|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Experimental Investigation into Characteristics of Plasma Aerodynamic Actuation Generated by Dielectric Barrier Discharge显示文摘This article carries out synthetic measurements and analysis of the characteristics of the asymmetric surface dielectric barrier discharge plasma aerodynamic actuation.The rotational and vibrational temperatures of an N2 (C3Пu) molecule are measured in terms of the optical emission spectra from the N2 second positive system.A simplified collision-radiation model for N2(C) and N2+(B) is established on the basis of the ratio of emission intensity at 391.4 nm to that at 380.5 nm and the ratio of emission intensity at 371.1 nm to that at 380.5 nm for calculating temporal and spatial averaged electron temperatures and densities.Under one atmosphere pressure,the electron temperature and density are on the order of 1.6 eV and 1011cm-3 respectively.The body force induced by the plasma aerodynamic actuation is on the order of tens of mN while the induced flow velocity is around 1.3m/s.Starting vortex is firstly induced by the actuation;then it develops into a near-wall jet,about 70 mm downstream of the actuator.Unsteady plasma aerodynamic actuation might stimulate more vortexes in the flow field.The induced flow direction by nanosecond discharge plasma aerodynamic actuation is not parallel,but vertical to the dielectric layer surface. | Wu Yun Li Yinghong Jia Min Song Huimin Su Changbing Pu Yikang | 2010 | Chinese Journal of Aeronautics2010，23，1： | 20 |
| 2 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 3 | N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression,Plant Development, and Stress Responses显示文摘N6-Methyladenine (6mA)DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes,including the dioot modelArabidopsis thaliana.However,the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive.Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars,Nipponbare (Nip;Japonica)and 93-11 (Indica).Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis.We found that 6mA levels are positively correlated with the expression of key stressrelated genes,which may be responsible for the difference in stress tolerance between Nip and 93-11. Moreover,we showed that mutations in DDM1 cause defects in plant growth and decreased 6mA level. Our results reveal that 6mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants. | Qian Zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian Zhang Jingrong Liu Adeel Riaz Pu Yao Min Liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu | 2018 | Molecular Plant2018，11，12： | 18 |
| 4 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 5 | Constitutive Modeling for Flow Behaviors of Superaustenitic Stainless Steel S32654 during Hot Deformation显示文摘Hot deformation behavior of superaustenitic stainless steel S32654 was investigated with hot compression tests at temperatures of 950-1 250 ℃ and strain rates of 0.001-10s^(-1).Above 1 150 ℃,with strain rate lower than 0.1s^(-1),the flow curves exhibit nearly steady-state behavior,while at higher strain rate,continuous flow softening occurs.To provide a precise prediction of flow behavior for the alloy,the constitutive modeling considering effect of strain was derived on the basis of the obtained experimental data and constitutive relationship which incorporated Arrhenius term and hyperbolic-sine type equation.The material constantsα,n,Q and lnA are found to be functions of the strain and can be fitted employing eighth-order polynomial.The developed constitutive model can be employed to describe the deformation behavior of superaustenitic stainless steel S32654. | En-xiang PU Han FENG Min LIU Wen-jie ZHENG Han DONG Zhi-gang SONG | 2016 | Journal of Iron and Steel Research(International)2016，23，2： | 14 |
| 6 | Idiopathic ventricular fibrillation with fragmented QRS complex and J wave in resting electrocardiogram显示文摘ObjectiveTo 在放松从 21 大小写的考察数据在我们的医院里使遭到的 electrocardiogram.MethodsWe 与碎裂的 QRS 建筑群( f-QRS )和 J 波浪描述自发的室的纤维性颤动( IVF )的临床的特征由于 IVF 在心脏的拘捕以后被复活并且在放松心电图估计了 f-QRS 和 J 波浪的流行( ECG )。所有盒子题目基于 electrocardiographic 形态学在三个组之中被分类:组我, f-QRS 和 J 波浪被观察(n = 6 ) ,组 II,仅仅 J 波浪被观察(n = 9 ) ,组 III,两 f-QRS 也不 J 波浪被观察(n = 6 ) 。人口特征,中略的历史或突然的心脏的拘捕,室的纤维性颤动( VF )的发生,和 VF 的情形在索引事件的三 groups.ResultsThe 发生之中被评估(中略,在可植入的 cardioverter 使用高压脉冲来消减心脏( ICD )或心律调整器记录的熬过的心脏的拘捕和 VF 事件)是 13.4 ± ;在组的 5.6 每年我, 10.8 ±在组 II 的 3.9 每年,和 9.8 ±在组 III 的 4.2 每年。在在三个组,之中的发生有重要差别最经常的索引事件在组被观察我。为发生的危险比率是 3.2 (95%CI, 1.1-7.9;P = 0.01 ) 。索引事件的历史和情形在这些组之中是不同的。在组我,所有索引事件在清早发生在睡觉期间。在组 II,四个题目在奋发的物理活动或焦虑状态期间承受了 VF,二在在清早的睡觉期间,三在里面平常的活动。在组 III ,一个题目在清早在睡觉期间承受了 VF ,处于焦虑状态的,四在平常的 activity.ConclusionsThis ,学习建议有在休息 ECG 的 f-QRS 和 J 波浪的联合外观的 IVF 病人承受 VF 的增加的风险, IVF 病人的这亚群有一个唯一的临床的特征。 | Jing Wang Min Tang Ke-Xiu Mao Jian-Min Chu Wei Hua Yu-He Jia Ying-Jie Zhao Wei Wei Xu-Hua Chen Jie-Lin Pu Shu Zhang | 2012 | Journal of Geriatric Cardiology2012，9，2： | 10 |
| 7 | The ultratrace detection of crystal violet using surface enhanced Raman scattering on colloidal Ag nanoparticles prepared by electrolysis显示文摘高度活跃、稳定、买得起的表面提高了散布的拉曼(重量的单位)底层被 electrolyzing 获得 AgNO 3的混合物( 4 × ; 10 −4 mol/L )并且 Na 3 C 6 H 5 O 7·H2 O ( 6 × ; 10 −5 mol/L )为 1 ,在 7 V 的 2 , 3 和 4 h 。与水晶紫(CV ) 作为一个测试分子,有 785 nm 激光刺激的一个便携式的拉曼分光计被采用执行 SERS 察觉。胶体的 Ag nanoparticles 与粒子尺寸为 3 h 由 electrolyzing 准备了(65 ± 17 ) nm 是为 CV 的极端踪迹察觉的完美的重量的单位底层,它显示了 ca 的一个改进因素。1.3 × 10 8 和 CV 的察觉限制对 ca 感到不满。10 −15 mol/L (ca。10 −4 ppb ) 与是的 10 −1 mol/L KBr 聚集代理人。因此,这重量的单位底层将在极端踪迹察觉提供有希望的前景。同时,从实验室带给拉曼分析在 situ,即时察觉和鉴定处理将提供可能性。 | Ren Ming Liu Yi Pu Kang Xing Fa Zi Ming Jun Feng Man Cheng Min Zhen Si | 2009 | Chinese Chemical Letters2009，20，6： | 10 |
| 8 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits显示文摘 | Zhou-Ying Liu Jian Huang Na-Na Liu Min Zheng Tao Zhao Bu-Chang Zhao Yi-Min Wang Jie-Lin Pu | 2017 | Chinese Medical Journal2017，，2： | 7 |
| 11 | Nutrition deficiency promotes apoptosis of cartilage endplate stem cells in a caspase-independent manner partially through upregulating BNIP3显示文摘营养缺乏被报导在兔子导致 chondrocytes 的 apoptosis 和软骨终板(CEP ) 的退化。软骨终板干细胞(CESC ) 为结构的完整和 CEP 的功能是重要的。(BNIP3 ) Bcl-2/adenovirus E1B 19-kDa-interacting 蛋白质 3 被报导了调整 apoptosis, autophagy,和 cytoprotection。在这研究,我们试图决定营养缺乏是否导致 CESC 的 apoptosis,并且 BNIP3 相关的小径是否在营养缺乏期间在 CESC 被激活。从堕落人的 CEP 孤立的 CESC 在正常或营养缺乏的状况下面是有教养的。然后, apoptosis 被流动 cytometry 分析。表示和 BNIP3 的细胞内部的本地化被量的即时聚合酶链反应,西方的污点分析,和 immunofluorescence 试金分别地检测。Mitochondrial 膜潜力(MMP ) 和 caspase-3 活动被 JC-1 染色和 caspase-3 活动试金测量。我们的结果证明那营养缺乏在 CESC 支持 apoptosis 和 BNIP3 表示。尤其是, BNIP3 击倒能部分减少营养 CESC 的导致缺乏的 apoptosis。另外,营养缺乏能也导致 BNIP3 的 upregulation,导致 BNIP3 的 mitochondrial translocation 和在以一种时间依赖者方式的 CESC 的 MMP 的损失。然而,营养缺乏没在 CESC 在 caspase-3 活动显示出效果。在摘要,营养缺乏可以通过 upregulating BNIP3 部分支持 CESC apoptosis,它可能以一种 caspase 独立的方式导致 BNIP3 相关的小径的激活和 CESC 的 apoptosis。 | Zhiliang He Luqiao Pu Chao Yuan Min Jia Jian Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 7 |
| 12 | Prevalence of Overweight and Obesity among Students Aged 7-22 Years in Jiangsu Province,China显示文摘Objective To report the prevalence and trend of overweight and obesity among students aged 7-22 years in Jiangsu,2010 to 2013.Methods This cross-sectional study was carried out as part of students physical fitness and health survey in Jiangsu province.A total of 255,581 subjects(50.03% males and 49.97% females) enrolled in 82 school and 10 universities in Jiangsu.Weights and heights were obtained for each subject and its body mass index(BMI) was calculated using the Chinese Working Group on Obesity in China(CWGO).Results Anthropometric measurement including bodyweight,height,BMI and bust were significantly different between males in urban compared to females living rural areas(P<0.001).The total prevalence of overweight and obesity was 12.4% and 5.7%.Males had a significantly higher rate than in female's student.The prevalence of overweight and obesity by age groups was(14.5%,10.3%) at age 7-11 years,(11.2%,6.8%) at age 12-14 years,(11.7%,3.1%) at age 15-17 years,and(11.4%,2.3%) at age 18-22 years.By regions;the highest prevalence of overweight obesity reported in Taizhou(10.0%,14.2%),Xuzhou(9.4%,12.5%),and Nanjing(9.2%,15.6%),respectively.Conclusion The finding declares that overweight and obesity are important health problems among students in Jiangsu Province.Early intervention programme are needed to address this problems. | Taha Hussein Musa WEI Li LI Xiao Shan PU Yue Pu WEI Ping Min | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 13 | Ethnic Differences in Preterm Birth Risks for Pregnant Women with Thyroid Dysfunction or Autoimmunity:A Meta-analysis显示文摘Objective Abnormal maternal thyroid function is associated with preterm birth.However,this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting data.This study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic differences.Methods Relevant studies were identified through searches of MEDLINE,Excerpta Medica,Wan Fang,China Biological Medicine disc,and China National Knowledge Infrastructure from inception to June 15,2016.Original articles in which an incidence or prevalence of thyroid dysfunction or autoimmunity before second trimester of pregnancy could be extracted were included.Results Thirty-two unique studies were included for the final meta-analysis.Patients involved were divided into two groups:Group 1(G1) and Group 2(G2) comprising of Asian and Caucasian populations,respectively.Positive thyroid antibodies were associated with the occurrence of preterm birth in both G1 [odds ratio(OR):3.62,95% confidence interval(CI):2.83-4.65] and G2(OR:1.35,95% CI:1.17-1.56);hypothyroidism,only in G2(OR:1.20,CI:1.09-1.33);and subclinical hypothyroidism or hypothyroxinemia,in neither group.Conclusion Thyroid autoimmunity may be a more favorable factor leading to preterm birth among pregnant women of different ethnicities,compared with thyroid dysfunction. | LI Min WANG Shao Wei WU Feng Li SHI Jin YU Pu Lin PENG Xiu Ling SUN Liang | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 14 | Correlation of Plant Morphological and Grain Quality Traits with Mineral Element Contents in Yunnan Rice显示文摘Correlations between four grain quality, 24 plant morphological traits and eight element contents of 653 accessions fromYunnan rice were analyzed. P, K, Ca and Mg contents of core collection were closely correlated to the most plant morphologicaland grain quality traits, and there were highly significant correlations (P <0.01) among some traits including P content to number ofstems and tillers, K content and amylose content, Ca content and plant height, Mg content and protein content. Mn, Zn, Cu and Fecontents of core collection were closely related to a few traits, such as Fe content and gel consistency (-0.1121 **), Zn content andseed setting rate (-0.1411 **), Cu content and number of grains per panicle (-0.1398**), Mn content and plant height (-0.2492**). | ZENG Ya-wen SHEN Shi-quan WANG Lu-xiang LIU Jia-fu Pu Xiao-ying Du Juan Qiu Min | 2005 | Rice science2005，12，2： | 5 |
| 15 | Pseudomonas aeruginosa:pathogenesis,virulence factors,antibiotic resistance,interaction with host,technology advances and emerging therapeutics显示文摘Pseudomonas aeruginosa(P.aeruginosa)is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis,burn wounds,immunodeficiency,chronic obstructive pulmonary disorder(COPD),cancer,and severe infection requiring ventilation,such as COVID-19.P.aeruginosa is also a widely-used model bacterium for all biological areas.In addition to continued,intense efforts in understanding bacterial pathogenesis of P.aeruginosa including virulence factors(LPS,quorum sensing,two-component systems,6 type secretion systems,outer membrane vesicles(OMVs),CRISPR-Cas and their regulation),rapid progress has been made in further studying host-pathogen interaction,particularly host immune networks involving autophagy,inflammasome,noncoding RNAs,cGAS,etc.Furthermore,numerous technologic advances,such as bioinformatics,metabolomics,scRNA-seq,nanoparticles,drug screening,and phage therapy,have been used to improve our understanding of P.aeruginosa pathogenesis and host defense.Nevertheless,much remains to be uncovered about interactions between P.aeruginosa and host immune responses,including mechanisms of drug resistance by known or unannotated bacterial virulence factors as well as mammalian cell signaling pathways.The widespread use of antibiotics and the slow development of effective antimicrobials present daunting challenges and necessitate new theoretical and practical platforms to screen and develop mechanism-tested novel drugs to treat intractable infections,especially those caused by multi-drug resistance strains.Benefited from has advancing in research tools and technology,dissecting this pathogen’s feature has entered into molecular and mechanistic details as well as dynamic and holistic views.Herein,we comprehensively review the progress and discuss the current status of P.aeruginosa biophysical traits,behaviors,virulence factors,invasive regulators,and host defense patterns against its infection,which point out new directions for future investigation and add to the design of novel and/or alternative therapeutics to combat this clinically significant pathogen. | Shugang Qin Wen Xiao Chuanmin Zhou Qinqin Pu Xin Deng Lefu Lan Haihua Liang Xiangrong Song Min Wu | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 5 |
| 16 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 17 | Radiofrequency ablation versus partial nephrectomy for the treatment of clinical stage 1 renal masses: a systematic review and meta-analysis显示文摘 | Wang Shangqian Qin Chao Peng Zhihang Cao Qiang Li Pu Shao Pengfei Ju Xiaobing Meng Xiaoxin Lu Qiang Li Jie Wang Meilin Zhang Zhengdong Gu Min Zhang Wei Yin Changjun | 2014 | Chinese Medical Journal2014，，13： | 5 |
| 18 | miR-410 induces both epithelial–mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer显示文摘Radiotherapy remains one of the major treatments for non-small cell lung cancer(NSCLC)patients;whereas intrinsic or acquired radioresistance limits its efficacy.Nevertheless,most studies so far have only focused on acquired resistance.The exact mechanisms of intrinsic radioresistance in NSCLC are still unclear.A few studies have suggested that epithelial–mesenchymal transition(EMT)is associated with radioresistance in NSCLC.However,little is known about whether the abnormal expression of specific microRNAs induces both EMT and radioresistance.We previously found that miR-410 has multiple roles as an oncomiRNA in NSCLC.In this study,we revealed that miR-410 overexpression promoted EMT and radioresistance,accompanied by enhanced DNA damage repair both in vitro and in vivo.Conversely,knockdown of miR-410 showed the opposite effects.We further demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays,and the miR-410-induced EMT and radioresistance were reversed by PI3K,Akt,and mTOR inhibitors or by restoring the expression of PTEN in NSCLC cells.In addition,we preliminarily found that the expression of miR-410 was positively correlated with EMT and negatively associated with the expression of PTEN in NSCLC specimens.In summary,these results demonstrated that miR-410 is an important regulator on enhancing both NSCLC EMT and radioresistance by targeting the PTEN/PI3K/mTOR axis.The findings suggest that miR-410-induced EMT might significantly contribute to the enhanced radioresistance.Therefore,miR-410 may serve as a potential biomarker or therapeutic target for NSCLC radiotherapy. | Yue Yuan Hu Liao Qiang Pu Xixian Ke Xueting Hu Yongfang Ma Xinmei Luo Qianqian Jiang Yi Gong Min Wu Lunxu Liu Wen Zhu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 19 | Two New Compounds from Schisandra propinqua var.propinqua显示文摘Schisanpropinoic acid(1),a new bergamotane sesquiterpenoid,and schisanpropinin(2),a new tetrahydrofuran lignan with a rare epoxyethane unit,were identified from the stems and leaves of Schisandra propinqua var.propinqua.Their structures were determined based on comprehensive spectroscopic and mass spectrometric analysis.The absolute configuration of 1 was determined by X-ray analysis.Compounds 1 and 2 were tested for their cytotoxic activity against five human tumor cell lines. | Miao Liu Zheng-Xi Hu Yuan-Qing Luo Min Zhou Wei-Guang Wang Xiao-Nian Li Xue Du Jian-Xin Pu Han-Dong Sun | 2017 | Natural Products and Bioprospecting2017，7，3： | 4 |
| 20 | Energy-level dependent H_2_O_2 production on metal-free,carbon-content tunable carbon nitride photocatalysts显示文摘Light-driven production of H_2O_2 from water and molecular oxygen could be a promising way for obtaining both solar fuels and fundamental chemicals. During that process, the H_2O_2 yield is strongly dependent on the reaction pathway associated with two-electron reduction of dioxygen by the photo-generated electrons. Herein, we synthesized a series of metal-free, carbon-content tunable carbon nitride photocatalysts(named C_3N_4-Carbon) by a facile hydrothermal reaction and subsequent thermal treatment at appropriate temperatures. The energy levels of the C_3N_4-Carbon catalysts vary with the carbon doping level, which is conveniently tuned by changing the initial glucose concentration during the hydrothermal reaction. The surface carbon species evolve with the carbon content and the nitrogen atoms in the structure of carbon nitride are partially substituted by foreign carbon atoms based on XPS measurements. The optimal catalyst leads to the highest H_2O_2 yield of 1271 μmol L^(-1) in an acidic aqueous solution(pH 3) after a reaction period of 4 h, twice higher than the pristine C_3N_4. In addition, the largest formation rate constant and the smallest decomposition rate constant of H_2O_2 are obtained on the optimal one according to the kinetics analyses. The decomposition tests of H_2O_2 indicate that the formation rate could be a dominant factor impacting the H_2O_2 yield. The conduction band position of the optimal catalyst is positively shifted to 0.06 V versus RHE, which is more favorable to the reduction of dioxygen to H_2O_2(O2/H_2O_2 at 0.69 V versus RHE). The positive shift of valence band also improves hole collection and leads to enhanced formation of H_2O_2. | Ruirui Wang Xin Zhang Fan Li Ding Cao Min Pu Dandan Han Junjiao Yang Xu Xiang | 2018 | Journal of Energy Chemistry2018，27，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员