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| 1 | Role of surgery in colorectal cancer liver metastases显示文摘Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their disease.Surgical resection represents the only chance of long-term survival.The goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic parenchyma.Although resection remains the only chance of long-term survival,management strategies should be tailored for each case.For patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and cure.The use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical treatment.Despite current treatment options,many patients still experience a recurrence after hepatic resection.More active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after surgery.Local tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor lesions.Formulation of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary team.The aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis. | ?zgür Akgül Erdin? ?etinkaya ?iyar Ers?z Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，20： | 40 |
| 2 | Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis显示文摘AIM: To evaluate the accuracy of red cell distribution width(RDW) to platelet ratio(RPR) to predict in-hospital mortality in acute pancreatitis(AP).METHODS: Between January 2010 and June 2012, 102 patients with AP were recruited to the study. In this retrospective cohort study, for all subjects, demographic data on hospital admission, AP etiology, comorbid diseases, organ failure assessment, laboratory parameters and length of hospital stay were examined. Additionally, we used a non-invasive prediction method in addition to the RPR to evaluate the disease severity. Multivariate logistic regression analyses were used to evaluate the impact of RPR on hospital admission to predict mortality.RESULTS:The male-female ratio(59/43)was 1.37with a median age of 56.5 years(17-89 years).In both univariate and multivariate analyses,RDW and RPR were presented as independent and significant variables on admission to predict mortality.The RPR obtained on hospital admission was persistently higher amongnon-survivors than among survivors(P<0.0001).The median RPR was 0.000087 in the non-survivor group and 0.000058 in the survivor group.RPR with a cutoff value of 0.000067 presented an area under the curve of 0.783(95%CI:0.688-0.878)in receiver operating characteristic curves and could predict the mortality of approximately 80%of the patients. | Erdin etinkaya Kazim Senol Baris Saylam Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，39： | 38 |
| 3 | Gastric carcinogenesis显示文摘Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called 'intestinal metaplasia'; phenotypic antralization of fundic units, which is called 'spasmolytic polypeptide-expressing metaplasia'; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research. | Ismail Gomceli Baris Demiriz Mesut Tez | 2012 | World Journal of Gastroenterology2012，18，37： | 25 |
| 4 | Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection显示文摘AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer. | özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 11 |
| 5 | Can biliary-cyst communication be predicted before surgery for hepatic hydatid disease: does size matter?显示文摘 | Mehmet Kilic Omer Yoldas Mahmut Koc Mehmet Keskek Nazile Karakose Tamer Ertan Erdal Gocmen Mesut Tez | 2008 | The American Journal of Surgery2008，，5： | 2 |
| 6 | Risk factors for surgical site infection after gastrectomy with D2 lymphadenectomy显示文摘 | Necdet ?zalp Bari? Zülfikaro?lu Erdal G??men Atahan Acar ?brahim Ekiz Mahmut Ko? Mesut Tez | 2009 | Surgery Today2009，，11： | 1 |
| 7 | Can Intraoperative Intraperitoneal Free Cancer Cell Detection Techniques Identify Patients at Higher Recurrence Risk Following Curative Colorectal Cancer Resection? A Meta-Analysis显示文摘 | Mesut Tez | 2008 | Annals of Surgical Oncology2008，，7： | 1 |
| 8 | Ecological view of carcinogenesis:Niche-altering(NC3)mechanisms显示文摘Over the last 30 years,a new actor in the area of ecology and evolution has emerged:niche construction theory(NCT).The fundamental premise of NCT is that organisms may actively influence evolutionary processes by modifying their circumstances[1].According to Trappes et al.,[2]the concept of niche construction should only be applied to species that alter their environment,which they believe to be its intuitive scope.They add two more terms to describe the ways that organisms engage with their surroundings and so influence their niches:when organisms choose their environment,this is known as niche choice,and when they adapt their phenotype to fit their environment,this is known as niche conformance.These three concepts are often referred to as niche-altering mechanisms,or NC3 mechanisms:niche conformance,niche construction,and niche choice.This is in line with definitions of mechanisms developed in scientific philosophy[2]. | Mesut Tez | 2023 | Cancer Innovation2023，2，2： | 0 |
| 9 | Clinical course of percutaneous cholecystostomies:A crosssectional study显示文摘BACKGROUND Although cholecystectomy is the standard treatment modality,it has been shown that perioperative mortality is approaching 19%in critical and elderly patients.Percutaneous cholecystostomy(PC)can be considered as a safer option with a significantly lower complication rate in these patients.AIM To assess the clinical course of acute cholecystitis(AC)in patients we treated with PC.METHODS The study included 82 patients with GradeⅠ,ⅡorⅢAC according to the Tokyo Guidelines 2018(TG18)and treated with PC.The patients’demographic and clinical features,laboratory parameters,and radiological findings were retrospectively obtained from their medical records.RESULTS Eighty-two patients,45(54.9%)were male,and the median age was 76(35-98)years.According to TG18,25 patients(30.5%)had GradeⅠ,34(41.5%)GradeⅡ,and 23(28%)GradeⅢAC.The American Society of Anesthesiologists(ASA)physical status score wasⅢor more in 78 patients(95.1%).The patients,who had been treated with PC,were divided into two groups:discharged patients and those who died in hospital.The groups statistically significantly differed only concerning the ASA score(P=0.0001)and WBCC(P=0.025).Two months after discharge,two patients(3%)were readmitted with AC,and the intervention was repeated.Nine of the discharged patients(13.6%)underwent interval open cholecystectomy or laparoscopic cholecystectomy(8/1)within six to eight weeks after PC.The median follow-up time of these patients was 128(12-365)wk,and their median lifetime was 36(1-332)wk.CONCLUSION For high clinical success in AC treatment,PC is recommended for high-risk patients with moderate-severe AC according to TG18,elderly patients,and especially those with ASA scores of≥Ⅲ.According to our results,PC,a safe,effective and minimally invasive treatment,should be preferred in cases suffering from AC with high risk of mortality associated with cholecystectomy. | Sadettin Er Hüseyin Berkem Sabri Ozden Birkan Birben Erdinc Cetinkaya Mesut Tez Bülent Cavit Yüksel | 2020 | World Journal of Clinical Cases2020，8，6： | 0 |
| 10 | Non-pharmacological pain palliation methods in chronic pancreatitis显示文摘Chronic pancreatitis(CP)is a condition characterized by persistent and often severe pain resulting from the inflammatory disease of the pancreas.While pharmacological treatments play a significant role in palliative pain management,some patients require non-pharmacological methods.This review article focuses on non-pharmacological approaches used to alleviate pain in CP.The article examines non-pharmacological palliation options,including surgery,endoscopic approaches,neurostimulation techniques,acupuncture,and other alternative medicine methods.The effectiveness of each method is evaluated,taking into consideration patient compliance and side effects.Additionally,this article emphasizes the importance of personalized pain management in CP and underscores the need for a multidisciplinary approach.It aims to summarize the existing knowledge on the use of non-pharmacological palliation methods to improve the quality of life for patients with CP. | Mesut Tez EdaŞahingöz Hüseyin Fahri Martlı | 2023 | World Journal of Clinical Cases2023，11，35： | 0 |
| 11 | Chaotic fractals:Why chaos is the dynamic of carcinogenesis显示文摘1|INTRODUCTION We can see the fractals in our environment every day(trees,snowflakes,broccoli,etc.).Even the shapes of the DNA helix and anatomical structures are fractal,for example,the branching of blood vessels,bronchi,and cell membranes[1].Unlike euclidean geometry,fractal geometry reveals how an object with irregularities in many dimensions can be identified by examining how the number of features in one dimension relates to the number of similarly shaped features in other dimensions[2]. | Mesut Tez | 2023 | Cancer Innovation2023，2，3： | 0 |
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