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| 1 | Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy显示文摘AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach cancer.Various clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression method.Furthermore,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same methods.The cumulative survival rate was calculated using the Kaplan-Meier method.The significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN metastasis.There was no case located on the lesser curvature in the Posi-tive Group.The numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN metastasis.There was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN metastasis.However,in cases where the tumor is located on the lesser curvature,splenectomy can be omitted. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki Kazuo Shirouzu | 2010 | World Journal of Hepatology2010，2，2： | 26 |
| 2 | Characteristics and prognosis of synchronous multiple early gastric cancer显示文摘AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative survival.Tumors were classified into groups on the basis of location and histology.Smoking habits were evaluated using the Brinkman index.Clinical and pathological factors were compared using either Fisher’s exact test or Pearson’sχ2test.Logistic regression analysis was performed to identify independent risk factors.Survival rate was calculated using the Kaplan-Meier method.RESULTS:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and drinkers.These tumors were typically macroscopically elevated and histologically differentiated.There were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant cancer.CONCLUSION:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases. | Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi Kazuo Shirouzu | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 3 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 4 | Tuning of band gaps for a two-dimensional piezoelectric phononic crystal with a rectangular lattice显示文摘In this paper,the elastic wave propagation in atwo-dimensional piezoelectric phononic crystal is studiedby considering the mechanic-electric coupling.The gener-alized eigenvalue equation is obtained by the relation of themechanic and electric fields as well as the Bloch-Floquet the-orem.The band structures of both the in-plane and anti-planemodes are calculated for a rectangular lattice by the plane-wave expansion method.The effects of the lattice constantratio and the piezoelectricity with different filling fractionsare analyzed.The results show that the largest gap width isnot always obtained for a square lattice.In some situations,a rectangular lattice may generate larger gaps.The band gapcharacteristics are influenced obviously by the piezoelectric-ity with the larger lattice constant ratios and the filling frac-tions. | Yize Wang Fengming Li Yuesheng Wang Kikuo Kishimoto Wenhu Huang | 2009 | Acta Mechanica Sinica2009，25，1： | 8 |
| 5 | Molecular targeting to treat gastric cancer显示文摘Trastuzumab that targets human epidermal growth factor receptor 2(HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However,trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors(VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. However,ramucirumab that targets VEGF receptor-2 prolonged overall survival in a large phase Ⅲ clinical trial and it might be an effective molecular targeting therapy for gastric cancer. The significance of molecular targeting therapy for gastric cancer remains controversial. A large-scale randomized clinical trial of novel molecular targeting agents with which to treat gastric cancer is needed. | Keishiro Aoyagi Kikuo Kouhuji Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 6 | WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS WITH INITIAL STRESS显示文摘在有起始的应力的混乱的周期的压电的杆的有弹性的波浪本地化用转移矩阵和 Lyapunov 代表方法被学习。电场作为伪静电干扰被接近。乐队差距特征上的起始的压力的效果被调查。本地化因素和本地化长度的数字计算被执行。它能从结果被观察乐队结构能被施加合适的起始的压力调节。为压电的杆长度和有弹性的常数的不同价值,乐队结构和本地化现象是很不同的。更大的混乱度能导致更多的明显的本地化现象。 | Yize Wang Fengming Li Kikuo Kishimoto Yuesheng Wang Wenhu Huang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 5 |
| 7 | WAVE PROPAGATION IN TWO-DIMENSIONAL DISORDERED PIEZOELECTRIC PHONONIC CRYSTALS显示文摘波浪繁殖用有限差别的时间域(FDTD ) 在二维的混乱压电的 phononic 晶体被学习方法。为混乱的不同的格,传播系数是计算的。乐队差距上的混乱的影响被调查。结果证明在压电的 phononic 晶体的混乱比在高频率在低频率区域在乐队差距上有更重要的影响。在乐队差距和位置混乱的方向的宽度之间的关系也被讨论。当位置混乱沿着对波浪传播垂直的方向时,压电的 phononic 晶体比沿着波浪传播方向的位置混乱的案例在低频率区域有更宽的乐队差距。乐队差距上的尺寸混乱的效果类似于地点混乱的,这能也被发现。当不安系数大时,它更多比在压电的 phononic 晶体与尺寸和地点混乱在压电的 phononic 晶体在通行证乐队上读了效果与单个混乱。在更高的频率区域,压电的效果减少传播系数。要不是更大的混乱度,压电的效果将被减少。 | Jinqiang Li Fengming Li Yuesheng Wang Kikuo Kishimoto | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 4 |
| 8 | Angiotensin II Antagonist Prevents Electrical Remodeling in Atrial Fibrillation显示文摘 | Hideko Nakashima Koichiro Kumagai Hidenori Urata Naoki Gondo Munehito Ideishi Kikuo Arakawa | 2000 | Circulation: Journal of the American Heart Association2000，，22： | 3 |
| 9 | Application of highwall mining system in weak geological condition显示文摘 | Takashi Sasaoka Tri Karian Akihiro Hamanaka Hideki Shimada Kikuo Matsui | 2016 | International Journal of Coal Science & Technology2016，3，3： | 3 |
| 10 | Effect of Application of Pipe Roof Method by Using Pipe Jacking on Behavior of Surrounding Soil显示文摘 | Hideki Shimada Akihiro Hamanakal Takashi Sasaoka Kikuo Matsui Toru Sato | 2013 | Journal of Physical Science and Application2013，3，6： | 2 |
| 11 | Indirect inguinal hernia containing portosystemic shunt vessel: A case report显示文摘BACKGROUND Inguinal hernia repair is one of the most common general surgical operations worldwide.We present a case of indirect inguinal hernia containing an expanded portosystemic shunt vessel.CASE SUMMARY We report a 72-year-old man who had a 4 cm×4 cm swelling in the right inguinal region,which disappeared with light manual pressure.Abdominal-pelvic computed tomography(CT)revealed a right inguinal hernia containing an expanded portosystemic shunt vessel,which had been noted for 7 years due to liver cirrhosis.We performed Lichtenstein’s herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ring.Then,we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the abdomen.The hernia sac was returned as well.We encountered no intraoperative complications.After discharge,groin seroma requiring puncture at the outpatient clinic was observed.CONCLUSION If an inguinal hernia patient has portal hypertension,ultrasound should be used to determine the contents of the hernia.When atypical vessels are visualized,they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair. | Masahiro Yura Kikuo Yo Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki AkiraHirata Kiminori Takano Kumiko Hongo Kimiyasu Yoneyama Motohito Nakagawa | 2021 | World Journal of Clinical Cases2021，9，2： | 2 |
| 12 | Metformin Inhibits Cytokine-Induced Nuclear Factor κB Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells显示文摘 | Yoshiyuki Hattori Kunihiro Suzuki Sachiko Hattori Kikuo Kasai | 2006 | Hypertension2006，，6： | 2 |
| 13 | Characteristics and prognosis of gastric cancer in young patients显示文摘 | Taro Isobe Kousuke Hashimoto Junya Kizaki Motoshi Miyagi Keishiro Aoyagi Kikuo Koufuji Kazuo Shirouzu | 2013 | Oncology Reports2013，，1： | 2 |
| 14 | Study on control of rock fragmentation at limestone quarry显示文摘The size distribution of a muck pile depends not on only the blasting standard but also on the mechanical properties,joint system,and crack density of the rock mass. As,the cracks in the rock masses are especially heavily developed at the limestone quar- ries in Japan,they,along with the joints,have a large impact on the effects of blasting, such as the size of the muck pile.Therefore,if the joint system and/or crack density in a rock mass can be determined and quantitatively evaluated,the blasting operation can be conducted more effectively,efficiently and safely.However,guidelines for designing ap- propriate blasting standards based on the rock mass conditions have not yet been scien- tifically developed.Therefore,blasting tests were conducted on different mines and faces, under different geological conditions and blasting standards,in order to determine the im- pacts of each factor on the effects of blasting.Summarized the results of a series of blast- ing tests and described the impacts of geological conditions on the size of the muck pile produced by blast. | SASAOKA Takashi SHIMADA Hideki SASAKI Takayuki ICHINOSE Masatomo MATSUI Kikuo | 2008 | Journal of Coal Science & Engineering(China)2008，14，3： | 2 |
| 15 | Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer显示文摘 | Kousuke Hashimoto Keishiro Aoyagi Taro Isobe Kikuo Kouhuji Kazuo Shirouzu | 2014 | Gastric Cancer2014，，1： | 2 |
| 16 | Determination of ultra-trace impurities in semiconduc-tor-grade waterand chemicals by inductively coupledplasma mass spectrometry following a concentration stepby boiling with mannitol显示文摘 | Kikuo Takeda Satoru Watanabe Hideo Naka | 1998 | Analytica Chimica Acta1998，，377： | 1 |
| 17 | Time frequeney analysis of dispersive wave by means of wavelets transform显示文摘 | Kikuo Kishimoto Hirotsugu Inoue | 1995 | Journal of Applied Mechanics1995，52，3： | 1 |
| 18 | Product variety optimization under modular architecture显示文摘 | Kikuo Fujita | 2002 | Computer-Aided Design2002，34，12： | 1 |
| 19 | Real-time nonintrusive monitoring and prediction driver fatigue显示文摘 | JI Qiang ZHU Zhiwei Kikuo Fujimura | 2004 | IEEE Trans on VehicularTechnology2004，53，4： | 1 |
| 20 | Propagating Mode in the Photonic Gap of 1D Resonant Bragg Reflector 显示文摘 | Kikuo Cho Takahiko Hirai Tomoe Ikawa | 2002 | Journal of Luminescence2002，100，14： | 1 |
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