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| 1 | Organ-specific efficacy in advanced non-small cell lung cancer patients treated with first-line single-agent immune checkpoint inhibitors显示文摘Background:Response to immune checkpoint inhibitors(ICIs)is affected by multiple factors.This study aimed to explore whether sites of metastasis are associated with clinical outcomes of ICIs in advanced non-small-cell lung cancer(NSCLC)patients.Methods::The data of NSCLC patients with high programmed death-ligand 1 expression and good performance status receiving first-line ICIs monotherapy from Guangdong Provincial People’s Hospital between May 2019 and July 2020 were retrospectively analyzed.Metastatic sites included liver,bone,brain,adrenal gland,pleura,and contralateral lung.Progression-free survival(PFS)and overall survival(OS)were compared between different metastatic sites and metastatic burden by the Kaplan-Meier method.Organ-specific disease control rate(OSDCR)of different individual metastatic sites was evaluated.Results:Forty NSCLC patients meeting the criteria were identified.The presence of liver metastasis was significantly associated with shorter PFS(3.1 vs.15.5 months,P=0.0005)and OS(11.1 months vs.not reached,P=0.0016).Besides,patients with bone metastasis tend to get shorter PFS(4.2 vs.15.5 months,P=0.0532)rather than OS(P=0.6086).Moreover,the application of local treatment could numerically prolong PFS in patients with brain metastasis(15.5 vs.4.3 months,P=0.1894).More metastatic organs involved were associated with inferior PFS(P=0.0052)but not OS(P=0.0791).The presence of liver metastasis or bone metastasis was associated with more metastatic organs(Phi[φ]:0.516,P=0.001).The highest OSDCR was observed in lung(15/17),and the lowest in the liver(1/4).Conclusions:Metastases in different anatomical locations may be associated with different clinical outcomes and local tumor response to ICIs in NSCLC.ICIs monotherapy shows limited efficacy in patients with liver and bone metastasis,thus patients with this type of metastasis might require more aggressive combination strategies. | Jiayi Deng Ming Gao Qing Gou Chongrui Xu Honghong Yan Mingyi Yang Jiakang Li Xiaorong Yang Xuewu Wei Qing Zhou | 2022 | Chinese Medical Journal2022，，12： | 2 |
| 2 | Effect of forging temperature on the microstructures and mechanical properties of the SiC_p/AZ91 magnesium matrix composite显示文摘In this paper,10 vol.pct SiCp/AZ91 magnesium matrix composite was fabricated by stir casting technology.The ingots were forged at temperatures of 320,370 and 420℃,respectively.XRD,OM and SEM were used to characterize microstructure of the composites.It was shown that the clusters of particles in the as-cast composite were largely eliminated,and that the tensile strength was improved obviously. | Kun WU Kunkun DENG Hai CHANG Yewei WU Xiaoshi HU Mingyi ZHENG | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，2： | 1 |
| 3 | Grassland rehabilitation and social development in the low mountain area of the Jinsha river valley, China显示文摘 | Fen Mingyi Yang Zhong Deng Yulin | 2003 | Mountain Research and Development2003，23，2： | 1 |
| 4 | Identification of a major antibody binding epitope in the non-structural protein 3D of foot-and-mouth disease virus in cattle and the development of a monoclonal antibody with diagnostic applications显示文摘 | Ming Yang Alfonso Clavijo Mingyi Li Kate Hole Hilary Holland He Wang Ming Y. Deng | 2007 | Journal of Immunological Methods2007，，1： | 1 |
| 5 | Comparative study on the inhibiting mechanism of inhibitor with primary amine groups and quaternary ammonium groups for sodium bentonite显示文摘Shale hydration and swelling is the main obstacle to the development of shale gas utilizing water-based drilling fluids(WBDFs).In this work,the inhibition mechanism of alkylammonium inhibitor and alkylamine inhibitor adsorbed on sodium bentonite(NaþBent)are investigated using infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),X-ray diffraction(XRD),zeta potential,particle size distribution tests,and thermogravimetry analysis(TGA).The results suggest that HTB and HMD can be inserted into the interlamination of NaþBent and minimize the basal spacing compared to hydrated NaþBent.HTB and HMD are inserted between the NaþBent layers in a single-layer tiled manner and replace the sodium ions that are firmly fixed between the layers.Eventually,water molecules are removed from the interlayer NaþBent.The interaction between the quaternary ammonium group and NaþBent is more significant than between the primary amine group and NaþBent.The inhibition performance suggests that HTB inhibits NaþBent hydration and swelling more substantially than other inhibitors,indicating that the inhibition performance of the two quaternary ammonium groups is greater than that of the two primary amine groups.Therefore,HTB can be used as intercalation inhibition in WBDFs and has tremendous application value. | Gang Xie Yujing Luo Chenglong Wang Mingyi Deng Yang Bai | 2023 | Petroleum2023，9，4： | 0 |
| 6 | Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing显示文摘Damaged skin cannot prevent harmful bacteria from invading tissues,causing infected wounds or even severe tissue damage.In this study,we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate(Cu-EGCG)nano-capsules.The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).It could also promote the proliferation and migration of L929 fibroblasts.In vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect.Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group.The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing. | Nanbo Liu Shuoji Zhu Yuzhi Deng Ming Xie Mingyi Zhao Tucheng Sun Changjiang Yu Ying Zhong Rui Guo Keluo Cheng Dehua Chang Ping Zhu | 2023 | Bioactive Materials2023，，6： | 0 |
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