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| 1 | Influence of Atmospheric Particulate Matter on Ozone in Nanjing,China:Observational Study and Mechanistic Analysis显示文摘Particulate matter with diameters of 2.5 μm or smaller(PM_(2.5)) and ozone(O_3) are major pollutants in the urban atmosphere. PM_(2.5) can affect O_3 by altering the photolysis rate and heterogeneous reactions. However, these two processes and their relative importance remain uncertain. In this paper, with Nanjing in China as the target city, we investigate the characteristics and mechanism of interactions between particles and O_3 based on ground observations and numerical modeling.In 2008, the average concentrations of PM_(2.5) and O_3 at Caochangmen station are 64.6 ± 47.4 μg m^(-3) and 24.6 ± 22.8 ppb,respectively, while at Pukou station they are 94.1 ± 63.4 μg m^(-3) and 16.9 ± 14.9 ppb. The correlation coefficient between PM_(2.5) and O_3 is -0.46. In order to understand the reaction between PM_(2.5) and O_3, we construct a box model, in which an aerosol optical property model, ultraviolet radiation model, gas phase chemistry model, and heterogeneous chemistry model,are coupled. The model is employed to investigate the relative contribution of the aforementioned two processes, which vary under different particle concentrations, scattering capability and VOCs/NOxratios(VOCs: volatile organic compounds;NOx: nitric oxide and nitrogen dioxide). Generally, photolysis rate effect can cause a greater O_3 reduction when the particle concentrations are higher, while heterogeneous reactions dominate O_3 reduction with low-level particle concentrations.Moreover, in typical VOC-sensitive regions, O_3 can even be increased by heterogeneous reactions. In Nanjing, both processes lead to O_3 reduction, and photolysis rate effect is dominant. Our study underscores the importance of photolysis rate effect and heterogeneous reactions for O_3, and such interaction processes should be fully considered in future atmospheric chemistry modeling. | Yawei QU Tijian WANG Yanfeng CAI Shekou WANG Pulong CHEN Shu LI Mengmeng LI Cheng YUAN Jing WANG Shaocai XU | 2018 | Advances in Atmospheric Sciences2018，35，11： | 33 |
| 2 | Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway显示文摘OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 pathway.METHODS: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation assay.RESULTS: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and STAT3.CONCLUSION: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis. | Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian Kang Liyuan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 11 |
| 3 | T cells promote the regeneration of neural precursor cells in the hippocampus of Alzheimer's disease mice显示文摘Alzheimer's disease is closely associated with disorders of neurogenesis in the brain, and growing evidence supports the involvement of immunological mechanisms in the development of the disease. However, at present, the role of T cells in neuronal regeneration in the brain is unknown. We injected amyloid-beta 1–42 peptide into the hippocampus of six BALB/c wild-type mice and six BALB/c-nude mice with T-cell immunodeficiency to establish an animal model of Alzheimer's disease. A further six mice of each genotype were injected with same volume of normal saline. Immunohistochemistry revealed that the number of regenerated neural progenitor cells in the hippocampus of BALB/c wild-type mice was significantly higher than that in BALB/c-nude mice. Quantitative fluorescence PCR assay showed that the expression levels of peripheral T cell-associated cytokines(interleukin-2, interferon-γ) and hippocampal microglia-related cytokines(interleukin-1β, tumor necrosis factor-α) correlated with the number of regenerated neural progenitor cells in the hippocampus. These results indicate that T cells promote hippocampal neurogenesis in Alzheimer's disease and T-cell immunodeficiency restricts neuronal regeneration in the hippocampus. The mechanism underlying the promotion of neuronal regeneration by T cells is mediated by an increased expression of peripheral T cells and central microglial cytokines in Alzheimer's disease mice. Our findings provide an experimental basis for understanding the role of T cells in Alzheimer's disease. | Jing Liu Yuxin Ma Sumin Tian Li Zhang Mengmeng Zhao Yaqiong Zhang Dachuan Xu | 2014 | Neural Regeneration Research2014，9，16： | 7 |
| 4 | Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification显示文摘有为散布的提高表面的拉曼(重量的单位) 分析的 ultrasensitive 的明确的 nanogaps 抓住伟人诺言的一致包含银的金属 nanostructures。不过,有强壮、稳定的重量的单位的如此的 nanostructures 的直接合成表明极其质问的遗体。这里,我们与内部 nanogaps 为金银的 nano 蘑菇的直接合成报导一条调停 DNA 的途径。这些 nano 蘑菇的重量的单位紧张极其依赖于在金头和银帽子之间的 nanogap 的区域。我们发现 nanogaps 的形成由控制在金 nanoparticles 上标记搁浅单人赛的 DNA (ssDNA ) 的 6-carboxy-X-rhodamine (ROX ) 的表面密度是细微地悦耳的。我们与 1.0 的一个高重量的单位信号改进因素在高产量获得了 nano 蘑菇我们作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Jianlei Shen Jing Su Juan Yan Bin Zhao Dongfang Wang Siyi Wang Kun Li Mengmeng Liu Yao He Sanjay Mathur Chunhai Fan Shiping Song | 2015 | Nano Research2015，8，3： | 4 |
| 5 | Insights into self-healing behavior and mechanism of dicalcium phosphate dihydrate coating on biomedical Mg显示文摘Self-healing coatings have been developed as smart surface coatings for Mg and its alloys to retain local corrosion from the coating damages.In this study,we prepared dicalcium phosphate dihydrate(DCPD)coating on biomedical Mg,and found that the artificial scratches in DCPD coating can be efficiently sealed by anti-corrosive products in both Hank's and normal saline(NS)solutions.Besides,the in-depth study revealed that DCPD was served as not only a physical barrier but also a self-healing agent,demonstrating an autonomous self-healing coating without embedded extra corrosion inhibitors.Moreover,Hank's solution provided foreign-aid filmforming ions to promote self-healing behavior.The findings might offer new opportunities for further studies and applications of efficient self-healing coatings on biodegradable Mg implants. | Qiangsheng Dong Xingxing Zhou Yuanjia Feng Kun Qian Huan Liu Mengmeng Lu Chenglin Chu Feng Xue Jing Bai | 2021 | Bioactive Materials2021，6，1： | 4 |
| 6 | The role and its mechanism of intermittent fasting in tumors:friend or foe?显示文摘Intermittent fasting(IF)is becoming a prevailing topic worldwide,as it can cause changes in the body’s energy metabolism processes,improve health,and affect the progression of many diseases,particularly in the circumstance of oncology.Recent research has shown that IF can alter the energy metabolism of tumor cells,thereby inhibiting tumor growth and improving antitumor immune responses.Furthermore,IF can increase cancer sensitivity to chemotherapy and radiotherapy and reduce the side effects of these traditional anticancer treatments.IF is therefore emerging as a promising approach to clinical cancer treatment.However,the balance between long-term benefits of IF compared with the harm from insufficient caloric intake is not well understood.In this article,we review the role of IF in tumorigenesis and tumor therapy,and discuss some scientific problems that remain to be clarified,which might provide some assistance in the application of IF in clinical tumor therapy. | Xu Zhao Jing Yang Ruoyu Huang Mengmeng Guo Ya Zhou Lin Xu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 7 | 3D-cubic interconnected porous Mg-based scaffolds for bone repair显示文摘Mg-based porous materials,as potential bone tissue engineering scaffolds,are considered an attractive strategy for bone repair owing to favorable biodegradability,good biocompatibility and suitable mechanical properties.In this work,3D-cubic interconnected porous Mg–xZn–0.3Ca(x=0,3,6)scaffolds were prepared to obtain desirable pore structures with a mean porosity up to 73%and main pore size of 400–500μm,which pore structures were close to the human cancellous bone.The structure–property relationships in the present scaffolds were analyzed by experiments and theoretical models of generalized method of cells(GMC).Mg–xZn–0.3Ca scaffolds exhibited good compression properties with a maximum above 5MPa in yield strength and about 0.4GPa in elastic modulus.This was attributed to not only the alloy strengthening but also the large minimum solid area.On the other hand,the scaffolds showed undesirable and relatively serious degradation behavior in Hank’s solution,resulting from Zn addition in Mg-based scaffolds and the high surface area ratio in the pore structure.Therefore,surface modifications are worth studying for controlled degradation in the future.In conclusion,this research would explore a novel attempt to introduce 3D-cubic pore structure for Mg-based scaffolds,and provide new insights into the preparations of Mg-based scaffolds with good service performances for bone repair. | Qiangsheng Dong Yang Li Huiqin Jiang Xingxing Zhou Huan Liu Mengmeng Lu Chenglin Chu Feng Xue Jing Bai | 2021 | Journal of Magnesium and Alloys2021，9，4： | 2 |
| 8 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 9 | The role of mechano growth factor in chondrocytes and cartilage defects:a concise review显示文摘Mechano growth factor(MGF),an isoform of insulin-like growth factor 1(IGF-1),is recognized as a typical mechanically sensitive growth factor and has been shown to play an indispensable role in the skeletal system.In the joint cavity,MGF is highly expressed in chondrocytes,especially in the damaged cartilage tissue caused by trauma or degenerative diseases such as osteoarthritis(OA).Cartilage is an extremely important component of joints because it functions as a shock absorber and load distributer at the weight-bearing interfaces in the joint cavity,but it can hardly be repaired once injured due to its lack of blood vessels,lymphatic vessels,and nerves.MGF has been proven to play an important role in chondrocyte behaviors,including cell proliferation,migration,differentiation,inflammatory reactions and apoptosis,in and around the injury site.Moreover,under the normalized mechanical microenvironment in the joint cavity,MGF can sense and respond to mechanical stimuli,regulate chondrocyte activity,and maintain the homeostasis of cartilage tissue.Recent reports continue to explain its effects on various cell types and sport-related tissues,but its role in cartilage development,homeostasis and disease occurrence is still controversial,and its internal biological mechanism is still elusive.In this review,we summarize recent discoveries on the role of MGF in chondrocytes and cartilage defects,including tissue repair at the macroscopic level and chondrocyte activities at the microcosmic level,and discuss the current state of research and potential gaps in knowledge. | Yi Liu Mengmeng Duan Demao Zhang Jing Xie | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 1 |
| 10 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 11 | MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect显示文摘 | Jie Fu Mengmeng Jiang Meng Zhang Jing Zhang Yu Wang Shensi Xiang Xiaojie Xu Qinong Ye Haifeng Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 1 |
| 12 | The photocatalytic ·OH production activity of g-C_(3)N_(4) improved by the introduction of NO显示文摘The efficiency of photocatalytic pollutant removal largely depends on the ability of the photocatalytic system to produce hydroxyl radicals(·OH).However,the capability of photocatalyst to produce·OH is not strong at present.Advancing the capacity of photocatalytic system to produce·OH has always been a tough problem and challenge in the field of environmental science.In this research,it was found that introducing nitric oxide(NO)into the graphitic carbon nitride(g-C_(3)N_(4))photocatalytic system could memorably enhance the ability of producing·OH group.This study provides a new idea for improving the capacity of photocatalytic·OH production. | Jun Jing Kai Qi Guohui Dong Mengmeng Wang Wingkei Ho | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 13 | Nanoinfiltration behavior of carbon nanotube based nanocomposites with enhanced mechanical and electrical properties显示文摘In this work,carbon nanotube(CNT)based nanocomposites with high mass fraction are proposed by in-situ bridging carbon matrix into CNT paper through optimized chemical vapor infiltration(CVI).Nanoinfiltration behavior of CNTs is basically investigated under the CVI process.The contact between each CNT can be strengthened and the conductive pathways can be established,resulting in the better mechanical and electrical properties.Compared with the pristine CNT paper,the CNT/C composite after pyrolysis process confirms a remarkable advance in tensile strength(up to 310±13 MPa)and Young’s modulus(up to 2.4±0.1 GPa).Besides,a notable feature of electrical conductivity also shows an improvement up to 8.5 S/cm,which can be attributed to the mass fraction of CNT(41 wt%)breaking the limits of percolation thresholds and the efficient densification of this sample to establish the conductive pathways.This study has a broad application in the development of the multi-functional electrical and engineering materials. | Mengmeng Wang Jinshan Yang Xiao You Chunjing Liao Jingyi Yan Jing Ruan Shaoming Dong | 2021 | Journal of Materials Science & Technology2021，，12： | 1 |
| 14 | PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway显示文摘Osteocytes are the main sensitive cells in bone remodeling due to their potent functional cell processes from the mineralized bone matrix to the bone surface&the bone marrow.Neighboring osteocytes communicate with each other by these cell processes to achieve molecular exchange through gap junction channels.Platelet-derived growth factor-AA(PDGF-AA)has been reported to enhance bone tissue remodeling by promoting cell proliferation,migration,&autocrine secretion in osteoid cell linage.However,the effect of PDGF-AA on intercellular communication between osteocytes is still unclear.In the present study,we elucidated that PDGF-AA could enhance the formation of dendritic processes of osteocytes&the gap junctional intercellular communication by promoting the expression of connexin43(Cx43).This modulation process was mainly dependent on the activation of phosphorylation of Akt protein by phosphatidylinositol 3-kinase(PI3K)/Akt(also known as protein kinase B,PKB)signaling.Inhibition of PI3K/Akt signaling decreased the Cx43 expression induced by PDGF-AA.These results establish a bridge between PDGF-AA&cell–cell communication in osteocytes,which could help us understand the molecular exchange between bone cells and fracture healing. | Yang Liu Mengmeng Duan Daimo Guo Shiyi Kan Li Zhang Munire Aili Demao Zhang Wei Du Jing Xie | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 15 | High-precision potassium isotope analysis using the Nu Sapphire collision cell(CC)-MC-ICP-MS显示文摘This study presents high-precision analyses of stable potassium(K)isotope ratio using the recently-developed,collision-cell multi-collector inductively coupled plasma mass spectrometry(CC-MC-ICP-MS,Nu Sapphire).The accuracy of our analyses is confirmed by measuring well-characterized geostandards(including rocks and seawater).Our results are consistent with literature values and a precision of 0.04‰(2SD)has been achieved based on multiple measurements of BCR-2 geostandard over a six-month period.We also evaluate factors that may lead to artificial isotope fractionations,including the mismatches in K concentration and acid molarity between samples and bracketing standards,as well as potential matrices.As the K adsorption capacity of AGW50-X8(200-400 mesh)is reduced with an increasing amount of matrix elements,less than 150µg K was loaded during the column chemistry.To evaluate the potential use of K isotopes as an archive of paleo seawater composition,δ^(41)K values of an international seawater standard(IAPSO),a Mn-nodule(NOD-P-1),and two iron formation standards(FeR-2 and FeR-4)are reported.The δ^(41)K value of IAPSO is consistent with other seawater samples reported previously,further substantiating a homogeneous K isotopic distribution in modern global oceans.The K isotopes in Mn-nodule(NOD-P-1:−0.121±0.013‰)and iron formation samples(FeR-2:−0.538±0.009‰;FeR-4:−0.401±0.008‰)seem to be an effective tracer of their formation genesis and compositional changes of ancient seawater.Our results suggest that high-precision measurements of stable K isotopes can be routinely obtained and open up a large variety of geological applications,such as continental weathering,hydrothermal circulation and alteration of oceanic crust. | Wenjun LI Mengmeng CUI Qiqi PAN Jing WANG Bingyu GAO Shanke LIU Meng YUAN Benxun SU Ye ZHAO Fang-Zhen TENG Guilin HAN | 2022 | Science China Earth Sciences2022，65，8： | 1 |
| 16 | Microenvironmental stiffness mediates cytoskeleton re-organization in chondrocytes through laminin-FAK mechanotransduction显示文摘Microenvironmental biophysical factors play a fundamental role in controlling cell behaviors including cell morphology,proliferation,adhesion and differentiation,and even determining the cell fate.Cells are able to actively sense the surrounding mechanical microenvironment and change their cellular morphology to adapt to it.Although cell morphological changes have been considered to be the first and most important step in the interaction between cells and their mechanical microenvironment,their regulatory network is not completely clear.In the current study,we generated silicon-based elastomer polydimethylsiloxane(PDMS)substrates with stiff(15:1,PDMS elastomer vs.curing agent)and soft(45:1)stiffnesses,which showed the Young’s moduli of~450 k Pa and 46 kPa,respectively,and elucidated a new path in cytoskeleton re-organization in chondrocytes in response to changed substrate stiffnesses by characterizing the axis shift from the secreted extracellular protein lamininβ1,focal adhesion complex protein FAK to microfilament bundling.We first showed the cellular cytoskeleton changes in chondrocytes by characterizing the cell spreading area and cellular synapses.We then found the changes of secreted extracellular linkage protein,lamininβ1,and focal adhesion complex protein,FAK,in chondrocytes in response to different substrate stiffnesses.These two proteins were shown to be directly interacted by Co-IP and colocalization.We next showed that impact of FAK on the cytoskeleton organization by showing the changes of microfilament bundles and found the potential intermediate regulators.Taking together,this modulation axis of lamininβ1-FAK-microfilament could enlarge our understanding about the interdependence among mechanosensing,mechanotransduction,and cytoskeleton re-organization. | Chenchen Zhou Mengmeng Duan Daimo Guo Xinmei Du Demao Zhang Jing Xie | 2022 | International Journal of Oral Science2022，14，2： | 0 |
| 17 | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization显示文摘Matrix vesicles(MVs)have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content.However,the role of MVs in the progression of osteoporosis is poorly understood.Here,we report that annexin A5,an important component of the matrix vesicle membrane,plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis.We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice.We then confirmed its potential in mediating the mineralization of the precursor osteoblast lineage via its initial binding with collagen type I to achieve MV adhesion and the subsequent activation of cellular autophagy.Finally,we proved its protective role in resisting bone loss by applying it to osteoporotic mice.Taken together,these data revealed the importance of annexin A5,originating from adherent MVs of osteoblasts,in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss. | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu | 2023 | Bone Research2023，11，4： | 0 |
| 18 | Scheduling optimization for upstream dataflows in edge computing显示文摘Edge computing can alleviate the problem of insufficient computational resources for the user equipment,improve the network processing environment,and promote the user experience.Edge computing is well known as a prospective method for the development of the Internet of Things(IoT).However,with the development of smart terminals,much more time is required for scheduling the terminal high-intensity upstream dataflow in the edge server than for scheduling that in the downstream dataflow.In this paper,we study the scheduling strategy for upstream dataflows in edge computing networks and introduce a three-tier edge computing network architecture.We propose a Time-Slicing Self-Adaptive Scheduling(TSAS)algorithm based on the hierarchical queue,which can reduce the queuing delay of the dataflow,improve the timeliness of dataflow processing and achieve an efficient and reasonable performance of dataflow scheduling.The experimental results show that the TSAS algorithm can reduce latency,minimize energy consumption,and increase system throughput. | Haohao Wang Mengmeng Sun Lianming Zhang Pingping Dong Yehua Wei Jing Mei | 2023 | Digital Communications and Networks2023，9，6： | 0 |
| 19 | Significantly enhanced photocatalytic hydrogen production performance of g-C_(3)N_(4)/CNTs/CdZnS with carbon nanotubes as the electron mediators显示文摘The electron mediator can effectively improve the performance of the direct Z-scheme heterojunction photocatalysts. However, it is still a great challenge to select cheap and efficient electron mediators and to design them into the Z-scheme photocatalytic system. In the present paper, the g-C_(3)N_(4)/CNTs/CdZnS Z-scheme photocatalyst was prepared using carbon nanotubes(CNTs) as the electron mediators, and its photocatalytic hydrogen production performance was studied. Compared with single-phase g-C_(3)N_(4),CdZnS and biphasic g-C_(3)N_(4)/CdZnS photocatalysts, the photocatalytic hydrogen production performance of the prepared g-C_(3)N_(4)/CNTs/CdZnS has been significantly enhanced. Meanwhile, g-C_(3)N_(4)/CNTs/CdZnS possesses very good photocatalytic hydrogen production stability. The enhanced photocatalytic hydrogen production performance of g-C_(3)N_(4)/CNTs/CdZnS is attributed to the fact that CNTs, as an electron mediator,can accelerate the recombination of the photogenerated holes in the valence band of g-C_(3)N_(4) and the photogenerated electrons in the conduction band of CdZnS, which makes the g-C_(3)N_(4)/CNTs/CdZnS Zscheme photocatalyst be easier to escape the photogenerated electrons, increases the concentration of the photogenerated carriers and prolongs the lifetime of the photogenerated carriers. This work provides a theoretical basis for the further development and design of CNTs as the intermediate electron mediator of the Z-scheme heterojunction photocatalyst. | Chang Feng Zhuoyuan Chen Jiangping Jing Mengmeng Sun Jing Tian Guiying Lu Li Ma Xiangbo Li Jian Hou | 2021 | Journal of Materials Science & Technology2021，，21： | 0 |
| 20 | MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer显示文摘Background:Angiogenesis plays an important role in the occurrence and development of non-small cell lung cancer(NSCLC).The atypical mitogen-activated protein kinase 4(MAPK4)has been shown to be involved in the pathogenesis of various diseases.However,the potential role of MAPK4 in the tumor angiogenesis of NSCLC remains unclear.Methods:Adult male C57BL/6 wild-type mice were randomly divided into the control group and p-siMAPK4 intervention group,respectively.The cell proliferation was analyzed with flow cytometry and immunofluorescence staining.The vascular density in tumor mass was analyzed by immuno-fluorescence staining.The expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining,and so on.Results:We found that the expression of MAPK4,which was dominantly expressed in local endothelial cells(ECs),was correlated with tumor angiogenesis of NSCLC.Furthermore,MAPK4 silencing inhibited the proliferation and migration abilities of human umbilical vein ECs(HUVECs).QKHZC-2020-4Y156,QKH-JC-2018-1428,QKH-RC-2019-5612;Collaborative Innovation Center of Chinese Ministry of Education,Grant/Award Number:2020-39;Program for Science and Technology Joint Fund Project in Zunyi Science and Technology Bureau and Zunyi Medical University,Grant/Award Numbers:ZSKH-RPT-2020-6,ZSKH-HZ-2021-193;Graduate Research Fund of Zunyi Medical University,Grant/Award Number:2023-ZYK-171 Global gene analysis showed that MAPK4 silencing altered the expression of multiple genes related to cell cycle and angiogenesis pathways,and that MAPK4 silencing increased transduction of the extracellular regulated protein kinases 1/2(ERK1/2)pathway but not Akt and c-Jun n-terminal kinase pathways.Further analysis showed that MAPK4 silencing inhibited the proliferation and migration abilities of HUVECs cultured in tumor cell supernatant,which was accompanied with increased transduction of the ERK1/2 pathway.Clinical data analysis suggested that the higher expression of MAPK4 and CD34 were associated with poor prognosis of patients with NSCLC.Targeted silencing of MAPK4 in ECs using small interfering RNA driven by the CD34 promoter effectively inhibited tumor angiogenesis and growth of NSCLC in vivo.Conclusion:Our results reveal that MAPK4 plays an important role in the angiogenesis and development of NSCLC.MAPK4 may thus represent a new target for NSCLC. | Jing Chen Jing Yang Yufang Liu Xu Zhao Juanjuan Zhao Lin Tang Mengmeng Guo Ya Zhou Chao Chen Dongmei Li Zhenke Wen Guiyou Liang Lin Xu | 2024 | Cancer Innovation2024，3，3： | 0 |
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