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| 1 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 2 | Dual-Mode Induction of Tunable Circularly Polarized Luminescence from Chiral Metal-Organic Frameworks显示文摘The general approach for fabricating solid-state materials showing circularly polarized luminescence(CPL)is still in its challenge.In this work,chiral metal-organic frameworks(MOFs)with full-color and white-color circularly polarized light emission are firstly achieved through a host-guest emitter-loading strategy.Chiral zeolitic imidazolate frameworks(ZIFs,a class of MOFs)are fabricated by a facile and simple mixed-ligand coassembly pathway.Meantime,achiral dyes,quantum dots(QDs),and upconversion nanoparticles(UCNPs)are easily loaded into the chiral ZIFs during the synthetic process.Size-matched dyes can be solely encapsulated into the chiral cages of ZIF,resulting in induced CPL and enhanced luminescence efficiency in solid-state ZIF⊃dye composites.Large-sized QDs,after embedding into the gap of the ZIF particles,also exhibited intense CPL activity.Furthermore,through modulating the blending ratio of colored dyes or QDs in chiral ZIFs,white light-emitting ZIFs with circular polarization could be constructed in a solid state.In addition,through loading rare earth element-based upconversion nanoparticles(UCNPs)into chiral ZIFs,upconverted CPL(UC-CPL)could be achieved with a high dissymmetry factor(glum).Thus,various achiral luminophores were endowed with CPL upon coupling with chiral ZIFs,which significantly deepened and enlarged the research scope of the chiroptical materials in a solid state. | Tonghan Zhao Jianlei Han Xue Jin Minghao Zhou Yan Liu Pengfei Duan Minghua Liu | 2020 | Research2020，，1： | 8 |
| 3 | SINGULAR BEHAVIORS OF INTERFACIAL CRACKS IN 2D MAGNETOELECTROELASTIC BIMATERIALS显示文摘The singular characteristics of stress,electric displacement and magnetic induction fields near the tip of impermeable interfacial cracks in two-dimensional magnetoelectroelastic bimaterials are studied using the generalized Stroh formalism.Two types of singularities are ob-tained:one is the oscillating singularity 1/2±iε,the other is the non-oscillating singularity 1/2±κ.It is found that the non-zero parameters ε and κ cannot coexist for one transversely isotropic MEE bimaterial,a similar result is obtained for transversely isotropic piezoelectric bimaterials. | Cuiying Fan Youhe Zhou Han Wang Minghao Zhao | 2009 | Acta Mechanica Solida Sinica2009，22，3： | 5 |
| 4 | Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean显示文摘There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. | Ying Zhao Pan Cao Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo Zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin Zhanguo Zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen | 2021 | Journal of Integrative Plant Biology2021，63，6： | 4 |
| 5 | Photosynthetic acclimation to long-term high temperature and soil drought stress in two spruce species (Picea crassifolia and P. wilsonii) used for afforestation显示文摘Picea crassifolia and P.wilsonii,commonly used for afforestation in northern China,are increasingly likely to be subjected to high temperatures and soil drought stress as a result of global warming.However,little is known about the effects of these stresses on foliar photosynthesis in the two species.To investigate how photosynthetic characteristics and sensitivity respond to prolonged high temperatures and soil drought,foliar gas exchange and other closely related parameters were recorded from four-year-old seedlings of both species.Seedlings were grown under two temperature treatments(25/15 and 35/25 °C) and four soil water regimes [80,60,40 and 20% of maximum field capacity(FC)] for 4 months.Although all treatments significantly reduced photosynthetic rates(P_n) of both species,P.crassifolia exhibited greater photosynthetic acclimation than P.wilsonii.Differences in photosynthetic acclimation were mainly related to variations in stomatal conductance(Cond) and the maximum quantum yield of PSII(F_v/F_m) between treatments.Indeed,higher Cond and F_v/F_m in all treatments were shown for P.crassifolia than for P.wilsonii.Moreover,photosynthesis in P.crassifolia exhibited inherently lower temperature sensitivities(broader span for the temperature response curves; lower b) and higher thermostability(invariable b between treatments).Further,severe drought stress(20% FC) limited the survival of P.wilsonii.Our results indicate that P.wilsonii is more susceptible to high temperatures and soil drought stress.Planting P.crassifolia would be more expected to survive these conditions and hence be of greater benefit to forest stability if predicted increases in drought and temperature in northern China occur. | Xiaowei Zhang Litong Chen Jingru Wang Minghao Wang Shuli Yang Changming Zhao | 2018 | Journal of Forestry Research2018，29，2： | 4 |
| 6 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 7 | Structural modification and antitumor activity of antimicrobial peptide HYL显示文摘HYL derived from the venom of the solitary bee Hylaeus signatus(Hymenoptera:Colletidae)is anα-helical antimicrobial peptide with 16 residues.To explore whether HYL can be applied in anti-tumor therapy,we synthesized HYL and further modified its structure by using a solid-phase synthesis method,and then evaluated their antitumor activities.Firstly,we identified the key residues of HYL by alanine scanning strategy,and then a series of stapled peptides were synthesized by hydrocarbon stapling strategy without destroying the key residues.All the stapled peptides of HYL showed significant improvement not only inα-helicity,but also in antitumor activity and protease resistance when compared to the parent peptide HYL.The results showed that hydrophobicity and amphiphilicity are important factors affecting the antitumor activity of HYL,and the stapling strategy can significantly affect the proteolytic stability and helicity of HYL.What’s more,we find that the stapled peptides HYL-14,HYL-16 and HYL-18 show a promising prospect for novel anti-tumor drug development. | Minghao Wu Qing Chen Yingdi Wang Yulei Li Xia Zhao Qi Chang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 8 | RiceENCODE:A comprehensive epigenomicdatabase as a rice Encyclopedia of DNA Elements显示文摘Dear Editor,Rice(Oryza sativa)is one of the most important crops in the worldand a common model plant for genomic research.The genomesofXian/IndicaandGeng/Japonicahave been completelysequenced and annotated with accurate genome information.Over the past few years,epigenomic information,including DNAmethylation,histone modification,and chromatin accessibility,has been characterized in theXian/IndicaandGeng/Japonicage-nomes(Zhao et al.,2020).Quite a few rice three-dimensionalgenome studies have been published in the meantime(Zhaoet al.,2019).However,it is still a big challenge for many groupsthat lack dedicated bioinformatic personnel or sufficientcomputational resources to utilize such epigenetic data. | Liang Xie Minghao Liu Lun Zhao Kai Cao Peng Wang Wenhao Xu Wing-Kin Sung Xingwang Li Guoliang Li | 2021 | Molecular Plant2021，14，10： | 2 |
| 9 | Using support vectormachine and evolutionary profiles to predict antifreeze protein se-quences显示文摘 | Zhao Xiaowei Ma Zhiqiang Yin Minghao | 2012 | Intemtional Journal of Molecular Science2012，13，2： | 1 |
| 10 | Asynchronous Observer Design for Switched Linear Systems: A Tube-Based Approach显示文摘This paper proposes a tube-based method for the asynchronous observation problem of discrete-time switched linear systems in the presence of amplitude-bounded disturbances.Sufficient stability conditions of the nominal observer error system under mode-dependent persistent dwell-time(MPDT)switching are first established. Taking the disturbances into account, a novel asynchronous MPDT robust positive invariant(RPI) set and an asynchronous MPDT generalized RPI(GRPI)set are determined for the difference system between the nominal and disturbed observer error systems. Further, the global uniform asymptotical stability of the observer error system is established in the sense of converging to the asynchronous MPDT GRPI set, i.e., the cross section of the tube of the observer error system. Finally, the proposed results are validated on a space robot manipulator example. | Minghao Han Ruixian Zhang Lixian Zhang Ye Zhao Wei Pan | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 1 |
| 11 | Boundary integral equations and the boundary element method for three dimensional fracture mechanics显示文摘 | Zhao Minghao Liu Yuanjie Cheng Changjun | 1994 | Engng Anal Bound Elem1994，13，： | 1 |
| 12 | Extended displacement discontinuity method for crack analysis in 3d two-phase transversdy isotropic magnetoelectroelastic media显示文摘 | ZHAO MingHao LI Na FAN CuiYing Liu Tong | 2008 | Journal of Mechanics of Materials and Structures2008，3，3： | 1 |
| 13 | Fracture of piezoelectric ceramics显示文摘 | Zhang Tong-Yi Zhao Minghao Tong Pin | 2001 | Adv Appl Mech2001，38，： | 1 |
| 14 | ' March Westwords' and a new look on China' s grand stragety 显示文摘 | Zhao Minghao | 2015 | Mediterranean Quarterly2015，26，1： | 1 |
| 15 | Transcriptome analysis suggests mechanisms for a novel flowering type: Cleistogamous wheat显示文摘Wheat is one of the most important staple crops worldwide.Fusarium head blight severely reduces wheat yield and quality.Cultivation of a novel type of cleistogamous wheat mutant,ZK001,which was created by static magnetic field treatment,is a new strategy for controlling Fusarium head blight.However,little is known about the mechanism of cleistogamy in wheat.The present study demonstrated that anthers of ZK001 were retained on the glumes at all flowering stages,whereas those of YM18 were extruded from the paleae and lemmae.There was a clear difference in the morphological characteristics of lodicules between YM18 and ZK001.Lodicule calcium and potassium contents were significantly higher in YM18 than in ZK001 from white to yellow anther stages.In Fusarium head blight resistance,the diseased kernel rate and deoxynivalenol content of ZK001 were markedly lower than those of YM18 and QM725.Comparative transcriptome analysis of YM18 and ZK001 was performed to identify regulatory mechanisms of cleistogamy.The main differentially expressed genes identified in the spikelets of YM18 and ZK001 at the green anther stage were associated with cell walls,carbohydrates,phytohormones,water channel,and ion binding,transport,and homeostasis.These differentially expressed genes may play an important role in regulating cellular homeostasis,osmotic pressure,and lodicule development.The results indicate that ZK001 lost the ability to push the lemmae and paleae apart during the flowering stage because of the thin lodicules.ZK001 was speculated to provide structural barriers for Fusarium head blight during the flowering stage.The thin lodicule of ZK001 results from low levels of soluble sugar,calcium ions,and potassium ions in the lodicules.These levels are regulated by differentially expressed genes. | Caiguo Tang Minghao Li Minghui Cao Ruiju Lu Huilan Zhang Chenghong Liu Shengwei Huang Pingping Zhang Hao Hu Weiwei Zhao Lifang Wu | 2020 | The Crop Journal2020，8，2： | 1 |
| 16 | Short-term prediction of wind power using EMD and chaotic theory显示文摘 | An Xueli Jiang Dongxiang Zhao Minghao | 2012 | Nonlinear Science and Numerical Simulation2012，，17： | 1 |
| 17 | Short-term prediction of wind power using emd and chaotic theory 显示文摘 | An Xueli Jiang Dongxiang Zhao Minghao | 2012 | Communications in Nonlinear Science and Numerical Simulations2012，17，2： | 1 |
| 18 | Determination of the Fracture Toughness of Glasses via Scratch Tests with a Vickers Indenter显示文摘Fracture toughness is an important index in safety evaluation for materials and structures.Its convenient and accurate characterization has attracted extensive attention.For small specimens,traditional testing methods of fracture toughness are not suitable due to limitations in sample size and shape.In this work,a new formula is proposed to determine the fracture toughness of glasses using scratch tests with a Vickers indenter based on dimensional analysis and finite element analysis.Fracture toughness of glasses could be calculated with elastic modulus,crack depth of scratched materials and normal force applied during the scratch tests.The effects of plastic deformation and interfacial friction between the Vickers indenter and scratched materials are considered,and the crack shape is consistent with experimental observations.The proposed formula is verified by comparing the fracture toughness of soda-lime and borosilicate glasses obtained from scratch tests with those obtained via indentation tests.This work provides an alternative method to determine the fracture toughness of glass materials. | Haitao Liu Jianwei Zhang Minghao Zhao Chunsheng Lu | 2022 | Acta Mechanica Solida Sinica2022，35，1： | 1 |
| 19 | Dielectric Breakdown Model for an Electrically Semi-Permeable Penny-Shaped Crack in Three-Dimensional Piezoelectric Media显示文摘The dielectric breakdown(DB) model for a penny-shaped crack under a semipermeable boundary condition in a three-dimensional piezoelectric medium is studied.An approximate analytical solution is derived by using the boundary integral equation with extended displacement discontinuity,and the corresponding boundary element method with double iterative approaches is developed to analyze the semi-permeable crack.The effect of electric boundary conditions on crack faces is discussed on the basis of DB model.By comparing the DB model with the polarization saturation(PS) model for different piezoelectric materials,some interesting phenomena related to the electric yielding zone and local J-integral are observed. | Minghao Zhao Huayang Dang Guangtao Xu Cuiying Fan | 2016 | Acta Mechanica Solida Sinica2016，29，5： | 1 |
| 20 | Analysis and Optimization of a Five-phase Hybrid Excitation Flux Switching Machine Based on the Consistency and Complementarity Principle显示文摘In this study,the general optimal stator poles/rotor teeth(P/T)combination equation of the E-core hybrid excitation flux switching(HEFS)machines are introduced,and a new HEFS machine is proposed and optimized.Firstly,the influences of three different P/T combinations(10/18,10/19,and 10/21)on the HEFS machines are investigated with two-dimensional(2D)finite element analyses(2D-FEA).Meanwhile,the consistency and complementarity principle of the armature windings is analyzed in detail to give reasonable explanations to the simulated results.The general optimal P/T combination equation of the E-core HEFS machines is deduced mathematically to provide an effective guidance on the selection of P/T combinations.The optimal P/T combination calculated by the general equation agrees with the simulated results which confirm the correctness of the mathematical inferences.Finally,the optimizations on the proposed HEFS machine are implemented to obtain higher output torque and better flux-regulation ratio characteristics based on which the cogging torque and torque ripple are reduced significantly. | Ming Cheng Zhiyuan Xu Minghao Tong Guishu Zhao Peng Han | 2021 | Chinese Journal of Electrical Engineering2021，7，3： | 1 |
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