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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Cathodoluminescence of CaWO4 and SrWO4 thin films prepared by spray pyrolysis显示文摘 | Lou Z D Cocivera Michael | 2002 | Materials Research Bulletin2002，37，9： | 1 |
| 3 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 4 | Analysis of musculoskeletal systems in the AnyBody modeling system显示文摘 | Michael D John R Mark D Z | 2006 | Simulation Model- ling Practice and Theory2006，14，8： | 1 |
| 5 | Extented-aperture Underwa-ter Acoustic Multisource Azimuth/elevation Direction-fioding Using Uniformly but Sparsely Spaced Vector Hy-drophones显示文摘 | Kainam T W Michaell D Z | 1997 | IEEE Oceanic Engineering1997，22，4： | 1 |
| 6 | Molecularly Imprinted Polymeric Nanospheres by Diblock Copolymer Self-Assembly显示文摘 | Li Z Ding J F Michael D | 2006 | Macromolecules2006，，39： | 1 |
| 7 | OFDM blind carrier offset estimation: ESPRIT显示文摘 | Tureli U Liu H Michael D Z | 2000 | IEEE Transactions on Communications2000，48，9： | 1 |
| 8 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 9 | Soil health and sustainability: managing the biotic component of soil quality显示文摘 | John W D Michael R Z | 2000 | Applied Soil Ecology2000，15，1： | 1 |
| 10 | The antecedents and consequences of man cooperation : an empirical test in the US and Japan 显示文摘 | MICHAEL S C ANTHONY D B YUSHAN Z | 2008 | Academy of Marketing Science2008，36，： | 1 |
| 11 | Predicting ripple roughness and sand resuspension under combined flows in a shoreface environment显示文摘 | Michael Z L Wright L D Carl L A | 1996 | Marine Geology1996，130，12： | 1 |
| 12 | An Injectable Calcium Phosphate-alginate Hydrogel-umbilical Cord Mesenchymal Stem Cell Paste for Bone Tissue Engineering显示文摘 | Liang Z Michael D W Hockin H K | | 0，，25： | 1 |
| 13 | Community-associated methicillin- resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic显示文摘 | Michael Z D Robert S | 2010 | Clin Microbiol Rev2010，23，3： | 1 |
| 14 | Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mu- cosa: Peptide isolation and cloning of a cDNA 显示文摘 | Gill D Michael Z Howard E | 1991 | Proe Natl Acad Sei USA1991，88，： | 1 |
| 15 | On the formation of very large WC crystals during sintering of ultrafine WC-Co alloys显示文摘 | MICHAEL S SCHUBERT W D ERICH Z | 2002 | International Journal of Refractory Metals and Hard Materials2002，20，1： | 1 |
| 16 | The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q Y DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L JONES M R SKELTON R L MURRAY J E CHEN C X QIAN W B SHEN J G DU P EUSTICE M TONG E TANG H B LYONS E PAULL R E MICHAEL T P WALL K RICE D W AL- BERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N A- COB R A GUAN P Z BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J K SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X Y BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRI- PATHI S NEUPANE K WEI H R IRIKURA B PAIDI M JIANG N ZHANG W L PRESTING G WINDSOR A NAVAJAS-P?REZ R TORRES M J FELTUS F A PORTER B LI Y J BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J M SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E DEPAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，7190： | 1 |
| 17 | Direct conversion from oral morphine to transdermal fentanyl: a multicentre study in patients with cancer pain 显示文摘 | Barbara D Michael Z Michael T | 1996 | Pain1996，64，3： | 1 |
| 18 | Direct conversion from oral morphine to transdermal fentanyl: a multicentre study in patients with cancer pain显示文摘 | Barbara D Michael Z Michael T | 1996 | Pain1996，64，3： | 1 |
| 19 | STATl-dependent and STATl-independent gene expression in murine immune cells following stimulation with interfer on-alpha显示文摘 | Gregory B L Michael D R | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 20 | Molecular cloning and characterisation of Ts8B1, Ts8B2 and Ts8B3, three new members of the Taenia solium metacestode 8<ce:hsp sp='0.25'/>kDa diagnostic antigen family显示文摘 | Elizabeth Ferrer Pedro Bonay Mildred Foster-Cuevas Luis Miguel González Iris Dávila María Milagros Cortéz Leslie J.S. Harrison R. Michael E. Parkhouse Teresa Gárate | 2007 | Molecular & Biochemical Parasitology2007，，1： | 1 |
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