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| 1 | Effects of Xiangsha Liujunzi decoction drug serum on gastric antrum smooth muscle cells from rats with functional dyspepsia by regulating gastrointestinal hormones显示文摘Objective:To observe the effect and mechanism of Xiangsha Liujunzi decoction(XSLJZD)drug serum on gastric antrum smooth muscle cells(SMCs)in rats with functional dyspepsia(FD).Methods:Gastric antrum SMCs from rats with FD were isolated,cultured,and then divided into six groups as follows:control,model,domperidone,low-dose XSLJZD(LXSLJZD),medium-dose XSLJZD(MXSLJZD),and high-dose XSLJZD(HXSLJZD).Each group was administered the corresponding drug serum for intervention.Drug serum intervention conditions and proliferative activity of SMCs were tested by cholecystokinin octapeptide.Ghrelin,gastrin,somatostatin,and substance P(SP)levels were measured by ELISA.Somatostatin and SP mRNA expression was measured by real-time PCR.Results:A concentration of 10%drug serum for 24 h was decided to be the best intervention condition for later study.The mean optical density value in the model group was lower than that in the control group(P紏.001).Optical density values in the domperidone and HXSLJZD groups were higher than those in the model group(P?.025,P?.032,respectively).Gastrin,SP,and ghrelin levels in the model group were lower(P?.007,P?.037,P?.005,respectively),but somatostatin levels were higher,compared with those in the control group(P?.031).Gastrin,SP,and ghrelin levels in the domperidone,MXSLJZD,and HXSLJZD groups were higher than those in the model group(all P<.05).Somatostatin levels in the four drug-treated groups were lower than those in the model group(P?.002,P?.007,P?.001,P?.009,respectively).SP mRNA levels in the model group were lower than those in the control,domperidone,MXSLJZD,and HXSLJZD groups(P?.037 P?.016,P?.025,P?.002,respectively).Somatostatin mRNA levels in the model group were higher than those in the control and MXSLJZD groups(P紏.042,P紏.035).Conclusions:XSLJZD and domperidone drug serum effectively promote proliferative activity of gastric antrum SMCs in an FD model.The mechanism of this activity may be regulated by gastrointestinal hormones. | Ning Dai Jinghong Hu Yan Liu Dongyu Ge Ruijuan Dong Fengzhi Wu Jiaojiao Yu Mindan Chen Deborah CMa Feng Li | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 6 |
| 2 | Lipids and membrane-associated proteins in autophagy显示文摘Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases.Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins.Here,we summarized membrane lipid composition,and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective.In particular,we focused on three important membrane remodeling processes in autophagy,lipid transfer for phagophore elongation,membrane scission for phago-phore closure,and autophagosome-lysosome membrane fusion.We discussed the significance of the discoveries in this field and possible avenues to follow for future studies.Finally,we summarized the membrane-associated biochemical techniques and assays used to study membrane properties,with a discussion of their applications in autophagy. | Linsen Li Mindan Tong Yuhui Fu Fang Chen Shen Zhang Hanmo Chen Xi Ma Defa Li Xiaoxia Liu Qing Zhong | 2021 | Protein & Cell2021，12，7： | 3 |
| 3 | Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways显示文摘 | Liyun Sang Julie J. Miller Kevin C. Corbit Rachel H. Giles Matthew J. Brauer Edgar A. Otto Lisa M. Baye Xiaohui Wen Suzie J. Scales Mandy Kwong Erik G. Huntzicker Mindan K. Sfakianos Wendy Sandoval J. Fernando Bazan Priya Kulkarni Francesc R. Garcia-Gonza | 2011 | Cell2011，，4： | 1 |
| 4 | Alterations in the extracellular matrix of the myocardium in essential hypertension 显示文摘 | Pardo Mindan FJ Panizo A | 1993 | Eur Heart J1993，14，： | 1 |
| 5 | Cystadenofibroma of fallopian tube显示文摘 | Valerdiz Casasola S Pardo Mindan J | 1989 | Appl Pathol1989，7，4： | 1 |
| 6 | Angiotensin converting enzyme inhibition prevents polyploidization in spontaneously hypertensive rats with left ventricular hypertrophy显示文摘 | Sola JJ Mindan FJP | 1995 | J Patho1995，177，3： | 1 |
| 7 | Cardiac contractility modulation elec- trical signals improve myocardial gane expression in patients with heart failure 显示文摘 | Butter C Restogi S Mindan HH | 2008 | J Am Coil Cardiol2008，51，18： | 1 |
| 8 | Liver changes in patients with hyperthyroidism显示文摘 | Sola J Pardo - Mindan F J Zozaya J | 1991 | Liver1991，11，4： | 1 |
| 9 | Are mast cells involved in hypertensive heart disease? 显示文摘 | PANIZO A MINDAN F J GALINDO M F | 1995 | J Hypertens1995，13，10： | 1 |
| 10 | Alterations in the extra- celluar matrix of the myocardium in essential hyperten- sion显示文摘 | Pardo Mindan F J Panizo A | 1993 | Eur Heart J1993，14，： | 1 |
| 11 | Targeted combination therapy for glioblastoma by co-delivery of doxorubicin,YAP-siRNA and gold nanorods显示文摘The combination of brain targeting drug delivery systems and multi-modal intervention pose a promising therapeutic approach for glioblastoma therapy.In this study,we developed an angiopep-2 peptide modified cationic liposome loaded with doxorubicin,YAP-siRNA and gold nanorods(D/R@Ang2-Lip+Au)simultaneously,which has high encapsulating efficiency for doxorubicin(95.4%)and effective binding of siRNA at N/P ratio of 20:1.The fluorescence imaging and flow cytometry analysis revealed high cellular uptake of D/R@Ang2-Lip+Au.Real-time quantitative polymerase chain reaction and western blot analysis indicated that D/R@Ang2-Lip+Au could effectively inhibit the expression of YAP protein.In vitro and in vivo studies showed that D/R@Ang2-Lip+Au had the ability to target glioblastoma cells,and achieved better anti-proliferative effects compared with non-targeted D/R@Lip+Au.Moreover,in vivo experiment demonstrated that D/R@Ang2-Lip+Au was able to cross the blood-brain barrier,and combination therapy could significantly inhibit tumor growth.Therefore,the multifunctional D/R@Ang2-Lip+Au might provide a novel approach for effectively delivery of DOX,YAP-siRNA and AuNRs into the glioblastoma cells simultaneously and exerting synergistic therapeutic effects. | Lihuang Li Qiuyan Guo Yanxiu Liu Mindan Lu Jun Yang Yunlong Ge Qiang Zhang Benqiang Sun Xiumin Wang Li Liang-cheng Lei Ren | 2021 | Journal of Materials Science & Technology2021，，4： | 0 |
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