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| 1 | Preliminary results pertaining to coseismic displacement and preseismic strain accumulation of the Lushan M_S7.0 earthquake,as reflected by GPS surveying显示文摘This paper presents the coseismic displacement and preseismic deformation fields of the Lushan MS7.0 earthquake that occurred on April 20,2013.The results are based on GPS observations along the Longmenshan fault and within its vicinity.The coseismic displacement and preseismic GPS results indicate that in the strain release of this earthquake,the thrust rupture is dominant and the laevorotation movement is secondary.Furthermore,we infer that any possible the rupture does not reach the earth’s surface,and the seismogenic fault is most likely one fault to the east of the Guanxian-Anxian fault.Some detailed results are obtainable.(1)The southern segment of the Longmenshan fault is locked preceding the Lushan earthquake.After the Wenchuan earthquake,the strain accumulation rate in the southeast direction accelerates in the epicenter of the Lushan earthquake,and the angle between the principal compressional strain and the seismogenic fault indicates that a sinistral deformation background in the direction of the seismogenic fault precedes the Lushan earthquake.Therefore,it is evident that the Wenchuan MS8.0 earthquake accelerated the pregnancy of the Lushan earthquake.(2)The coseismic displacements reflected by GPS data are mainly located in a region that is 230 km(NW direction)×100 km(SW direction),and coseismic displacements larger than 10 mm lie predominantly in a100-km region(NW direction).(3)On a large scale,the coseismic displacement shows thrust characteristics,but the associated values are remarkably small in the near field(within 70 km)of the earthquake fault.Meanwhile,the thrust movement in this70-km region does not correspond with the attenuation characteristics of the strain release,indicating that the rupture of this earthquake does not reach the earth’s surface.(4)The laevorotation movements are remarkable in the 50-km region,which is located in the hanging wall that is close to the earthquake fault,and the corresponding values in this case correlate with the attenuation characteristics of the strain release. | WU YanQiang JIANG ZaiSen WANG Min CHE Shi LIAO Hua LI Qiang LI Peng YANG YongLin XIANG HePing SHAO ZhiGang WANG WuXing WEI WenXin LIU XiaoXia | 2013 | Chinese Science Bulletin2013，58，28： | 33 |
| 2 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 3 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 4 | Preseismic deformation in the seismogenic zone of the Lushan MS7.0 earthquake detected by GPS observations显示文摘A continuous GPS array across the southern segment of the Longmenshan fault zone recorded the deformation during the process of the Lushan MS7.0 earthquake that occurred on April 20, 2013. Such data can provide meaningful information regarding the dynamic evolution of crustal deformation in the seismogenic zone. Our studies have shown that the occurrence of the Wenchuan earthquake led to the loading of compressive and sinistral shearing strain on the southern segment of the Maoxian-Wenchuan fault, whereby the extrusion strain accumulated at a greater rate than before the Wenchuan earthquake. The strain time series in the seismogenic zone revealed that the principal compression strain rates decreased from west to east in the direction of N30°–45°W. Furthermore, the area to the east of Beichuan-Yingxiu fault behaved as a zone of compressive deformation with obvious sinistral shearing deformation. The surface strain and the first shearing strain time series decreased with time, while the area to the west of the Beichuan-Yingxiu fault behaved as a zone of dextral shear deformation that increased with time. Furthermore, the regional deformation field before the Lushan earthquake showed that the rate of extrusion strain accumulation in the southern segment of the Longmenshan fault zone was obviously larger than before the Wenchuan earthquake. Moreover, the sinistral shearing strain accumulated in the area of the southern segment of the Maoxian-Wenchuan fault. Based on the above analysis, we consider that the eastward movement of the Bayan Har block increased considerably following the Wenchuan earthquake, which enhanced the accumulation of compression strain in the southern segment of the Longmenshan fault zone. | LIU XiaoXia WU YanQiang JIANG ZaiSen ZHAN Wei LI Qiang WEI WenXin ZOU ZhenYu | 2015 | Science China Earth Sciences2015，58，9： | 6 |
| 5 | A hierarchical heterostructure of CdS QDs confined on 3D ZnIn_(2)S_(4) with boosted charge transfer for photocatalytic CO_(2) reduction显示文摘Metal sulfide based materials as photocatalysts for energy conversion are essential to produce value-added chemical fuels,but their intrinsically slow carrier dynamics and low activity are yet to be resolved.Herein,we developed a unique heterogeneously nanostructured ZnIn_(2)S_(4)-CdS heterostructure that involves zero-dimensional(0D)CdS quantum dots uniformly confined on three-dimensional(3D)ZnIn_(2)S_(4)nanoflowers,which achieves an excellent catalytic performance of CO_(2) photoconversion under visible-light irradiation.The obtained hierarchical heterostructure can significantly enhance the light harvesting,shorten the migration distance of carriers,and obviously accelerate the transport of electrons.As evidenced by the ultrafast transient absorption spectroscopy,the formed interface can effectively facilitate charge separation and transport.This work opens up a new avenue to carefully design the elaborate heterostructures for achieving optimal charge separation efficiency by lowering interfacial kinetic barriers and energy losses at the interface. | Zezhou Zhu Xiaoxia Li Yunteng Qu Fangyao Zhou Zhiyuan Wang Wenyu Wang Changming Zhao Huijuan Wang Liqiang Li Yagang Yao Qun Zhang Yuen Wu | 2021 | Nano Research2021，14，1： | 6 |
| 6 | Broadband near-infrared luminescence and energy transfer of Cr^(3+),Ce^(3+) co-doped Ca_(2)LuHf_(2)Al_(3)O_(12) phosphors显示文摘Broadband near-infrared phosphors are highly desirable for food testing.Targeted Ca_(2)LuHf_(2)Al_(3)O_(12):Cr^(3+)(CLHA:Cr^(3+)) and Ca_(2)LuHf_(2)Al_(3)O_(12):Ce^(3+),Cr^(3+)(CLHA:Ce^(3+),Cr^(^(3+))) phosphors were synthesized by the conventional high-temperature solid state reaction.The CLHA:Cr^(3+)phosphor,with a good thermal stability,shows a red shift owing to radiation reabsorption and non-radiative transition with increasing Cr^(3+)content.For co-doped sample,the emission intensity of Cr^(3+)can be enhanced by three times due to the energy transfer from Ce^(3+)to Cr^(3+),which can be evidenced by a significant overlap between the PLE of Cr^(3+)single-doped phosphor and the PL of Ce^(3+)single-doped phosphor.In addition,the mechanism of energy transfer is identified as a quadrupole-quadrupole interaction according to decay Lifetime and Dexter’s energy transfer formula.The broadband NIR emission peaked at 775 nm of CLHA:Cr^(3+),Ce^(3+)phosphor shows a bright prospect in nondestructive quality-control analysis systems for food. | Jinpin Wu Weidong Zhuang Ronghui Liu Yuanhong Liu Tongyu Gao Chunpei Yan Min Cao Junhang Tian Xiaoxia Chen | 2021 | Journal of Rare Earths2021，39，3： | 6 |
| 7 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 8 | Excessive gestational weight gain in early pregnancy and insufficient gestational weight gain in middle pregnancy increased risk of gestational diabetes mellitus显示文摘Background:Gestational weight gain(GWG)is associated with the risk of gestational diabetes mellitus(GDM).However,the effect of weight gain in different trimesters on the risk of GDM is unclear.This study aimed to evaluate the effect of GWG on GDM during different trimesters.Methods:A birth cohort study was conducted from 2017 to 2020 in Shenzhen,China.In total,51,205 participants were included comprising two models(early pregnancy model and middle pregnancy model).Gestational weight(kg)was measured at each prenatal clinical visit using a standardized weight scale.Logistic regression analysis was used to assess the risk of GDM.Interaction analysis and mediation effect analysis were performed in the middle pregnancy model.Results:In the early pregnancy model,the risk of GDM was 0.858 times lower(95%confidence interval[CI]:0.786,0.937)with insufficient GWG(iGWG)and 1.201 times higher(95%CI:1.097,1.316)with excessive GWG after adjustment.In the middle pregnancy model,the risk of GDM associated with iGWG increased 1.595 times(95%CI:1.418,1.794)after adjustment;for excessive GWG,no significant difference was found(P=0.223).Interaction analysis showed no interaction between GWG in early pregnancy(GWG-E)and GWG in middle pregnancy(GWG-M)(F=1.268;P=0.280).The mediation effect analysis indicated that GWG-M plays a partial mediating role,with an effect proportion of 14.9%.Conclusions:eGWG-E and iGWG-M are associated with an increased risk of GDM.Strict control of weight gain in early pregnancy is needed,and sufficient nutrition should be provided in middle pregnancy. | Aiqi Yin Fuying Tian Xiaoxia Wu Yixuan Chen Kan Liu Jianing Tong Xiaonian Guan Huafan Zhang Linlin Wu Jianmin Niu | 2022 | Chinese Medical Journal2022，，9： | 5 |
| 9 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 10 | Exploration and practice of general practitioner responsibility system in an urban community of Shanghai显示文摘Objective:The Minhang district of Shanghai was selected as the subject and its public health management model was investigated.Methods:Minhang became a pilot location for the implementation of the general practitioner responsibility system(GPRS)in 2011.Since then,the management model of public health services in the district has gradually merged with the GPRS through a series of actions:the adjustment of organizations and the coordination mechanism in community public health services,the integration of basic public health services and clinic practice,the establishment of an informationized Internet service platform,comprehensive budgeting management of public health service programs,and performance assessment management of health workers.Results:By the end of 2014,the number of residents who had a contractual relationship with a general practitioner(GP)in Minhang had reached 1.4367 million and all of them had family health records.Compared with 2010,both the rate of maternal management and the rate of children management stayed at high level(≥96%),the rate of hypertension management increased(40.73%vs.28.70%),the rate of blood pressure control increased(82.13%vs.77.51%),the incidence of diabetes decreased(21.93%vs.37.85%),the rate of effective control of blood glucose for dia-betic patients increased(82.43%vs.62.77%),and the rate of child health management increased(99.79%vs.91.54%).Conclusion:The GPRS has helped to create a better community health environment.How-ever,the development of this system is limited by several factors,including the following:the shortage of GPs,most GPs do not have good public health service skills and a correct public health concept,unclear division of different services,and imperfect department coordination. | Yan Wu Yanping Zhao Xiaoxia Huang Junyan Wang Huilin Xu Hualin Su | 2015 | Family Medicine and Community Health2015，3，4： | 5 |
| 11 | Facile synthesis of Co and Ce dual-doped Ni3S2 nanosheets on Ni foam for enhanced oxygen evolution reaction显示文摘Nano Research volume 13,pages2130–2135(2020)Cite this article 376 Accesses 2 Citations Metrics details Abstract Developing efficient and stable oxygen evolution reaction(OER)electrocatalysts via doping strategy has well-documented for electrochemical water splitting.Herein,a homogeneous structure(denoted as Co/Ce-Ni3S2/NF)composed of Co and Ce dual doped Ni3S2 nanosheets on nickel foam was synthesized by a facile one-step hydrothermal method.Co and Ce dopants are distributed inside the host sulfide,thereby raising the active sites and the electrical conductivity.Besides,the CeOx nanoparticles generated by part of the Ce dopants as a cocatalyst further improve the catalytic activity by adding defective sites and enhancing the electron transfer.As a consequence,the obtained Co/Ce-Ni3S2/NF electrode exhibits better electrocatalytic activity than single Co or Ce doped Ni3S2 and pure Ni3S2,with low overpotential(286 mV)at 20 mA-cm^−2,a small Tafel slope and excellent long-term durability in strong alkaline solution.These results presented here not only offer a novel platform for designing transition metal and lanthanide dual-doped catalysts,but also supply some guidelines for constructing catalysts in other catalytic applications. | Xiaoxia Wu Tong Zhang Jiaxu Wei Pengfei Feng Xingbin Yan Yu Tang | 2020 | Nano Research2020，13，8： | 5 |
| 12 | Increased immune escape of the new SARS-CoV-2 variant of concern Omicron显示文摘On 24 November,a new detected variant B.1.1.529 of SARS-CoV-2 by South Africa was reported to WHO.After only 2 days,this variant was designated as“variant of concern”(VOC)and named as Omicron.In the past few weeks,Omicron had reported from more than 80 countries.It has been reported as the dominant SARS-CoV-2 in U.S.due to the rapid spread of Omicron.A new wave of infection driven by Omicron is in progress. | Jie Hu Pai Peng Xiaoxia Cao Kang Wu Juan Chen Kai Wang Ni Tang Ai-long Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 4 |
| 13 | Comparative study of the effects of Danhong injection with different doses on ischemic stroke: A substudy of hospital-based Danhong injection registry显示文摘OBJECTIVE: To compare the effects of Danhong injection(DHI) with different doses on ischemic stroke.METHODS: Chinese hospital registered DHI study is a perspective observational study, in which a total of 1292 patients with ischemic stroke were treated with DHI. Two different doses of DHI were used in the present study. The patients were matched by acute phase of ischemic stroke(within 2 weeks after onset), partial anterior circulation infraction, sex, age, and National Institute of Health Stroke Scale(NIHSS) score. Finally 148 patients were grouped into the 20 or 40 mL DHI group with 74 in each. The primary endpoint was the improvement of NIHSS score at 14-day after treatment.RESULTS: Of the 148 patients with ischemic stroke,the 74 in the 40 mL DHI group had clinically important improvements in the NIHSS score. The baseline and 14-day NIHSS score for the 40 mL DHI group were 6.6 ± 4.3 and 2.4 ± 2.5 respectively, versus 6.3± 5.7 and 3.6 ± 4.2, for the 20 mL DHI group(change from baseline in the 40 mL DHI group vs change from baseline in the 20 mL DHI group,-1.49points; P = 0.029). Improvements were maintained after the baseline characteristics and other drugs were controlled(P = 0.012). No adverse events were observed.CONCLUSION: Effects of DHI on partial anterior circulation infarction in patients with acute phase of ischemic stroke is dose-dependent; however, further studies with larger sample sizes are needed to validate our findings(Chinese Clinical Trial Register,Number: ChiCTR-ONC-13003230). | Du Yawei Wang Xiaoxia Zhong Liqun Wu Shengxian | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 14 | Preparation,characterization and performance of an electrospun carbon nanofiber mat applied in hexavalent chromium removal from aqueous solution显示文摘Hexavalent chromium, Cr(VI), a highly toxic oxyanion known as a carcinogen and mutagen,is an issue of concern due to its adverse impact on human health. Therefore, development of effective technologies and/or materials for Cr(VI) removal from water has been of great interest for researchers. In this study, an electrospun carbon nanofiber(CNF) mat was prepared via electrospinning polyacrylonitrile(PAN), followed by thermal pre-oxidation and carbonization. Scanning electron microscopy(SEM) observation showed that the fiber diameter of the CNF with carbonization temperature of 950°C(CNF_(950)) was about 266 nm.Potentiometric titration analysis demonstrated that the point of zero charge p H(pHpzc) of CNF_(950) was around 7.93. CNF_(950) demonstrated high adsorption capacity and fast adsorption kinetics for Cr(VI) at pH < 3. Langmuir isotherm calculations showed that the maximum adsorption capacity of Cr(VI) on CNF_(950) was 118.8 mg/g at pH 2. The adsorption isotherm of Cr(VI) on CNF_(950) was well described by the Redlich–Peterson model, revealing that Cr(VI)adsorption was the result of a combination of monolayer and multilayer adsorption,depending on the initial Cr(VI) concentration. Solution pH greatly affected Cr(VI) adsorption onto CNF_(950) due to the electrostatic interaction, and the adsorption capacity was relatively high when pH was below 3. X-ray photoelectron spectroscopy(XPS) analysis revealed that the removal of Cr(VI) might be the result of a combination of redox reaction and electrostatic adsorption. The adsorption-saturated CNF_(950) could be regenerated by NaOH solution. This study extends the potential applicability of electrospun CNF mats for Cr(VI)-contaminated water purification. | Zhihua Yuan Xiaoxia Cheng Lubin Zhong Renxiang Wu Yuming Zheng | 2019 | Journal of Environmental Sciences2019，31，3： | 4 |
| 15 | Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean显示文摘There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. | Ying Zhao Pan Cao Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo Zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin Zhanguo Zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen | 2021 | Journal of Integrative Plant Biology2021，63，6： | 4 |
| 16 | Copper-copper iodide hybrid nanostructure as hole transport material for efficient and stable inverted perovskite solar cells显示文摘A CuI coated Cu hybrid nanostructure by partial iodation of Cu nanowires was used as hole transport material(HTM) to enhance the charge transfer in inverted perovskite solar cells(PSCs). The outer CuI achieved efficient charge extraction, and the inner copper facilitated the extracted charges to be rapidly transferred, further improving the overall cell performance. Furthermore,we employed a mixture of [6,6]-phenyl-C71-butyric acid methyl ester(PCBM) and ZnO nanoparticles as electron transport material(ETM) to achieve the fabrication of stable PSCs. The best efficiency was up to 18.8%. This work represents a fundamental clue for the design of efficient and stable PSCs using the chemical in-situ construction strategy for HTM and integration of PCBM and ZnO as ETM. | Jing Cao Binghui Wu Jian Peng Xiaoxia Feng Congping Li Yu Tang | 2019 | Science China Chemistry2019，62，3： | 4 |
| 17 | Molecular evolution and genetic diversity analysis of SFTS virus based on next-generation sequencing显示文摘SFTS virus(SFTSV)is a novel bunyavirus,which was discovered as the etiological agent of severe fever with thrombocytopenia syndrome(SFTS)in China in 2009,and was now prevalent in at least 25 provinces in China.SFTS was subsequently identified in South Korea and Japan in 2012.To explore themolecular evolution and genetic characteristics of this newly identified pathogen,we reported 72 whole genome sequences of SFTSV,and built a dataset of SFTSV genome sequences containing 292 L-segment,302 M-segment and 502 S-segment.We clearly divided SFTSV into six genotypes,Genotype A-F.It was found that genotype F was the dominant epidemic genotype of Japan,South Korea,and Zhejiang province of China.The coalescent analysis supported that SFTSV originated in the early 18th century from Zhejiang province,and Genotype F was the most primitive one.Henan,Hubei,and Anhui provinces which are located in Dabie Mountain area weremainly epidemic of Genotype A,which emerged relatively late but distributed widely.A total of 37 recombination events were identified,making SFTSV with a high recombination frequency(L segment 5.1%,Msegment 3.6%,S segment 0.8%)among negative-strand segmented RNA viruses.It was identified that 19 reassortant strains belonged to 12 reassortment forms of SFTSV genome containing 6 newly identified forms.The reassortment virus and recombination in tick were both found for the first time.We also found many of genotype-specific mutation sites,7 of which could be considered as potential molecular marker for genotype classification.This study promoted a more comprehensive understanding of the phylogeny and origin,and the genetic diversity of SFTSV,and it could help the studies of other newly discovered tick-borne bunyavirus as reference data and research ideas. | Aqian Li Lin Liu Wei Wu Yang Liu Xiaoxia Huang Chuan Li Di Liu Jiandong Li Shiwen Wang Dexin Li Mifang Liang | 2021 | Biosafety and Health2021，3，2： | 4 |
| 18 | Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair显示文摘The repair of infective bone defects is a great challenge in clinical work.It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration.A porous mineralized collagen(MC)scaffold containing poly(D,L-lactide-co-glycolic acid)(PLGA)microspheres loaded with two antibacterial synthetic peptides,Pac-525 or KSL-W was developed and characterized via scanning electron microscopy(SEM),porosity measurement,swelling and mechanical tests.The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties.Through toxicity analysis,cell morphology and proliferation analysis and alkaline phosphatase evaluation,the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity.The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term.Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities,thus providing a great promise for the treatment of infective bone defects. | Yuzhu He Yahui Jin Xiaoxia Ying Qiong Wu Shenglian Yao Yuanyuan Li Huiying Liu Guowu Ma Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，5： | 3 |
| 19 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 20 | Rapid,visual,and equipment-free point-of-care testing for Staphylococcus aureus by direct recombinase polymerase amplification with SYBR GreenΙ显示文摘Food-borne diseases mainly caused by bacterial pathogens and the safety of genetically modified(GM)food have become global concerns[1].As a leading bacterial pathogen,Staphylococcus aureus can not only cause a variety of diseases[2]but also contaminate different kinds of animal food products[3].In addition,GM foods whose impact on human health and the natural environment is still a matter of controversy have gradually entered the commercial markets[4].Therefore,many countries have decided to implement labeling regulations for authorized genetically modified organisms(GMOs)to protect the consumers’right to know[5].Hence,it is critical to develop a rapid,simple,equipment-free,and on-site testing method to detect the GM contents in food samples and pathogen to ensure food safety. | Xiaorui Fan Fangti Han Binan Zhao Yan Xu Xiao Zhao Xinyi Pu Yanan Du Qi Zhang Xiaoxia Zhang Wanjing Zhang Wenjing Wu Zhiwei Chen Kai Zhao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 3 |
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