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| 1 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 2 | 5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by “click” chemistry显示文摘Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent al- ternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries. | CHEN MiaoJuan QU DeZhong CHI WeiLin WANG Wei REN XiaoShuai CONG ShuJie LIANG PeiZhou FENG ShiPeng ZHANG BiLiang | 2011 | Science China Chemistry2011，54，11： | 6 |
| 3 | Effect of miniscalpel-needle on relieving the pain of myofascial pain syndrome: a systematic review显示文摘OBJECTIVE: To evaluate the effect and safety of miniscalpel-needle(MSN) on reducing the pain of myofascial pain syndrome(MPS).METHODS: We reviewed the available literatures inception up to February 2014 using Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Database, Chinese Biomedical Database and Wanfang Database.RESULTS: Eight randomized controlled trials were finally identified. The main controls involved acupuncture, medications, injection, massage and cupping. We found that all of the studies agreed on the potential benefit of MSN as a strategy for MPS and the superiority compared to the controls, however,randomized methods applied in most of the trials could be criticized for their high or unclear risk of bias. Further research is also needed to clarify questions around the appropriate frequency and number of treatment sessions of MSN.CONCLUSION: This review shows that MSN might have the effect on MPS, even though there were some limitations in the studies included in the review. Studies with robust methodology are warranted to further test its pain-relieving effect on MPS. | Liu Tong Peng Yuanyuan Zhu Shipeng Chen Huan Li Fuyun Hong Peixin Cao Bingyan Peng Bo Fan Yifan Chen Yupei Zhang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 6 |
| 4 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 5 | Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats显示文摘OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) rats.METHODS: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. Acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) analyses.RESULTS: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip analysis.CONCLUTION: Acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism. | Guo Yan Lu Juan Liang Jingrong Zhao Ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma Liangxiao | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 4 |
| 6 | Uptake of graphene enhanced the photophosphorylation performed by chloroplasts in rice plants显示文摘New and enhanced functions were potentially imparted to the plant organelles after interaction with nanoparticles.In this study,we found that∼44%and∼29%of the accumulated graphene in the rice leaves passively transported to the chloroplasts and thylakoid,respectively,significantly enhanced the fluorescence intensity of chloroplasts,and promoted about 2.4 times higher adenosine triphosphate production than that of controls.The enhancement of graphene on the photophosphorylation was ascribed to two reasons:One is that graphene facilitates the electron transfer process of photosystem II in thylakoid,and the other is that graphene protects the photosystem II against photo-bleaching by acting as a scavenger of reactive oxygen species.Overall,our work here confirmed that graphene translocating in the thylakoid promoted the photosynthetic activity of chloroplast in vivo and in vitro,providing new opportunities for designing biomimetic materials to enhance the solar energy conversion systems,especially for repairing or increasing the photosynthesis activity of the plants grown under stress environment. | Kun Lu Danlei Shen Shipeng Dong Chunying Chen Sijie Lin Shan Lu Baoshan Xing Liang Mao | 2020 | Nano Research2020，13，12： | 4 |
| 7 | Research Progress on Photocatalytic Reduction of the Nitrate Radical显示文摘Due to a large number of application of the nitrogen fertilizer,unreasonable treatments of the animal wastes,domestic sewage and industrial sewage including nitrogen,and garbage stacking in recent years,the concentration of NO 3 that was toxic to humans in worldwide ground water presented rise trend at different degrees.Photocatalytic removal technology of the nitrogen had many advantages and was widely valued.Cost was low,and there was no secondary pollution.Reaction condition was mild,and reaction time was short.The photocatalytic reduction research of nitrate at home and abroad was reviewed in detail,including photocatalyst,scavenger and reaction mechanism.In particular,perspectives for photocatalytic reduction of the nitrate were detailedly analyzed. | Yingchun Miao Guang Chen Gang Wang Yaling Gao Shipeng Wu | 2013 | Meteorological and Environmental Research2013，4，1： | 3 |
| 8 | High per- formance graphene oxide based rubber composites显示文摘 | Mao Yingyan Wen Shipeng Chen Yulong | 2013 | Scien- tific Reports2013，3，3： | 1 |
| 9 | Montmoril- lonite/polypro -pylene Nanocomposites: Mechanical Properties, Crystallization and Rheological Behav -iors 显示文摘 | Zhu Shipeng Chen Jinyao Zuo Yuan | 2011 | Applied Clay Science2011，52，12： | 1 |
| 10 | Friction and wear behavious and mechanisms of Fe and SiO2 in Cu-based P/M friction materials显示文摘 | Xiang Xiong Jie Chen Pingping Yao Shipeng Li Baiyun Huang | 2007 | Wear2007，262，： | 1 |
| 11 | The application of pseudo template molecularly imprinted polymer to the solid‐phase extraction of cyromazine and its metabolic melamine from egg and milk显示文摘 | Xianhua Wang Qiuxue Fang Shipeng Liu Lei Chen | 2012 | Science2012，，12： | 1 |
| 12 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 13 | Preparation of a magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples显示文摘 | Xianhua Wang Qiuxue Fang Shipeng Liu Lei Chen | 2012 | Analytical and Bioanalytical Chemistry2012，，5： | 1 |
| 14 | A DECENTRAL- IZED MULTI-PARTY VIDEO CONFERENCING SYSTEM 显示文摘 | Ling Chen Chong Luo Jiang Li Shipeng Li | 2004 | Institute of Electrical and Electronics Engineers Inc2004，，6： | 1 |
| 15 | WIOB- SS:The Chinese low-power digital ionosonde for ionospheric backscattering detection显示文摘 | Chen Gang Zhao Zhengyu Li Shipeng | 2009 | Advances in Space Research2009，43，9： | 1 |
| 16 | High per- formance graphene oxide based rubber composites显示文摘 | Mao Yingyan Wen Shipeng Chen Yulong | 2013 | Scien- tific Reports2013，3，： | 1 |
| 17 | The application of pseudo template molecularly imprinted polymer to the solid‐phase extraction of cyromazine and its metabolic melamine from egg and milk显示文摘 | Xianhua Wang Qiuxue Fang Shipeng Liu Lei Chen | 2012 | J Sep Science2012，，12： | 1 |
| 18 | Photoconductivity of bulk-film-based graphene sheets显示文摘 | Fu Shipeng Wan Xiangiian Chen Yongsheng | 2009 | Small2009，5，14： | 1 |
| 19 | Prevalence of nonalcoholic fatty liver disease in mainland of C hina: A meta‐analysis of published studies显示文摘 | ZhanZhan Li Jing Xue Peng Chen LiZhang Chen ShiPeng Yan LiYa Liu | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 20 | Influence of poly (ethylene glycol)/montmorilonite hybrids on the rheological behaviors and mechanical properties of polypropylen显示文摘 | ZHU Shipeng CHEN Jinyao LI Huilin | 2009 | Polym Bull2009，63，： | 1 |
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