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| 1 | Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma显示文摘Background: Percutaneous radiofrequency ablation(RFA) is a first?line treatment for very?early?stage hepatocellular carcinoma(HCC), whereas the efficacy of percutaneous microwave ablation(MWA) for very?early?stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very?early?stage HCC.Methods: Clinical data of 460 patients who were diagnosed with very?early?stage HCC and treated with percutane?ous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Mili?tary Medical University, in Shanghai, China were retrospectively analyzed. Of these 460 patients, 159 received RFA, 301 received MWA. Overall survival(OS), recurrence?free survival(RFS), local tumor progression(LTP), complete ablation, and complication occurrence rates were compared between the two groups, and the prognostic factors associated with survival were analyzed.Results: No significant differences were observed between the two groups in terms of the 1?, 3?, or 5?year OS rates(99.3%, 90.4%, and 78.3% for MWA vs. 98.7%, 86.8%, and 73.3% for RFA, respectively; P = 0.331). Furthermore, no signif?icant differences were observed between the two groups in terms of the corresponding RFS rates(94.4%, 71.8%, and 46.9% for MWA vs. 89.9%, 67.3%, and 54.9% for RFA, respectively; P ete ablation rates(98.3% vs. 98.1%, P = 0.309), the LTP rates(9.6% vs. 10.1%, P = 0.883), the compl multivariate analysis, LTP, an= 0.860), or the occurrence rates of major complications(0.7% vs. 0.6%, P = 0.691). Bytiviral therapy, and treatment of recurrence were independent risk fac?tors for OS(P < 0.001), and the alpha?fetoprotein level was an independent prognostic factor for RFS(P = 0.002).Conclusions: MWA is as safe and effective as RFA in treating very?early?stage HCC, supporting MWA as a first?line treatment option for this disease. | Yun Xu Qiang Shen Neng Wang Pan-Pan Wu Bin Huang Ming Kuang Guo-Jun Qian | 2017 | Chinese Journal of Cancer2017，36，5： | 15 |
| 2 | Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: a predictive model using contrast-enhanced ultrasound显示文摘AIM To develop a contrast-enhanced ultrasound(CEUS)predictive model for distinguishing intrahepatic cholangiocarcinoma(ICC) from hepatocellular carcinoma(HCC) in high-risk patients.METHODS This retrospective study consisted of 88 consecutive high-risk patients with ICC and 88 high-risk patients with HCC selected by propensity score matching between May 2004 and July 2016. Patients were assigned to two groups, namely, a training set and validation set, at a 1:1 ratio. A CEUS score for diagnosing ICC was generated based on significant CEUS features. Then, a nomogram based on the CEUS score was developed, integrating the clinical data. The performance of the nomogram was then validated and compared with that of the LR-M of the CEUS Liver Imaging Reporting and Data System(LI-RADS).RESULTS The most useful CEUS features for ICC were as follows: rim enhancement(64.5%), early washout(91.9%), intratumoral vein(58.1%), obscure boundary of intratumoral non-enhanced area(64.5%), and marked washout(61.3%, all P < 0.05). In the validation set, the area under the curve(AUC) of the CEUS score(AUC = 0.953) for differentiation between ICC and HCC was improved compared to the LI-RADS(AUC = 0.742)(P < 0.001). When clinical data were added, the CEUS score nomogram was superior to the LI-RADS nomogram(AUC: 0.973 vs 0.916, P = 0.036, Net Reclassification Improvement: 0.077, Integrated Discrimination Index: 0.152). Subgroup analysis demonstrated that the CEUS score model was notably improved compared to the LIRADS in tumors smaller than 5.0 cm(P < 0.05) but not improved in tumors smaller than 3.0 cm(P > 0.05).CONCLUSION The CEUS predictive model for differentiation between ICC and HCC in high-risk patients had improved discrimination and clinical usefulness compared to the CEUS LIRADS. | Li-Da Chen Si-Min Ruan Jin-Yu Liang Zheng Yang Shun-Li Shen Yang Huang Wei Li Zhu Wang Xiao-Yan Xie Ming-De Lu Ming Kuang Wei Wang | 2018 | World Journal of Gastroenterology2018，24，33： | 14 |
| 3 | Combined vascular resection and analysis of prognostic factors for hilar cholangiocarcinoma显示文摘BACKGROUND: Hilar cholangiocarcinoma(HCCA) is a devastating malignancy arising from the bifurcation of the hepatic duct,whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors. METHODS: Clinical data of 154 HCCA patients who had been treated from January 2005 to December 2012 were retrospectively analyzed. The patients were divided into three groups based on vascular resection: those without vascular resection; those with portal vein resection alone and those with hepatic artery resection. The survival and complication rates were compared among the three groups. Multivariate analysis was made to determine prognostic factors.RESULTS: No significant differences were found in survival and complication rates among the three groups(P>0.05). Multivariate analysis showed that 3 factors were related to survival: lymph node metastasis,tumor size(>2.5 cm),and positive resection margin.CONCLUSIONS: Vascular resection improved the survival rate of patients with HCCA involving the hepatic artery or portal vein. Lymph node metastasis,tumor size(>2.5 cm) and positive resection margin were poor prognostic factors in patients with HCCA. | Shu-Tong Wang Shun-Li Shen Bao-Gang Peng Yun-Peng Hua Bin Chen Ming Kuang Shao-Qiang Li Qiang He Li-Jian Liang | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 12 |
| 4 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies显示文摘 | Guo-Jun Qian Neng Wang Qiang Shen Yue Sheng Jie-Qiong Zhao Ming Kuang Guang-Jian Liu Meng-Chao Wu | 2012 | European Radiology2012，，9： | 3 |
| 6 | Numerical simulation of flow hydrodynamics of struvite pellets in a liquid–solid fluidized bed显示文摘Phosphorus recovery in the form of struvite has been aroused in recent decades for its dual advantages in eutrophication control and resource protection.The usage of the struvite products is normally determined by the size which is largely depended on the hydrodynamics.In this study,flow behavior of struvite pellets was simulated by means of Eulerian–Eulerian two-fluid model combining with kinetic theory of granular flow in a liquid–solid fluidized bed reactor(FBR).A parametric study including the mesh size,time step,discretization strategy,turbulent model and drag model was first developed,followed by the evaluations of crucial operational conditions,particle characteristics and reactor shapes.The results showed that a cold model with the mesh resolution of 16 × 240,default time step of 0.001 sec and first order discretization scheme was accurate enough to describe the fluidization.The struvite holdup profile using Syamlal–O'Brien drag model was best fitted to the experimental data as compared with other drag models and the empirical Richardson–Zaki equation.Regarding the model evaluation,it showed that liquid velocity and particle size played important roles on both solid holdups and velocities.The reactor diameter only influenced the solid velocity while the static bed height almost took no effect.These results are direct and can be applied to guide the operation and process control of the struvite fluidization.Moreover,the model parameters can also be used as the basic settings in further crystallization simulations. | Xin Ye Dongyuan Chu Yaoyin Lou Zhi-Long Ye Ming Kuang Wang Shaohua Chen | 2017 | Journal of Environmental Sciences2017，29，7： | 3 |
| 7 | SARS-CoV-2 spike protein interacts with and activates TLR41显示文摘Dear Editor,Accumulating clinical data suggest the main causes of death by COVID-19 include respiratory failure and the onset of sepsis.1 Importantly,sepsis has been observed in nearly all deceased patients.2,3,4,5 It remains elusive how SARS-CoV-2 infection results in viral sepsis in humans.Toll-like receptor 4(TLR4)mediates anti-gram-negative bacterial immune responses by recognizing lipopolysaccharide(LPS)from bacteria.6 We recently found that SARS-CoV-2 infection provoked an anti-bacterial like response at the very early stage of infection via TLR4.However,the identity of the original trigger initiating these abnormal immune responses during SARS-CoV-2 infection is unknown. | Yingchi Zhao Ming Kuang Junhong Li Ling Zhu Zijing Jia Xuefei Guo Yaling Hu Jun Kong Hang Yin Xiangxi Wang Fuping You | 2021 | Cell Research2021，31，7： | 3 |
| 8 | Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)显示文摘Introduction Liver cancer remains a global health challenge,and its incidence is increasing worldwide.It is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation. | Min Xu Li-Ting Xie Yue-Yong Xiao Ping Liang Qi-Yu Zhao Zhong-Min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu Ming Kuang Li-Zhi Niu Chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An Jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic Medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional Minimally Invasive Therapy Special Committee of China Medicine Education Association | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 2 |
| 9 | Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound显示文摘 | Xiao-Hua Xie Hui-Xiong Xu Xiao-Yan Xie Ming-De Lu Ming Kuang Zuo-Feng Xu Guang-Jian Liu Zhu Wang Jin-Yu Liang Li-Da Chen Man-Xia Lin | 2010 | European Radiology2010，，1： | 2 |
| 10 | Treatment response evaluation with three-dimensional contrast-enhanced ultrasound for liver cancer after local therapies显示文摘 | Hui-Xiong Xu Ming-De Lu Xiao-Hua Xie Xiao-Yan Xie Ming Kuang Zuo-Feng Xu Guang-Jian Liu Zhu Wang Li-Da Chen Man-Xia Lin | 2009 | European Journal of Radiology2009，，1： | 1 |
| 11 | Clinical presentations of patients from different age cohorts with biliary tract stone diseases显示文摘 | Kuang‐Chun Hu Horng‐Yuan Wang Wen‐Hsiung Chang Cheng‐Hsin Chu Shee‐Chan Lin Chun‐Jen Liu Ming‐Shiang Wu Shou‐Chuan Shih | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 12 | Reactivity study and kinetic evaluation of CuO-based oxygen carriers modified by three different ores in chemical looping with oxygen uncoupling(CLOU)process显示文摘In the chemical looping with oxygen uncoupling(CLOU)process,CuO is a promising material due to the high oxygen carrier capacity and exothermic reaction in fuel reactor but limited by the low melting point.The combustion rate of carbon is faster than the decoupling rate of oxygen carrier(OC).Hence,high temperature tolerance and rapid oxygen release rate of CuO modified by three different ores were investigated in this study.The kinetics analysis of oxygen decoupling with Cu-based oxygen carriers was also evaluated.Results showed that CuO modified by chrysolite had faster oxygen release rate than that of CuO.Limestone showed obvious positive effect on the oxidization process.The selected OCs could keep stable in at least 20 cycles,for about 1200 min.Shrinking core model(SCM)fitted well for the decoupling process in the temperature range of 1123-1223 K.Reduction rate kinetic information may aid in the development of chemical looping with oxygen uncoupling(CLOU)technologies during reactor design and process modeling.Ternary doped copper oxide with chrysolite and limestone could improve the reactivity of CuO in decoupling and coupling process and also improve the high temperature tolerance. | Cao Kuang Shuzhong Wang Ming Luo Jun Zhao | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 13 | Arsenate adsorption by Mg/Al-NO3 layered double hydroxides with varying the Mg/Al ratio显示文摘 | Shan-Li Wang Cheng Hua Liu Ming Kuang Wang | | 0，，43： | 1 |
| 14 | Monocyte/macrophage‐elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions显示文摘 | Yan Wu Dong‐Ming Kuang Wei‐Dong Pan Yun‐Le Wan Xiang‐Ming Lao Dian Wang Xue‐Feng Li Limin Zheng | 2013 | Hepatology2013，，3： | 1 |
| 15 | Review of recent developments in solid acid, base, and enzyme catalysts(Heterogeneous) for biodiesel production via transesterification 显示文摘 | Rajabathar Jothiramalingam Ming Kuang Wang | 2009 | Ind Eng Chem Res2009，48，： | 1 |
| 16 | Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies显示文摘 | Guo-Jun Qian Neng Wang Qiang Shen Yue Sheng Jie-Qiong Zhao Ming Kuang Guang-Jian Liu Meng-Chao Wu | 2012 | European Radiology2012，，9： | 1 |
| 17 | Factors Influencing the Elemental Distribution in Iron-Manganese Cutans of Three Subtropical Soils显示文摘 | Li Huang Fan Liu Ming Kuang Wang Wenfeng Tan | 2011 | Soil Science2011，，1： | 1 |
| 18 | Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs显示文摘 | Hanwei Jiao Li Du Yongchang Hao Ying Cheng Jing Luo Wenhua Kuang Donglin Zhang Ming Lei Xiaoxiao Jia Xiaoru Zhang Chao Qi Hongxuan He Fengyang Wang | 2013 | Folia Microbiologica2013，，4： | 1 |
| 19 | Induction of jasmonate signalling regulators MaMYC2s and their physical interactions with MaICE1 in methyl jasmonate‐induced chilling tolerance in banana fruit显示文摘 | MING‐LEI ZHAO JUN‐NING WANG WEI SHAN JIA‐GENG FAN JIAN‐FEI KUANG KE‐QIANG WU XUE‐PING LI WEI‐XIN CHEN FANG‐YUAN HE JIAN‐YE CHEN WANG‐JIN LU | 2012 | Plant Cell & Environment2012，，1： | 1 |
| 20 | Arsenateadsorption by Mg/Al-N03 layered double hydroxides with varyingthe Mg/Al ratio 显示文摘 | Shan-Li Wang Cheng Hua Liu Ming Kuang Wang | 2009 | Applied Clay Science2009，43，： | 1 |
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