT proton conductors operating at subzero temperature. | Quanjie Lin Yingxiang Ye Lizhen Liu Zizhu Yao Ziyin Li Lihua Wang Chulong Liu Zhangjing Zhang Shengchang Xiang | 2021 | Nano Research2021，14，2： | 2 |
| 2 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 3 | The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA PolⅡfrom Binding to HIV-1 LTR显示文摘The CREB-regulated transcriptional co-activators(CRTCs),including CRTC1,CRTC2 and CRTC3,enhance transcription of CREB-targeted genes.In addition to regulating host gene expression in response to cAMP,CRTCs also increase the infection of several viruses.While human immunodeficiency virus type 1(HIV-1)long terminal repeat(LTR)promoter harbors a cAMP response element and activation of the cAMP pathway promotes HIV-1 transcription,it remains unknown whether CRTCs have any effect on HIV-1 transcription and HIV-1 infection.Here,we reported that CRTC2 expression was induced by HIV-1 infection,but CRTC2 suppressed HIV-1 infection and diminished viral RNA expression.Mechanistic studies revealed that CRTC2 inhibited transcription from HIV-1 LTR and diminished RNA PolⅡoccupancy at the LTR independent of its association with CREB.Importantly,CRTC2 inhibits the activation of latent HIV-1.Together,these data suggest that in response to HIV-1 infection,cells increase the expression of CRTC2 which inhibits HIV-1 gene expression and may play a role in driving HIV-1 into latency. | Ling Ma Shumin Chen Zhen Wang Saisai Guo Jianyuan Zhao Dongrong Yi Quanjie Li Zhenlong Liu Fei Guo Xiaoyu Li Pingping Jia Jiwei Ding Chen Liang Shan Cen | 2021 | Virologica Sinica2021，36，4： | 1 |
| 4 | Downregulation of cancer stem cell properties via mTOR signaling pathwayinhibition by rapamycin in nasopharyngeal carcinoma显示文摘 | Chunguang Yang Yue Zhang Yu Zhang Ziheng Zhang Jianhua Peng Zhi Li Liang Han Quanjie You Xiaoyu Chen Xingwang Rao Yi Zhu Zhisu Liao | 2015 | International Journal of Oncology2015，，3： | 1 |
| 5 | Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein显示文摘Ebola virus(EBOV)infection leads to staggeringly high mortality rate.Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa.In this study,we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in vivo.Our work further showed that berbamine hydrochloride acts by directly binding to the cleaved EBOV glycoprotein(GPcl),disrupting GPcl interaction with viral receptor Niemann-Pick C1,thus blocking the fusion of viral and cellular membranes.Our data support the probability of developing anti-EBOV small molecule drugs by targeting viral GPcl.More importantly,since berbamine hydrochloride has been used in clinic to treat leukopenia,it holds great promise of being quickly repurposed as an anti-EBOV drug. | Dongrong Yi Quanjie Li Han Wang Kai Lv Ling Ma Yujia Wang Jing Wang Yongxin Zhang Mingliang Liu Xiaoyu Li Jianxun Qi Yi Shi George F.Gao Shan Cen | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
| 6 | Study on the factors of affecting determination of fogging characteristics of trim leather in the interior of car 显示文摘 | Fu Lihong Wang Quanjie li Tianduo | 2006 | The 7th Asian International Conference of Leather Science and Technology2006，，： | 1 |
| 7 | Self-assembly of Pyrene-modified Rhomboidal Metalloden- drimers via Directional Metal-ligand Bonding Approach显示文摘设计并且经由方向性的 metal-ligand 的修改分核的长斜方形的 metallodendrimers R1R6 自己组装结合的途径被描述。由采用包含分核 120 敺搠獩牴扩瑵潩 ? 景 ? 偄华 ? 敷敲搠瑥牥業敮 ? 祢搠湹浡捩氠杩? | Menglan He Qing Han Jiuming He Quanjie Li Zeper Abliz Hongwei Tan Lin Xu Haibo Yang | 2013 | Chinese Journal of Chemistry2013，31，5： | 1 |
| 8 | An Algorithm for Available Bandwidth Estimation of IPv6 Network显示文摘 | Qiu Quanjie Li Zhiguo Wu Zhongfu | 2010 | Lecture Notes inComputer Science2010，，2： | 1 |
| 9 | Analysis of the Hydraulic Performances of a New Liquid Emitter Based on a Leaf Vein Concept显示文摘The leaf-vein drip irrigation emitter is a new type of drip emitter based on a bionic structure able to support shunting,sharp turns,and increased dissipation.In the present work,the results of twenty-five tests executed in the framework of an orthogonal design strategy are presented in order to clarify the influence of the geometrical parameters of the flow channel on the hydraulic characteristics of such emitter.The corresponding flow index and head loss coefficient are determined through numerical simulations and model testing.The results show that the flow index of the flow channel is 0.4970∼0.5461,which corresponds to good hydraulic performances.The head loss coefficient of the flow channel is 572.74∼3933.05,which in turn indicates a good energy dissipation effect.The order of influence of the leaf vein flow channel parameters on the flow index can be represented in a synthetic way as a>b>c>d>e,where(a)is the width of the inlet,(b)is the horizontal distance of the front water inlet,(c)is the vertical distance of the inner edge of the front end,(d)is the horizontal distance of the rear water outlet and(e)is the vertical distance of the outer edge of the front end.The flow index increases with d,decreases with a,first decreases,and then increases with b,and first increases and then decreases with the increase of c and e.The coefficient(R^(2))of the fitted model related to geometric parameters and flow index is 0.9986-0.9999.The relative errors among experimental testing,simulation calculation and predictive estimates are shown to be less than 5%. | Tianyu Xu Zhouming Su Yanru Su Zonglei Li Quanjie Chen Shuteng Zhi Ennan Zheng Kaili Meng | 2023 | Fluid Dynamics & Materials Processing2023，19，8： | 0 |
| 10 | SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis显示文摘The coronavirus disease 2019(COVID-19)pandemic has devastated global health.Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future viral outbreaks.Here,we have identified host proteins that associate with nonstructural protein 12(nsp12),the RNA-dependent RNA polymerase(RdRp)of SARS-CoV-2 using a mass spectrometry(MS)-based proteomic approach.Among the candidate factors,CDK2(Cyclin-dependent kinase 2),a member of cyclin-dependent kinases,interacts with nsp12 and causes its phosphorylation at T20,thus facilitating the assembly of the RdRp complex consisting of nsp12,nsp7 and nsp8 and promoting efficient synthesis of viral RNA.The crucial role of CDK2 in viral RdRp function is further supported by our observation that CDK2 inhibitors potently impair viral RNA synthesis and SARS-CoV-2 infection.Taken together,we have discovered CDK2 as a key host factor of SARS-CoV-2 RdRp complex,thus serving a promising target for the development of SARS-CoV-2 RdRp inhibitors. | Saisai Guo Xiaobo Lei Yan Chang Jianyuan Zhao Jing Wang Xiaojing Dong Qian Liu Zixiong Zhang Lidan Wang Dongrong Yi Ling Ma Quanjie Li Yongxin Zhang Jiwei Ding Chen Liang Xiaoyu Li Fei Guo Jianwei Wang Shan Cen | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
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