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| 1 | Multiple forms of vitamin B_(6) regulate salt tolerance by balancing ROS and abscisic acid levels in maize root显示文摘Salt stress causes osmotic stress,ion toxicity and oxidative stress,inducing the accumulation of abscisic acid(ABA)and excessive reactive oxygen species(ROS)production,which further damage cell structure and inhibit the development of roots in plants.Previous study showed that vitamin B_(6)(VB_(6))plays a role in plant responses to salt stress,however,the regulatory relationship between ROS,VB_(6) and ABA under salt stress remains unclear yet in plants.In our study,we found that salt stress-induced ABA accumulation requires ROS production,in addition,salt stress also promoted VB_(6)(including pyridoxamine(PM),pyridoxal(PL),pyridoxine(PN),and pyridoxal 5′-phosphate(PLP))accumulation,which involved in ROS scavenging and ABA biosynthesis.Furthermore,VB_(6)-deficient maize mutant small kernel2(smk2)heterozygous is more susceptible to salt stress,and which failed to scavenge excessive ROS effectively or induce ABA accumulation in maize root under salt stress,interestingly,which can be restored by exogenous PN and PLP,respec-tively.According to these results,we proposed that PN and PLP play an essential role in balancing ROS and ABA levels under salt stress,respectively,it laid a foundation for VB_(6) to be better applied in crop salt resistance than ABA. | Chongchong Lu Yuan Tian Xuanxuan Hou Xin Hou Zichang Jia Min Li Mingxia Hao Yanke Jiang Qingbin Wang Qiong Pu Ziyi Yin Yang Li Baoyou Liu Xiaojing Kang Guangyi Zhang Xinhua Ding Yinggao Liu | 2022 | Stress Biology2022，2，1： | 1 |
| 2 | Anchoring Group Effects of Surface Ligands on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents显示文摘 | Jianfeng Zeng Lihong Jing Yi Hou Mingxia Jiao Ruirui Qiao Qiaojuan Jia Chunyan Liu Fang Fang Hao Lei Mingyuan Gao | 2014 | Adv. Mater2014，，17： | 1 |
| 3 | In situ growth CNT@MOFs core-shell structures enabling high specific supercapacitances in neutral aqueous electrolyte显示文摘Conductive metal-organic frameworks(c-MOFs)are promising active electrode materials for electrochemical double-layer capacitors with a performance that already exceeds most carbon-based materials.However,their excellent supercapacitance is primarily based on organic or alkaline electrolytes,which largely impede their broad applications and sustainabilities.In this work,we propose a new synthesis approach for fabricating carbon nanotubes and c-MOFs(CNT@MOFs)core–shell structures,which result in high supercapacitance in neutral aqueous electrolytes.We identify that CNTs provide abundant active sites to ensure high capacitance,and Ni3(2,3,6,7,10,11-hexaiminotriphenylene(HITP))2 nanoarrays that in situ grow on the surface of CNTs bundles can significantly improve the conductivity and provide enough ion transport pathways in aqueous electrolytes.Specifically,using CNT@MOFs core-shell structures as an electrode,we obtained a high initial capacitance of 150.7 F·g^(−1) at 0.1 A·g^(−1) in 1 M Na2SO4 solution and good capacity retention of 83.5%after 10,000 cycles at 4 A·g^(−1).We also found that the carboxyl groups on the surface of CNTs provide better anchor sites for the in situ growth of c-MOF,which promotes the uniform growth of c-MOF shells on the CNT surface and improves aqueous electrolyte accessibility.We believe that the high supercapacitance in aqueous electrolytes reported in this work would provide a good prospect for deploying c-MOF based energy storage devices into biomedical and other healthcare electronic applications. | Mingxia Lu Gang Wang Xiping Yang Bo Hou | 2022 | Nano Research2022，15，7： | 0 |
| 4 | MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis显示文摘The mesencephalic astrocyte-derived neurotrophic factor(MANF)has been recently identified as a neurotrophic factor,but its role in hepatic fibrosis is unknown.Here,we found that MANF was upregulated in the fibrotic liver tissues of the patients with chronic liver diseases and of mice treated with CCl4.MANF deficiency in either hepatocytes or hepatic mono-macrophages,particularly in hepatic mono-macrophages,clearly exacerbated hepatic fibrosis.Myeloid-specific MANF knockout increased the population of hepatic Ly6C^(high)macrophages and promoted HSCs activation.Furthermore,MANF-sufficient macrophages(from WT mice)transfusion ameliorated CCl4-induced hepatic fibrosis in myeloid cells-specific MANF knockout(MKO)mice.Mechanistically,MANF interacted with S100A8 to competitively block S100A8/A9 heterodimer formation and inhibited S100A8/A9-mediated TLR4-NF-κB signal activation.Pharmacologically,systemic administration of recombinant human MANF significantly alleviated CCl_(4)-induced hepatic fibrosis in both WT and hepatocytes-specific MANF knockout(HKO)mice.This study reveals a mechanism by which MANF targets S100A8/A9-TLR4 as a“brake”on the upstream of NF-κB pathway,which exerts an impact on macrophage differentiation and shed light on hepatic fibrosis treatment. | Chao Hou Dong Wang Mingxia Zhao Petek Ballar Xinru Zhang Qiong Mei Wei Wang Xiang Li Qiang Sheng Jun Liu Chuansheng Wei Yujun Shen Yi Yang Peng Wang Juntang Shao Sa Xu Fuyan Wang Yang Sun Yuxian Shen | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 5 | Adsorption of trichlorphon on phyllosilicate minerals:Effect of low-molecular-weight organic acids显示文摘The use of trichlorphon in large quantities causes a large number of organic pollutants to enter water, sediments, and soils. Phyllosilicate minerals are considered effective adsorbents for organic pollutants. However, the adsorption behavior of organic pollutants on soil minerals affected by low-molecular-weight organic acids(LMWOAs) is not fully understood. In this study, the effect of LMWOAs on the adsorption behavior of trichlorphon on phyllosilicate minerals was investigated using a combination of adsorption measurements and molecular spectroscopic techniques(attenuated total reflection-Fourier transform infrared spectroscopy(ATR-FTIR) and X-ray photoelectron spectroscopy(XPS)). The adsorption of trichlorphon onto kaolinite(KAO) and montmorillonite(MON) was suppressed by increasing pH, indicating that electrostatic interaction played a key role in adsorption, especially at low pH. In the presence of citric acid(CA), there was an obvious promotion of trichlorphon adsorption on KAO and MON. In the presence of oxalic acid(OA), the adsorption of trichlorphon on KAO was promoted, whereas the adsorption on MON was inhibited, especially at pH 4.0. The presence of CA and OA increased the adsorption by increasing the exposure of hydrophobic sites of KAO and MON. The results from ATR-FTIR and XPS also indicated that the hydrophobic Si–O sites of phyllosilicate minerals were the preferred adsorption sites for trichlorphon in the presence of CA and OA, probably driven by the hydrophobic effect. However, the weak effect of OA on MON caused an increase in the electrostatic repulsion between MON and trichlorphon molecules, thus inhibiting adsorption. This study is significant for a deeper understanding of self-purification of soil and sediment systems in the presence of organic pollutants. | Hongfeng CHEN Zhouyang HE Mingxia HOU Cilai TANG Yonghong WU | 2024 | Pedosphere2024，34，1： | 0 |
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