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| 1 | Roles of TGF-β family signaling in stem cell renewal and differentiation显示文摘转变生长因素(TGF )- 尾 s 和他们的家庭成员,包括骨头形态基因的蛋白质(BMP ) ,节并且 activins,在各种各样的器官,干细胞在起重要作用的发展和维护被含有。干细胞被他们自我更新的能力描绘并且区分了特别纸巾的房间产生,并且被分类进胚胎、体的干细胞。胚胎的茎(ES ) 房间自我更新无止境地并且贡献所有三主要细菌层的衍生物。相反,体的干细胞,能在各种各样的成年机关被识别,在大多数情况中为自强和区别展出有限能力。ES 房间和体的干细胞的多系区别能力为基因、恶意、退化的疾病为房间代替治疗打开了可能性。以便为治疗学的应用利用干细胞,理解调整干细胞的自强和区别的外来、内在的因素是必要的。更最近,导致了 pluripotent 茎(iPS ) 细胞从经由四个抄写因素的宫外的表示类似于 ES 细胞的老鼠和人的成纤维细胞被产生了。iPS 房间可以在再生药有一个优点,自从他们克服 immunogenicity 和 ES 房间的道德的争吵。而且,最近的研究在癌症,包括的白血病, glioma,和乳癌的各种各样的类型的形成和前进期间加亮癌症干细胞的参与。这里,我们在 ES 房间,体的干细胞,和癌症干细胞的维护和区别说明 TGF- 尾家庭成员的角色。 | Tetsuro Watabe Kohei Miyazono | 2009 | Cell Research2009，19，1： | 50 |
| 2 | Intracellular and extracellular TGF-β signaling in cancer: some recent topics显示文摘 | Kohei Miyazono Yoko Katsuno Daizo Koinuma Shogo Ehata Masato Morikawa | 2018 | Frontiers of Medicine2018，12，4： | 16 |
| 3 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 4 | TGF-β signalling from cell membrane to nucleus through Smad proteins显示文摘 | Heldin CH Miyazono K ten Dijke P | 1997 | Nature1997，390，6659： | 2 |
| 5 | Molecular detection of circulating cancer cells during surgery in patients with biliary-pancreatic cancer显示文摘 | Futoshi Miyazono Sonshin Takao Shoji Natsugoe Keiichirou Uchikura Fumio Kijima Kuniaki Aridome Hiroyuki Shinchi Takashi Aikou | 1999 | The American Journal of Surgery1999，，6： | 2 |
| 6 | TGF-βsignaling from celhnembrane to nueleus through SMAD proteins 显示文摘 | Heldin CH Miyazono K Dijke PT | 1997 | Nature1997，390，6659： | 1 |
| 7 | Surgical maneuversenhance molecular detection of circulating tumor cells during gas-tric cancer surgery显示文摘 | Miyazono F Natsugoe S Takao S | 2001 | Ann Surg2001，233，2： | 1 |
| 8 | Use of the stomach as an esophageal substitute显示文摘 | Akiyama H Miyazono H Tsurumaru M | 1978 | Ann Surg1978，188，5： | 1 |
| 9 | TGFbeta signalling: a complex web in cancer progression显示文摘 | Ikushima H Miyazono K | 2010 | Nat Rev Cancer2010，10，6： | 1 |
| 10 | Infiltration of antitumor immunocytes into the sentinel node in gastric cancer显示文摘 | Sumiya Ishigami M.D. Shoji Natsugoe M.D. Yoshikazu Uenosono M.D. Yoichi Hata M.D. Aikihiro Nakajo M.D. Futoshi Miyazono M.D. Masataka Matsumoto M.D. Shuichi Hokita M.D. Takashi Aikou M.D | 2003 | Journal of Gastrointestinal Surgery2003，，6： | 1 |
| 11 | Extracellular fibrillar structure of latent TGF beta binding protein-l: role in TGF beta-dependent endothelial-mesenehymal transformation during endocardial cushion tissue formation in mouse embryonic heart 显示文摘 | NAKAJIMA Y MIYAZONO K KATO M | 1997 | J Cell Biol1997，136，1： | 1 |
| 12 | TGF-beta signaling from cell membrane to nucleus through SMAD proteins显示文摘 | Heldin CH Miyazono K ten Dijke P | 1997 | Nature1997，390，6659： | 1 |
| 13 | Two surgical cases of internal carotid-ophthalmic artery aneurysms:special refer ence to the usefulness of three-dimensional CT angiography显示文摘 | Kawashima M Matsushima T Miyazono M | 2002 | Neurol Res2002，24，8： | 1 |
| 14 | TGF-beta/SMAD signaling and its involvement in tumor progression显示文摘 | Miyazono K | 2000 | Biol Pharm Bull2000，23，3： | 1 |
| 15 | Identification of an- giogenic activity and the cloning and expres-sion of platelet-derived endothelial-cell growth factor 显示文摘 | Ishikawa F Miyazono K Hellman U | 2009 | Nature2009，338，15： | 1 |
| 16 | Chromosomal localization of three human genes encoding bone morphogenetic protein receptors显示文摘 | Anna-Karin ?str?m Donald Jin Takeshi Imamura Eva R?ijer Bradley Rosenzweig Kohei Miyazono Peter ten Dijke G?ran Stenman | 1999 | Mammalian Genome1999，，3： | 1 |
| 17 | Regulation of TGF-beta sig- naling and its roles in progression of tumors 显示文摘 | Miyazono K Suzuki H Imamura T | 2003 | Cancer Sci2003，94，3： | 1 |
| 18 | IntranasalAdministration of Rotenone in Mice Attenuated OlfactoryFunctions through the Lesion of Dopaminergic Neurons in theOlfactory Bulb显示文摘 | SASAJIMA H MIYAZONO S NOGUCHI T | 2015 | Neurotoxicology2015，51，： | 1 |
| 19 | TGF-beta/SMAD signaling and its involvement in tumor progression显示文摘 | Miyazono K | 2000 | Biol Pharm Bull2000，23，： | 1 |
| 20 | TGF-beta signaling by Smad proteins显示文摘 | Miyazono K ten-Dijke P Heldin C H | 2000 | Adv Immunol2000，75，： | 1 |
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