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| 1 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 2 | Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy显示文摘OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC7901/ADR to cisplatin[diamminedichloroplatinum(Ⅱ),DDP]and adriamycin(ADR)in vitro.METHODS:SGC7901,SGC7901/DDP,and SGC7901/ADR were treated with various concentrations of PTL alone or in combination with DDP or ADR.The effects on cell proliferation,apoptosis,and expression/activity of several proliferation/apoptosis-related proteins[B-cell lymphoma-2(Bcl-2),cyclin D1,nuclear factor-kappa B(NF-κB),and Caspase-8]and drug transporters(P-glycoprotein and multidrug resistance protein-1)were measured using flow cytometry,Western blotting,and in vitro activity assays.RESULTS:Treatment of SGC7901 cells with PTL inhibited cell growth,increased apoptosis,and sensitized the cells to DPP.Mechanistically,PTL treatment resulted in downregulation of NF-κB activity and Bcl-2 expression,and upregulation of Caspase-8 activity.Similarly,PTL co-treatment of SGC7901/DDP and SGC7901/ADR overcame their resistance to DDP and ADR,respectively,with concomitant inhibition of NF-κB,Bcl-2,Cyclin D1,P-glycoprotein,and multidrug resistance protein-1 expression and/or activity.CONCLUSION:PTL treatment decreases drug resistance in SGC7901,SGC7901/DDP,and SGC7901/ADR cells,as reflected by induction of apoptosis,inhibition of proliferation,downregulation of pro-survival and drug resistance pathways,and upregulation of pro-apoptotic pathways.Our results suggest that co-treatment with PTL may thus complement existing therapies for gastric cancer. | Liu Minghua Yang Ying Liu Dajun Cao Ye Li Yan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 3 | A New Positioning Method for Location-Based Services in Wireless LANs显示文摘 | ZHANG Minghua ZHANG Shensheng CAO Jian | 2008 | Chinese Journal of Electronics2008，17，1： | 4 |
| 4 | Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation显示文摘The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte containing calcium and phosphate,a hydrothermal treatment enabled secondary microporous hydroxyapatite(HA)coating,and a further bone morphogenetic protein-2(BMP-2)loading treatment through immersion and freeze-drying.The treatment led to an orderly secondary microporous coating containing HA nano-particles and evenly distributed BMP-2 in the porous coatings.As a result,osteoblasts could adhere and grow well on the coatings with a high cell adhesion rate and cell functional activity.The in-situ shear testing indicated that the interfacial strength had been enhanced significantly.Improvement of the bond formation and osseointegration with the titanium implant is attributed to increased surface area for the cell to attach,creating voids for the cell to grow in,and activating titanium surface by introducing bioactive ingredients such as HA and BMP-2. | Sen Yu Zhe Yu Dagang Guo Hui Zhu Minghua Zhang Jianye Han Zhentao Yu Yemin Cao Gui Wang | 2022 | Journal of Materials Science & Technology2022，，5： | 3 |
| 5 | The Application of Fuzzy Mathematic in Fabrics Feel Valuation显示文摘This paper not only introduce fuzzy mathematic method into the evaluation of fabrics’ style and put forward a new comprehensive fuzzy method on the fabric’s evaluate, but also develop a set of software to set automatic valuation of fabric’s style, “the intelligent system evaluation of fabric”. The system quoted the expert system principle. | Wu Zanmin Tianjin Polytechnic University, China Tianjin, 300160 Cao Minghua China Textile Science Academe,University, China Beijing, 100025 | 2006 | China Textile2006，，4： | 2 |
| 6 | Immune Recognition Method Based on Analogy Reasoning in Intrusion Detection System显示文摘In this paper, we propose an analogy based immune recognition method that focuses on the implement of the clone selection process and the negative selection process by means of analogy similarity. This method is applied in an IDS(Intrusion Detection System) following several steps. Firstly, the initial abnormal behaviours sample set is optimized through the combining of the AIS(Artificial Immune System) and the genetic algorithm. Then, the abnormity probability algorithm is raised considering the two sides of abnormality and normality. Finally, an intrusion detection system model is established based on the above algorithms and models. | ZHANG Changyou CAO Yuanda YANG Minghua YU Jiong ZHU Dongfeng | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 1 |
| 7 | Overexpression of oxidored-nitro domain containing protein 1 inhibitshuman nasopharyngeal carcinoma and cervical cancer cell proliferation and inducesapoptosis: Involvement of mitochondrial apoptotic pathways显示文摘 | Jue Ouyang Minghua Wu Chen Huang Li Cao Guiyuan Li | 2013 | Oncology Reports2013，，1： | 1 |
| 8 | Carbon materials for metal-ion batteries显示文摘Metal-ion(Li-,Na-,Zn-,K-,Mg-,and Al-ion)batteries(MIBs)play an important role in realizing the goals of“emission peak and carbon neutralization”because of their green production techniques,lower pollution,high voltage,and large energy density.Carbon-based materials are indispensable for developing MIBs and are widely adopted as active or auxiliary materials in the anodes and cathodes.For example,carbon-based materials,includ-ing graphite,Si/C and hard carbon,have been used as anode materials for Li-and Na-ion batteries.Carbon can also be used as a conductive coating for cathodes,such as in LiFePO 4/C,to achieve better performance.In addition,as new high-valence MIBs(Zn-,Al-,and Mg-ion)have emerged,a growing number of novel carbon-based mate-rials have been utilized to construct high-performance MIBs.Herein,we discuss the recent development trends in advanced carbon-based materials for MIBs.The impact of the structure properties of advanced carbon-based materials on energy storage is addressed,and a perspective on their development is also proposed. | Zhong Qiu Feng Cao Guoxiang Pan Chen Li Minghua Chen Yongqi Zhang Xinping He Yang Xia Xinhui Xia Wenkui Zhang | 2023 | ChemPhysMater2023，2，4： | 0 |
| 9 | Optical Space Time Pulse Position Modulation over Exponential Weibull Turbulence Channel显示文摘An optical space time pulse position modulation(OSTPPM)scheme is proposed to satisfy the communication requirement of high transmission rate and better reliability.For the OSTPPM scheme,an improved threshold judgment-based orthogonal matching pursuit(IT-OMP)algorithm with low-complexity and near optimal performance is proposed.The average bit error rate of OSTPPM-IT-OMP scheme is investigated over the exponential Weibull channel,and its analytical expression is verified via Monte Carlo simulation.With the same simulation parameters,the signal to noise ratio of(4,4,2)-OSTPPM-IT-OMP is respectively 3.75 dB and 8.5 dB better than that of spatial pulse position modulation(SPPM)scheme and generalized spatial pulse position modulation(GSPPM)scheme at a bit error rate of 1×10^(−3).With the same transmission bits per symbol,the computational complexity of(3,4,2)-OSTPPM-IT-OMP scheme is reduced by 90.47%and 75.4%compared with(16,4,2)-SPPM and(5,4,2)-GSPPM schemes,respectively. | Yue ZHANG Huiqin WANG Xuemei MA Minghua CAO Qingbin PENQ | 2024 | Chinese Journal of Electronics2024，33，2： | 0 |
| 10 | PI3K/Akt/mTOR Signaling as Targets for Developing Anticancer Agents from Marine Organisms显示文摘The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in cancer.Targeting the PI3K-mediated pathway has been an important strategy for developing novel anticancer agents.In the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical stages.Temsirolimus,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the treatment.Novel compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly required.Over the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine organisms.In the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were reviewed.The molecular entities and their modes of action were presented.The marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted. | GUO Mingyue ZUO Ling QIAO Gan LIU Minghua CAO Shousong LIN Xiukun | 2021 | Journal of Ocean University of China2021，20，3： | 0 |
| 11 | Pt_(1)/Ni_(6)Co_(1)layered double hydroxides/N-doped graphene for electrochemical non-enzymatic glucose sensing by synergistic enhancement of single atoms and doping显示文摘The development of novel single-atom catalysts is important for highly efficient electrochemical catalysis and sensing.In this work,a novel Pt single atoms(SAs)supported on Ni_(6)Co_(1)layered double hydroxides/nitrogen-doped graphene(Pt_(1)/Ni_(6)Co_(1)LDHs/NG)was constructed for electrochemical enzyme-free catalysis and sensing towards glucose.The loading of Pt single atoms increases with doping of Co atoms that generate more anchoring sites for Pt SAs.The resulting Pt_(1)/Ni_(6)Co_(1)LDHs/NG exhibits low oxidative potential of 0.440 V with high sensitivity of 273.78μA·mM^(−1)·cm^(−2)toward glucose,which are 85 mV lower and 15 times higher than those of Ni(OH)_(2),respectively.Pt_(1)/Ni_(6)Co_(1)LDHs/NG also shows excellent selectivity and great stability during 5-week testing.Theoretical and experimental results show that the boosted performance of Pt_(1)/Ni_(6)Co_(1)LDHs/NG originates from its stronger binding energy with glucose and the synergistic effect of Pt SAs,Co doping,and NG.This work provides a general strategy of designing highly active SACs for extending their application in electrochemical sensing. | Baojun Long Peiyu Cao Yuanmeng Zhao Qianqian Fu Yan Mo Yueming Zhai Juejing Liu Xingyi Lyu Tao Li Xiaofeng Guo Changsheng Shan Minghua Zeng | 2023 | Nano Research2023，16，1： | 0 |
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