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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Photoreduction of C02 on BiOCI nanoplates with the assistance of photoinduced oxygen vacancies显示文摘 | Ling Zhang WenzhongWang Dong Jiang Erping Gao Songmei Sun | 2015 | Nano Research2015，8，3： | 13 |
| 3 | Bi2WO6 quantum dot-intercalated ultrathin montmo- rillonite nanostructure and its enhanced photocatalytic performance显示文摘在电子洞再结合和水氧化之间的运动比赛是为切开材料的有效的太阳的水的发展的关键限制。在这研究,我们在场由构造量解决这挑战的一个解决方案设置点的 nanostructure。第一次,我们证明设置的 nanostructure 的夹层费用能显著地在光催化禁止电子洞再结合。为双性人<潜水艇class=“ a-plus-plus ”> 2 WO <潜水艇class=“ a-plus-plus ”> 6 个量点( QD )在 montmorillonite ( MMT )设置了 nanostructure 作为一个例子, photogenerated 费用搬运人的平均一生被构造设置的 nanostructure 从 3.06 s 增加到 18.8 s 。增加的一生显著地改进了双性人的 photocatalytic 表演 < 潜水艇 class= “ a-plus-plus ” > 2 WO < 潜水艇 class= “ a-plus-plus ” > 在太阳的水氧化和环境纯化的 6 。这个工作不仅提供一个方法生产设置 QD 的 ultrathin nanostructures 而且一条一般线路为太阳的燃料产生和环境纯化设计有效基于半导体的 photoconversion 材料。 | Songmei Sun Wenzhong Wang Dong Jiang Ling Zhang Xiaoman Li Yali Zheng Qi An | 2014 | Nano Research2014，7，10： | 10 |
| 4 | Photocatalytic oxidation of ammonia by Bi_2WO_6 nanoplates using fluorescent light显示文摘Photocatalytic oxidation under fluorescent light with Bi2WO6was used to oxidize ammonia.The results showed that the NH4+/NH3 could be totally converted into NO3-and trace amount of NO2-in an alkaline solution.It was revealed that the photocatalytic oxidation efficiency was affected by the pH values and the initial concentration of the pollutant.Possible mechanism of photocatalytic oxidation in the system is proposed.The superoxide species(?O2-)captured by the superoxide dismutase levels could accelerate the photocatalytic oxidation reaction.The indoor fluorescent lamp as the light source will be a promising option for future applications of photocatalytic technology. | Ling Zhang Wenzhong Wang Songmei Sun | 2014 | Chinese Science Bulletin2014，59，18： | 4 |
| 5 | Adsorption performance and mechanism of Schiff base functionalized polyamidoamine dendrimer/silica for aqueous Mn(Ⅱ) and Co(Ⅱ)显示文摘Schiff base functionalized polyamidoamine(PAMAM) dendrimer/silica were prepared for the adsorption of aqueous Mn(Ⅱ) and Co(Ⅱ).The effects that influence the adsorption were investigated systematically and the adsorption mechanism was illustrated by theoretical calculation.The optimum adsorption pH are 4 and 6 for Mn(II) and Co(Ⅱ).Adsorption kinetics follow pseudo-second-order model and the ratecontrolling step is film diffusion process.Adsorption isotherm shows that high initial metal ion concentration facilitates the uptake of metal ions.The adsorption capacity increases first and then decreases in the temperature range of 15-35℃.Density functional theory(DFT) calculation demonstrates that Schiff base functionalized PAMAM dendrimer tends to coordinate Mn(Ⅱ) and Co(Ⅱ) with the oxygen atoms of hydroxyl and carbonyl groups,nitrogen of tertiary amine and imino groups.The imino and tertiary amine groups mainly dominate the adsorption.The reproducibility of the adsorbents indicates they can be regenerated by 5% thiourea and 0.5 mol/L HNO_(3) solution efficiently. | Wenzhu Qiao Peixu Zhang Lixiang Sun Songmei Ma Wenlong Xu Shengguang Xu Yuzhong Niu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 6 | CTAB-assisted synthesis of monoclinic BiVO 4 photocatalyst and its highly efficient degradation of organic dye under visible-light irradiation显示文摘 | Wenzong Yin Wenzhong Wang Lin Zhou Songmei Sun Ling Zhang | 2009 | Journal of Hazardous Materials2009，，： | 1 |
| 7 | Efficient con- taminant removal by Bi2WO6 films with nanoleaflike struc- tures through a photoelectrocatalytic process 显示文摘 | Sun Songmei Wang Wenzhong Zhang Ling | 2012 | The Jour- nal of Physical Chemistry C2012，116，19： | 1 |
| 8 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 9 | Elimination of BPA endocrine disruptor by magnetic BiOBr@SiO 2 @Fe 3 O 4 photocatalyst显示文摘 | Ling Zhang Wenzhong Wang Songmei Sun Yuanyuan Sun Erping Gao Zhijie Zhang | 2014 | Applied Catalysis B: Environmental2014，，： | 1 |
| 10 | Enhanced photocatalytic activity of Bi2WO6loaded with Agnanoparticles under visible light irradiation显示文摘 | Jia Ren Wenzhong Wang Songmei Sun Ling Zhang etal | | Applied0，，： | 1 |
| 11 | Bi2WO6nanocrystals with high photocatalytic activities under visible light显示文摘 | SHANG Meng WANG Wenzhong SUN Songmei | 2008 | Journal of Physical Chemistry C2008，112，10： | 1 |
| 12 | Bi2 WO6 nanocrystals with high photocatalytic activities under visible light显示文摘 | Shang Meng Wang Wenzhong Sun Songmei | 2008 | The Journal of Physical Chemistry C2008，112，10： | 1 |
| 13 | Efficient contaminant removal by Bi2WO6 films with nanoleaflike structures through a photoelectrocatalytic process显示文摘 | Songmei Sun Wenzhong Wang Ling Zhang | 2012 | The Journal of Physical Chemistry C2012，116，19： | 1 |
| 14 | Hybrid Bi2SiO5 mesoporous microspheres with light response for environment decontamination 显示文摘 | Zhang Ling Wang Wenzhong Sun Songmei | 2010 | Applied Catalysis B: Environmental2010，100，： | 1 |
| 15 | Enhanced photo- catalytic activity of Bi2WO6 loaded with Ag nanopartieles under visible light irradiation 显示文摘 | REN Jia WANG Wenzhong SUN Songmei | 2009 | Appl Catal B: Environ2009，92，12： | 1 |
| 16 | Enhanced Photocatalytic Activity of Bi2WO6 Loaded with Ag Nanoparti- clesunder Visible Light Irradiation显示文摘 | Ren Jia Wang Wenzhong Sun Songmei | 2009 | Appl Catal B2009，92，12： | 1 |
| 17 | Photocatalytic degradation of phenol over cage-like Bi2MoO6 hollow spheres under visible-light irradiation 显示文摘 | Wenzong Yin Wenzhong Wang Songmei Sun | 2010 | Catalysis Communications2010，11，： | 1 |
| 18 | Visiblelight-induced photocatalytic oxidation of phenol and aqueous ammonia in flowerlike Bi2Fe4O9 suspensions 显示文摘 | Sun Songmei Wang Wenzhong Zhang Ling | 2009 | The Journal of Physical Chemistry C2009，113，12： | 1 |
| 19 | Efficient visible light-induced photocatalytic degradation of contaminant by spindle-like PANI/BiVO4显示文摘 | Shang Meng Wang Wenzhong Sun Songmei | 2009 | J Phys Chem C2009，113，20： | 1 |
| 20 | Efficient gene transfection of suspension cells by highly branched poly(β-amino ester)显示文摘Suspension cells play a crucial role in many biological processes. However, compared to adherent cells, it is particularly challenging to introduce exogenous genes into suspension cells to regulate their biological functions with non-viral gene vectors, mainly due to the low cellular uptake and endosomal escape of polyplexes. Herein, to improve the interactions of polyplexes with cellular membranes, we design and synthesize highly branched poly(β-amino ester)(HPAE) via an “A2 + B4 + C2” Michael addition strategy.Results show that branching significantly increases DNA condensation of HPAE, cellular uptake and endosomal escape of HPAE/DNA polyplexes. In mast cells(MCs), HPAE exhibits up to 80-fold higher gene transfection efficiency compared to the corresponding linear poly(β-amino ester)(LPAE) and the leading commercial gene transfection reagents PEI25k, jetPEI, and Lipofectamine 3000, without causing obvious cytotoxicity. Our study establishes a reliable non-viral platform for efficient gene transfection of suspension cells. | Delu Che Chenfei Wang Zhili Li Kaixuan Wang Shuaiwei Sun Xinyue Zhang Yi Li Zhengju Chen Lei Guo Yajing Hou Dezhong Zhou Songmei Geng | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
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