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| 1 | Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration显示文摘Cardiovascular disease is still one of the leading causes of death in the world,and heart transplantation is the current major treatment for end-stage cardiovascular diseases.However,because of the shortage of heart donors,new sources of cardiac regenerative medicine are greatly needed.The prominent development of tissue engineering using bioactive materials has creatively laid a direct promising foundation.Whereas,how to precisely pattern a cardiac structure with complete biological function still requires technological breakthroughs.Recently,the emerging three-dimensional(3D)bioprinting technology for tissue engineering has shown great advantages in generating micro-scale cardiac tissues,which has established its impressive potential as a novel foundation for cardiovascular regeneration.Whether 3D bioprinted hearts can replace traditional heart transplantation as a novel strategy for treating cardiovascular diseases in the future is a frontier issue.In this review article,we emphasize the current knowledge and future perspectives regarding available bioinks,bioprinting strategies and the latest outcome progress in cardiac 3D bioprinting to move this promising medical approach towards potential clinical implementation. | Nanbo Liu Xing Ye Bin Yao Mingyi Zhao Peng Wu Guihuan Liu Donglin Zhuang Haodong Jiang Xiaowei Chen Yinru He Sha Huang Ping Zhu | 2021 | Bioactive Materials2021，6，5： | 4 |
| 2 | Parentage assignment and parental contribution analysis in large yellow croaker Larimichthys crocea using microsatellite markers显示文摘 | Xiande LIU Guangtai ZHAO Zhiyong WANG Mingyi CAI Hua YE Qiurong WANG | 2012 | Current Zoology2012，58，2： | 4 |
| 3 | Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment显示文摘Umbilical cord mesenchymal stem cells(UCMSCs)transplantation has been proposed as a promising treatment modality for myocardial infarction(MI),but the low retention rate remains a considerable challenge.Injectable natural polymer hydrogels with conductivity ability are highly desirable as cell delivery vehicles to repair infarct myocardium and restore the cardiac function.In this work,we developed a hydrogel system based on gelatin methacrylate(GelMA)and oxidized dextran(ODEX)as cell delivery vehicles for MI.And dopamine could be used as a reductant of graphene oxide(GO)to form reductive GO(rGO).By adjusting the amount of rGO,the conductivity of hydrogels with 0.5 mg/mL rGO concentration(≈10^(-4)S/cm)was similar to that of natural heart tissue.In vitro cell experiments showed that the prepared hydrogels had excellent biocompatibility and cell delivery ability of UCMSCs.More importantly,GelMA-O5/rGO hydrogel could promote UCMSCs growth and proliferation,improve the myocardial differentiation ability of UCMSCs,and up-regulate the expression of cTnI and Cx43.Further in vivo experiments demonstrated that GelMA-O5/rGO/UCMSCs Hydrogel could significantly improve the ejection fraction(EF)of rats and significantly reduce myocardial infarct area compared to PBS group,promote the survival of UCMSCs,enhance the expression level of cTnI and Cx43,and decrease the expression level of caspase-3.The findings of this study suggested that the injectable conductive GelMA-O5/rGO hydrogel encapsulating UCMSCs could improve damaged myocardial tissue and reconstruct myocardial function,which will be a promising therapeutic strategy for cardiac repair. | Shuoji Zhu Changjiang Yu Nanbo Liu Mingyi Zhao Zerui Chen Jian Liu Ge Li Huanlei Huang Huiming Guo Tucheng Sun Jimei Chen Jian Zhuang Ping Zhu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 4 | A phase field study for influence of elastic energy on L1_0→L1_2 transient ordering in Ni_(75)Al_(17)Zn_8显示文摘The influence of the elastic energy on L10→L12 transient ordering transformation was investigated by microscopic phase field method. It is found that there are three stages experienced in atomic ordering: solute clustering+L10 short range ordering → L10 long range ordering → L12 long range ordering. Before the formation of the high ordered L12 phase, it has firstly taken place the transformation from matrix to L10 phase, and then held the L10→L12 secondary transformation. Elastic energy is proved to take little effect on the stage of short range ordering, but as the elastic energy is multiplied, it obviously shortened the course of the solute clustering, and speeded up the proceeding of the L10 long range ordering transition. Accordingly, the increased elastic energy also strengthens the single crystalline directionality of L10 phase projecting on 2D plane and makes the ordered degree of Al and Zn atoms enhanced. With the temperature elevation, Al's and Zn's ordered degree decreased in L10 phase. | ZHAO Yan CHEN Zheng WANG YongXin ZHANG MingYi ZHANG Jing | 2010 | Chinese Science Bulletin2010，55，26： | 2 |
| 5 | Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas显示文摘 | Mingyi Wu Rong Huang Dandan Wen Na Gao Jiangbo He Zi Li Jinhua Zhao | 2011 | Carbohydrate Polymers2011，，1： | 2 |
| 6 | Physical simulation of fluid flow and production performance in extra-low permeability porous media显示文摘For extra-low permeability reservoirs,with a permeability of about 0.3×10-3 μm2,fluid flow and production performance in cores were studied.A long core holder with a multi-location piezometric measurement was specially designed.An artificial long core,about 700 mm long and with a cross section of 45mm×45mm,was used.In the experiment,pressure distribution along the core can be measured in real time.Single phase flow in the core was investigated.Different modes of production in long cores were also simulated including natural depletion,water flooding,and advanced water flooding.Through physical simulation,flow parameters were collected and production characteristics in extra-low permeability cores were studied.From experimental results,it can be seen that fluid flow in extra-low permeability cores is different from that in high permeability cores.Transmission of pressure in extra-low permeability cores is very slow,and it needs a long time for the pressure to become stable.The distribution curve of pressure along the core is nonlinear and the production rate in extra-low permeability reservoirs decreases sharply.The development effects of different production modes in extra-low permeability cores were compared with one another.Among the production modes,advanced water flooding has much potential for effective development of extra-low permeability reservoirs.Natural depletion and conventional water flooding can also be used in early production periods.In addition,the countermeasures and some ideas especially for the potential development of extra-low permeability reservoirs are suggested. | You Yuan Yue Xiang’an Li Mingyi Zhao Chunpeng Zhang Tao | 2009 | Petroleum Science2009，6，4： | 2 |
| 7 | MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)显示文摘 | Xuyang Jiao Lin Zhao Mengtao Ma Xuefeng Bai Miao He Yuanyuan Yan Yan Wang Qiuchen Chen Xinnan Zhao Mingyi Zhou Zeshi Cui Zhihong Zheng Enhua Wang Minjie Wei | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 8 | Physieoehemieal eharaeteristies and anticoagulant activities of low molecular, weight fractions by free-radical depolymerization of a fueosylated ehondroitin sulphate from sea cucumber Thelenata ananas显示文摘 | IWu Mingyi Xu Shinmin Zhao Jinhua | 2010 | Food Chemistry2010，122，3： | 1 |
| 9 | Soil Nu-trient and soil enzyme activity of the slopes with differ-ent ecological protection Technologies显示文摘 | Zhao Zichao Xia Zhenyano Li Mingyi | 2012 | Advanced Ma-terials Research2012，356，： | 1 |
| 10 | Microstructures and Key Properties of Mechanically Deposited Zn-Al Coatings显示文摘Zn-Al coatings can provide protection to exposed steel parts in most environments. For this reason,the investigation of Zn-Al coatings become very popular in recent years. In order to study the microstructures and properties of mechanically deposited Zn-Al coating,zinc powders and aluminum powders were used to deposit Zn-Al coating by mechanical plating. The microstructures,phase constitutes and compositions of the coating were observed and analyzed with optical microscopy (OM),scanning electron microscopy(SEM),X-ray diffraction(XRD) and X-ray energy-dispersive spectroscopy(EDS). The results of observation show that the coating consists of almost spherically shaped zinc particles point contacting with each other; the coatings are composed of zinc particles,aluminum particles,interstice,and tin; extra fine zinc powders and some smaller interspersed inclusions are positioned in the interstices. Porosity and thickness of the coating were tested by ferroxyl test and magnetic method. The corrosion resistance of coatings was studied by neutral salt spraying test(NSS) ,immersion test and electrochemical polarization. It is found that the thickness of the coating dose lacks uniformity,with an uneven thickness distribution and an average variation of approximately 2-5μm; the coating can afford cathodic protection to the steel substrate; the corrosion resistance of Zn-Al coatings is better than that of the mechanically plated zinc coatings with same thickness. These conclusions can be applied to improve anti-corrosion performance by mechanically deposit Zn-Al coatings. | WANG Shengmin HE Mingyi ZHAO Xiaojun PENG Zenghua LIU Li | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 1 |
| 11 | Bonding Mechanism of Mechanically Deposited Coating/ Substrate显示文摘 | WANG Shengmin HE Mingyi ZHAO Xiaojun | 2013 | Physics Procedia2013，50，： | 1 |
| 12 | Kidney organoids as a promising tool in nephrology显示文摘Kidney disease has become a global public health problem affecting over 750 million people worldwide and imposing a heavy economic burden on patients.The complex architecture of the human kidney makes it very difficult to study the pathophysiology of renal diseases in vitro and to develop effective therapeutic options for patients.Even though cell lines and animal models have enriched our understanding,they fail to recapitulate key aspects of human kidney development and renal disease at cellular and functional levels.Organoids can be derived from either pluripotent stem cells or adult stem cells by strictly regulating key signalling pathways.Today,these self-differentiated organoids represent a promising technology to further understand the human kidney,one of the most complex organs,in an unprecedented way.The newly established protocols improved by organ-on-chip and coculture with immune cells will push kidney organoids towards the next generation.Herein,we focus on recent achievements in the application of kidney organoids in disease modelling,nephrotoxic testing,precision medicine,biobanking,and regenerative therapy,followed by discussions of novel strategies to improve their utility for biomedical research.The applications we discuss may help to provide new ideas in clinical fields. | Mengyuan Wu Tingting Hu Ping Zhu Moussa Ide Nasser Jie Shen Fang Sun Qingnan He Mingyi Zhao | 2022 | Genes & Diseases2022，9，3： | 1 |
| 13 | An animal model of buccal mucosa cancer and cervical lymph node metastasisinduced by U14 squamous cell carcinoma cells显示文摘 | Xin Zhao Liang Pang Yu Qian Qiang Wang Yong Li Mingyi Wu Zilan Ouyang Zhi Gao Lihua Qiu | 2013 | Experimental and Therapeutic Medicine2013，，4： | 1 |
| 14 | Broadband mid-infrared nonlinear optical modulator enabled by gold nanorods:towards the mid-infrared regime显示文摘Mid-infrared pulsed lasers operating around the 3 μm wavelength regime are important for a wide range of applications including sensing, spectroscopy, imaging, etc. Despite the recent advances in technology, the lack of a nonlinear optical modulator operating in the mid-infrared regime remains a significant challenge. Here, we report the third-order nonlinear optical response of gold nanorods(GNRs) ranging from 800 nm to the mid-infrared regime(2810 nm) enabled by their size and overlapping behavior-dependent longitudinal surface plasmon resonance. In addition, we demonstrate a wavelength-tunable Er3+-doped fluoride fiber laser modulated by GNRs, which can deliver pulsed laser output, with the pulse duration down to 533 ns, tunable wavelength ranging from 2760.2 to 2810.0 nm, and spectral 3 d B bandwidth of about 1 nm. The experimental results not only validate the GNRs’ robust mid-infrared nonlinear optical response, but also manifest their application potential in high-performance broadband optoelectronic devices. | BIN HUANG ZHE KANG JIE LI MINGYI LIU PINGHUA TANG LILI MIAO CHUJUN ZHAO GUANSHI QIN WEIPING QIN SHUANGCHUN WEN PARAS N.PRASAD | 2019 | Photonics Research2019，7，6： | 0 |
| 15 | Distribution of lightning spatial modes and climatic causes in China显示文摘本文利用中国气象局国家雷电监测网(CNLDN)的地闪观测数据集,分析了2010-2020年中国陆地区域地闪空间模态分布特征及其可能的气候成因.研究发现,夏季地闪第一模态的方差贡献率为32.86%,其分布从北到南呈现出“-+-”的经向跷跷板模式,当东太平洋和印度洋的海温异常增暖,西北太平洋的海温异常变冷时,在中国黄海,东海及热带西太平洋地区激发出气旋性环流,随着水汽南下至华南地区,与来自孟加拉湾的水汽汇合,上升运动在此加强,从而使得该地区的雷电活动增强.表明厄尔尼诺-南方涛动(ENSO)现象,是发生在中国陆地区域的地闪活动的气候驱动因子。 | Mingyi Xu Xiushu Qie Chenxi Zhao Shanfeng Yuan Ji Li Yuyu Tao Guangyu Shi Wenjing Pang Lijuan Shi | 2023 | Atmospheric and Oceanic Science Letters2023，16，2： | 0 |
| 16 | Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules显示文摘Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells.In vertebrates,both α-and β-tubulins have multiple isotypes encoded by different genes,which are intrinsic factors in regulating microtubule functions.However,the structures of microtubules composed of different tubulin isotypes,especially α-tubulin isotypes,remain largely unknown.Here,we purify recombinant tubulin heterodimers composed of different mouseα-tubulin isotypes,including α1A,α1C and α4A,with the β-tubulin isotype β2A.We further assemble and determine the cryo-electron microscopy(cryo-EM)structures of α1A/β2A,α1C/β2A,and α4A/β2A microtubules.Our structural analysis demonstrates that α4A/β2A microtubules exhibit longitudinal contraction between tubulin interdimers compared with α1A/β2A and α1C/β2A microtubules.Collectively,our findings reveal that α-tubulin isotype composition can tune microtubule structures,and also provide evidence for the“tubulin code”hypothesis. | Lei Diao Wei Zheng Qiaoyu Zhao Mingyi Liu Zhenglin Fu Xu Zhang Lan Bao Yao Cong | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 17 | Characterization of a new hexaploid triticale 6D(6A) substitution line with increased grain weight and decreased spikelet number显示文摘Hexaploid triticale(×Triticosecale,AABBRR)is an important forage crop and a promising energy plant.Transferring D-genome chromosomes or segments from common wheat(Triticum aestivum)into hexaploid triticale is attractive in improving its economically important traits.Here,a hexaploid triticale 6D(6A)substitution line Lin 456 derived from the cross between the octoploid triticale line H400 and the hexaploid wheat Lin 56 was identified and analyzed by genomic in situ hybridization(GISH),fluorescence in situ hybridization(FISH),and molecular markers.The GISH analysis showed that Lin 456 is a hexaploid triticalewith 14 rye(Secale cereale)chromosomes and 28 wheat chromosomes,whereas non-denaturing fluorescence in situ hybridization(ND-FISH)and molecular marker analysis revealed that it is a 6D(6A)substitution line.In contrast to previous studies,the signal of Oligo-pSc119.2 was observed at the distal end of 6DL in Lin 456.The wheat chromosome 6D was associatedwith increased grain weight and decreased spikelet number using the genotypic data combined with the phenotypes of the F2 population in the three environments.The thousand-grain weight and grain width in the substitution individuals were significantly higher than those in the non-substitution individuals in the F2 population across the three environments.We propose that the hexaploid triticale 6D(6A)substitution line Lin 456 can be a valuable and promising donor stock for genetic improvement during triticale breeding. | Zhiyu Feng Zhongqi Qi Dejie Du Mingyi Zhang Aiju Zhao Zhaorong Hu Mingming Xin Yingyin Yao Huiru Peng Qixin Sun Zhongfu Ni | 2019 | The Crop Journal2019，7，5： | 0 |
| 18 | Temporal and dimensional distribution of sulfate-reducing bacteria (SRB) groups and quantity in the sediments of Lake Erhai显示文摘 | Mingyi WANG Xiaobing LIANG Yaping ZHENG Youzhi ZHAO Zhongqing WEI | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 19 | Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing显示文摘Damaged skin cannot prevent harmful bacteria from invading tissues,causing infected wounds or even severe tissue damage.In this study,we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate(Cu-EGCG)nano-capsules.The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).It could also promote the proliferation and migration of L929 fibroblasts.In vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect.Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group.The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing. | Nanbo Liu Shuoji Zhu Yuzhi Deng Ming Xie Mingyi Zhao Tucheng Sun Changjiang Yu Ying Zhong Rui Guo Keluo Cheng Dehua Chang Ping Zhu | 2023 | Bioactive Materials2023，，6： | 0 |
| 20 | Per-unit Scheme for Integrated Solution of Hybrid Power-water Flow Problem显示文摘When applying the widely-used Newton-Raphson(N-R)method to the integrated solution of the hybrid power-water flow problem of the power-water integrated energy system(PW-IES),it is found that there are numerical differences among Jacobian elements,which may yield an ill-conditioned Jacobian matrix and even cause convergence problem.Therefore,this letter proposes to per-unitize the water distribution network(WDN)to reduce the numerical differences and thus to improve the Jacobian matrix conditioning and the integrated N-R solution to the hybrid power-water flow problem. | Xia Zhao Hong Tan Luo Wang Mingyi Sun | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，2： | 0 |
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