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| 1 | Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation显示文摘 | XU Guo-jun GAN Tian-yi TANG Bao-peng CHEN Zu-heng Mahemuti Ailiman ZHOU Xian-hui JIANG Tao SONG Jian-guo GUO Xia LI Yao-dong MIAO Hai-jun ZHANG Yu LI Jin-xin | 2013 | Chinese Medical Journal2013，，8： | 11 |
| 2 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 3 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
| 4 | N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys显示文摘瞄准:为了在血管收缩素 II (Ang II ) 上调查 ROS scavenger N-acetylcysteine (NAC ) 的效果,调停了在 vivo 并且在 vitro.Methods 的肾的纤维变性:老鼠受到单方的 ureteral 阻塞(UUO ) ,然后与车辆或 NAC 对待(250 mg/kg, ip ) 为 7 天。妨碍的肾的组织学的变化与 Massons 被观察三色的染色。ROS 层次被检测, DHE 染色。在妨碍的肾的相关蛋白质的表示用西方的弄污的试金被估计。肾的成纤维细胞 NRK-49F 房间在 vitro experiments.Results 被用于的有教养的老鼠:在妨碍的肾, Ang II 层次显著地被提高,并且骨胶原我在空隙的空格被积累。而且, ROS 生产和 p47 (NADPH oxidase 建筑群的一个关键子单元) 的表示以一种时间依赖者方式被增加;fibronectin 的表示, α -SMA 和 TGF-β是 upregulated。NAC 的管理显著地在妨碍的肾减轻了 fibrotic 回答。在有教养的 NRK-49F 房间,有 Ang II 的处理(0.001-10 μ mol/L ) 增加了 fibronectin 的表示,骨胶原我, α -SMA 和 TGF-β在剂量依赖者和时间依赖者礼貌。Ang II 也增加了 ROS 生产和 Smad3 的 phosphorylation。有 NAC 的预告的处理(5 μ mol/L ) 在 cells.Conclusion 的堵住的 Ang 导致 II 的氧化压力和 ECM 生产:在老鼠妨碍了肾,从 Ang II upregulation 的 fibrotic 回答结果能被 ROS scavenger N-acetylcysteine 减轻。 | Yang SHEN Nai-jun MIAO Jin-lan XU Xin-xin GAN Dan XU Li ZHOU Hong XUE Wei ZHANG Li-min LU | 2016 | Acta Pharmacologica Sinica2016，37，5： | 7 |
| 5 | A Fast Averaging Synchronization Algorithm for Clock Oscillators in Nonlinear Dynamical Network with Arbitrary Time-delays显示文摘 | CHEN Jie | 2010 | 自动化学报2010，36，6： | 7 |
| 6 | Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells显示文摘 | Jing-qiu LI Xian WU Lu GAN Xiang-liang YANG Ze-hong MIAO | 2017 | Acta Pharmacologica Sinica2017，38，12： | 6 |
| 7 | Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect显示文摘Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and potentials, but little attention has been paid to liposomal membrane rigidity. Herein, we sought to demonstrate the effects of cholesterol-tuned liposomal membrane rigidity on tumor penetration and anti-tumor effects. In this study, liposomes composed of hydrogenated soybean phospholipids(HSPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000](DSPE-PEG2000) and different concentrations of cholesterol were prepared. It was revealed that liposomal membrane rigidity decreased with the addition of cholesterol. Moderate cholesterol content conferred excellent diffusivity to liposomes in simulated diffusion medium, while excessive cholesterol limited the diffusion process. We concluded that the differences of the diffusion rates likely stemmed from the alterations in liposomal membrane rigidity, with moderate rigidity leading to improved diffusion. Next, the in vitro tumor penetration and the in vivo anti-tumor effects were analyzed. The results showed that liposomes with moderate rigidity gained excellent tumor penetration and enhanced anti-tumor effects. These findings illustrate a feasible and effective way to improve tumor penetration and therapeutic efficacy of liposomes by changing the cholesterol content, and highlight the importance of liposomal membrane rigidity. | Hangyi Wu Miaorong Yu Yunqiu Miao Shufang He Zhuo Dai Wenyi Song Yuan Liu Sha Song Ejaj Ahmad Dongkai Wang Yong Gan | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 8 | SND p102 promotes extracellular matrix accumulation and cell proliferation in rat glomerular mesangial cells via the ATIR/ERK/Smad3 pathway显示文摘 | Jin-lan XU Xin-xin GAN Jun NI De-cui SHAO Yang SHEN Nai-jun MIAO Dan XU Li ZHOU Wei ZHANG Li- min LU | 2018 | Acta Pharmacologica Sinica2018，39，9： | 5 |
| 9 | Synthesis of MnO2/N-doped ultramicroporous carbon nanospheres for high-performance supercapacitor electrodes显示文摘We demonstrate a simple and highly efficient strategy to synthesize MnO_2/nitrogen-doped ultramicroporous carbon nanospheres(MnO_2/N-UCNs) for supercapacitor application.MnO_2/N-UCNs were fabricated via a template-free polymerization of resorcinol/formaldehyde on the surface of phloroglucinol/terephthalaldehyde colloids in the presence of hexamethylenetetramine,followed by carbonization and then a redox reaction between carbons and KMnO_4.As-prepared MnO_2/N-UCNs exhibits regular ultramicropores,high surface area,nitrogen heteroatom,and high content of MnO_2.A typical MnO_2/N-UCNs with 57 wt.%MnO_2 doping content(denoted as MnO_2(57%)/N-UCNs) makes the most use of the synergistic effect between carbons and metal oxides.MnO_2(57%)/N-UCNs as a supercapacitor electrode exhibits excellent electrochemical performance such as a high specific capacitance(401 F/g at 1.0 A/g) and excellent charge/discharge stability(86.3%of the initial capacitance after 10,000 cycles at 2.0 A/g) in 1.0 mol/L Na_2SO_4 electrolyte.The well-designed and high-performance MnO_2/N-UCNs highlight the great potential for advanced supercapacitor applications. | Wen-Jing Lu Shi-Ze Huang Ling Miao Ming-Xian Liu Da-Zhang Zhu Liang-Chun Li Hui Duan Zi-Jie Xu Li-Hua Gan | 2017 | Chinese Chemical Letters2017，28，6： | 3 |
| 10 | Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells显示文摘Acetylthevetin B (ATB ) ,从 Thevetia peruviana (Pers ) 的种子的心脏的 glycoside K Schum (黄夹竹桃) ,展出不仅 antitumor 活动而且潜在的心脏的毒性。在现在的学习,我们试图提高它的 antitumor 行动和减少它经由 chitosan-Pluronic P123 (CP ) micelle 封装的不利效果。二装载 ATB 的 CP 微粒(ATB-CP1, ATB-CP2 ) 用一种乳剂 / 溶剂蒸发技术被准备。他们在有 40-50 nm 的一种粒子尺寸的形状是球形的,显示出一个中立希腊语的第六个字母潜力,并且有可接受的封装效率(>90%) 。比作免费 ATB (IC 50=2.94 mol/L ) ,装载 ATB 的 CP 微粒与更低的 IC 50 价值对人的肺癌症 A549 房间施加了强壮得多的 cytotoxicity (为 ATB-CP1 和 ATB-CP2 的 0.76 和 1.44 mol/L,分别地) 。在在老鼠的单个剂量的管理以后,分别地,在肿瘤和肺的装载 ATB 的 CP1 微粒的累积象免费 ATB 的一样高是 15.31 褶层和 9.49 褶层。为 21 d 与装载 ATB 的 CP1 微粒对待的 A549 异种皮移植肿瘤鼠标显示出最小的肿瘤卷(那中的四分之一个个在控制组织) 并且在所有治疗之中的最高的抑制率(85.6%) 组织。在 21-d 治疗以后,没有重要病理学的变化在心和另外的主要纸巾被观察。在摘要, ATB 可以用作有希望的 antitumor 为肺癌症的化学疗法的代理人,和它的 antitumor 功效被 CP 微粒显著地改进,与更低的不利效果。 | Jing-jing ZHU Xin-xin ZHANG Yun-qiu MIAO Shu-fang HE Dan-mei TIAN Xin-sheng YAO Jin-shan TANG Yong GAN | 2017 | Acta Pharmacologica Sinica2017，38，2： | 3 |
| 11 | Highly N/O co-doped ultramicroporous carbons derived from nonporous metal-organic framework for high performance supercapacitors显示文摘A new nonporous Zn-based metal-organic framework(NPMOF) synthesized from a high nitrogencontaining rigid ligand was converted into porous carbon materials by direct carbonization without adding additional carbon sources.A series of NPMOF-derived porous carbons with very high N/O contents(24.1% for NPMOF-700,20.2% for NPMOF-800,15.1% for NPMOF-900) were prepared by adjusting the pyrolysis temperatures.The NPMOF-800 fabrica ted electrode exhibits a high capacitance of220 F/g and extremely large surface area normalized capacitance of 57.7 μF/cm~2 compared to other reported MOF-derived porous carbon electrodes,which could be attributed to the abundant ultramicroporosity and high N/O co-doping.More importantly,symmetric supercapacitor assembled with the MOF-derived carbon manifests prominent stability,i.e.,99.1 % capacitance retention after 10,000 cycles at 1.0 A/g.This simple preparation of MOF-derived porous carbon materials not only finds an application direction for a variety of porous or even nonporous MOFs,but also opens a way for the production of porous carbon materials for superior energy storage. | Yangyi Gu Ling Miao Ying Yin Mingxian Liu Lihua Gan Liangchun Li | 2021 | Chinese Chemical Letters2021，32，4： | 2 |
| 12 | Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel显示文摘Lung cancer is one of the leading causes of cancer-related death worldwide.Various therapeutic failed in the effective treatment of the lung cancer due to their limited accumulation and exposure in tumors.In order to promote the chemotherapeutics delivery to lung tumor,we introduced chitosan oligosaccharide(CSO)modification on the liposomes.CSO conjugated Pluronic P123 polymers with different CSO grafting amounts,called as CP50 and CP20,were synthesized and used to prepare CSO modified liposomes(CP50-LSs and CP20-LSs).CP50-LSs and CP20-LSs displayed significantly enhanced cellular uptake in A549 cells in vitro as well as superior tumor accumulation in vivo compared with non-CSO modified liposomes(P-LSs).This phenomenon was related to the increased affinity between CSO modified liposomes and tumor cells following massive adsorption of collagen,which was highly expressed in lung tumors.In the A549 tumor-bearing mouse model,intravenous injection of paclitaxel(PTX)-loaded CP50-LSs every 3 days for 21 days resulted in optimal antitumor therapeutic performance with an inhibition rate of 86.4%.These results reveal that CSO modification provides promising applicability for nanomedicine design in the lung cancer treatment. | Yun-qiu Miao Ming-shu Chen Xin Zhou Lin-miao Guo Jing-jing Zhu Rui Wang Xin-xin Zhang Yong Gan | 2021 | Acta Pharmacologica Sinica2021，42，10： | 2 |
| 13 | Tree ring based drought variability in Northwest Tajikistan since 1895 AD显示文摘Determining the mechanisms controlling the changes of wet and dry conditions will improve our understanding of climate change over the past hundred years,which is of great significance to the study of climate and environmental changes in the arid regions of Central Asia.Forest trees are ecologically significant in the local environment,and therefore the tree ring analysis can provide a clear record of regional historical climate.This study analyzed the correlation between the tree ring width chronology of Juniperus turkestanica Komarov and the standardized precipitation evapotranspiration index(SPEI)in Northwest Tajikistan,based on 56 tree ring samples collected from Shahristan in the Pamir region.Climate data including precipitation,temperature and the SPEI were downloaded from the Climate Research Unit(CRU)TS 4.00.The COFECHA program was used for cross-dating,and the ARSTAN program was used to remove the growth trend of the tree itself and the influence of non-climatic factors on the growth of the trees.A significant correlation was found between the radial growth of J.turkestanica trees and the monthly mean SPEI of February–April.The monthly mean SPEI sequence of February–April during the period of 1895–2016 was reconstructed,and the reconstruction equation explained 42.5%of the variance.During the past 122 a(1895–2016),the study area has experienced three wetter periods(precipitation above average):1901–1919,1945–1983 and 1995–2010,and four drier periods(precipitation below average):1895–1900,1920–1944,1984–1994 and 2011–2016.The spatial correlation analysis revealed that the monthly mean SPEI reconstruction sequence of February–April could be used to characterize the large-scale dry-wet variations in Northwest Tajikistan during the period of 1895–2016.This study could provide comparative data for validating the projections of climate models and scientific basis for managing water resources in Tajikistan in the context of climate change. | YANG Meilin YU Yang ZHANG Haiyan WANG Qian GAN Miao YU Ruide | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 14 | Correlation Between CCG Polymorphisms and CAG Repeats During Germline Transmission in Chinese Patients with Huntington’s Disease显示文摘Dear Editor,Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by movement disorder,progressive dementia,and psychiatric and behavioral changes.It is caused by unstable expanded CAG trinucleotide repeats in exon 1 of the huntingtin (HTT)gene,located on chromosome 4p16.3 [1]. | Hong-Rong Cheng Xiao-Yan Li Hui-Li Yu Miao Xu Yan-Bin Zhang Shi-Rui Gan Hong-Lei Li Zhi-Ying Wu | 2020 | Neuroscience Bulletin2020，36，7： | 2 |
| 15 | In-situ Al2O3 particle-reinforced Al and Cu matrix composites synthesized by displacement reactions显示文摘 | Yang Bin Sun Miao Gan Guisheng | 2010 | Journal of Alloys and Compounds2010，494，12： | 1 |
| 16 | FOXO1 expression influence proliferation and apoptosis of pancreatic 13 ceils 显示文摘 | Lu Z Y Gan L X Miao H M | 2009 | Chin J Biochem Mol Biol2009，25，1： | 1 |
| 17 | Synthesis and characterization of a new activated carbon supported ammonium molybdophosphate composite and its cesium-selective adsorption properties显示文摘 | Miao Feng Li Wang Yongsheng Zhao Chunxia Liu Zhen Chen Lian Yan Gan Tian Hang Wang Shoujian Li | 2010 | International journal for chemical aspects of nuclear science and technology2010，，1： | 1 |
| 18 | Trapping precursor-level functionalities in hierarchically porous carbons prepared by a pre-stabilization route for superior supercapacitors显示文摘Versatile module design of precursor networks enables flexible functionalization of nano-carbon electrode materials to meet the adaptable energy-storage demand. Functionalized heterogeneous networks are more likely to decompose by swift temperature programming together with predesign module removal, so high functionality/network transfer from precursor to carbon is still a work in progress. A pre-stabilization route is proposed here to enhance the network strength at early pyrolysis and pin up precursor-level functionalities on the final carbon. Such strategy successfully fixes more electroactive N(4.28-8.86 wt%) into the resultant carbon microspheres compared with non-pretreated carbon(2.89wt%), as well as achieves broad ion-accessible platforms of 1575-2269 m^(2)/g with preset structural superiorities. As a result, a typical acidic device reveals an outstanding specific capacitance of 383 F/g at 10 mV/s. Taking advantage of a novel LiNO_(3)-PAM polymer electrolyte, the upgraded symmetric device displays the maximum specific capacitance of 229 F/g, along with a boosted energy density of 41.1 Wh/kg at 643.4 W/kg. This work opens up a feasible insight into realizing highly efficient precursor/electrode design toward superior system with outstanding energy/power feature and temperature applicability. | Mulati Mansuer Ling Miao Yang Qin Ziyang Song Dazhang Zhu Hui Duan Yaokang Lv Liangchun Li Mingxian Liu Lihua Gan | 2023 | Chinese Chemical Letters2023，34，3： | 1 |
| 19 | Highly active N,O-doped hierarchical porous carbons for high-energy supercapacitors显示文摘Highly active N,O-doped hierarchical porous carbons(NOCs)are fabricated through the in-situ polymerization and pyrolysis of o-tolidine and p-benzoquinone.As-prepared NOCs have a variety of faradaic-active species(N-6,N-5 and O-I),high ion-accessible platform(1799 m^2/g)and hierarchically micro-meso-macro porous architecture.Consequently,the resultant NOC electrode delivers an advantageous specific capacitance(311 F/g),with a pseudocapacitive contribution of 37%in a threeelectrode configuration,and an enhanced energy output of 18.0 Wh/kg@350 W/kg owing to the enlarged faradaic effect in an aqueous redox-active cell.Besides,a competitive energy density(74.9 Wh/kg)and high-potential durability(87.8%)are achieved in an ionic liquid(EMIMB F4)-assembled device.This study sheds light on a straightforward avenue to optimize the faradaic activity and nanoarchitecture for advanced supercapacitors. | Ziyang Zhou Hui Duan Zhiwei Wang Yaokang Lv Wei Xiong Dazhang Zhu Liangchun Li Mingxian Liu Lihua Gan | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 20 | From interpenetrating polymer networks to hierarchical porous carbons for advanced supercapacitor electrodes显示文摘Hierarchical porous carbons (HPCs) are obtained via in-situ activation of interpenetrating polymer networks (IPNs) obtained from simultaneous polymerization of resorcinol/formaldehyde (R/F) and polyacrylamide (PAM). The hierarchically micro-, meso-and macroporous structure of as-prepared HPCs is attributed to the synergistic pore-forming effect of PAM and KOH, including PAM decomposition, KOH chemical activation, and a foaming process of potassium polyacrylate formed by partial hydrolysis of PAM in KOH aqueous solution. The typical HPC electrode with the highest surface area (2544 m2/g) shows a high specific capacitance of 261 F/g at 1.0 A/g and a superior rate capability of 216 F/g at 20 A/g in alkaline electrolyte. Moreover, the electrode maintains the capacitance retention of 90.8% after 10000 chargingdischarging cycles at 1.0 A/g, exhibiting long cycling life. This study highlights a new avenue towards IPNs-derived carbons with unique pore structure for promising electrochemical applications. | Ling Miao Xiaoyu Qian Dazhang Zhu Ting Chen Guchuan Ping Yaokang Lv Wei Xiong Yafei Liu Lihua Gan Mingxian Liu | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
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