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| 1 | NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease显示文摘AIM: To analyse allelic frequency of NOD2 gene variantsand to assess their correlation with inflammatory bowel disease(IBD) in Algeria.METHODS: We studied 132 unrelated patients diagnosed with IBD, 86 with Crohn's disease(CD) and 46 with ulcerative colitis(UC). Data was prospectively collected between January 2011 and December 2013. The demographic and clinical characteristics were recorded for all the patients. A group of 114 healthy unrelated individuals were selected as controls. All groups studied originated from different regions of North Algeria and confirmed the Algerian origin of their parents and grandparents. Informed and written consent was obtained from each of the participants. All individuals were genotyped for the three CDassociated NOD2 variants(p.Arg702 Trp, p.Gly908 Arg and p.Leu1007 fsins C mutations) using the polymerase chain reaction-restriction fragment length polymorphism method. Allele and genotype frequencies in patients and control subjects were compared by χ2 test and Fisher's exact test where appropriate. Odds ratios(OR) and 95% confidence intervals(95%CI) were also estimated. Association analyses were performed to study the influence of these variants on IBD and on clinical phenotypes.RESULTS: The p.Arg702 Trp mutation showed the highest frequency in CD patients(8%) compared to UC patients(2%)(P = 0.09, OR = 3.67, 95%CI: 0.48-4.87) and controls(5%)(P = 0.4, OR = 1.47, 95%CI: 0.65-3.31). In CD patients allelic frequencies of p.Gly908 Arg and p.Leu1007 fsins C variants compared to HC were 3% vs 2%(P = 0.5, OR = 1.67, 95%CI: 0.44-6.34); 2% vs 1%(P = 0.4 OR = 2.69 95%CI: 0.48-14.87 respectively). In UC patients, allelic frequencies of p.Gly908 Arg and p.Leu1007 fsins C variants compared to HC were 1% vs 2%(P = 1, OR = 1.62, 95%CI: 0.17-4.74) and 2% vs 1%(P = 0.32, OR = 0.39, 95%CI: 0.05-2.87). The total frequency of the mutated NOD2 chromosomes was higher in CD(13%), than in HC(8%) and UC(5%). In addition, NOD2 variants were linked to a particular clinical sub-phenotype in CD in this Algerian cohort. As expected, the three NOD2 variants showed a significant association with CD but did not reach statistical significance, despite the fact that the allele frequency of NOD2 variants was in the range found in most of the European populations. This might be due to the non-exposure of the NOD2 carriers to environmental factors, required for the expression of the disease.CONCLUSION: Further analyses are necessary to study genetic and environmental factors in IBD in the Algerian population, using larger patient groups. | Aziza Boukercha Hamida Mesbah-Amroun Amira Bouzidi Houria Saoula Mhamed Nakkemouche Maryline Roy Jean-Pierre Hugot Chafia Touil-Boukoffa | 2015 | World Journal of Gastroenterology2015，21，25： | 3 |
| 2 | Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties显示文摘 | Mhamed Ramchoun Hicham Harnafi Chakib Alem Berthold Büchele Thomas Simmet Mustapha Rouis Fouad Atmani Souliman Amrani | 2012 | e-SPEN Journal2012，，3： | 2 |
| 3 | Improving the prognosis of pediatric hodgkin lymphoma in developing countries: A moroccan society of pediatric hematology and oncology study显示文摘 | Laila Hessissen Rachida Khtar Abdellah Madani Maria El Kababri Amina Kili Mhamed Harif Mohamed Khattab Souha Sahraoui Nouredine Benjaafar Samir Ahid Scott C. Howard Said Benchekroun | 2013 | Pediatr Blood Cancer2013，，9： | 1 |
| 4 | The use of the instantaneous-reactive-power signature analysis for rotorcage-fault diagnostics in three-phase induction motors显示文摘 | Mhamed D Cardoso A J M | | 0，，11： | 1 |
| 5 | Application of multivariate statistical analysis methods to the dam hydrologic impact studies显示文摘 | Martin Matteau Ali A. Assani Mhamed Mesfioui | 2009 | Journal of Hydrology2009，，1： | 1 |
| 6 | Gazit ' Gil' : A New Avocado Cultivar显示文摘 | Lahav E Lavi U Mhameed S | 1995 | HortScienee1995，30，1： | 1 |
| 7 | Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties显示文摘Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan.Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus(T. atlanticus), Thymus satureioides and Thymus zygis(T. zygis)] were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging, ferric reducing antioxidant power assay, radical scavenging activity method, the inhibition of 2,2'-azobis(2-amidinopropane) dihydrochloride that induces oxidative erythrocyte hemolysis and thiobarbituric acid reactive substances assay. The anti-inflammatory activity of aqueous extracts was evaluated in vivo using croton oil-induced ear edema and carrageenan-induced paw edema in mice and rats, respectively. This extracts were evaluated in vitro for their anticoagulant activity at the different concentrations by partial thromboplastin time and prothrombin time activated. Results: All thyme varieties were found to possess considerable antioxidant activity and potent anti-inflammatory activity in the croton oil-induced edema. Administration of aqueous extracts of two varieties(50 mg/kg)(T. zygis and T. atlanticus) reduced significantly the carrageenaninduced paw edema similar to non-steroidal anti-inflammatory drug(indomethacin, 10 mg/kg). In partial thromboplastin time and prothrombin time tests, T. atlanticus and T. zygis extracts showed the strongest anticoagulant activity. In contrast, Thymus satureioides did not show the anticoagulant activity in these tests. Conclusions: All aqueous extracts possess considerable antioxidant activity and are rich in total polyphenol and flavonoid but they act differently in the process of inflammatory and coagulation studied. This study shows great variability of biological activities in thyme varieties. | Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，8： | 1 |
| 8 | MDA-Based ATL Transformation to Generate MVC 2 Web Models 显示文摘 | Mhamed Rahmouni Samir Mbarki | 2011 | International Journal of Computer Science & Information Technology2011，3，4： | 1 |
| 9 | The use of the instantaneous-reactive- power signature analysis for rotor-cage-fault diagnostics in three-phase induction motors 显示文摘 | Mhamed D Cardoso A J M | 2009 | IEEE Transactions on Industrial Electronics2009，56，11： | 1 |
| 10 | Association be- tween markers and loci controlling avocado traits显示文摘 | Sharon D Hillel J Mhameed S | 1998 | J Am Soc Hort Sci1998，123，3： | 1 |
| 11 | Fast computation of separable two-dimensional discrete invariant moments for image classification显示文摘 | Abdeslam H Mhamed S Hassan Q | 2015 | Pattern Recognition2015，48，： | 1 |
| 12 | An integrat- ed genetic linkage map of avocado显示文摘 | Sharon D Cregan P B Mhameed S | 1997 | Theor Appl Genet1997，95，1： | 1 |
| 13 | The determination of safety of Muhanse M4, a traditional herbal preparation used to treat HIV/AIDS- related conditions and diseases in Tanzania 显示文摘 | Mhame PP Nyigo VA Mbogo GP | 2005 | Tanzan Health Res Bull2005，7，3： | 1 |
| 14 | Weld defect detection using a modi- fied anisotropic diffusion model 显示文摘 | IB Mhamed S Abid | 2012 | Journal on Advances in Signal Processing2012，35，12： | 1 |
| 15 | Molecular markers in tropical and subtropical horticulture 显示文摘 | Lavi U Sharon D Mhameed S | 1998 | Acta Hort1998，461，： | 1 |
| 16 | Bounds on the value-at-risk for the sum of possibly dependent risks显示文摘 | Mhamed Mesfioui and Jean-Francois Quessy | 2005 | Insurance:Mathematics and Economics2005，37，1： | 1 |
| 17 | DNA fingerprint in plant using simple sequence repeat and minisatellite probes显示文摘 | Sharon D Adato A Mhameed S | 1995 | Hort Science1995，30，1： | 1 |
| 18 | The use of theinstantaneous-reactive-power signature analysis for rotor-cage-fault diagnostics in three-phase induction motors显示文摘 | Mhamed D Cardoso A J M | 2009 | IEEE Transactions on Industrial Electronics2009，56，11： | 1 |
| 19 | Application of multivariate statistical analysis methods to the dam hydrologic impact studies 显示文摘 | Matteau Martin Assani Ali A Mesfioui Mhamed | 2009 | Journal of Hydrology2009，371，14： | 1 |
| 20 | DNA fingerprint in plant using simple sequence repeat and minisatellite probes显示文摘 | SHARON D ADATO A MHAMEED S | 1995 | HortScience1995，30，1： | 1 |
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