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| 1 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 2 | Model division multiple access for semantic communications显示文摘In a multi-user system,system resources should be allocated to different users.In traditional communication systems,system resources generally include time,frequency,space,and power,so multiple access technologies such as time division multiple access(TDMA),frequency division multiple access(FDMA),space division multiple access(SDMA),code division multiple access(CDMA),and non-orthogonal multiple access(NOMA)are widely used.In semantic communication,which is considered a new paradigm of the next-generation communication system,we extract high-dimensional features from signal sources in a model-based artificial intelligence approach from a semantic perspective and construct a model information space for signal sources and channel features.From the high-dimensional semantic space,we excavate the shared and personalized information of semantic information and propose a novel multiple access technology,named model division multiple access(MDMA),which is based on the resource of the semantic domain.From the perspective of information theory,we prove that MDMA can attain more performance gains than traditional multiple access technologies.Simulation results show that MDMA saves more bandwidth resources than traditional multiple access technologies,and that MDMA has at least a 5-dB advantage over NOMA in the additive white Gaussian noise(AWGN)channel under the low signal-to-noise(SNR)condition. | Ping ZHANG Xiaodong XU Chen DONG Kai NIU Haotai LIANG Zijian LIANG Xiaoqi QIN Mengying SUN Hao CHEN Nan MA Wenjun XU Guangyu WANG Xiaofeng TAO | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，6： | 2 |
| 3 | Near-infrared dyes, nanomaterials and proteins显示文摘Taking the advantage of reduced scattering and low autofluorescence background, the NIR fluorescence probes, such as fluorescence proteins, organic molecules and nanoparticles, not only hold the promise of in vivo imaging of biological processes in physiology and pathology with high signal-to-noise ratio, but also for clinical diagnosis. In this review, we provide an overview of the recent progress on NIR probes,focusing on fundamental mechanisms of NIR dyes and nanoparticles, and protein engineering strategies for NIR proteins. | Zong Chang Feng Liu Liang Wang Mengying Deng Chunhua Zhou Qinchao Sun Jun Chu | 2019 | Chinese Chemical Letters2019，30，10： | 1 |
| 4 | The bacterial small RNAs: The new biomarkers of oral microbiotaassociated cancers and diseases显示文摘The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and ishighly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balanceexisting between the oral microbiota and host may be disturbed and result in the development of diseases. Numerousobservations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions.Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacioustherapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria or host cellsin oral cancers via small RNAs are hot topics of research. Current studies also have begun to elucidate the key role oforal microbiota in the development of systemic diseases. This article discusses existing findings and nascent mechanismsgoverning the small RNA-based interactions between oral microbiota and associated diseases. The knowledge of suchinteractions is key in planning approaches to reverse dysbiosis to achieve health. | MENGYING MAO TING DONG YANJING LIANG KEYONG YUAN QIAOQIAO JIN PENGFEI ZHANG ZHENGWEI HUANG | 2023 | BIOCELL2023，47，10： | 0 |
| 5 | Study on the secondary structure and hydration effect of human serum albumin under acidic pH and ethanol perturbation with IR/NIR spectroscopy显示文摘Human serum albumin(HSA)is the most abundant protein in plasma and plays an essential physiological role in the human body.Ethanol precipitation is the most widely used way to obtain HSA,and pH and ethanol are crucial factors affecting the process.In this study,infrared(IR)spectroscopy and near-infrared(NIR)spectroscopy in combination with chemometrics were used to investigate the changes in the secondary structure and hydration of HSA at acidic pH(5.6-3.2)and isoelectric pH when ethanol concentration was varied from 0%to 40%as a perturbation.IR spectroscopy combined with the two-dimensional correlation spectroscopy(2DCOS)analysis for acid pH system proved that the secondary structure of HSA changed significantly when pH was around 4.5.What's more,the IR spectroscopy and 2DCOS analysis showed different secondary structure forms under different ethanol concentrations at the isoelectric pH.For the hydration effect analysis,NIR spectroscopy combined with the McCabe-Fisher method and aquaphotomics showed that the free hydrogen-bonded water fluctuates dynamically,with ethanol at 0-20%enhancing the hydrogen-bonded water clusters,while weak hydrogen-bonded water clusters were formed when the ethanol concentration increased continuously from 20%to 30%.These measurements provide new insights into the structural changes and changes in the hydration behavior of HSA,revealing the dynamic process of protein purification,and providing a theoretical basis for the selection of HSA alcoholic precipitation process parameters,as well as for further studies of complex biological systems. | Hui Zhang Mengying Liang Shuangshuang Li Mengyin Tian Xiaoying Wei Bing Zhao Haowei Wang Qin Dong Hengchang Zang | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 6 | 材料、能源、机械工程中高效的电流变技术——从机理到应用显示文摘电流变(ER)技术是一种基于电流变效应的先进技术。电流变技术中最常见的材料是电流变液(ERF)。电流变液是一种软物质智能材料,其黏度可以通过施加电场来可逆地调节。电流变液的衍生物、一种新型的电响应软物质材料——电流变弹性体(ERE),由于其不沉降、易封装的优点也得到了越来越多的关注。电流变材料由于其可逆可调、快速响应、低能耗等特性在机械工程中有着广泛的应用。除了基础的电流变材料的合成和应用以外,电流变技术还应用在了能源材料制备、石油运输、储能等诸多领域。电流变技术在能源领域的应用为其在其他领域的潜在应用提供了一个很好的范例。本文结合最新的研究成果,从机理到应用,系统地综述了电流变技术在材料、能源和机械工程等领域的研究现状和未来发展前景。 | Yudai Liang Dongyang Huang Xuefeng Zhou Ziqiu Wang Quan Shi Yaying Hong Huayan Pu Mengying Zhang Jinbo Wu Weijia Wen | 2023 | Engineering2023，，5： | 0 |
| 7 | Exploiting styrene-maleic acid copolymer grafting chromatographic stationary phase materials for separation of membrane lipids显示文摘High performance liquid chromatography-mass spectrometry is one of the most commonly used strategies for lipid analysis.The development of versatile chromatographic stationary phases to meet the increasing demands for separation of complex lipids is very important.Styrene-maleic acid(SMA)copolymer is an amphiphilic polymer,which has been proven to have the ability to solubilize lipid molecules of various structures.In this study,styrene-maleic anhydride copolymer coated silica was first prepared by the thiol-ene click reaction.With L-cysteine hydrochloride or dodecanol as the post-modification reagents,Sil-SMA-amino acid and Sil-SMA-dodecanol stationary phase materials were further successfully fabricated via nucleophilic ring-opening reaction.The Fourier-transform infrared,thermogravimetric analysis,and elemental analysis results confirmed the two stationary phase materials were successfully prepared.Furthermore,both the Sil-SMA-dodecanol column and the Sil-SMA-amino acid column possessed reversed-phase/hydrophilic interaction/ion exchange mixed-mode retention mechanisms.The column efficiency of the Sil-SMA-derivatives columns reached 77,300 N/m.Based on the mixed-mode retention characteristics,the Sil-SMA-derivatives columns achieved both the lipid classes and species separation via a single column.The Sil-SMA-amino acid column was further successfully used to separate lipid extract from gastric cancer cell membrane.All these results demonstrated that the SMA-based stationary phase materials have a good potential for use in lipid separation. | Mengying Liang Delu Liu Yangyang Nie Yanli Liu Xiaoqiang Qiao | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 8 | Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque显示文摘Dear Editor,COVID-19 caused by SARS-Co V-2,is still a big threat to human populations around the world.As of Jan 2022,over 292 million cases were reported worldwide with more than 5.4 million deaths.After it was first reported in China in December 2019,the virus kept circulating and evolving and several variants with different transmissibility emerged in different countries and regions(WHO,2021a). | Ge Gao Xue Hu Yiwu Zhou Juhong Rao Xiaoyu Zhang Yun Peng Jiaxuan Zhao Yanfeng Yao Kunpeng Liu Mengying Liang Hang Liu Fei Deng Han Xia Chao Shan Zhiming Yuan | 2022 | Virologica Sinica2022，37，2： | 0 |
| 9 | An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice显示文摘Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis. | Shuang Han Qingqian Wu Mengying Wang Miqi Yang Chen Sun Jiaqi Liang Xiaozhen Guo Zheyu Zhang Jingya Xu Xinyuan Qiu Cen Xie Siyu Chen Yue Gao Zhuo-Xian Meng | 2023 | Journal of Molecular Cell Biology2023，15，3： | 0 |
| 10 | Progress in the Use of Natural Products for the Treatment of Lung Cancer显示文摘Lung cancer is a malignant disease with high morbidity and mortality,which affects the quality of life of patients.It has become one of the most serious public health problems in the world.Most natural products have a variety of anti-tumor activities.In recent years,scholars at home and abroad have studied the anti-tumor effect and mechanism of natural products from many aspects,especially in lung cancer.In this paper,the review on the active components of natural products in the treatment of lung cancer will provide a basis for subsequent treatment of lung cancer. | Song Teng Zhuoxuan Liang Tong Lyu Yuntao Yang Mengying Gou Xiaoqiong He | 2022 | Proceedings of Anticancer Research2022，6，3： | 0 |
| 11 | Dynamically integrated regression model for online auction data显示文摘We propose a dynamically integrated regression model to predict the price of online auctions,including the final price.Different from existing models,the proposed method uses not only the historical price but also the information from bidding time.Consequently,the prediction accuracy is improved compared with the existing methods.An estimation method based on B-spline approximation is proposed for the estimation and the inference of parameters and nonparametric functions in this model.The minimax rate of convergence for the prediction risk and large-sample results including the consistency and the asymptotic normality are established.Simulation studies verify the finite sample performance and the appealing prediction accuracy and robustness.Finally,when we apply our method to a 7-day auction of iPhone 6s during December 2015 and March 2016,the proposed method predicts the ending price with a much smaller error than the existing models. | Mengying You Huazhen Lin Hua Liang | 2022 | Science China Mathematics2022，65，7： | 0 |
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