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| 1 | Effects of 4 GPa Pressure Heat Treatment on Thermal Physical Properties of the Cu-AI Alloy显示文摘 | Xiaoping Guan Mengmeng Cheng Guirong Peng Jianhua Liu Ruijun Zhang | 2011 | 材料科学与工程(中英文版)2011，5，4： | 6 |
| 2 | 5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction显示文摘The neuroprotective role of 5-hydroxymethyl-2-furfural(5-HMF)has been demonstrated in a variety of neurological diseases.The aim of this study is to investigate the effect of 5-HMF on multiple sclerosis(MS).IFN-γ-stimulated murine microglia(BV2 cells)are considered a cell model of MS.With 5-HMF treatment,microglial M1/2 polarization and cytokine levels are detected.The interaction of 5-HMF with migration inhibitory factor(MIF)is predicted using online databases.The experimental autoimmune encephalomyelitis(EAE)mouse model is established,followed by a 5-HMF injection.The results show that 5-HMF facilitates IFN-γ-stimulated microglial M2 polarization and attenuates the inflammatory response.According to the network pharmacology and molecular docking results,5-HMF has a binding site for MIF.Further results show that blocking MIF activity or silencing CD74 enhances microglial M2 polarization,reduces inflammatory activity,and prevents ERK1/2 phosphorylation.5-HMF inhibits the MIF-CD74 interaction by binding to MIF,thereby inhibiting microglial M1 polarization and enhancing the anti-inflammatory response.5-HMF ameliorates EAE,inflammation,and demyelination in vivo.In conclusion,our research indicates that 5-HMF promotes microglial M2 polarization by inhibiting the MIF-CD74 interaction,thereby attenuating inflammation and demyelination in EAE mice. | Dongsheng Guan Yingxia Li Yinglin Cui Huanghong Zhao Ning Dong Kun Wang Deqi Ren Tiantian Song Xiaojing Wang Shijie Jin Yinghe Gao Mengmeng Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 3 | Vector analysis of electric-field-induced antiparallel magnetic domain evolution in ferromagnetic/ferroelectric heterostructures显示文摘Electric field(E-field)control of magnetism based on magnetoelectric coupling is one of the promising approaches for manipulating the magnetization with low power consumption.The evolution of magnetic domains under in-situ E-fields is significant for the practical applications in integrated micro/nano devices.Here,we report the vector analysis of the E-field-driven antiparallel magnetic domain evolution in FeCoSiB/PMN-PT(011)multiferroic heterostructures via in-situ quantitative magneto-optical Kerr microscope.It is demonstrated that the magnetic domains can be switched to both the 0°and 180°easy directions at the same time by E-fields,resulting in antiparallel magnetization distribution in ferromagnetic/ferroelectric heterostructures.This antiparallel magnetic domain evolution is attributed to energy minimization with the uniaxial strains by E-fields which can induce the rotation of domains no more than 90°.Moreover,domains can be driven along only one or both easy axis directions by reasonably selecting the initial magnetic domain distribution.The vector analysis of magnetic domain evolution can provide visual insights into the strain-mediated magnetoelectric effect,and promote the fundamental understanding of electrical regulation of magnetism. | Xinger ZHAO Zhongqiang HU Jingen WU Ting FANG Yaojin LI Yuxin CHENG Yifan ZHAO Mengmeng GUAN Dan XIAN Chenying WANG Qi MAO Bin PENG Ren-Ci PENG Ziyao ZHOU Zhiguang WANG Zhuang-De JIANG Ming LIU | 2021 | Journal of Advanced Ceramics2021，10，6： | 0 |
| 4 | Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells显示文摘Targeted gene therapy has become a promising approach for lung cancer treatment.In our previous work,we reported that the targeted expression of microRNA-7(miR-7)operated by thyroid transcription factor-1(TTF-1)promoter inhibited the growth of human lung cancer cells in vitro and in vivo;however,the intervention efficiency needed to be further improved.In this study,we identified the core promoter of TTF-1(from-1299 bp to-871 bp)by 5’deletion assay and screened out the putative transcription factors nuclear factor-1(NF-1)and activator protein-1(AP-1).Further analysis revealed that the expression level of NF-1,but not AP-1,was positively connected with the activation of TTF-1 core promoter in human non-small-cell lung cancer(NSCLC)cells.Moreover,the silencing of NF-1 could reduce the expression level of miR-7 operated by TTF-1 core promoter.Of note,we optimized four distinct sequences to form additional NF-1-binding sites(TGGCA)in the sequence of TTF-1 core promoter(termed asTTF-1 promoter),and verified the binding efficiency of NF-1 on theTTF-1 promoter by electrophoretic mobility shift assay(EMSA).As expected,theTTF-1 promoter could more effectively drive miR-7 expression and inhibit the growth of human NSCLC cells in vitro,accompanied by a reduced transduction of NADH dehydrogenase(ubiquinone)1αsubcomplex 4(NDUFA4)/protein kinase B(Akt)pathway.Consistently,TTF-1 promoter-driven miR-7expression could also effectively abrogate the growth and metastasis of tumor cells in a murine xenograft model of human NSCLC.Finally,no significant changes were detected in the biological indicators or the histology of some important tissues and organs,including heart,liver,and spleen.On the whole,our study revealed that the optimized TTF-1 promoter could more effectively operate miR-7 to influence the growth of human NSCLC cells,providing a new basis for the development of microRNA-based targeting gene therapy against clinical lung cancer. | Shipeng CHEN Lian GUAN Xu ZHAO Jing YANG Longqing CHEN Mengmeng GUO Juanjuan ZHAO Chao CHEN Ya ZHOU Yong HAN Lin XU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 0 |
| 5 | Venous thromboembolism in children with acute lymphoblastic leukemia in China:a report from the Chinese Children’s Cancer Group-ALL-2015显示文摘Venous thromboembolism(VTE)is a complication in children with acute lymphoblastic leukemia(ALL).The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China,and epidemiology,clinical characteristics,and risk factors associated with VTE were analyzed.We collected data on VTE in a multiinstitutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December 2019.First,VTE occurred in 159(2.08%)patients,including 90(56.6%)during induction therapy and 108(67.92%)in the upper extremities.T-ALL had a 1.74-fold increased risk of VTE(95%CI 1.08–2.8,P=0.022).Septicemia,as an adverse event of ALL treatment,can significantly promote the occurrence of VTE(P<0.001).Catheter-related thrombosis(CRT)accounted for 75.47%(n=120);and,symptomatic VTE,58.49%(n=93),which was more common in patients aged 12–18 years(P=0.023),non-CRT patients(P<0.001),or patients with cerebral thrombosis(P<0.001).Of the patients with VTE treated with anticoagulation therapy(n=147),4.08%(n=6)had bleeding.The VTE recurrence rate was 5.03%(n=8).Patients with VTE treated by non-ultrasoundguided venous cannulation(P=0.02),with residual thrombus(P=0.006),or with short anticoagulation period(P=0.026)had high recurrence rates.Thus,preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence. | Mengmeng Yin Hongsheng Wang Xianmin Guan Ju Gao Minghua Yang Ningling Wang Tianfeng Liu Jingyan Tang Alex WK Leung Fen Zhou Xuedong Wu Jie Huang Hong Li Shaoyan Hu Xin Tian Hua Jiang Jiaoyang Cai Xiaowen Zhai Shuhong Shen Qun Hu | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 6 | Unconventional piezoelectric coefficients in perovskite piezoelectric ceramics显示文摘Piezoelectric ceramics exhibit three conventional piezoelectric coefficients,i.e.,d33,d31,d15,due to their∞mm crystal symmetry.Unconventional piezoelectric coefficients,such as d11,d12,d13,d14,d16,etc.,can only be extracted from piezoelectric single crystals of special symmetry with specific cut direction.Here we demonstrate a rotated poling method to realize unconventional piezoelectric coefficients in perovskite piezoelectric ceramics.This method is elaborated in theory and experimentally proven to be effective.Full nonzero piezoelectric coefficients in the 36 piezoelectric coefficients matrix can be obtained by combining these“quasi(effective)piezoelectric coefficients”with the conventional piezoelectric coefficients,which would expand applications in a wide variety of piezoelectric devices. | Jingen Wu Zhongqiang Hu Xiangyu Gao Miaomiao Cheng Xinger Zhao Wei Su Liqian Wang Mengmeng Guan Yongjun Du Ruohao Mao Zhiguang Wang Ziyao Zhou Shuxiang Dong Ming Liu | 2021 | Journal of Materiomics2021，7，2： | 0 |
| 7 | Guanine-assisted N-doped ordered mesoporous carbons as efficient capacity decaying suppression materials for lithium–sulfur batteries显示文摘Lithium–sulfur(Li–S)batteries are considered promising next-generation energy storage devices due to their high weight capacities and theoretical energy densities,which are significantly higher than those of conventional lithium-ion batteries.However,the sulfur cathode presents two major drawbacks,specifically low specific capacity caused by the poor electrical conductivities of the active materials and fast capacity decay caused by polysulfide dissolution/shuttling.Herein,a high-rate and high-stability dendritic material consisting of N-doped ordered mesoporous carbons(NOMCs)was successfully synthesized via a facile and low-cost calcination method.The highly ordered mesoporous carbon skeleton limited the growth of the sulfur nanofiller within its channels and provided the necessary electrical contact with the insulating sulfur.Furthermore,N-doped heteroatoms presented strong binding sites for trapping polysulfide intermediates,achieving high electrochemical activity,which promoted polysulfide conversion reactions.As a result,the prepared NOMC-2/S cathode material with 1.2-1.5 mg cm^(-2)of sulfur displayed excellent electrochemical performance with a high-rate capability of 460.5 m Ah g^(-1)at 1 C,a high specific capacity of 530.9 m Ah g^(-1)after 200 cycles at 0.1 C,and a decay rate of~0.19%per cycle. | Riguang Cheng Yanxun Guan Yumei Luo Chenchen Zhang Yongpeng Xia Sheng Wei Mengmeng Zhao Qi Lin Hao Li Shiyou Zheng Federico Rosei Lixian Sun Fen Xu Hongge Pan | 2022 | Journal of Materials Science & Technology2022，，6： | 0 |
| 8 | Parallel evolution of twoAIM24 protein subfamilies and their conserved functions in ER stress tolerance in land plants显示文摘Despite decades of efforts in genome sequencing and functional characterization,some important protein families remain poorly understood.In this study,we report the classification,evolution,and functions of the largely uncharacterized AIM24 protein family in plants,including the identification of a novel subfamily.We show that two AIM24 subfamilies(AIM24-A and AIM24-B)are commonly distributed in major plant groups.These two subfamilies not only have modest sequence similarities and different gene structures but also are of independent bacterial ancestry.We performed comparative functional investigations on the two AIM24 subfamilies using three model plants:the moss Physcomitrium patens,the liverwort Marchantia polymorpha,and the flowering plant Arabidopsis thaliana.Intriguingly,despite their significant differences in sequence and gene structure,both AIM24 subfamilies are involved in ER stress tolerance and the unfolded protein response(UPR).In addition,transformation of the AIM24-A gene from P.patens into the AIM24-B null mutant of A.thaliana could at least partially rescue ER stress tolerance and the UPR.We also discuss the role of AIM24 genes in plant development and other cellular activities.This study provides a unique example of parallel evolution in molecular functions and can serve as a foundation for further investigation of the AIM24 family in plants. | Yanlong Guan Guanxiao Chang Jinjie Zhao Qia Wang Jiali Qin Mengmeng Tang Shuanghua Wang Lan Ma Jianchao Ma Guiling Sun Yun Zhou Jinling Huang | 2023 | Plant Communications2023，4，3： | 0 |
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