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| 1 | Effects of Fluoride on Lipid Peroxidation, DNA Damage and Apoptosis in Human Embryo Hepatocytes显示文摘Objective To investigate the effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocyte L-02 cells. Methods Lipid peroxide (LPO) level, reduced glutathione (GSH) content, DNA damage, apoptosis, and cell cycle analysis were measured after in vitro cultured L-02 cells were exposed to sodium fluoride at different doses (40 μg/mL, 80 μg/mL, and 160 μg/mL) for 24 hours. Results Fluoride caused an increase of LPO levels and a decrease of GSH content in L-02 cells. There appeared to be an obvious dose-effect relationship between the fluoride concentration and the observed changes. Fluoride also caused DNA damage and apoptosis and increased the cell number in S phase of cell cycle in the cells tested. There was a statistically significant difference in DNA damage and apoptosis when comparing the high dose of fluoride treated cells with the low dose of fluoride treated cells. Conclusion Fluoride can cause lipid peroxidation, DNA damage, and apoptosis in the L-02 cell experimental model and there is a significant positive correlation between fluoride concentration and these pathological changes. | AI-GuoWANG TAOXIA QI-LONGCHU MINGZHANG FANGLIU XUE-MINCHEN KE-DIYANG | 2004 | Biomedical and Environmental Sciences2004，17，2： | 18 |
| 2 | Multi-detector CT enterography with iso-osmotic mannitol as oral contrast for detecting small bowel disease显示文摘AIM: To assess the feasibility and usefulness of multi-detector CT enterography with orally administered iso-osmotic mannitol as negative contrast in demonstrating small bowel disease.METHODS: Thirteen volunteers and 38 patients with various kinds of small bowel disease were examined. We administered about 1 500 mL iso-osmotic mannitol as negative contrast agent and then proceeded with helical CT scanning on a Siemens Sensation 16 scanner. All volunteers and patients were interviewed about their tolerance of the procedure. Two radiologists postprocessed imaging data with MPR, thin MIP, VRT and INSPACE when necessary and then interpreted the scans,and adequacy of luminal distention was evaluated on a four-point scale. Demonstration of features of various kinds of small bowel disease was analyzed.RESULTS: The taste of iso-osmotic mannitol is good (slightly sweet) and acceptable by all. Small bowel distention was excellent and moderate in most volunteers and patients. CT features of many kinds of diseases such as tumors, Crohn's disease,and small bowel obstruction,etc. were clearly displayed.CONCLUSION: Multi-detector CT enterography with iso-osmotic mannitol as negative contrast to distend the small bowel is a simple, rapid, noninvasive and effective method of evaluating small bowel disease. | Lian-HeZhang Shi-ZhengZhang Hong-JieHu MinGao MingZhang QianCao Qiao-weiZhang | 2005 | World Journal of Gastroenterology2005，11，15： | 9 |
| 3 | China's New International Financial Strategy amid the Global Financial Crisis显示文摘中国政府促进了它的开车重建它在亚素数危机以后的国际金融策略在 2008 发展成一个全球金融危机。策略的主要目的是在外贸,跨边阶的大写的流动和外汇储备管理在美元上减少这个国家的依赖。策略能被划分成三级:国际钱的政体的人民币国际化,地区性的钱的合作和重建。到目前为止,中国政府在所有三级的应用程序做了很好。我们认为尽管有它面对的各种各样的挑战,中国政府应该以一种协调方式在一样的方向继续。 | MingZhang | 2009 | China & World Economy2009，17，5： | 8 |
| 4 | Expert Recommendations for Tracheal Intubation in Critically Ill Patients with Noval Coronavirus Disease 2019显示文摘Coronavirus Disease 2019(COVID-19),caused by a novel coronavirus(SARS-Co V-2),is a highly contagious disease.It firstly appeared in Wuhan,Hubei province of China in December 2019.During the next two months,it moved rapidly throughout China.Most of the infected patients have mild symptoms including fever,fatigue and cough,but in severe cases,patients can progress rapidly and develop into acute respiratory distress syndrome,septic shock,metabolic acidosis and coagulopathy.The new coronavirus was reported to spread via droplets,contact and natural aerosols from human to human.Therefore,aerosol-producing procedures such as endotracheal intubation may put the anesthesiologists at high risk of nosocomial infections.In fact,SARSCo V-2 infection of anesthesiologists after endotracheal intubation for confirmed COVID-19 patients have been reported in hospitals in Wuhan.The expert panel of airway management in Chinese Society of Anaesthesiology has deliberated and drafted this recommendation,by which we hope to guide the performance of endotracheal intubation by frontline anesthesiologists and critical care physicians.During the airway management,enhanced droplet/airborne personal protective equitment(PPE)should be applied to the health care providers.A good airway assessment before airway intervention is of vital importance.For patients with normal airway,awake intubation should be avoided,and modified rapid sequence induction is strongly recommended.Sufficient muscle relaxant should be assured before intubation.For patients with difficult airway,good preparation of airway devices and detailed intubation plans should be made. | Mingzhang Zuo Yuguang Huang Wuhua Ma Zhanggang Xue Jiaqiang Zhang Yahong Gong Lu Che 无 | 2020 | Chinese Medical Sciences Journal2020，35，2： | 7 |
| 5 | The insecticide resistance in stripped stem borer,Chilo suppressalis(Walker)显示文摘The stripped stem borer (SSB), Chilo suppressalis (Walker) is one of the major insect pests of rice in China. Chemical control has been a common practice in SSB management since 1950s. Insecticides used included BHC before 1983;organophosphorus insecticides (methyl-parathion, trichophon, methamidophos, and monocrotophos), and chlordimeform in mid-1970s-1980s; Shachongshuang (dimehypo) and Shachongdan (monousltap) since early 1980s. In recent years, SSB population and its damage to rice increased rapidly and failures on control has been reported. To find out the cause of failure and to put forward the suitable control methods, we studied the resistance of SSB to major insecticides used in China. | CAO Mingzhang SHEN Jinliang LIU Xiaoyu Li Mei Dept of Pesticide Sci,College of Plant Protection,Nanjing Agri Univ,Nanjing 210095,China | 2001 | Chinese Rice Research Newsletter2001，9，1： | 5 |
| 6 | Protective effects of silybin and analogues against X-ray radiation-induced damage显示文摘Silybin (SLB ) 和类似的类似物,也就是 hesperetin (HESP ) , naringenin (NAN ) 和 naringin (NAR ) ,被相信是为某些癌症作为 chemopreventive 代理人被报导了的自然 flavonoids 的活跃成分。而且, SLB 和类似物被决定了快由脉搏 radiolysis 技术从氧化损坏修理 DNA 底。现在的学习被设计评估 SLB 的保护的效果,软 X-ray-induced 上的类似物在 vitro 损坏 DNA 到 plasmid。DNA 损坏被 agarose 胶化电气泳动决定。SLB 和类似物被发现在 micromolar 集中保护 DNA 免受放射损坏的伤害。在测试的混合物之中, HESP 和 SLB 在阻止 DNA 单个海滨的裂缝(SSB ) 的 X-ray-induced 形成是最有效的。有另外的实验的这些结果的比较证明 SLB 和类似物的能力与混合物的能力相关在 vitro 禁止 DNA 损坏清除自由激进分子。我们的工作表明自然 flavonoids, SLB 和类似物可以对放射损坏被用作有势力辐射防护药物。 | Haiying Fu Mingzhang Lin Yosuke Katsumura Akinari Yokoya Kuniki Hata Yusa Muroya Kentaro Fujii Naoya Shikazono | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 4 |
| 7 | Synthesis, characterization and performance of a polycarboxylate superplasticizer with amide structure显示文摘 | Xiao Liu Ziming Wang Jie Zhu Yunsheng Zheng Suping Cui Mingzhang Lan Huiqun Li | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，，： | 2 |
| 8 | Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis显示文摘难题有交错的脑叶的塑造片的 Arabidopsis 叶人行道房间(PC ) 并且缩排是一个好模型系统调查在纸巾以内协调房间极性和形状形成的机制。植物生长素被显示了 GTPase 依赖的发信号由激活 ROP 协调 interdigitation 小径。识别另外的部件或机制,我们与反常 PC 形态发生为异种屏蔽了并且发现细胞激动素发信号调整 PC interdigitation 模式。在细胞激动素累积的减小和在细胞激动素发信号的缺点(例如在 ARR7-over-expressing 线, ahk3cre1 细胞激动素受体异种,和 ahp12345 细胞激动素表明异种) 提高的 PC interdigitation,而细胞激动素的生产过剩和细胞激动素在一根 ARR20 在表示上线发信号的在激活上在整个子叶推迟了或废除 PC interdigitation。基因、生物化学的分析建议表明 ROP 在上游的行为压制交错的模式的形成的那细胞激动素。我们的结果提供控制 PC 形状的小径的新奇机械学的理解并且揭开为细胞激动素在房间形态发生发信号的一个新角色。 | Hongjiang Li Tongda Xu Deshu Lin Mingzhang Wen M ingtang Xie Jērōme Duclercq Agnieszka Bielach Jungmook Kim G Venugopala Reddy Jianru Zuo Eva Benková Jiгi Friml Hongwei Guoz Zhenbiao Yang | 2013 | Cell Research2013，23，2： | 2 |
| 9 | Anti-inflammatory effects of leaf and twig of Tripterygium wilfordii on paw edema in mice显示文摘 | Longjiang Yu Mingzhang Ao Junmei Wan Yongzhong Zhang | 2008 | Fitoterapia2008，，7： | 1 |
| 10 | Linearly Scaled, Rate‐Invariant Normal Limits for QT Interval: Eight Decades of Incorrect Application of Power Functions显示文摘 | PENTTI M.RAUTAHARJU ZHU‐MINGZHANG | 2003 | Journal of Cardiovascular Electrophysiology2003，，12： | 1 |
| 11 | Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case–control study in China显示文摘 | Lian‐YuanTao Xiao‐DongHe QiangQu LeiCai WeiLiu LiZhou Shang‐MingZhang | 2009 | Liver International2009，，2： | 1 |
| 12 | Synthesis of Carbon-11 Labeled Sulfonanilide Analogues as New Potential PET Agents for Imaging of Aromatase in Breast Cancer显示文摘 | Wang M Lacy G Gao Mingzhang | 2007 | Bioorg Med Chem2007，17，： | 1 |
| 13 | Three-dimensional reconstruction of specular surface for gas tungsten arc weld pool显示文摘 | Hong Shengsong Yu Mingzhang | 2007 | Measurement Sci- ence and Technology2007，18，10： | 1 |
| 14 | Fibrinogen-γ C-terminal Fraggments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-mediated and RhoA-dependent Mechanism显示文摘 | Mingzhang Guo Dayle Daines | 2009 | Arterioscler Thromb Vasc Biol2009，29，3： | 1 |
| 15 | 316L Stainless Steel with Gradient Porosity Fabricated by Selective Laser Melting显示文摘 | Ruidi Li Jinhui Liu Yusheng Shi Mingzhang Du Zhan Xie | 2010 | Journal of Materials Engineering and Performance2010，，5： | 1 |
| 16 | DNA polymerase ξ:new insight into eukaryotic mutagenesis and mammalian embryonic development显示文摘Information about the mechanisms that generate mutationsin eukaryotes is likely to be useful for understanding humanhealth concerns, such as genotoxicity and cancer.Eukaryotic mutagenesis is largely the outcome of attacksby' endogenous and environmental agents. Except for DNArepair, cell cycle checkpoints and DNA damage avoidance,cells have also evolved DNA damage tolerance mechanism,by which lesion-targeted mutation might occur in thegenome during replication by specific DNA polymerases tobypass the lesions (translesion DNA synthesis, TLS), ormutation on undamaged DNA templates (untargetedmutation) might be induced. DNA polymerase ζ (poiζ),which was found firstly in budding yeast Saccharomycescerevisiae and consists of catalytic subunit scRev3 and stimulating subunit scRev7, has Received more attention in recent years. Poi ζ is a member of DNA polymerase δsubfamily, which belongs to DNA polymerase B family, and exists in almost all eukaryotes. Human homolog of the scRev3gene is located in chromosome region 6q21, and the mouse equivalent maps to chromosome 10, distal to the c-myb gene and close to the Macs gene. Alternative splicing, upstream out-of frame ATG can be found in yeast scRev3, mouse and human homologs. Furthermore, the sequence from 253-323 immediate upstream of the AUG initiator codon has the potential to form a stem-loop hairpin secondary structure in REV3 mRNA, suggesting that human REV3 protein may be expressed at low levels in human cells under normal growth conditions. The functional domain analysis showed that yeast Rev3-980 tyrosine in conserved region II is at the polymerase active site. Human REV3 amino acid residues 1 776-2 195 provide a REV7binding domain, and REV7 amino acid residues 1-211provide a bind domain for REV1, REV3 and REV7 itself.More interestingly, REV7 interacts with hMAD2 and therefore might function in the cell cycle control by affecting the activation of APC (anaphase promoting complex).Currently it has been known that poi ζ is involved in most spontaneous mutation, lesion-targeted mutation via TLS,chemical carcinogen induced untargeted mutation and somatic hypermutation of antibody genes in mammalian.In TLS pathway, polζ acts as a 'mismatch extender' with combination of other DNA polymerases, such as pol t. Unlike in yeast, it was found that pol ζ also functioned in mouse embryonic development more recently. It was hypothesized that the roles of pol ζ in TLS and cell cycle control might contribute to mouse embryonic lethality. | FengZhu MingZhang | 2003 | World Journal of Gastroenterology2003，9，6： | 1 |
| 17 | C50 for Propofol-Remifentanil Target-Controlled Infusion and Bispectral Index at Loss of Consciousness and Response to Painful Stimulus in Chinese Patients: A Multicenter Clinical Trial显示文摘 | Zhipeng Xu Fang Liu Yun Yue Tiehu Ye Bingxi Zhang Mingzhang Zuo Mingjun Xu Rongrong Hao Yuan Xu Ning Yang Xiangming Che | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 18 | Effectiveness of chemical biliary duct embolization for chemical hepatectomy显示文摘 | FU‐YULI JING‐QIUCHENG NINGLI SHENGHE MING‐MINGZHANG JIA‐HONGDONG LI‐SHENGJIANG NAN‐SHENGCHENG | 2006 | Journal of Gastroenterology and Hepatology2006，，5： | 1 |
| 19 | Survey of susceptibilities to monosultap, triazophos, fipronil, and abamectin in Chilo suppressalis显示文摘 | HE Yueping GAO Congfeng CAO Mingzhang | 2007 | Journal of Economic Entomology2007，100，6： | 1 |
| 20 | Observation of continental shelf wave propagating along the eastern Taiwan Strait during Typhoon Meranti 2016显示文摘This study is the fi rst to depict typhoon-induced continental shelf wave(CSW)propagation in the eastern Taiwan Strait(TWS)during the passage of Typhoon Meranti in 2016 using tidal gauge data and along-track satellite altimeter data.The strong amplitude response of sea level oscillations(within the range of 0.30–0.54 m)as a free,barotropic CSW after Meranti,which impacted the TWS,was clearly detected in time and frequency(in bands of 64–81 h)using wavelet and cross-wavelet analyses.The measured group and phase speeds were consistent with the dispersion curves for CSW with the fi rst-mode derived from the cross-shelf sections of the eastern TWS,with the mean speeds reaching 3 and 5.6±0.7 m/s,respectively.Coincidentally,the typhoon-induced sea level anomaly(SLA)was also captured by the satellite altimeter before this CSW entered into the TWS.Using the theoretical cross-shore CSW modes to fi t the SLA data,the results indicated that the fi rst three wave modes can interpret this CSW event appeared in the southern TWS very well,with the fi rst mode being the dominant one. | Junqiang SHEN Shanwu ZHANG Junpeng ZHANG Mingzhang ZENG Wendong FANG | 2021 | Journal of Oceanology and Limnology2021，39，1： | 1 |
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